MCQs on IMMUNOLOGY

1. The immunoglobulins are differentiated and also named on the basis

A. Sedimentation coefficient like 7S, 19S etc.
B. Heat stability
C. Molecular weight
D. Electrophilic mobility
2. All immunoglobulins contain
A. 2 L chains and 2 H chains
B. 3 L chains
C. 4 L chains
D. 4 L chains
3. An immunoglobulins molecule always contains
A. 2 or 2 chains
B. 2 and 2 type of chains
C. 1 and 3 type of chains
D. 3 and 1 type of chains
4. The number of hypervariable region in H chain is
A. 4
B. 3
C. 2
D. 1
5. The immunoglobulins are classified on the basis of
A. Heavy chains
B. Light chains
C. Carbohydrate content
D. Electrophoretic mobility
6. The number of types of H chains identified in human is
A. 5
B. 4
C. 3
D. 2
7. The number of hypervariable regions in L chain is
A. 4
B. 3
C. 2
D. 1
8. The number of hypervariable regions in H chain is
A. 1
B. 2
C. 3
D. 4

9. Type H chain is present in

A. Ig M
B. Ig A
C. Ig D
 D. Ig G
10. Type H chain is present in
A. Ig A
B. Ig D
C. Ig M
D. Ig E
11. A ‘J’ chain is present in
A. Ig G
B. Ig D
C. Ig M
D. Ig E
12. Type H chain is present in
A. Ig M
B. Ig D
C. Ig A
D. Ig E
13. Type H chain is present in
A. Ig A
B. Ig M
C. Ig D
D. Ig G
14. A pentamer immunoglobulin is
A. Ig E
B. Ig A
C. Ig G
D. Ig M
15. A secretory protein T chain ( T protein ) is present in
A. Ig A
B. Ig M
C. Ig D
D. Ig E
16. The smallest immunoglobulin is
A. Ig A
B. Ig D
C. Ig E
D. Ig G
17. The portion of the immunoglobulin molecule that binds the specific antigen is
formed by
A. Variable regions of H and L chains
B. Constant region of L chain
C. Constant region of H chain
D. Hinge region
18. Hinge region, the region of Ig molecule which is flexible and more exposed to
enzymes is the
A. Region between second and third constant regions of H chain ( C H 2 and C H 3)
B. Region between first and second constant regions of H chain (domains C H 1 and
C H 2)
 C. Variable regions of L chains
D. Variable regions of H chains
19. The class specific function of the different immunoglobin molecules is constituted by
A. Constant region of H chain
B. Variable region of H chain
C. Variable region of L chain
D. Constant region particularly C H 2 and C H 3 chain
20. Most abundant Ig subclass in the serum is
A. Ig G4
B. Ig G3
C. Ig G2
D. Ig G1
21. The number of sub classes of Ig G is
A. 8
B. 4
C. 3
D. 2
22. The immunoglobulin which can cross the placenta is
A. Ig D
B. Ig G
C. Ig M
D. Ig A
23. The normal serum level of Ig G is
A. 1200 mg %
B. 300 mg %
C. 200 mg%
D. 500 mg %
24. Most heat labile immunoglobulin is
A. Ig D
B. Ig M
C. Ig A
D. Ig G
25. The half life of Ig G is
A. 2-8 days
B. 19-24 days
C. 1-4 days
D. 6 days
26. The immunoglobulin possessing lowest concentration of carbohydrate
A. Ig G
B. Ig M
C. Ig E
D. Ig A
27. The normal serum level of Ig D is
A. 1 mg %
B. 5 mg %
C. 3 mg %
D. 2 mg %
28. The half life of Ig D is
A. 20 – 24 days
B. 10-15 days
C. 2-8 days
D. 1 day
29. The immunoglobulin possessing highest concentration of carbohydrate is
A. Ig D
B. Ig M
C. Ig A
D. Ig G

