Coimbra Health School abstract supplement of Annual Meeting 2021 ii3

Antibacterial bioglass in dental implants: a canine metronidazole cream: firmness, shear, consistency and cohe-
clinical study sion throughout the study remained stable. High performance
liquid chromatography in the full stability study showed that
Silvia Gavinho1, Manuel Graca1, Pedro Prezas2, João Borges3, metronidazole concentrations did not fluctuate within  5%.
Jorge Silva4, Eduardo Pires5, Henrique Armes6, Jose Coucelo6 Stress factors such as acid media, alkaline media, hydrogen
1
Aveiro University peroxide, daylight and heat did not affect the stability of the
2
University of Aveiro
3
FCT - Nova University of Lisbon
cream. A microbiological examination of the metronidazole
4
FCT-Nova University of Lisbon cream suited European Pharmacopoeia requirements.
5
6
Bioceramed, Lda Conclusions
HVSB, Lisbon The extemporaneously made metronidazole cream were stable
Background for 6 months.
Peri-implantitis is considered the most challenging biological Keywords: pharmacy, metronidazole, treatment.
complication in implantology, as untreated disease can

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progress and result in implant loss. Therefore, disease
The influence of an aquatic exercise program on
prevention is crucial in daily clinical practice. It has been
balance in patients with ankylosing spondylitis
reported that the use of bioactive glass, as an implant coating,
can stimulate tissue integration and accelerate tissue regenera-
Margarida Ferreira1, Cristina Mesquita1,2, Paula Santos1,3,
tion. Besides these properties, it is possible to promote João Borges1, Maria Graça4, Ana Henriques4, Sofia Lopes1,2,5
bacterial activity by inserting silver into the bioglass 1
Escola Superior de Saúde - IPPorto
Methods 2
Centro de Investigação e Reabilitação
3
Bioglass with composition 45S5 was synthesised by the fusion CIAFEL - Centro de Investigação em Atividade Fı́sica, Saúde e Lazer
4
Escola Superior de Saúde de Aveiro
method, replacing the amount of Na2CO3 by AgNO3 (BG 2% 5
Escola Superior de Saúde do Vale do Sousa
wt). The implants were resealed by the CoBlastÕ technique. Background
Clinical cases with pathology of the mandible/maxilla were Ankylosing spondylitis (AS) is a chronic inflammatory
selected and implants dimensioned for the canine bone rheumatic disease that leads to a limitation of mobility,
structure were applied. which can cause postural deficits and progressive loss of
Results balance. Aquatic exercise improves this health condition. The
Three months after implantation, imaging exams, namely CT objetive is to verify the influence of an aquatic exercise
scans, showed no signs of early rejection by septic or cytotoxic program, on balance and functionality, in individuals with AS.
loss. No decrease or loss of peri-implant bone was observed. In Methods
all cases the implants remained without signs of instability, and Pre-experimental study carried out on 6 individuals with AS.
with sufficient support for the application of the exo- All individuals were assessed at baseline (M0) and 12 weeks
prosthesis or dental crown. The results of histological analysis after the intervention (M1) using the Bath indices (BASMI,
showed no signs of infection or osteolysis. The zone of peri- BASFI and BASDAI) and the balance assessment protocol
implant fibrosis was not observable in the samples, showing a (‘Body Sway’) by the Physiosensing Platform. Data were
good evolution in implant osteointegration. analyzed using the Statistical Program Statistical Package for
Conclusions the Social Sciences (SPSS), version 26. Were used descriptive
The results show promising evidences for the use of this statistics and Wilcoxon test to compare M0 and M1. The
biomaterial as a coating, since aseptic rejection, later on, and significance value was 0.05.
Results
We verify improvements in BASMI (P = 0.046), BASFI
(P = 0.042) and BASDAI (P = 0.027) scores. Through the
analysis of the center of pressure variables, there were no
significant differences, between moments, in the
Stability study of metronidazole cream,
protocol. However, when assessing balance, in the anteropos-
extemporaneously made in pharmacy
terior mean distance in both the protocol (eyes open) and in
the protocol (eyes closed), in the root mean square in both
Andrius Dambrauskas
Faculty of Medicine, Department of Pharmacy Techniques, Kaunas
protocols and in mediolateral mean velocity, only in the
University of Applied Sciences, K. Petrausko st. 15, Kaunas LT-44162,
Lithuania
Background
Rosacea is a chronic recurrent disease, characterized by facial
redness, dilated blood vessels, inflammatory rash elements on
the face. The pharmacy produces 2% metronidazole cream
extemporaneously for the treatment of the disease, as there is
no such cream concentration on the market. The treatment of
the disease is usually long, so the shelf life of the cream is very
important for the patient, especially for those who do not have
the opportunity to reach the manufacturing pharmacy. The
aim of this investigation was to determine the stability and
shelf life of metronidazole cream.
Methods
Long-term stability study of metronidazole cream was applied
at 25  2 C, 60  5% relative humidity; accelerated stability
test at 40  2  C, 75  5% relative humidity. The influence of
stress conditions were evaluated on the stability of metroni-
dazole cream. It was determined metronidazole cream texture
and microbiological examination was applied.
Results
It was found that color (white), odor (odorless), integrity
(homogeneous), pH (6.8) did not change during storage of
metronidazole (6 months). Mechanical properties of the