ANDHERI / BORIVALI / DADAR / CHEMBUR / THANE / NERUL / KHARGHAR / POWAI

TOPIC: Principles of Inheritance and Variation

1. Pick out the CORRECT statements.

a. Haemophilia is a sex-linked recessive character
b. Down's syndrome is due to aneuploidy
c. Phenylketonuria is an autosomal recessive gene disorder
d. Sickle cell anaemia is an X-linked recessive gene disorder 
(1) a, b, c correct (2) a, c, d correct  (3) a, b,d correct  (4) a, b, c, d correct

2. If 75% of the offspring show dominant character, the parents are

(1) both hybrids (2) one dominant and one recessive
(3) both recessive (4) both dominant

3. Given below is a pedigree chart with symbols for trait in humans 

The trait of the above pedigree chart is

(1) Recessive Y-linked  (2) Recessive X-linked 
(3) Dominant Y-linked  (4) Autosomal dominant

4. A family of five daughters is expecting their sixth issue. The chance of its being a son is
(1) Zero  (2) 25%  (3) 50% (4) 100%

5. Distance between the genes a, b, c and d in map units is a-d = 3.5; b-c = 1; a-b=6; c-d=1.5 and a-c=5.
Find out the sequence of the genes
(1) a d c b (2) a c d b  (3) a b c d  (4) a c b d

6. A chromosome with sub-terminal centromere is

(1) Acentric  (2) Acrocentric (3) Metacentric  (4) Telocentric

7. Due to nondisjunction of chromosome during spermatogenesis some sperms carry both sex
chromosomes (22A + XY) while others do not carry any sex chromosome (22A + O). If these
sperms fertilize normal eggs (22A + X), what type of genetic disorders appear among the offspring
(1) Turner's syndrome and Kilinefelter's syndrome
(2) Down's syndrome and Kilinefelter's syndrome 
(3) Down's syndrome andTurner's syndrome 
(4) Down's syndrome and Cri-du-chat syndrome

8. Mendel failed to get linkage because

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 (1) genes of seven types of traits selected by him were located on four different chromosomes and
behaved independently
(2) genes selected by him were discrete and stable
(3) genes selected by him were located on seven non homologous chromosomes
(4) pea plant does not show linkage

9. Match the columns

Column I Column II
a. Monoploidy 1. 2n-1
b. Monosomy 2. 2n+1
c. Nullisomy 3. 2n+2
d. Trisomy 4. 2n-2
e. Tetrasomy 5. n
6. 3n

(1) a - 6, b - 5, c -3, d - 4, e - 2  (2) a - 5, b - 2, c -4, d - 1, e - 3 

(3) a - 5, b - 1, c -4, d - 2, e – 3 (4) a - 1, b - 5, c -3, d - 2, e – 4

10. In Mendelian dihybrid cross, how many individuals are homozygous recessive for one of the
character only in generation?
(1) 1/16 (2) 2/16 (3) 3/16 (4) 6/16

11. In Drosophila, white eye colour is recessive X-linked trait while red eye colour is dominant. A white
eyed female is crossed with red eyed male. The female off spring with red eye colour would be
(1) 100% (2) 50%  (3) 25%  (4) Zero

12. Sickle cell anaemia is due to transversion. This is due to

(1) instead of glutamic acid, valine comes at number 6th position in chain of Hb
(2) instead of valine, glutamic acid is inserted at number 6th position of -chain of Hb
(3) valine is inserted at number 6th position in chain of Hb
(4) glutamic acid is substituted by valine at number 6th position of -chain of Hb

13. Lack of independent assortment between two genes A and B would be due to
(1) Crossing over  (2) Linkage (3) Repulsion  (4) Recombination

14. Sex chromosomes of birds are

(1) ZZ – ZW (2) ZZ - WW  (3) XX - XY  (4) XO – XX

15. Drosophila is used in the study of genetics because

(1) it is hermophrodite
(2) generation period is 90-120 days
(3) a single mating can produce large number of flies
(4) all of the above