30. The half life of Ig M is

A. 8 days
B. 5 days
C. 4 days
D. 2 days
31. The immunoglobulin having least concentration in serum is
A. Ig D
B. Ig M
C. Ig E
D. Ig A
32. The half life of Ig E protein is
A. 20 days
B. 10 days
C. 2-8 days
D. 1-6 days
33. The immunoglobulin having highest molecular weight is
A. Ig A
B. Ig E
C. Ig M
D. Ig G
34. The immunoglobulin having highest sedimentation coefficient is
A. Ig G
B. Ig D
C. Ig M
D. Ig A
35. The carbohydrate content of Ig M is about
A. 10.2%
B. 8.0%
C. 6.4%
D. 2.8%
36. The immunoglobulin associated with reaginic antibody is
A. Ig E
B. Ig D
C. Ig M
D. Ig A
37. The normal serum level of Ig M is
 A. 50 mg %
B. 200 mg %
C. 120 mg %
D. 300 mg %
38. The immunoglobulin which provides highest antiviral activity is
A. Ig G
B. Ig A
C. Ig E
D. Ig D
39. The half life of Ig A is
A. 12-20 days
B. 5-10 days
C. 2-4 days
D. 6 days
40. Proantigen
A. Causes delayed type hypersensitivity
B. Induces antibody formation
C. Both of above
D. None of above
41. The normal serum level of Ig A is
A. 400 mg%
B. 300 mg %
C. 200 mg %
D. 100 mg %
42. The smallest unit of antigenicity is
A. Crypt antigen
B. Epitope
C. Immunoglobulin
D. Antigen
43. An example of isoantigen is
A. HL – A ( Human leukocyte antigen )
B. Human Erythrocyte antigen
C. H-2 in mice and AgB in rats
D. All of the above
44. An example of “self antigen “ is
A. AgB in rats
B. HL – A
C. RBC’s antigen
D. Sperm
45. The first Immunoglobulin appears in the
A. IgD
B. IgM
C. IgE
D. IgA
46. T-lymphocytes are sensitized in
A. Thyroid
B. Parathyroid
 C. Thymus
D. Bursa of Fabricius
47. The largest Lymphoid organ is
A. Bursa fabricius
B. Bone marrow
C. Thymus
D. Spleen
48. Mucosa associated lymphoid tissues (MALT ) occurs in the lining of
A. Alimentary canal
B. Genito urinary tract
C. Respiratory tract
D. All of the above
49. Most natural antigens are
A. Nucleic acid
B. Lipids
C. Monosaccharides
D. Proteins
50. The plasma immunoglobulins play a major role in the
A. Body’s defence mechanism
B. Complement system
C. Oxygen transportation
D. Blood coagulation
51. In higher animals, the B-lymphocytes are mainly derived from
A. Spleen
B. Liver
C. Bone marrow
D. Bursa of Fabricus
52. An example of cell mediated Immunologic process is
A. Defense against malignant cells and Viruses
B. Hypersensitivity reaction
C. Graft rejection
D. All of the above
53. The “Millionaire molecule “ is
A. Ig D
B. Ig G
C. Ig M
D. Ig A
54. Cytokines bind to receptors on the cell that produce them are called
A. Autocrines
B. Lymphokines
C. Both
D. None
55. Interleukin – I (IL-1) is produced by
A. Macrophages
B. Monocytes
C. -cells
D. All of the above
56. The cytotoxic cytokine is
A. IFN- B
B. GM-CSF
C. TNF-B
D. IL-10
57. Cytokine produces by Leukocytes and Inhibits viral replication is
A. Tumor necrosis factor (TNF)
B. Interferon (IFN)
C. IL-10
D. GM-CSF
58. The normal count of CD4-T cells (per mm3) in healthy person is
A. 2000-4000
B. 1100-1500
C. 900-1500
D. 600-1000
59. The total number of nucleotides in each of its two identical single stranded RNA
genomes of HIV is
A. 10255
B. 9749
C. 5674
D. 2000
60. A positive HIV-ELISA test must be confirmed by a second procedure called
A. Agglutination
B. Immunoblotting
C. Radioimmunology
D. All of the above
61. The target host cells of HIV are
A. CD – 3 T cells
B. CD – 4 T cells
C. B- cells
D. All of the above
62. HIV-Immunoblot test is an example of
A. Southern blotting
B. Northern blotting
C. Western blotting
D. All of the above
63. A polyclonal antiserum contains
A. Single antigen
B. Single antibody
C. Mixture of antigens
D. Mixture of antibodies
64. The antigen- antibody complex is recognized by the complement
A. C4
B. C3
C. C2
D. C1