RAJIV GANDHI GOVT.

POST GRADUATE AYURVEDIC COLLEGE,

PAPROLA DISTT. KANGRA (H.P.) 176115

SYNOPSIS FOR
PROPOSED THESIS WORK FOR THE DEGREE OF AYURVEDA VACHASPATI
M.D. (Ayu.) DRAVYAGUNA

TITLE
“A Pharmacognostical study on Shati (Hedychium spicatum Buch. Ham. ex. Smith)
and Karchura (Curcuma zedoaria Rosc.) for its identification and to evaluate the
clinical efficacy of Karchura (Curcuma zedoaria Rosc.) in Tamaka Shwasa.”

Research Scholar
Dr. Shefali Rana
B.A.M.S.
(Dayanand Ayurvedic College & Hospital, Jalandhar, Punjab)
Guide
Dr. Navneet Sharma
M.D. (Ayu.)
Reader
P.G. Deptt. Of Dravyaguna
R.G.G.P.G. Ayurvedic College & Hospital, Paprola, Kangra (H.P.) 176115

Co-Guide
Dr. Rashmi Srivastava

M.D. (Ayu.), Ph.D.

Reader
P.G. Deptt. Of Dravyaguna
R.G.G.P.G. Ayurvedic College & Hospital, Paprola, Kangra (H.P.) 176115

Place of Study: P.G. Deptt. Of Dravyaguna,

R. G. G. P. G. Ayurvedic College & Hospital, Paprola Distt.
Kangra (H.P.) 176115 Drug Testing Library (ISM), Joginder Nagar
Session : 2021-2024
From : Dr. Shefali Rana
M.D. (Ayu.) Dravyaguna, First year Research Scholar
R.G.G.P.G. Ayurvedic College & Hospital, Paprola, Kangra (H.P.)
176115
To
The Chairman
Departmental Research Committee
P. G. Deptt. Of Dravyaguna
R. G. Govt. P. G. Ayurvedic College & Hospital, Paprola, Kangra (H.P.)
176115

Subject: Application for registration of title of thesis for M.D (Ayu)

Dravayaguna, Final examination.

Respected Sir,

Kindly allow me to submit synopsis for registration of title for M.D.

(Ayu.) Dravyaguna, Final examination. Please find enclosed herewith synopsis of my
thesis work entitled “A Pharmacognostical study on Shati (Hedychium spicatum
Buch. Ham. ex. Smith) and Karchura (Curcuma zedoaria Rosc.) for its
identification and to evaluate the clinical efficacy of Karchura (Curcuma zedoaria
Rosc.) in Tamaka Shwasa.” This is the research work I propose to undertake during
second and third year of M.D. (Dravayaguna).

Thanking you,
Date……………. Yours sincerely,

Place: Paprola Dr. Shefali Rana

M.D. (Ayu.) Research Scholar
P. G. Deptt. Of Dravyaguna
R.G.G.P.G Ayurvedic College &
Hospital, Paprola, Dist. Kangra
(H.P)-176115
 CERTIFICATE OF SUPERVISION

This is to certify that the plan of the proposed research work entitled “A
Pharmacognostical study on Shati (Hedychium spicatum Buch. Ham. ex. Smith)
and Karchura (Curcuma zedoaria Rosc.) for its identification and to evaluate the
clinical efficacy of Karchura (Curcuma zedoaria Rosc.) in Tamaka Shwasa.” has
been prepared by Dr. Shefali Rana under our supervision and further research work
will also be carried out during M.D.(Ayu.) course under the guidance of the
undersigned.

Scholar Dr. Shefali Rana

_________________
M.D. (Ayu.) Research Scholar
P. G. Deptt. Of Dravyaguna
R.G.G.P.G. Ayurvedic College & Hospital,
Paprola, Distt. Kangra (H.P.) 176115

Guide Dr. Navneet Sharma ________________

M.D. (Ayu.)
Reader
P.G. Deptt. Of Dravyaguna
R.G.G.P.G. Ayurvedic College & Hospital,
Paprola, Distt. Kangra (H.P.) 176115

