LoGhook PRatibum faRMAs! FIsik Nama 2 Rindiani Npm 2 217205083 Judur Percoboon kelaratan {nidinsit’ Obed ketes /Gowonman 2 B Farmasi /18 Hari, Tanggar : Rabu, 20 Art go22 Jam Pralisum —* OF00- 12-00 wie Dosen pombimbing ‘Apt’ Kturnta Pahayu Pos, Mse- A+ Tuan percoboan- Memperkenaikein tons an proses fendutung Rtiarttan 0! furan pevomeler ketewuran zat (obot)- bat dein menen B- Alat dan Bahan t Alat : + Plat aiat geias + Contcar tube + Magneke stirer + Thermostatic waterbath + Spettropotometer Uv — vis 2+ Bahan : © Aquadest oo Dioksan o kapein Scanned with CamScannerr — C Cam kena Vitimbang Fagin squmiah ig Sthanyak 4X Oimasuzan masing = masing tagein kedatam 4 ‘Célonrean tube 4 Dibuat campuron dorsan (6 = (10) dan atuedest (+ 23-5) squmiah ool pada parameter elarutan campuran 12r 14 (6% (8 dengan mnenggunaken yetsarean yarg ace. J Dierasuean conpuron fersebut Fedaiam 4 cplenteat tube: | igor dara sharing thermostatic waterbath setama 26 menit pede Suhu 27°C. Diseneregugast Setama to menit- Drambt Fembai ors ml tapsan atas (supemnaian) dan dimasukin bedevam tabu takar $0/0 m) | Ditambahken Atuades $0 mt (yengenceran tor Diambit tembati ors mi dart hasit pengenceran dan dimesuran kedatam faba tokar $0r0 ml! " Ditambehean Arvacest som Cpengenceran t0ee0 x.) Diukur absorbansinya dengan Spekiropotometri UV tamdas 272 nm Dirertrasi untue & Yang tein. Dibuat grape hubungan antara parameter Felaraton soen clengan kelane| intunsie obat + J Ditentukan paromeer peiarotan Kapein olan data yang dliperoh » Dlxnding dan pusb. Scanned with CamScannerD- Data pethitengan- (+ Pethitungan votume ioksan - Air. § dlionsan = 10 & air > 2s S Campuron = 12,14, be 8 UV campuron = 10 ml Misar + voume dioksan : x Vorume air ) Scamp Veonp > Sorin. Vaeran + Sar. Va ( a) Scompuran = 12 (2-0 = (ox 4 235+ [lo-x) (20 > (Ox +4 235- 235 x (asx 2 ts x 2 es ml Udionsm > Qi mb Vair > fo- 05 5 b> Scampuran > 4 He = (orn ¢ 23:5 (t0-x) Wo = lx § 235-2305 (3x 2 95 x = Ssis Vdiorson = 710 mL Voie = to- to > 3 ml + (o-x) ©) & campuran = Ie (10: (ox + 248- [lo-x) [co = Wx €235- 245% Wise 2 15 x = Bhs Viiorsan = 506 ml Voie = to-oe = mt 4) § campuran > (@ (0-00 > lox 4 23:3. (t0-x) 100 = lox + 236 - 2315 sx 2 $F x = Sims Vdiowsan > 4a; Vaie = 10-42 sg ml Scanned with CamScanner2) kurva baka tupeia- 7 [Reider (ppm) | ABsoRBANS! 01128 Otdapatean = oO oy = 0; 0405 0, 33t b= 070480 on4ay T= 01990 Ost7 VY: beta Onto 4= ov04eox + Or040s Or 754 X= Y= 0/0405 or800 | 70180 0/637 01982 ket: x = feadar (e¢m) —> gpm = mg ft Y + Absorbansi b> Data Absorbanst _percoboon- S& | Avsorpasi Rengenceron CF (2 01832 {0000 Xx 4] ose (000 x © | o@a3 Cael to | 0263 os B. Perhitungan Frars moi tage berdesarkan data prtcoboon- Gm kopein = (9 Bm diokson = Govt Om air ¢ P— dorsan = 1708 $/mt air = 1 a/mL yn Y= 0/0400 + 0/ovos x > $- 0/0405 , Ep 0/0480 x 2(01532 - 0/0405) x (0000 010480 x = (02395/63,.m9-/L 7. x = 10239 8[toml Scanned with CamScannerMot kagein > kadar feagein /8M = troesg/14 119 = 0) 00527 mot 2 5/27 