Lippincott’s

MedMaps
Lippincott’s Lippincott’s
MedMaps
Lippincott’s
MedMaps The Ultimate Biochemistry Study Aid
Lippincott's Biochemistry Map is a portable, full-color wall chart
MedMaps
that allows for faster memorization, understanding, and retention of
biochemical processes. Through color-coded figures and diagrams
and an "at-a-glance" presentation style, this tool guides students
through the "domino effects" of biochemical processes for better,
faster comprehension.
Biochemistry The Biochemistry MedMap is a must for students preparing for
Saeid Karandish
Saeid Karandish, M.D. the USMLE Step 1.

DNA MOLECULES
The DNA molecule is double stranded and the
RNA molecule is single stranded. Two strands
of DNA are antiparalleland complementary to
5’ 3’ Parvovirus and Rotavirus
form a double helix.
• Most DNA molecules in nature are right- • Parvovirus has a single-stranded DNA
handed and known as Watson-Crick DNA genome. Parvovirus B19 causes fifth disease
or B-DNA. and also aplastic crisis in sickle cell anemia.
• Left-handed form of DNA is called Z-DNA • Rotavirus has a double-stranded RNA
and may play a role in chromatin structure genome. This virus is the most common
G C
and transcription.

• Mechlorothamine G C
cause of severe diarrhea in children.
✔ Maximizes Study Time:
A T • 6-Mercaptopurine
• Cyclophosphamide
• Nitrosoureas (carmustine and lomustine)
• Procarbazine Minor
• 6-Thioguanine
(antineoplastic, guanine analog)
33 full-color panels depict the most
• Cisplatin and carboplatin
(antineoplastic drugs that alkylate the N7
groove
C G
• Acyclovir
(anti-HSV, guanine analog)
• Entecavir
frequently tested biochemical processes
nitrogen of guanine, causing cross-linkages A T –
between guanine residues in a DNA molecule)
C G
– (anti-HBV, guanine analog)
• Cisplatin
and related conditions
• Dactinomycin T A (antineoplastic that alkylates guanine)
Major • Dacarbazine
(antineoplastic that intercalates into minor
(antineoplastic that methylates guanine)

✔ Facilitates Clinical Application:

groove of the DNA, between G-C pairs) groove
–
A T • Zidovudine (AZT)
• Cladribine
–
(adenosine anolog used in hairy cell leukemia)
–
G C
A T
• Stavudine (d4T)
(anti-HIV, thymidine analog) Boxes are color coded with relevant ✔ "All-in-one" rapid review
• Bleomycin
(make single-strand breaks by
• Zalcitabine (ddc)
(anti-HIV, deoxycytidine analog)
enzymes, drawing immediate clinical highlights the most frequently
Karandish

Karandish
producing O2- and OH-)
• Doxorubicin and daunorubicin
A T • Gemcitabine
(antineoplastic, deoxycytidine analog) connections to biochemical mechanisms tested topics for Step 1
(makes single-strand breaks by producing • Cytarabine (ara-C)
O2- and H2O2) 3’ 5’ (antineoplastic, deoxycytidine analog)

DNA REPLICATION Topoisomerase Unwinds the helix ✔ Provides a Visual Guide ✔ Biochemical pathways map to
Leading strand (continuous strand) SSB
5’
for USMLE Test Preparation: clinical correlations in a portable,
3’

5’
DNA polymerase
III Chart format allows for simultaneous full-color format
––

Elongates
Elongates lagging strand
leading strand
Helicase presentation of complex associations
5’
DNA polymerase 3 ’
III
3’
✔ Color coding maximizes study
Lagging strand (discontinuous strand) Parent DNA
and review time
• Topoisomerase cleaves and reseals DNA to relieve torsional strain. In Eukaryotic Cells
• Helicase unzips the DNA. • DNA polymerase d synthesizes the leading strand.
• SSBs (single strand–binding proteins) hold the DNA strands apart. • DNA polymerase a synthesizes the lagging strand.
• Primase makes an RNA primer on the template. • DNA polymerase g replicates mitochondrial DNA.
• Okazaki fragments cause synthesis of DNA on the lagging strand. • DNA polymerase b repairs DNA.
• DNA ligase joins Okazaki fragments. • DNA polymerase b and e elongate DNA.

DNA polymerase III initiates elongation of the chain on the RNA

primer. DNA replication is semiconservative (each new strand
In Prokaryotic Cells ISBN 10: 1608311694
• DNA polymerase III elongates the DNA strand.
consists of half of the original template and half new material). • DNA polymerase I removes the RNA primer and fills the gap. ISBN 13: 9781608311699

® ®

9 781608 311699
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