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PHYSICAL THERAPY MANAGEMENT OF TUBERCULOUS ARTHRITIS OF

THE ELBOW

Amit Murli Patel BPT, MPT-Orthopaedics*

ABSTRACT
BACKGROUND AND PURPOSE: Tuberculous arthritis is not commonly seen by physical therapists in India.
The purpose of this case report is to describe a case of tuberculous arthritis of the elbow. CASE
DESCRIPTION: The patient was a 35-year-old man referred for physical therapy evaluation and intervention
for chronic elbow pain. After an evaluation and a trial of physical therapy, the patient was referred back to a
primary care provider for additional tests to rule out systemic pathology. An open debridement of the synovium
and a biopsy of the capitellum and radial head was positive for acid-fast bacilli, which was later identified as
Mycobacterium tuberculosis. OUTCOMES: The patient was placed on a 4-drug antituberculosis regimen that
resolved all patient complaints and restored full elbow function. DISCUSSION: Tuberculous arthritis has
characteristic findings during examination and in diagnostic tests. Although tuberculous arthritis is uncommon, it
should be considered when patients have chronic or vague musculoskeletal complaints.

KEYWORDS: Tuberculous arthritis, Elbow arthritis, Knee effusion, Physical therapy managemet.

INTRODUCTION of the bones or joints of the body but is usually


Tuberculous arthritis occurs in approximately confined to one location, with 10% of tuberculous
5
1% to 5% of all patients with TB. It can involve any arthritis in the upper extremity6 and up to 8% in the

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elbow.7 The sites most frequently affected are the and joint deformities may develop.8 The
spine, sacroiliac, hip, and knee.8 Because weight- granulomatous process eventually imparts a “boggy”
bearing joints are the most frequently involved, or “doughy” feeling to the joint and periarticular
some authors5 suspect that trauma plays a role in the structures.9 Localized pain may precede other
pathogenesis of bone and joint TB. symptoms of inflammation or radiograph changes by
Tuberculous arthritis is usually secondary to weeks or even months.9 Other symptoms include
hematogenous dissemination of tubercle bacilli from joint stiffness, reduced range of motion, fever, night
1,8
a primary pulmonary lesion. Less commonly, it sweats, or weight loss.8,11 Because of the rarity of
can occur by spreading through the lymphatic tubercular infections of joints and because the usual
8
system or into adjacent tissue. Joints can become signs of inflammation (eg, erythema, heat) do not
infected by activation of dormant lymphatic or blood occur, diagnosis of tuberculous arthritis affecting
stream areas of morbidity.9 In the long bones, TB peripheral joints is often delayed.8,11 When diagnosis
originates in the epiphysis in response to is not timely, joint contractures and limited
mycobacteria and causes tubercle formation in the functional improvement after treatment are more
marrow, with secondary infection of the trabeculae.8 likely to occur, especially if bone and articular
The joint synovium responds to the cartilage are destroyed.12 Authors have reported
mycobacteria by developing an inflammatory diagnoses of olecranon bursitis,13,14 tennis elbow,15
reaction, followed by formation of granulation and pyogenic arthritis, osteomyelitis, neopathic
tissue. The pannus of granulation tissue formed then articular disease, and neoplasm before an eventual
begins to erode and destroy cartilage and eventually diagnosis of tuberculous arthritis.
5
bone, leading to demineralization. Because TB is The purpose of this case report is to describe a
not a pyogenic infection, proteolytic enzymes, which case of tuberculous arthritis of the elbow. The
destroy peripheral cartilage, are not produced. The patient described in this report had numerous
joint space, therefore, is preserved for a considerable previous diagnoses for chronic elbow pain and was
time. If allowed to progress without treatment, ultimately referred for physical therapy evaluation
however, abscesses may develop in the surrounding and intervention.
5
tissue.
Asaka et al10 described an abscess around the CASE DESCRIPTION
elbow joint and between the biceps brachii and Patient: The patient was a 35-year-old, Athlete,
brachioradialis muscles in a patient with tuberculous right-hand–dominant man who reported
arthritis. experiencing intermittent sharp pain with insidious
In India, the most common early symptoms of onset and swelling in his left elbow 10 months
tuberculous arthritis are insidious onset of local pain previously. He reported that his symptoms were
and swelling around the joint. In advanced cases, aggravated with movements of the elbow and eased
which occur primarily in countries where TB is more with rest. There was no known history of left elbow
common and often is allowed to progress, sinuses or arm injury. The patient did not report any recent

