Benzodiazepines

WHAT ARE BENZODIAZEPINES?

The first benzodiazepine, which is chlordiazepoxide, was

synthesized (created) by chance in 1961.
Structurally
Benzodiazepines are the most used anxiolytic drugs. they have a
7 element
-Reduces the activity. ring
-Agents suppressant.
-Potentially addictive.
QUALITIES

-Replacement of barbiturates and meprobamate.

-Lethal dose is a thousand times higher than the topical therapeutic
dose.
-They action the limbic system.
-There is no antipsychotic, analgesic activity.
-They do not affect the central nervous system
Action mechanism

- BZDs are central nervous system depressants

- They are full agonists
- GABA
- The specific binding site for BZDs in the GABAA receptor is
called the benzodiazepine binding site, and it is made up
mainly of the aminoacid histidine.
- Increase in the ion channel
USE OF BENZODIAZEPINES

SEDATIVE

TRANQUILIZING
 ● Psychomotor agitation
● -Generalized anxiety. ● Anxiety crisis.
● Irritability
●
● Excess of worry
● Anxiety disorders.
● Nervousness
● Muscle tension.
 DOSAGE AND METHOD OF ADMINISTRATION.

● The treatment has a limit ● Oral ● If you want better results

CLASSIFICATION OF
BENZODIACEPINES,
CLASSIFICATION BY ITS HALF LIFE:

● Ultra short half life: Triazolam,

Midazolam.
● Short half life: Lorazepam,
Temazepam, Oxazepam.
● Intermediate half life: Clonazepam,
Flunitrazepam.
● Long half life: Diazepam,
Flurazepam, Bromazepam.
 Lipidic nature.
can go
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e unio
n

Blood-brain Blood
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Albumin.
CLASSIFICATION BY ITS EFFECTS.

Classification. Drug example.

Pre-anesthetics. Midazolam.
Anticonvulsants. Clonazepam, Clorazepate.
Anxiolytics. Alprazolam, Diazepam, Lorazepam,
Clorazepate, Chloradiazepapoxide.
For insomnia. Triazolam, Nitrazepam, Flunitrazepam,
Flurazepam, Quazepam and Temazepam.
SIDE EFFECTS.
UNLIMITED USE.

● Lightheadedness.
● Laxity.
● Increased reaction time.
● Motor incoordination.
● Mental function disorders.
● Confusion.
● Retrograde amnesia.
SIDE EFFECTS.

NOT TO DO: ANTIDOTE:

● Drive. ● Flumazenil.
● Drink alcohol.
● Consume with no limit.