16. According to genic balance theory, Drosophila is metamale with value

(1) 1.5  (2) 0.67  (3) 0.5  (4) 0.33

17. A lady carrier for haemophilia marries a normal man. Sons of such a lady would be
(1) 50% normal and 50% carrier (2) 50% normal and 50% haemophilic
(3) 25% carrier and 75% haemophilic  (4) 75% carrier and 25% haemophilic

18. Frequency of A allele is 0.6 and that of a allele is 0.4. What would be frequency of heterozygotes in
random mating population?
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 (1) 0.36  (2) 0.16  (3) 0.24  (4) 0.48

19. Mutations can be induced in bacteria by

(1) Growing different strains in same culture  (2) Starvation 
(3) Providing growth substances  (4) High energy radiation

20. Genes located on differential region of Y-chromosomes are called

(1) XY linked genes  (2) Holandric gene (3) Autosomal genes  (4) Mutant genes

21. Bateson used the terms coupling and repulsion for linkage and crossing over. Name the CORRECT
parental or coupling type along with its cross over or repulsion
(1) Coupling AABB, aabb; Repulsion AABB AAbb 
(2) Coupling AAbb, aaBB; Repulsion Aa Bb, aabb 
(3) Coupling aaBB, aabb; Repulsion AABB, aabb 
(4) Coupling AABB, aabb; Repulsion AAbb, aaBB

22. Plant A has 2n = 12 chromosomes while plant B has 2n = 16 chromosomes. An allotetraploid is

raised from them. What is its chromosome number
(1) 7  (2) 14  (3) 28 (4) 32

23. Queen Victoria of England was

(1) haemophiliac carrier  (2) Colour blind 
(3) AIDS patient  (4) Deaf

24. If one parent has blood group A and the other parent has blood group B, the offspring have which
blood group?
(1) AB (2) O (3) BO (4) A, B, AB, O

25. In Morgan's experiments on linkage, the percentage of white eyed miniature winged recombinants in
F2 generation is
(1) 1.3 (2) 62.8  (3) 37.2 (4) 73.2

26. Diagrammatic representation of chromosomes is

(1) Karyotype  (2) Idiogram  (3) Chromosome map  (4) Phenogram

27. Alleles of different genes found on same chromosome may separate due to
(1) Epistasis   (2) Crossing over
(3) Continuous variations   (4) Pleiotropy

28. A normal couple has seven children (2 daughter and 5 sons). Three of the sons suffer from a
hereditary disorder but none of the daughters is affected. Which is the inheritance type?
(1) Sex-limited (2) Autosomal dominant 
(3) Sex-linked dominant  (4) Sex-linked recessive

29. Shape of chromosomes is determined by position of

(1) Centrosome  (2) Centromere (3) Telomere  (4) Micromere

30. The male has a mutation in his mitochondria. During segregation, the mutation is found in
(1) None of the progeny (2) One third of progeny 
(3) Half of progeny  (4) Whole of progeny

31. Select the INCORRECT statement from the following

(1) Baldness is an X-linked recessive trait.
(2) Linkage is an exception to the principle of independent assortment. 

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 (3) Phenylketonuria is autosomal recessive trait. 
(4) Multiples alleles are found in a population.

32. A recessive mutation is

(1) Not expressed 
(2) Rarely expressed 
(3) Expressed only in homozygous and hemizygous states
(4) Expressed only in hetrozygous state

33. Match the coloumns:

Column I
1 Down’s syndrome
2 Cri-du-chat syndrome
3 Klinefelter’s syndrome
4 Turner’s syndrome
Column II
P An additional sex chromosome
Q Loss of a part of chromosome
R Absence of sex chromosome
S Presence of an extra chromosome
T Presence of two extra chromosome

(1) 1 - S, 2 - Q, 3 - P, 4 – R (2) 1 - T, 2 - S, 3 - P, 4 - Q
(3) 1 - S, 2 - Q, 3 - T, 4 - R (4) 1 - S, 2 - Q, 3 - R, 4 - P

34. In breeding experiments, emasculation is performed

(1) in bisexual flowers produced by plant that is used as female parent
(2) in neuter flowers
(3) in bisexual flowers produced by plant that is used as male parent
(4) in pistillate flowers