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fever or weight loss, and he said that he was healthy


except for the elbow pain. He stated that he had been
an intravenous (IV) drug user for 5 years, during
which he used his left arm for injections, but he said
he had not used any IV drugs for 2 years prior to the
physical therapist examination and evaluation. The
patient was not working at the time of the
examination His goal was to play Tennis pain-free.
The patient had a 10-month history of evaluations
for left elbow pain, swelling, and decreased range of
motion. The patient had been diagnosed with lateral
epicondylitis, degenerative joint disease, synovitis,
and tenosynovitis by 3 different physicians at 3 Figure 1. Anteroposterior radiograph of elbow
different facilities, and he had been treated with showing cyst-like structures (arrows).
nonsteroidal anti-inflammatory drugs. After 10
months, an orthopedic surgeon examined the patient.
The physician referred the patient to the physical
therapist for examination, evaluation, and
intervention for chronic elbow pain and ordered
electromyography (EMG) and nerve conduction
studies (NCS).
Three series of elbow radiographs were taken
prior to the physical therapy evaluation. Each of the
Figure 2. Lateral radiograph of elbow showing a
3 series of elbow radiographs was taken at a posterior fat-pad sign (arrows)
different facility
The third radiographic series 4 months before
The first series, taken 10 months previously,
the physical therapy evaluation revealed a posterior
showed no noticeable abnormalities. Two months
fat-pad sign, which the radiologist suggested may
later, a second series was negative for fracture, but
have been created by joint effusion or an occult
there were cyst-like structures and mild exostotic
fracture (Fig. 2). Normally, the posterior fat pad,
bone formation in the region of the lateral
which lies deep in the olecranon fossa, is not visible
epicondyle, and there was another cyst-like structure
on the lateral view. It can be displaced out of the
in the proximal shaft of the ulna (Fig. 1). The lateral
fossa by blood or synovial fluid within the joint, thus
view showed exostotic bone formation at the
becoming visible.17 The radiologist who interpreted
anterior distal humerus, which the radiologist stated
the third series recommended further evaluation if
may have been indicative of an old injury.
the patient’s complaints continued.

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Nerve conduction studies of motor and sensory stopped. The wrist was cleared when overpressure
components of the left median, ulnar, and radial was performed during active flexion and extension.
nerves completed just prior to the physical therapy Because both procedures failed to reproduce the
evaluation were within normal limits. patient’s elbow pain, the therapist considered the
Electromyograms of the middle deltoid, biceps shoulder and wrist cleared as the source of his
brachii, brachioradialis, pronator teres, abductor pathology. The therapist tested light touch sensation
pollicis brevis, and first dorsal interosseus muscles by moving the index fingers along the patient’s C4-
also were within normal limits. The patient had T2 dermatomes and upper-extremity nerve fields
positive purified protein derivative (PPD) tests since bilaterally. Sensation was recorded as intact and
the previous year. A standard posteroanterior chest symmetrical. Muscle stretch reflexes were not tested.
radiograph for patients with a positive PPD test was Manual muscle tests of the upper-extremity
normal. A normal chest radiograph shows no musculature were performed during the examination
pleurisy with effusion. as described by Kendall and McCreary.19 The
Pleurisy with effusion results when the pleural trapezius, middle deltoid, wrist flexor, dorsal and
space is seeded with Mycobacterium tuberculosis.18 palmar interosseus, and extensor pollicis longus
muscles were painless and rated normal bilaterally.
EXAMINATION The patient said that he was unable to hold the left
The patient held his left elbow in a flexed biceps brachii, triceps brachii, and wrist extensor
position and apparently was guarding the elbow muscles in the test position against resistance
against his body. He had diffuse left elbow effusion, because he said that it reproduced his pain. Because
with the left elbow joint girth 1.5 cm greater than the pain limited the patient’s effort during these muscle
right elbow joint girth measured at the elbow flexion tests, grading was not done.
crease. There was no ecchymosis at the time of Palpation revealed a mild increase in warmth
examination, but wasting of the biceps and triceps around the left elbow compared with the right
muscles was noticeable. The patient had elbow elbow. Palpation at the olecranon and both lateral
active and passive range of motion of 30 to 110 and medial epicondyles caused a sharp pain that did
degrees, with pain at both flexion and extension end not radiate. Palpation of the patient’s entire anterior
ranges. Wrist range of motion was normal, but the forearm also reproduced his elbow pain.
patient did have a sharp pain at the lateral and
medial condyles during end ranges of pronation and EVALUATION
19
supination, respectively. The shoulder was cleared A posterior fat-pad sign has been reported to be
for pathology using overpressure during active a possible sign of interarticular fracture or
flexion, abduction, and while the patient was swelling.17 Due to local tenderness, swelling, and a
reaching behind his back. The therapist performed documented fat-pad sign on this patient’s
overpressure by applying a force to the patient’s end radiographic report, the therapist chose to rule out
range at the point where his active range of motion systemic pathology or a fracture before initiating

