Portfolio Holdings and weightings as of 7:00 AM ET 02/18/2022

Symbol Company Name Weight Identifier Shares Held

UNH UNITEDHEALTH GROUP INC COMMON STOCK USD.01 9.05% 91324P102 6,422,291
JNJ JOHNSON + JOHNSON COMMON STOCK USD1.0 8.88% 478160104 17,951,295
PFE PFIZER INC COMMON STOCK USD.05 5.61% 717081103 38,267,666
ABBV ABBVIE INC COMMON STOCK USD.01 5.24% 00287Y109 12,061,252
ABT ABBOTT LABORATORIES COMMON STOCK 4.36% 002824100 12,057,660
TMO THERMO FISHER SCIENTIFIC INC COMMON STOCK USD1.0 4.35% 883556102 2,685,198
MRK MERCK + CO. INC. COMMON STOCK USD.5 3.94% 58933Y105 17,224,016
LLY ELI LILLY + CO COMMON STOCK 3.91% 532457108 5,414,024
DHR DANAHER CORP COMMON STOCK USD.01 3.50% 235851102 4,336,566
BMY BRISTOL MYERS SQUIBB CO COMMON STOCK USD.1 3.06% 110122108 15,135,580
MDT MEDTRONIC PLC COMMON STOCK USD.1 2.79% G5960L103 9,172,684
CVS CVS HEALTH CORP COMMON STOCK USD.01 2.76% 126650100 9,006,331
AMGN AMGEN INC COMMON STOCK USD.0001 2.55% 031162100 3,840,863
ANTM ANTHEM INC COMMON STOCK USD.01 2.24% 036752103 1,655,135
ISRG INTUITIVE SURGICAL INC COMMON STOCK USD.001 2.07% 46120E602 2,434,647
ZTS ZOETIS INC COMMON STOCK USD.01 1.87% 98978V103 3,226,202
SYK STRYKER CORP COMMON STOCK USD.1 1.73% 863667101 2,290,568
GILD GILEAD SCIENCES INC COMMON STOCK USD.001 1.57% 375558103 8,557,456
BDX BECTON DICKINSON AND CO COMMON STOCK USD1.0 1.56% 075887109 1,960,028
CI CIGNA CORP COMMON STOCK USD.01 1.54% 125523100 2,259,854
EW EDWARDS LIFESCIENCES CORP COMMON STOCK USD1.0 1.36% 28176E108 4,251,703
REGN REGENERON PHARMACEUTICALS COMMON STOCK USD.001 1.35% 75886F107 720,875
BSX BOSTON SCIENTIFIC CORP COMMON STOCK USD.01 1.25% 101137107 9,718,182
HCA HCA HEALTHCARE INC COMMON STOCK USD.01 1.23% 40412C101 1,633,186
VRTX VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01 1.21% 92532F100 1,733,759
HUM HUMANA INC COMMON STOCK USD.1666666 1.12% 444859102 877,070
MRNA MODERNA INC COMMON STOCK USD.0001 1.05% 60770K107 2,405,256
ILMN ILLUMINA INC COMMON STOCK USD.01 1.01% 452327109 1,065,707
CNC CENTENE CORP COMMON STOCK USD.001 0.99% 15135B101 3,974,873
IQV IQVIA HOLDINGS INC COMMON STOCK USD.01 0.88% 46266C105 1,302,666
IDXX IDEXX LABORATORIES INC COMMON STOCK USD.1 0.85% 45168D104 578,072
MCK MCKESSON CORP COMMON STOCK USD.01 0.85% 58155Q103 1,041,186
BAX BAXTER INTERNATIONAL INC COMMON STOCK USD1.0 0.85% 071813109 3,408,244
A AGILENT TECHNOLOGIES INC COMMON STOCK USD.01 0.81% 00846U101 2,064,288
DXCM DEXCOM INC COMMON STOCK USD.001 0.77% 252131107 660,311
ALGN ALIGN TECHNOLOGY INC COMMON STOCK USD.0001 0.75% 016255101 500,018
RMD RESMED INC COMMON STOCK USD.004 0.70% 761152107 991,961
MTD METTLER TOLEDO INTERNATIONAL COMMON STOCK USD.01 0.67% 592688105 156,673
BIIB BIOGEN INC COMMON STOCK USD.0005 0.63% 09062X103 1,001,678
WST WEST PHARMACEUTICAL SERVICES COMMON STOCK USD.25 0.59% 955306105 504,794
CERN CERNER CORP COMMON STOCK USD.01 0.55% 156782104 2,014,824
LH LABORATORY CRP OF AMER HLDGS COMMON STOCK USD.1 0.51% 50540R409 652,634
ZBH ZIMMER BIOMET HOLDINGS INC COMMON STOCK USD.01 0.51% 98956P102 1,425,812
PKI PERKINELMER INC COMMON STOCK USD1.0 0.46% 714046109 860,598
STE STERIS PLC COMMON STOCK USD75.0 0.46% G8473T100 680,023
ABC AMERISOURCEBERGEN CORP COMMON STOCK USD.01 0.43% 03073E105 1,021,103
COO COOPER COS INC/THE COMMON STOCK USD.1 0.39% 216648402 335,808
WAT WATERS CORP COMMON STOCK USD.01 0.39% 941848103 418,198
VTRS VIATRIS INC COMMON STOCK 0.37% 92556V106 8,243,854
HOLX HOLOGIC INC COMMON STOCK USD.01 0.36% 436440101 1,727,982
CTLT CATALENT INC COMMON STOCK USD.01 0.34% 148806102 1,161,445
TECH BIO TECHNE CORP COMMON STOCK USD.01 0.32% 09073M104 264,985
DGX QUEST DIAGNOSTICS INC COMMON STOCK USD.01 0.32% 74834L100 832,999
CAH CARDINAL HEALTH INC COMMON STOCK 0.31% 14149Y108 1,921,419
TFX TELEFLEX INC COMMON STOCK USD1.0 0.31% 879369106 320,554
CRL CHARLES RIVER LABORATORIES COMMON STOCK USD.01 0.30% 159864107 343,937
ABMD ABIOMED INC COMMON STOCK USD.01 0.29% 003654100 310,545
BIO BIO RAD LABORATORIES A COMMON STOCK USD.0001 0.26% 090572207 146,420
INCY INCYTE CORP COMMON STOCK USD.001 0.26% 45337C102 1,281,359
XRAY DENTSPLY SIRONA INC COMMON STOCK USD.01 0.25% 24906P109 1,496,213
HSIC HENRY SCHEIN INC COMMON STOCK USD.01 0.24% 806407102 952,003
STATE STREET INSTITUTIONAL LIQ STATE ST INST LIQ RES PREM 0.21% 964WKM905 69,539,579
UHS UNIVERSAL HEALTH SERVICES B COMMON STOCK USD.01 0.20% 913903100 498,596
OGN ORGANON + CO COMMON STOCK USD.01 0.19% 68622V106 1,734,246
DVA DAVITA INC COMMON STOCK USD.001 0.16% 23918K108 444,796
US DOLLAR 0.00% 999USDZ92 1,652