35. In four O’ clock plant, ____ cross will yield seeds, which when sown can yield red, white, pink
flowers?
(1) RR rr (2) RR Rr (3) Rr rr (4) Rr Rr

36. 45+X0 is the genetic make up of ______

(1) Down’s syndrome (2) Haemophilia
(3) Klinetelter’ssyndarn (4) Turner’s syndrome

37. A cross in between the dominant phenotype with the recessive parent in order to check its genotype
is called
(1) test cross (2) out cross (3) monohybrid cross (4) dihybrid cross

38. Which one of the following conditions CORRECTLY describes the manner of determining the sex in
the given example?
(1) Homozygous sex chromosomes (XX) produce male in Drosophila
(2) Homozygous sex chromosomes (ZZ) determine female sex in birds
(3) XO type of sex chromosomes determine male sex in grasshopper
(4) Homozygous sex chromosomes (XX) produce male in honey bees.

39. Find out total number of Mendelian disorder from the following:
Cystic Fibrosis, Klinefelter’s syndrome, Haemophilia, Down’s syndrome, Sickle cell anaemia,
Colorblindness, Turner’s syndrome, Thalesemia, Phenyllketonuria
(1) 4 (2) 5 (3) 6 (4) 3
40. A woman (whose father is colour blind but mother is normal) marries a haemophilic man with
hypertrichosis. What percentage of progeny will show genotypically any two of the traits out of the
three mentioned above at a given time?
(1) 0 % (2) 25 % (3) 50 % (4) 75 %

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41. If a negro marries a white skin female, the mulattoes are born. If such mulattoes intermarry, progeny
will show a gradual gradation of skin colour in ratio of
(1) 9 : 3 : 3 : 1 (2) 1 : 4 : 6 : 4 : 1
(3) 1 : 4 : 6 : 15 : 20 : 15 : 6 : 4 : 1 (4) 1 : 6 : 15 : 20 : 15 : 6 : 1

42. Given pedigree shows inheritance of autosomal recessive gene. What is the genotype of given
parents?

(1) AA, aa (2) Aa, AA (3) aa, aa (4) Aa, Aa

43. Individuals homozygous for cd genes were crossed with wild type ++. The dihybrid thus produced
was test crossed, it produced progeny in the following ratio ++ 900; +d115; cd 880; c + 105.
(1) 47 units (2) 88 units (3) 11 units (4) 5.75 units

44. How many different types of genetically different gametes will be produced by a heterozygous plant
having the genotype AABbCc?
(1) Two (2) Four (3) Six (4) Nine

45. Match the following

Column - I Column - II
A. Dominant epistasis i. 9:7
B. Complementory genes ii. 12:3:1
C. Polymeric genes iii. 9:6:1
D. Collaborative genes iv. 9:3:3:1
v. 9:3:4
(1) A - v; B - iii; C - ii; D - iv (2) A - ii; B - i; C - iii, D - iv
(3) A - iv, B - ii, C - i, D - iii (4) A - i; B - ii; C - iii, D - v

ANDHERI / BORIVALI / DADAR / CHEMBUR / THANE / NERUL / KHARGHAR / POWAI

TWT – (NCERT) - TOPIC: Principles of Inheritance and Variation - (ANSWER KEY)
CENTERS: MUMBAI / DELHI / AKOLA / LUCKNOW / NAGPUR / NASHIK / PUNE / GOA / BOKARO / DUBAI # 5
 1. (1) 2. (1) 3. (4) 4. (3) 5. (1)
6. (2) 7. (1) 8. (1) 9. (3) 10. (4)
11. (1) 12. (1) 13. (2) 14. (1) 15. (3)
16. (4) 17. (2) 18. (4) 19. (4) 20. (2)
21. (4) 22. (3) 23. (1) 24. (4) 25. (3)
26. (1) 27. (2) 28. (4) 29. (2) 30. (1)
31. (1) 32. (3) 33. (1) 34. (1) 35. (4)
36. (4) 37. (1) 38. (3) 39. (3) 40. (3)
41. (4) 42. (1) 43. (3) 44. (2) 45. (2)

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