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aggressive stretching or joint immobilization During the week 4 follow-up evaluation, the
intervention. The patient began a light physical patient reported increased pain in the area of the
therapy regimen of active range of motion exercises medial and lateral epicondyles. Examination of
for 10 to 15 minutes 3 times a week on an upper- elbow girth, active and passive ranges of motion,
body cycle to maintain his present range of motion, and palpation revealed no other changes. Based on
followed by ice massage for 10 minutes. The patient the patient’s continued pain and swelling, the
was instructed to use ice bags for 10 to 15 minutes physician and Therapist agreed that a magnetic
on his own throughout the day. He was also resonance image (MRI) could be informational. At
instructed to stop playing tennis. The therapist the same time, the physician referred the patient
discussed the case with a physician, who back to the orthopedic surgeon for re-evaluation
subsequently ordered follow-up radiographs, following the MRI. Physical therapy was
including an oblique view to rule out an discontinued until the MRI and orthopedic
interarticular fracture as was originally advised in evaluations were completed. The MRI showed a
the most recent radiologist’s report. large joint effusion and increased marrow signal
within the radial neck (Fig. 3).
RE-EVALUATION AND INTERVENTION
The new radiographs showed a smaller
posterior fat-pad sign but no fractures or evidence of
other pathologies in osseous structures. Therefore,
the patient continued his physical therapy program
and was re-evaluated 2 weeks after the initial
evaluation. During the week 2 follow-up, the patient
reported that the pain had lessened and that his
elbow was tender to palpation only at the olecranon.
Both active and passive ranges of motion were
unchanged, as was the elbow flexion crease girth.
Resistive exercises were added because the patient
expressed concern about the atrophy in his biceps
Figure 3. T2 weighted sagittal view of the elbow.
and triceps muscles. Because he was reporting less Note the increased marrow signal within the
elbow pain with palpation and range of motion end radial neck (arrows).
ranges, the therapist decided to allow the patient to
Signal intensity refers to the strength of the
perform seated biceps muscle curls and supine
radiowave that a tissue emits following excitation.
triceps muscle extension exercises in a pain-free
The strength of the radio wave determines the degree
range. The patient performed 3 sets of 10 repetitions,
of brightness of the imaged structures. A bright
3 times a week, in the clinic under the therapist’s
(white) area in any image is said to demonstrate a
supervision.