Co-Guide Dr. Rashmi Srivastava __________________

M.D. (Ayu.), Ph.D.
Reader, P.G. Deptt. Of Dravyaguna
R.G.G.P.G. Ayurvedic College & Hospital,
Paprola, Distt. Kangra (H.P.) 176115
 ETHICAL JUSTIFICATION
CERTIFICATE
TO WHOM IT MAY CONCERN

This is certified that clinical study namely “A Pharmacognostical study on Shati

(Hedychium spicatum Buch. Ham. ex. Smith) and Karchura (Curcuma zedoaria Rosc.)
for its identification and to evaluate the clinical efficacy of Karchura (Curcuma
zedoaria Rosc.) in Tamaka Shwasa.” being conducted in the P.G. Department Of
Dravyaguna under the supervision of Dr. Navneet Sharma is well defined as per texts
of Ayurveda and will not cause any inconvenience to the patient. The reference of the
drug under trial and there therapeutic indication under taken in the present clinical trial
are well explained in Ayurvedic literature.
The patient and the parents/guardian will be explained about the nature of
disease and clinical trial. They shall be explained the need of relevant investigation
required for diagnosis in the language they understand. They will also be explained
about the treatment modality they will receive and the duration of the treatment.
During this trial the patient will not be subjected to any additional procedure or
expenditure and the study will be conducted on only those patients who will give their
consent. The study is purely designed to create the evidence based efficacy of the trial
drug.

Supervisor Scholar

Dr. Navneet Sharma Dr. Shefali Rana

Date:
Place: R.G.G.P.G. Ayurvedic College & Hospital,
Paprola, Distt Kangra (H.P.) 176115
 FORMAT FOR REGISTRATION OF TITLE OF THESIS
FOR M.D. (AYU.) DRAVYAGUNA

1. a) Name of the candidate : Dr. Shefali Rana

b) Name of the course : M.D. (Ayu.) Dravyaguna
c) Year and month of registration : Feb 2021
d) Year and month of examination : Feb 2024
when due to appear

2. Title of proposed thesis : A Pharmacognostical study on Shati

(Hedychium spicatum Buch. Ham. ex. Smith) and Karchura (Curcuma zedoaria
Rosc.) for its identification and to evaluate the clinical efficacy of Karchura
(Curcuma zedoaria Rosc.) in Tamaka Shwasa.

3. Name of the Guide : Dr. Navneet Sharma

M.D. (Ayu.),
Reader
P.G. Deptt. Of Dravyaguna
R.G.G.P.G Ayu. College &
Hospital, Paprola, Distt Kangra
(H.P.) 176115

4. Name of the Co-Guide : Dr. Rashmi Srivastava

M.D. (Ayu.), Ph.D.
Reader
P.G. Deptt. Of Dravyaguna
R.G.G. P. G. Ayu. College, Paprola,
Distt Kangra (H.P.) 176115

5. a) Deptt. Where thesis work will : P.G. Deptt. Of Dravyaguna,

be carried out R.G.G.P.G. Ayu. College& Hospital,
Paprola , Distt Kangra (H.P.) 176115

b) Which other department of the : Ras Shastra & Bhaishajya Kalpana,

institute will cooperate in the Rog nidan evam Vikriti Vigyan and
proposed thesis Kayachikitsa

6. Any work pertaining to the proposed: No

work has been done earlier in this
institute
Brief resume of intended work

7. Introduction
 Ayurveda is traditional holistic healing system of Indian medicine which
depends on plant support to form major chunk of its medicines.

 The aim of Ayurvedic science is to maintain the health of healthy individual and
to cure the diseases of the patients, which can be achieved by use of Ayurvedic
herbs which offer a variety of health benefits, including improving physical and
mental health and keeping the mind, body and spirit in balance.

 This ever vibrant science of life ‘Ayurveda’ has bestowed us with innumerable
number of herbs which have great potential in managing various types of
ailments, some of which were considered impossible to treat by other fields of
medical sciences and have shown marvelous results.

 Because of above reason, Ayurvedic herbs have become very popular in last few
decades and gaining more interest of modern world.

