7/14/2019 Slide Sentriol

SENTRIOL
Duanti Oktarani Tisadewi
Imanuel Gidion
Tonny Kurniawan
Kurniawan

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Struktur Sentriol

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Penampang melintang sentriol

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Main Functions of Centriole :

• Cell Division (However, more recent experiments have demonstrated that
cells whose centrioles have been removed via laser ablation can still progress
through the G1 stage of interphase before centrioles can be re-synthesized
later)

• Celiogenesis (the formation of cilia and flagella on the surface of cells)

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Peran Sentriol dalam Pembelahan Sel

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(3)
(2)

(1) Pengarah,
kompleks kemenarik
arah
(1)
membran sel
(2) Titik awal pembentukan
benang spindel
(mikrotubulus)
(3) Berikatan dengan
pasangannya untuk
(5) menunjang pembelahan
(4) (4) Berikatan dengan
sentromer kromosom
(5) Sepasang Kinetochore
disebut sentromer

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Ciliogenesis oleh sentriol

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Gradually
be
destroyed

Over-expressed pericentrin

Alternatif Rute Replikasi Sentriol

*  Henrietta Lacks (HeLa) Chinese Hamster Ovary
 

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(a) Centrosomes of metazoan cells, including those of humans, consist of a pair of

centrioles and a surrounding protein lattice called pericentriolar material (PCM), which
serves to secure -tubulin-containing microtubule nucleation sites. As cells enter S phase,
new centrioles begin to form near each of the two pre-existing centrioles and establish an
orthogonal arrangement for each centriole pair with the nascent centriole extending
from the proximal wall of the older centriole. During late S and G 2 phases of the cell cycle,
the newly formed centrioles elongate to near mature length. As cells prepare for mitosis,
the centrosome matures by acquiring additional PCM and -tubulin, and then the two pairs
of centrioles and their associated PCM separate to function as two mitotic spindle poles
of the dividing cell. As cells pass through anaphase, the individual centrioles of each pair
separate a short distance from one another in a process called centriole disengagement.
Finally, with the completion of cell division, each G1 daughter cell inherits one spindle pole
(centrosome) that contains a disoriented pair of centrioles. (b) Laser ablation studies
show that when the younger centriole of a pair is destroyed, a new centriole emerges
within several hours in both HeLa and CHO cells. However, when the older centriole of a
pair is destroyed, a new centriole re-emerges only in CHO cells. (c) CHO cells expressing
excess pericentrin form multiple nascent centrioles.
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  onclusion

• Sentriol tersusun atas mikrotububulus

• Sepasang sentriol diselimuti PCM (Pericentriolar Material)
membentuk sentrosom
• Sentriol berperan dalam pembelahan sel dan ciliogenesis
• “Formation of new centrioles is initiated in the PCM cloud and that the

role of the older centriole is not to provide a template for the assembly
of new centrioles, but rather to organize and restrict the size of the
PCM, thereby limiting new centriole formation.” 

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