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Index
Sl.No. Topic Pg.No.
1. Hitsorical Milestones 09
2. Pre-Operative Assessment 13
3. Pre-Operative Medications 19
5. Inhaled Anesthetics 23
6. Intravenous Anesthetics 27
7. Monitoring Anesthesia 29
9. Anesthesia Equipments 55
Anaesthesia
Historical Milestones
Oliver Wendell Holmes Horace Wells
Reference :
https://www.britannica.com/biography/Joseph-Priestley
https://en.wikipedia.org
10
:
ooo
ether as a surgical anesthetic in 1846.
“World Anaesthesia Day“ is on October 16th.
Father of Modern Anaesthesia.
German surgeon.
Father of Anaesthesia. He was the first to perform spinal
On 7 April 1853, Queen Victoria asked John anesthesia and intravenous regional
Snow to administer chloroform during the anesthesia.
delivery of her eighth child, Leopold. When is wold World Anesthesia Day ?
12
ooo
Canadian anesthesiologist
on January 23, 1942, when he and
resident Enid Johnson used curare for ooo
American anesthesiologist.
the first time during anesthesia to
ooo
He was known for his studies on the
produce muscle relaxation uptake and distribution of
inhalational anesthetics, as well for
defining the various stages of
general anesthesia.
ooo
The development of early anaesthetic machines.
ooo
His design included cylinders for the gases and a "Boyle's Bottle" to vaporize diethyl ether.
an anaesthetic machine was often referred to as a "Boyle's Machine" in honour of his
contribution.
13
Preoperative Assessment
American Society of Anesthesiologists Physical
Status Classification System
•
Most commonly used method by anesthesiologists to assess overall perioperative
risk is the ASA-PS classification system
AIRWAY EVALUATION
Mallampati classification
•
Used to predict the ease of endotracheal intubation(difficult airway).
class I - soft palate, fauces, entire uvula, pillars;
•
class III - soft palate, base of uvula; Mallampati Grading is
class IV - hard palate only. used for assessment of ?
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller 7th Ed. Pg:190
Miller’s Anesthesia 9th Ed,Pg : 987,925
14
•
Grade - 1 : Entire glottic opening from the Anterior to Posterior Commissure can be
visualised.
• Grade - 2 : Just the posterior portion of glottis can be visualised.
•
Grade - 3 : Epiglottis only
• Grade - 4 : Only Soft tissue with nor identifiable airway anatomy.
Grade 1 Grade 2
Grade 3 Grade 4
Reference : https://openairway.org/tag/cormack-lehane/
15
A reduction in the extension of the joint can cause difficulty with laryngoscopic
view and intubation.
A : Thyromental distance
: It is measured from thyroid
cartilage to Mentum(chin)
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg: 209
https://openairway.org/tag/cormack-lehane/
16
÷
Oral anticoagulants -(Warfarin 4 days prior)
Heparin -(Low molecular weight 12 hours before)
Anti platelets except aspirin (Clopidogrel 7 days prior)
Thrombolytic -(10 days prior)
NSAIDs -(48 hours prior if used with other antiplatets)
• High dose estrogen OCP -(4 weeks prior)
• Viagra -(24 hours prior)
• Disulfiram -(10 days prior)
All herbal medications -(7 days before)
: Smoking -(8 weeks before)
Oral hypoglycemics.
•
Reference:
Short Textbook of Anesthesia by Ajay Yadav 6th Ed Pg 51
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg: 206
17
:
•
Corticosteroids
Insulin
•
Rest all medications are continued in the same dosages and same regime with
morning dose on the day of surgery to be taken with a sip of water.
Reference :
Short Textbook of Anesthesia by Ajay Yadav 6th Ed 51
Miller’s Anesthesia 9th Ed,Pg : 952
18
Reference :
https://www.researchgate.net/figure/Fig1-Difficult-Airway-Society-difficult-intubation-guidelines-overview-Difficult-
Airway_fig1_283686715
19
Preoperative medications
Goals
1.To relieve anxiety.
•
benzodiazepine of choice is Midazolam.
2.To produce hemodynamic stability.