7.1 Justification for the selection of drugs for the Pharmacognostical study :

 Shati (Hedychium spicatum Ham-ex-smith) also known as Kapurkachari is a

perennial tall stout herb with fleshy rhizomes, thick straight stem with broadly
lanceolate leaves. The rhizomes have a strong aromatic odor and bitter taste and
its extract has been reported to contain essential oil, starch, resins, organic acids,
glycosides, albumin and saccharides, which has been advocated for blood
purification and treatments of bronchitis, indigestion, eye disease and
inflammations and possess anti-asthmatic, hypoglycemic, vasodilator,
spasmolytic, hypotensive, cytotoxic and antimicrobial properties.

 Whereas Karchura (Curcuma zedoaria. Rosc) also known as white turmeric, is

also a perennial rhizomatous herb composed of an upright pseudo stem, a corm
and underground cylindrical branches or rhizomes and fleshy roots. From March
to April the axillary buds of the corm and apical buds of the third-order rhizomes
emerge above the ground as inflorescences. This basal flower spike, which grows
about 30 cm tall, appears just before the foliage. On the node closest to the flower
spike, a vegetative shoot always develops. No additional floral buds sprout but
more vegetative shoots develop. New branches start to develop on corms of
recently formed aerial shoots. By autumn, the above-ground foliage dies back.
Various parts of this plant are used in Ayurveda and other folk medicines for the
 treatment of different ailments such as diarrhea, cold, cough, cancer, flatulence,
dyspepsia etc. The species also possesses analgesic, anti-pyretic, anti-allergic,
hepato-protective properties and anti-inflammatory properties.

 Both the plants are Himalayan species belong to same family Zingiberaceae,
distributed wildly in Himachal Pradesh, Uttarakhand, Nepal and Sikkim and both
have Shwasahara Karma as per Ayurvedic classics but in comparison to each
other, Shati is well established Shwasahara drug.

 Because of same family, both plants share similar morphological characters that
create confusion in their identification and because of this confusion, both drugs
are used as substitute to each other in the market. Moreover there is no proper
authentication of both drugs. So with this purpose, a pharmacognostical study is
selected for their identification to standardize the authenticity of both drugs for
further use in future.

7.2 Justification for the selection of disease for the Clinical study :

 Life of Human beings mainly runs on three “B’s”. First BRAIN, second BEAT
and third last but not least BREATH i.e. Shwasan.

 Respiration is an important physiological process necessary for the existence of

life. In Ayurveda the functions of Prana Vayu is held responsible for the process
of respiration in human body. The channels or tracts (Srotas) in which Pranavayu
flows are called Pranavaha Srotas.

 Any disturbance in this process may lead to Shwasa Roga. Tamaka Shwasa is one
of the important disease of such disturbance of Pranvaha Srotasa. ‘Tamaka
Shwasa’ has two component words. The term Shwasa refers to both physiological
and pathological state of respiration and the word Tamaka indicates the specific
variety of the Shwasa Roga and emphasizes specific symptom ‘darkness in front
of eyes’ or ‘tiredness of eyes’ without much strenuous work to the organ.

 Thus the nomenclature ‘Tamaka Shwasa’ clearly indicates the disease where
difficult breathing associated with feeling of merging in darkness. It has the
predominance of Vata and Kapha Doshas and mentioned as Yapya Vyadhi i.e. a
disease of chronic nature in Charaka Samhita, while Sushruta considered it as
Krichchra Sadhya Vyadhi.
 Acharya Charaka quoted that “Shwasa & Hicca are two diseases, which are
much fatal to life amongst all other diseases” as mentioned below -

तस्मात् साधारणावेतौ मतौ परमदु र्जयौ। (च.चच.१७/९)

 This indicates the importance of need of Shwasa Chikitsa.

 As per various survey suggest that in Himachal Pradesh, diseases related to upper
respiratory tract like Kasa-Shwasa-Hicca has more prevalence as compare to
other diseases. This is either because Himachal Pradesh considered as Anupa
Desha (mountain climatic condition) where there is predominance of Kapha
Dosha, thereby people are more susceptible to diseases related to Kapha Dosha
or due to excessive use of tobacoo and smoking.

 Because of above mentioned reasons, Tamaka Shwasa is a very common disease

and it affects most of the population of this area.
 In current modern pathy, there is no satisfactory result for this. So keeping these
facts in mind, the present disease is being selected for study to provide a suitable
remedy for this problem and to revalidate the efficacy of Ayurvedic medicines
against modern pathy.

