Coenzyme Q10 and Selenium

for Heart Health

How can they affect heart health?
An infographic by Gemady Langfelder

Heart disease is the leading cause of death for both men and
women in the United States and worldwide. Coenzyme Q10
(CoQ10) and selenium are powerful antioxidants in the body.
Supplementation of these nutrients were found to have
benefits for people with heart disease.

Effect on cholesterol
CoQ10 decreased total cholesterol and
increased HDL cholesterol.
No effect on LDL cholesterol and
triglycerides.
Selenium did not affect cholesterol.

Cardiac function
CoQ10 improved endothelial function in
patients with heart failure.
Did you know? Over half
Not all studies on heart failure reported
of American adults take
improvements. at least one dietary
supplement.

Oxidative stress & Inflammation

Supplementation with
Both CoQ10 and selenium:
CoQ10 and selenium was
safe for heart disease Reduced inflammatory markers: C-
patients reactive protein, interleukin-6
Increase antioxidant enzyme
activity: glutathione peroxidase,
superoxide dismutase

Cardiac-related mortality
Fewer hospitalizations and cardiac
events
Fewer reported deaths related to
heart disease

Ask your patient if antioxidant supplementation is part of

their treatment plan.

References:
1. Centers for Disease Control and Prevention. Heart disease facts. Updated February 7, 2022. Accessed May 27, 2022. Available at
https://www.cdc.gov/heartdisease/facts.htm.
2. Jorat MV, Tabrizi R, Mirhosseini N, et al. The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery
disease: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. 2018;17(1).
3. Ju W, Li X, Li Z, et al. The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of
randomized controlled trials. J Trace Elem Med Biol. 2017;44(44):8-16.
4. Kawashima C, Matsuzawa Y, Konishi M, et al. Ubiquinol improves endothelial function in patients with heart failure with reduced ejection
fraction: A single-center, randomized double-blind placebo-controlled crossover pilot study. Am J Cardiovasc Drugs. 2020;20(4):363-372.
5. Sobirin MA, Herry Y, Sofia SN, Uddin I, Rifqi S, Tsutsui H. Effects of coenzyme Q10 supplementation on diastolic function in patients with heart
failure with preserved ejection fraction.
6. Alehagen U, Aaseth J, Lindahl TL, Larsson A, Alexander J. Dietary supplementation with selenium and coenzyme Q10 prevents
increase in plasma D-dimer while lowering cardiovascular mortality in an elderly Swedish population. Nutrients. 2021;13(1344).