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high signal intensity, and a dark (black) area patient had recovered normal elbow range of motion,
demonstrates a decreased intensity.17 Hematopoietic and manual muscle tests of the biceps brachii,
marrow normally displays a low to intermediate triceps brachii, and wrist extensor muscles were
signal intensity, whereas fluid displays a higher normal and painless.19 He said that he was working
signal intensity on T2 weighted MRI.17 The and playing Tennis without pain. The patient
radiologist suspected infection and recommended performed janitorial work, which consisted of Room
aspiration of synovial fluid and a biopsy. During the cleaning, walls, and bathroom fixtures.
second orthopedic evaluation, 2 months after the
MRI, the surgeon aspirated the elbow and ordered a DISCUSSION
bone scan. A culture of the aspirated fluid was Tuberculous arthritis usually occurs in an
negative for growth, but the bone scan image was insidious manner, with pain and swelling of the
consistent with possible septic arthritis and affected joint. It is rare among people born in the
osteomyelitis. India and is more often found in people born in other
countries or those with a compromised immune
At the orthopedic follow-up 3 months later, the
system. The patient in this case report had chronic
surgeon ordered an open debridement and biopsy
elbow pain and swelling without signs of infection.
based on the bone scan reports and performed an
Lack of signs of infections is consistent with other
arthrotomy of the left elbow with open debridement
cases of tuberculous arthritis described.15,16 He also
of synovium and biopsy of the capitellum and radial
reported a history of IV drug use, which, along with
head the next day. The culture was positive for acid-
direct joint trauma, interarticular steroid injections,
fast bacilli, which was later identified as
and systemic illness, has been found to be a
Mycobacteria tuberculosis. Following identification
predisposing factor for tuberculous arthritis.16 These
of TB, a physician specializing in infectious diseases
factors and this patient’s history suggest an onset of
evaluated the patient. The bacterium was sensitive to
TB that is consistent with reports of other patients
ethambutol, pyrazinamide, isoniazid, and rifampin,
who developed tuberculous arthritis.
and the patient began a 4-drug anti-TB regimen for
Joint effusion, such as that seen in this patient,
no less than 1 year.
often occurs with tuberculous arthritis and has been
shown to affect muscles and nerves around the
OUTCOMES
elbow.20,21 Chen and Eng20 noted compression of the
Four months after initiating the drug regimen,
posterior interosseous nerve at the region of the
the patient reported that he was pain-free, and he
arcade of Frohse. Prem et al21 noted wasting of
was discharged from the orthopedic surgeon’s care.
muscles around the upper limbs and shoulder girdle
The therapist attended a weekly orthopedic clinic
along with obliteration of bony landmarks due to
during which patient was evaluated by an orthopedic
swelling around an elbow infected with tuberculous
surgeon.
arthritis. Yao and Sartoris1 also stated that weakness
At 12 months after the diagnosis of TB, the
and muscle wasting could be present around

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involved joints. The patient in this case report did appearance in the involved bone is not uncommon.
not have sensory deficits, but he did have noticeable The third set of radiographs revealed no
wasting of his biceps and triceps muscles. Persistent abnormalities in bone or joint space, with the
effusion in the knee affects afferent activity of exception of a positive fat-pad sign. Greenspan17
intracapsular receptors and can cause reflex reported that a positive fat-pad sign could be
22–24
inhibition of the quadriceps femoris muscle. A indicative of interarticular swelling or a fracture. The
similar mechanism may have occurred in this fourth set of radiographs eliminated the possibility
patient, causing wasting of the biceps and triceps of a fracture that had not been diagnosed, but they
muscles due to capsular distention and intracapsular revealed a smaller fat-pad sign, which most likely
pressures. An alternative hypothesis might also appeared because of interarticular swelling. When
attribute the muscle wasting to disuse secondary to radiographs are normal, an MRI may be beneficial
pain during elbow motion. by revealing early changes such as edema that are
Radiographs can be powerful diagnostic tools, not visible on radiographs.27 The patient’s MRI
but they are not always beneficial during evaluation identified the complex effusion in his elbow, but a
of a patient with tuberculous arthritis. Some authors biopsy that was needed for the definitive diagnosis.
have described normal chest radiographs in patients Biopsy is the most definitive test for
with tuberculous arthritis20,25 and old or active tuberculous arthritis. 6,9,13,15
Some authors have
pulmonary disease evident in only 50% of chest reported that synovial fluid or tissue cultures
8,16
radiographs in patients with tuberculous arthritis. establish a diagnosis in 90% of the cases of
Elbow radiographs can also be negative, even when tuberculous arthritis.11 Material for the culture may
the disease is present.15 Unlike pyogenic organisms be obtained from aspiration of joint fluid, but this
that produce rapid destruction of bone, TB has a may be inconclusive, as it was in this patient’s case.
26
gradual progression of symptoms. It has been Laboratory tests such as sedimentation rate,
reported to begin in the distal end of the humerus, granulocyte count, and lymphocyte count are not
olecranon, or synovium of the elbow joint.13,25 The thought to be helpful.7 This patient’s prior tuberculin
first radiograph report of the patient’s elbow was skin tests were positive, which is consistent with
normal. researchers’ findings for patients with tuberculous
The second series of radiographs identified a arthritis.6,10,20,25 However, as was described in cases
cyst-like structure and mild exostotic bone formation involving a 66-year-old woman15 and a 76-year-old
that was not identified on the first and final man16 with tuberculous arthritis of the elbow, a
radiographs. Munk and Lee26 contended that a negative TB skin test does not exclude diagnosis of
normal appearance on imaging is the rule with TB tuberculous arthritis. Repeated negative tuberculin
infections because the underlying bone reacts (by tests, however, practically eliminate TB as a possible
forming cysts and producing sclerotic borders at the etiology.7 Before the advent of anti-TB
margins of the infected lesion) in an attempt to wall chemotherapy, the classic treatment in adults
off the infectious process. Thus, a cyst-like consisted of excision or arthrodesis of the elbow