7.3 Justification for the selection of drug for the Clinical study :
 Our Acharyas have listed many herbs which have Shwasahara action. The
Shwasahara drugs include respiratory tonics and naturally occurring broncho-
dilators and immuno-modulators. Karchura (Curcuma zedoaria.Rosc) is one such
herbal drug, which acts as Shwasahara as mentioned in classics and it is
abundantly available in Himachal Pradesh and cost effective which may satisfy the
need of present day situation by acting as potent herbal bronchodilator but
clinically its efficacy on Tamaka Shwasa as Shwasahara drug, is still not popularly
known as compared to Shati. So with this perspective, the drug Karchura
(Curcuma zedoaria. Rosc) is selected to evaluate the clinical efficacy in Tamaka
Shwasa.
7.4 Aim and Objectives
 To review the classical and modern literature of Shati (Hedychium spicatum Buch.
Ham. ex. Smith) and Karchura (Curcuma zedoaria Rosc.).
 To carry out macroscopic and microscopic study on Shati (Hedychium spicatum
Buch. Ham. ex. Smith) and Karchura (Curcuma zedoaria Rosc.) for its
identification to standardize the trial drugs.
 To prepare standard quality medicine as per GMP & classical Ayurvedic texts.
 To review the literature of Tamaka Shwasa, as per classical references.
 To evaluate the effect of Karchura (Curcuma zedoaria Rosc.) in Tamaka Shwasa.

8. Review of literature
 A detailed review of Shati and Karchura will be done from Ayurvedic
literature, journals, internet and recent research works for its identification.
 Ayurvedic and modern literature will be reviewed thoroughly to know Tamaka
Shwasa in detail and its treatment, according to Ayurvedic therapeutics.

8.1 Previous work done on Karchura - Yes

 Vijay Kappathanwar, Roshi Mahajan , Paramjeet Puri , Rekha Sharma and
Shipra Sharma. “A research article on Evaluation of Shwasahara Effect of
Karchura (Curcuma zedoaria Rosc) with special reference to Bronchodilator
Action, published on 10/01/19, Int J Ayu Pharm Chem 2019 Vol. 10 Issue 1
page number - 346” - In this experimental study, the test drug Karchura in its
two different forms viz. Mula Churna and Mula Kashaya were taken, whereas
Churna form of the test drug Karchura yielded better results as compared to
Kashaya form.
8.2 Previous work done on the same topic in the institute - No
8.3 Previous work done on Karchura in the institute - NO

8.4 SELECTION OF DRUG FOR THE STUDY

 INTRODUCTION
 PLANT DESCRIPTION:
1. Name of Drug - Shati
2. Botanical Name - Hedychium spicatum Buch. Ham. ex. Smith
3. Family - Zingiberaceae

 PROPERTIES AND ACTIONS:

Rasa - Katu, Tikta, Kashaya

Guna - Laghu, Tikshana

Veerya - Ushna

Vipaka - Katu

Karma - Shwasahara, Kapha-Vatahara

Useful part - Rhizome

 PLANT DESCRIPTION:
4. Name of Drug - Karchura
5. Botanical Name - Curcuma zedoaria Rosc.
6. Family - Zingiberaceae

 PROPERTIES AND ACTIONS:

Rasa - Katu, Tikta

Guna - Laghu, Tikshana

Veerya - Ushna

Vipaka - Katu

Karma - Shwasahara, Kapha-Vatahara

Useful part - Rhizome

 (भा.प्र.कर्पूरादिवर्ू )

(च.सप.२७)

 On the basis of above references, the trial drug has been selected for present
research work.

9. Materials and method :

9.1 Source of data:

1. Literary source: All classical literature and latest information like website will
be reviewed and documented.

2. Source of plant: Plant will be identified authentically and collected from the
natural sources.

3. Pharmacognostical laboratory

4. Clinical study will be carried out in patients suffering from the Tamaka
Shwasa.

9.2 Method of collection of data:

 Collection of the drug: Shati and Karchura will be freshly collected, found in
mid hill zone of Distt. Kangra (H.P.).