x10" mo. Plavotan« Viacuran » (Padtotsan vaiorson) + (Paie- vowme air) Paratan + (es-ais) + (us) = trozss $/mi Plarutan Massa fautan = P taran + Vierwron > 1/0255. (0 = (0/255 gram Massa kapin = mor kapan Bm = $127 x03 - (94/19 40234 gam Massa (dioksonég: Massa tarutan - massa kapein 3 (0/255 gram = 1/0239 gram = 9/2316 gram Rasio massa diorsan > massa ics (vd- pa) = (va + pa) = (G15: tos) : (ust) Or755 3 Us Massa dioksan = 75S x (massa dioksan + ar) ONES Us 1755 giasie = 1188 gram OrIss +5 massa arr = 9,23" - RSS7 > [1 3903 drum Mo! diokson + massa dioeson (am + 7/0557 / Atte mot airs massa cit [Bm + 1 RAL Fraksi mot tapein by Mot__karen Mot kagetn + mor dioksan + mor air poets 5127 x (0 4 018694 + 0/0780 5 $127 KF 0716367 = 0/0310 0293 = 31p0G0 x10" Scanned with CamScannerb) Sy Y= 00480%x 4 0,040 > Ys 070103. gp or04go x = (orsts~ ovo4es) ca000 roves 90-4305 mg/L oraegy §— ¢/mol * ‘ Mor tape = bador leagein (om = 019044 / 194.44 20100507 mol = S107 X10" moi Praruran Vreruran + (Pdionson . Vatorean) + (Pait- Vir) Praruion - to = (3-20) +03 Praruran * 110210 9 /mt Massa taruton > Prarwtan- Viewton > [rO2b- (0 = Leralo rant Massa kapein > mot kaftin- BM > $/07 x (0° - (94/18 = Or BOYS Bram massa(dtersanter) > massa larutan- massa tagein = (01 2t0 gram - 0194845 gram > 9)2255 Sram asi massa diotsan : massa oir > (V4-pa) = (Vata) = {to- 103) 2 (3 2 a3 massa diocesan = tx (massa dorson tar) Wats = ict x 91t2ss = Gr st4@ Sram Tees Massa air = G,2255- Gistye = 2, 1107 Gram mor dioeson + Massa diotsan [am = 615146 /06K0 = 010733 mot mot air = Massa arr (Bon 2s TWOT/@ = 011506 py Sro7 x03 “$07 eo 4070739 40713 > 01022084767 + 2/2085 x 10* Fraesi moc kogein Scanned with CamScannerOo § & Y= 0, 040% + 0/0405 x B= 0/005 y Bp 070480 x = 01093 - 0/0405 x 10000 1040 X = (17-GoWet7_-mg/t x 217760 4 fmt tot tagan = kadar fapein [am : 7160/1949 = or00914 = Gly x10" Mot Ptacctert Veeroras o (teens \itersan)* Uae 4 er Parton » (0 = (103. sie) + (16 44) Praweon (0168 9 /mi Massa (aruton = Praruan- Viarwton 2 t0lbe. (0 2 (Orl6e Sram massa bapein = mor kopein Bm: HU RCO™S . (Y/IG = VT74G 9A massa (diorsan tere) > Massa tarutan - mossa Fapein (01GB ~ 117749 61 3931 Sram Rasio massa diorsun > massa ait = (ya. ea) : (Va-Pa) + (sets) > (44-1) + S/T? 2 WY Massa diowsan = $/76@ x (Massa dioksant ait ) $1760 + 414 > S178. % Gr 393 = 4 7EN Sram 51% 4 Hy Massa ater = Gr 3931 ~ ATG = 37632 ram or dioesan = massa evatsal (om> 4,76 [220 = 010540 Mol masse our (Bra > 31632 (10 = 072018 rm) mol air Fraesi mol bape = 9/14 x tonF 411y x 103 + OrOS40 6/2018 2 9rl¥ x to"3 Or teuay = 01034490576 2 5/44wx (0°* Scanned with CamScannera Se Y= oro40aox + Oroos k= Y- o1040S y pp 010 4go x = (01263 — 01045) x (0000 01 Ove x= 46-3547 mg /e x 2 Orye3s — $/mol Mot kage = kodar tafein [Br = 014635 / (gy) 19 = 0700239 = 1133 xloF Praroron - Viarutan = (Pa vd) + (Aan -vax) Parutan @ > (nos-M) + (5:0) >. Gos mt massa (aratan > P.tarvten - Vraroror > WOI2S “10 2 (01123 Gram Massa tapen = mo kage -BMm = 1/39x103 - Q¥/19 = 0 44! gram massa (diotsantair) = massa (aruton- massa Fogem (0/123 gram - 0464! gram = 916809 dram Casio massa chorson : massa air = (Va-pd) = ( Vor - Paw) 2 CYa.ti03) (sea) = 4,223 3 99 massa diorsan = 4,923 x (mossa ctorsan tar) Was § $19, = 4123 GiGseg = 410294 Gram 43 tS Massa air = 9,6509 - 4,024 > 96295 Sram Mot dioksan > massa dioesan [Boa > 410239 / 8,10 : 010457 mol mor aie = massa air [Om = S/6r95/ 18 = Or 127 MOI Prakst mor kapen > = 2) 39xt0F 2134x103 $0 /048)¢ 01307 = __239x03 01 36009 = 0/006 637229 SOL = Gi6372 103 Scanned with CamScannerC: ketorutan fapein dari Hap parameter seceira teoritis Atig = S400 kar /mor e 467 par /mmo1 “ke v 37"c = Bot fe To = 236°C = su OF Vo = tay ¢m3/mor Ke = Frost mot a) Siz = log > Alp (32 )- (s-s1)* (% x0 ) 21383.1,987-30 \ 2,303 — leg x2 = $400 (sx-39 4 (a= wa? ( gx? 11308 (907-80 om 2303+ (987-310, - oj Xa = $Yoo (2) xfomr ser ese) ( a (asa \ 50 ee = oy Xa = ( s4066 + 012993) + (4an.ortors) ~ WS X22 = 179459 (0g x2 = - 1/9459 Xa 2 O,ons, by Su nto $400 t (4-190? ( tag x 1% ) 113903 - W@7-310 11503 -)907- 310 3X2 > 14985 log x2 > - 14903 Xa 2 0/0317 Scanned with CamScannerC) Se - log Xz = (09 ¥2 103, Xe x a4) ge ~ (09 X_ = (03 Xe (69 Xa xe 5400 21303 + 1-9 G7 310 > 2103%% 2 > 2,034 = 0100146 Se Stoo 21203-11907 - 316 = 1, log = = 2/(019 = 010073,, (a x tt su 30 1303-1) 907-3 su } + (w- Ma tay x 2 2303-198 (saa) 4 + (0-141) ( Scanned with CamScannerD- Parometer elarutan tagein berdosartan hasit pereoboan -log X= Ate (@2t )t (gene — D303 Pr es 21308 PT x Bios OF ns $1 > hi - VE wa xr Ate (2 Ve xpit 21303 eT ST a) $a Gr 212K og (51100 x 2) ~ S00. (su=308 J 238-083 1 03-U 987 30 21383 -(967-310 st =—Ve Se = yluso770)- (Stee) (4 zo 1-158) ty S02 (2-Ysorre) = (04979) x F157 Su = rVlorowwai x deste) irs 2-Yoorss Gir = 6198p, Scanned with CamScannerfli ieee ci Saceee Lov sie ei Pa Madtha end Rae ee b) Su — Su = 1y MEvag (2:2 065 x10*2) —_ $400 3130) earns z303.0997.310\ §" 49 x(t SuewNCC 16559-4973} x 4105 Siq = y-VOnsae x Hash Sy = Wo Vise Sy = 12/7S004, oo Se Bu: ~NE9 (3440 x02) -_$400 (see) 2303-1407 $10 2,303-1987- 310 \ tag xt Se = -V(v4ca ~ 19973) x 9,4512 Sw = -V(-orosst xa esia V-0- sysé - VO 3He FY Vsresq2 1 9ey, 4) Se So = te-VE tog (Grose xto8) - S408 (se) 1/303- (907-318 21303.1907-36 | *" tay x Sia = 1 -YaAT@O = 114973) 4,512 Sia = t8-Y (0, Ge07) x 4,@si2 So = (8-V 6/1057 S10 = Wy 2925, parameter Eetarvtan Fagein rata-Falas (1/6769 + (2175004 + (LAE) + 2) 7% , 2 G1 4S24y Scanned with CamScanner#* Rangkuman Data [& [prose or tears (Kevervton ot ta] Fras mot proboan (Fontan mer pcb) | Ww 670113 3/1060 x 10-* [w 01037 22005 X to"? 7 Or oe 010079. Scanned with CamScannerE- besimpuran Doyat memperkenaitan Fonsep clan proses pendukung Felaratan Obat dan menentuken parameier zat (obal) dengan hasit paremder (31 = 16790) (Sw = 12, 75004) i (Se =~ Wane) (Bie = tr 2925) Yogyakarta, 20 aprit 2022 Dosen pembimbing Pravtizan Apt burnia Pahoyu p-s, M-s¢- Bindiani Scanned with CamScanner