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joint.28 The disadvantage of arthrodesis was loss of patient’s elbow to being pain-free with full range of
motion, and the risk of excision was an unstable motion. Chen et al12 reported that a continuous
elbow.28 Anti-TB agents are effective in halting the passive movement (CPM) device improved
destructive process and treating the infection. functional results after synovectomy and intra-
However, they cannot repair the anatomical defects articular debridement. Following surgery, the arc of
8
that can occur in later stages. During these stages, movement was set at 30 to 90 degrees and then
fibrous tissue can result in ankylosis of the joint. increased to a level that the patients were able to
Similarly, the untreated cases can evolve to bony tolerate. Patients used the CPM device for 2 to 4
ankylosis.16 The literature provides few specifics for weeks until movement exceeded 120 degrees. The
the physical therapist management of TB. average flexion deformity in a group of 8 patients
29
Investigators have reported using prolonged who used the CPM device was 24 degrees versus 34
immobilization for an average of 18 months. With degrees in a group of 8 patients who were treated
the introduction of TB drugs, this is no longer with active and passive movement. Active and
12 6,28
necessary. Some authors advocated passive movement was not defined.
immobilizing the elbow for 1 to 2 months at 90 The patient in this report responded well to
degrees to relieve pain and, in the event of fusion, to antibiotics and regained full elbow function without
achieve a functional position. After removing the immobilization or surgery. This improvement could
cast, rehabilitation proceeded daily for 3 to 6 have been due, in part, to the location of the disease
months, with a back splint used between therapy in the joint. Vohra and Kang25 stated that prognosis
sessions to prevent extension deformity and help the is excellent in synovial and extra-articular lesions,
6
elbow flexors regain power. No specific whereas involvement of articular cartilage reduces
descriptions of the splint or interventions were the chances of maintaining good range of motion. In
reported. addition, this patient’s improvement could have been
Surgery may be necessary in certain cases when due to diagnosing tuberculous arthritis early and
the disease does not respond to drugs or to correct administering anti-TB treatment before severe
8
deformities or improve joint function. Vohra and destruction occurred. Chen et al12 noted that joints
Kang25 treated 6 cases of elbow TB, ranging from with severe intra- and extra-articular destruction
the disease being restricted to within the synovial usually become stiff with fibrosis and adhesions.
membrane to extensive articular cartilage Martini and Gottesman28 hypothesized that, unlike
involvement. Patients were treated with 3 to 6 weeks the lower-limb joints, the elbow is non–weight
of immobilization after surgery followed by bearing and therefore more able to recover a normal,
encouraging active movements and using night painless range of motion, as this patient was able to
splints for 2 to 5 months. No other intervention do.
30
specifics were given. Other authors reported that
using a hinged long arm brace for a month after CONCLUSION
surgically removing granulation tissue returned the Patients with tuberculous arthritis are not often

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examined or treated by physical therapists in India physical therapist and other health care providers.
due to the relative rarity of TB infections of joints. Physical therapists and other health care providers
Because of its often slow progression, can learn from this case to consider tuberculous
tuberculous arthritis is a frequently misdiagnosed arthritis in the differential diagnosis of unexplained
condition, which delays treatment and can lead musculoskeletal complaints, especially in patients
deformities and functional deficits. with compromised immunity or from an area where
This patient’s disease was identified as a result TB is endemic.
of diagnostic tests and communication between a

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CORRESPONDING AUTHOR:

* Amit Murli Patel BPT, MPT-Orthopaedics, Assistant Professor & Vice Principal, College Of Physiotherapy,
Ahmedabad E-Mail : patelmpt@Yahoo.Com

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