 Pharmacognostical study: The drug will be identified and collected

authentically from the natural sources and will be taken for the detailed
macroscopic and microscopic study of trial drugs (Shati and Karchura).

 Formulation: Karchura Churna of raw drug to be prepared.

  Preparation of drug: The selected trial drug will be collected locally and after
proper verification by the experts of Deptt. Of Dravyaguna, Churna (powder
form) of the dried rhizomes will be prepared under the guidance of Deptt. Of
Rasa Shastra Evum Bhaishjya Kalpana in the college pharmacy.

 Clinical study: After preparation of the trial drug, clinical study will be done
on the patients presenting with symptomology of Tamaka Shwasa selected
from OPD and IPD of R. G. G. P. G. Ayurvedic College and Hospital, Paprola,
Distt. Kangra (H.P.), irrespective of caste and religion.

10. Protocol of research

 ICE Approval: The ethical clearance will be taken for the research from
Institutional Ethics Committee (IEC) before starting the study.

 Consent of patient: Awareness about the duration and nature of the trial and
written informed consent will be taken.

 Registration of the patients who fulfill the inclusion criteria.

 Investigation mentioned will be advised to the patient before and after the
treatment.

 Patient information sheet: The detail about the nature of disease, various
aspects of clinical study will be shared with the patients and their quires will be
addressed.
 Case Record Proforma: The detailed case record proforma will be prepared
for the assessment of the patient before treatment and after treatment.
 Data so available and deducted clinically will be statistically analyzed.

11. Protocol for clinical study

 Sample size and grouping of patients - Study will be conducted on 30
patients suffering from Tamaka Shwasa and assigned as single group.

 Criteria for selection of patients:

 Inclusion criteria -Patients fulfilling the following criteria will be included

in the trial-

a) Patients willing for trial

 b) Age - 16 - 70 years

c) Gender - Both Male and Female

d) Patients presenting with classical features of Tamaka Shwasa as mentioned

in Ayurvedic classics-

 Shwasa Kricchrata (Difficulty in breathing)

 Asino Labhate Soukhyam ( Relief on sitting posture)

 Kasa (Cough)

 Nistivanam (Phlegm)

 Ghurghurukam (Wheezing sound)

 Peenasa (Watery nasal discharge)

 Exclusion Criteria -

a) Patients not willing for trial.

b) Known case of any major chest pathology

c) Patient aged less than 16 yrs. and more than 70 yrs.

d) Asthma due to other systemic disorders, and other respiratory disorders.

e) Asthma in pregnancy.

f) Occupational Asthma.

g) Emergency condition of the patient, who requires oxygen inhalation.

 Dose of drug and Route of administration

o Orally, 1gm of Churna (powder) form twice daily.

o Duration of trial- 4 weeks

 Follow up

o There will be a follow up after 7, 14, 21 days during treatment and one after
completion of trial.

12.Criteria for assessment

 Effect of therapy will be assessed according to improvement in signs and
symptoms of Tamaka Shwasa.
  Depending upon subjective and objective parameter, assessment of response
will be made based on Gradation index as mentioned below, before and after
treatment -

Grading of assessment criteria

o Subjective criteria

 Shwasa Kricchrata Score

 No Shwasa Kricchrata. -0

 On excessive exercise, Shwasa Kricchrata - mild -1

 On moderate exercise, Shwasa Kricchrata - moderate -2

 On gentle exercise, Shwasa Kricchrata - severe

-3
 At rest, Shwasa Kricchrata - very severe
-4

 Frequency of Shwasa Vega

 No Vega during one month -0

 Frequency of Vegas once in a month -1

 Frequency of Vegas once in 2 weeks -2

 Frequency of Vegas once or more than once in a week -3

 Frequency of Vegas once or more than once in a day -4

 Asino Labhate Soukhyam

 Relief on lying position -0

 Sometime feels better on lying position -1

 Not able to continue lying position for long time -2

 Dyspnoea in lying position, only sitting position gives relief -3

 Neither lying position nor sitting position gives relief -4

 Kasa

 No cough -0

 Coughing for 2-5 min, Freq. 1-2 time/day without pain -1

 Coughing for >10 min, Freq. > 5-10 times/day without pain -2

 Coughing for >15 min, Freq. >5-10 times/day with pain -3

 Frequent coughing due to which patient becomes fatigued -4

 Nistivanam

 No Nistivanam -0

 Nistivanam white in color, not more than 2-5ml/day -1

 Nistivanam yellowish white in color, more than 20ml/day -2

 Nistivanam deep yellow in color, more than 50ml/day -3

 Nistivanam with blood stained -4

 Ghurghurukam

 No wheezing -0

 Wheezing only at early morning or during physical exertion -1

 Intermittent wheezing present only during attack -2

 Constant wheezing throughout the day. -3

 Constant wheezing along with other added respiratory sound -4

 Peenasa

 No Peenasa -0

 Peenasa during attack and subsided 1-2 days after asthma attack -1
  Peenasa during attack and persist for week after asthma attack -2

 Peenasa very often, without asthma attack -3

 Peenasa always persisting -4

o Objective criteria – It includes

 Respiration rate

RESPIRATORY RATE (b/m) GRADE

Respiratory rate 12-20/m 0
Respiratory rate 21-25/m 1
Respiratory rate 26-30/m 2
Respiratory rate 31-35/m 3
Respiratory rate > 35/m 4

13. Laboratory investigations

 Estimation of Hb%, TLC, DLC, ESR and FBS will be carried out for general
assessment of patients and exclusion of other pathologies. After treatment
investigation will be done in those cases where before treatment hematological
values are found abnormal.

 Absolute eosinophil count

 Chest X-Ray P.A. view

 Sputum for A.F.B.

 To rule out respiratory conditions or infections and confirm clinical

diagnosis.

14. Diagnosis criteria –

 The signs and symptoms of Tamaka Shwasa like Shwasa Kricchrata, Asino
Labhate Soukhyam, Kasa, Nistivanam, Ghurghurakam, Peenasa - mentioned in
Ayurvedic texts and objective laboratory investigations mentioned above, will
be the criteria for the diagnosis.
15. CRITERIA FOR OVER AL L EFFECT OF THERAPY:
 Patients will be assessed before and after the treatment for improvement in
symptoms on the basis of above said scoring pattern and percentage of
improvement will be calculated.

 Result : Final result based on clinical study, will be statistically evaluated and
categorized according to the following grades:

Complete 100% Relief in the Subjective and Objective

Remission Parameters.
Marked More than 75% Relief in the Subjective and Objective
Improvement Parameters.
Moderate 50% -74% Relief in the Subjective and Objective
Improvement Parameters.

Mild Improvement 25%-49% Relief in the Subjective and Objective

Parameters.
Unchanged Result below 25% considered as unchanged.
 Does the study requires any investigations or interventions to be conducted
on patients or other humans or animals? If so please describe:

Study design – A clinical observational study.

Study will be conduct on human only, no animal experimentation will be

conducted.

REQUIREMENTS

o Well established library

o Raw drug and other equipment’s for processing of drug

o GMP approved pharmacy

o Well-equipped laboratory

o Drug testing laboratory

o Latest national and international magazines and research journals

 This is expected that the findings obtained through this research trial will
certainly prove fruitful to enrich the present knowledge of subject.
 P.G. DEPARTMENT OF DRAVYAGUNA
R.G.G.P.G. Ayurvedic College & Hospital, Paprola (H.P.)
CONSENT FORM

Case Sr. No. -

Name of Patient -

Name of Research Scholar - Dr. Shefali Rana

Name of Guide - Dr. Navneet Sharma

I…………………………….. age………………yrs. R/o………………………. have

been informed adequately, about the study “A Pharmacognostical study on Shati
(Hedychium spicatum Buch. Ham. ex. Smith) and Karchura (Curcuma zedoaria
Rosc.) for its identification and to evaluate the clinical efficacy of Karchura (Curcuma
zedoaria Rosc.) in Tamaka Shwasa.” I have understood the information sheet for
above study i.e. purpose of clinical study, nature of trial and follow up including lab
investigations.
I have been given the opportunity to question Dr. Shefali Rana on all aspects of the
study. I hope to complete the study but I am also aware of my right to withdraw at any
time during the course of study without any reason.

I have been informed to my satisfaction about the trial and agree to take part in
clinical trial for a period of 4 weeks.

I will not make any claim for compensation for any hazardous effect if it occurs
during or after the treatment.

Name of patient with signature Name of witness with signature

I confirm that I have explained the nature, purpose and possible hazards of the above
mentioned study to Mr. /Mrs.………………………….

Date Signature of the Research Scholar

 P.G. DEPARTMENT OF DRAVYAGUNA
R.G.G.P.G. Ayurvedic College & Hospital, Paprola (H.P.)

Patient Information Sheet

Study title - “A Pharmacognostical study on Shati (Hedychium spicatum Buch. Ham.

ex. Smith) and Karchura (Curcuma zedoaria Rosc.) for its identification and to
evaluate the clinical efficacy of Karchura (Curcuma zedoaria Rosc.) in Tamaka
Shwasa.”

Invitation – As an ideal candidate for research study conducted by Dr. Shefali Rana
you are being invited to take part in it, but before starting the trial it is necessary to
know about the purpose and nature of trial. Read the following information carefully
and decide whether you will take part in it or not.

Purpose of the study – This is a research study being conducted by research scholar
Dr. Shefali Rana under the guidance of Dr. Navneet Sharma to prove the efficacy and
safety of Ayurvedic drug and assess the effect of the drug on Tamaka Shwasa.

Procedure of the trial – If you are agree to take part in this study, you will be given
Karchura Churna two times orally in 1gm dose for period of 4 weeks.

You have to undergo investigation before and after the trial for assessment.

Expected side effects - The trial drug as such involves no side effects but yet
individual specific variations may occur at any time during the course of clinical trial.

If you want to ask anything about the clinical trial, you are free to ask at any stage of
trial. A copy of the information sheet and signed consent form will also be given to
you.

All your information will be kept confidential and the result will be published in
leading medical journals so that other doctors get benefit from the result.

Contact for further information…………………..

Signature Date
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;g शोध MkW- uouhr शर्ाू ds र्ार्ूिशू न esa MkW- शैफाली राणा

}kjk शटी और कचचजर का
औषधीय अध्ययन द्वारा पहचान व कचचजर का तमक श्वास पर प्रभाव tkuus ds fy, fd;k tk
jgk gSA
fuea=.k
izLrqr vuqla/kku ds fy, mi;qDr ik= le>rs gq, vkidks शो/k gsrq iathdj.k ds
fy, ”kkfey fd;k tk jgk gSA ijarq ”kks/k izkjaHk djus ls iwoZ ;g vko”;d gS fd ”kks/k
dk m|s”; o ml ls lEcfU/kr iw.kZ tkudkjh izkIr dj ysaA jksxh lwpuk i= dk
/;kuiwoZd v/;;u dj ysa o rRi”pkr ”kks/k esa lfEefyr gksus ;k u gksus dk fu/kkZj.k
djsaA
;fn vki lgHkkfxrk ds fy, lger gSa rks 4 सप्ताह rd vkidks 1 xzke कचचजर dk
चचणज fnu esa nks ckj eq[k }kjk xzg.k djus ds fy, fn;k tk,xkA vkidks iqu % ijh{k.k gsrq
fpfdRlk dky esa 7 fnu ds varjky ij 1 ckj vkuk gksxkA
vkidks ijh{k.k ds iwoZ ,oa i”pkr lkekU; ”kkjhfjd ijh{k.k o jDr vkfn
iz;ksx”kkyh; ijh{k.k djokuk gksxkA
nq”izHkko
;|fi ”kks/k gsrq iz;qDr vkS‘k/k nq”izHkko jfgr gS fdUrq O;fDrxr foijhr izfrfdz;k
gks ldrh gS ftldh lwpuk rqjUr ”kks/kdrkZ dks nsAa
vkidh lwpuk,a xksiuh; j[kh tk,axhA fpfdRlk iz;ksx ds ifj.kke eq[; fpfdRlk
izi=ksa esa izdkf”kr fd, tk,axs rkfd vU; ”kks/kdrkZ ,oa fpfdRld bu ifj.kkeksa dk ykHk
mBk ldsAa

vU; lwpukvksa ds fy, lEidZ djsaA---------------------------

gLrk{kj fnukad