3.To induce sedation (good sleep) and reduce metabolic rate.
4.To provide analgesia and amnesia.
5.To decrease the chances of aspiration.
•drugs for aspiration prophylax:is, i.e. metoclopramide, antacids and
H2 blockers
6.To control oral and respiratory secretions.
•
Anticholinergics available to control secretions are atropine, glycopyrrolate.
they should be used only when required (like oral surgeries where dry mouth
is the requirement of surgery), not routinely in all patients.
7.To prevent postoperative nausea and vomiting.
•
In current dny practice 5-HT3 antagonists are the first-line medications
for prophylaxis as well as treatment of postoperative nausea and vomiting.
8.To control infection.
•antibiotic prophylaxis must be given within 60 minutes before skin incision.
A- 1114519
Glycopyrrolate is used as a
Pre Anesthetic agent for ?
20
Phase I blockade.
Phase II blockade, which resembles the blockade produced by
•
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg:161
21
:
onset of action of 3 to 5 minutes
•
Atracurium
•Bisquaternary benzylisoquinolinium
Onset of action of 3 to 5 minutes
: Duration of action of 20 to 35 minutes
Clearance of this drug is by :
:
-a chemical mechanism (Hofmann elimination) and
-biologic mechanism
(ester hydrolysis by nonspecific plasma esterases).
Laudanosine is the major metabolite of both pathways.(In high,
nonclinical concentrations, cause central nervous system stimulation)
•
Clearance independent of hepatic and renal function.
•Can cause hypotension and tachycardia.
22
Cisatracurium
•
benzylisoquinolinium nondepolarizing NMBD.
•an onset of action of 3 to 5 minutes
•duration of action of 20 to 35 minutes.
•principally undergoes degradation by Hofmann elimination.
•
Drug clearance is organ independent.
•
devoid of histamine-releasing effects
Rocuronium
monoquaternary aminosteroid
•
Mivacurium
benzylisoquinolinium nondepolarizing NMBD
: onset of action of 2 to 3 minutes
duration of action of 12 to 20 minutes.
•
Inhaled Anesthetics
most commonly used inhaled anesthetics in modern anesthesia include volatile liquids
i.
(i.e., halothane, enflurane, isoflurane, desflurane, and sevoflurane) and a single gas (i.e.,
nitrous oxide)
Halothane
Advantages includes : non-flammability,a pleasant
odor,lesser organ toxicity, and pharmacokinetic
properties allowing a much faster induction of anesthesia
and emergence.
Disadvantages :
•
Methoxyflurane Enflurane
•
metabolized to inorganic fluoride and
could cause evidence of seizure activity
•
dose-related nephrotoxicity because of on the electroencephalogram (EEG),
the inorganic fluoride that resulted from especially when administered at high
the metabolism of this anesthetic. concentrations and in the presence of
hypocapnia.
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg:85
24
:
-Elderly patients
Electrolyte Disturbance
-Hyponatremia
Other Factors
-Anemia (hemoglobin < 5 g/dL)
-Hypercarbia
-Hypothermia
-Hypoxia
-Pregnancy
POTENCY
Inversely proportional to MAC (Minimum Alveolar Concentration).
: Halothane > Isoflurane > Enflurane > Ether > Sevoflurane > Desflurane > Xenon > Nitrous
Oxide
Speed of Onset and Recovery
Inversely proportional to Blood Gas Partition Coefficient
: Desflurane > N2O > Sevoflurane > Isoflurane > Halothane > Methoxyflurane
26
:
less soluble in blood and tissues, allowing faster awakening and recovery
Isoflurane
Intravenous Anesthesia
Pharmokinetics of Drugs
PROPOFOL
•
most frequently administered anesthetic drug for
induction of anesthesia.
used during maintenance of anesthesia
:
Cause “dissociative anesthesia”
can be administered by multiple routes (intravenous,
intramuscular, oral, rectal, epidural).
•Norketamine, the primary active metabolite excreted
in urine.
unique properties, including profound analgesia,
stimulation of the sympathetic nervous system,
bronchodilation, and minimal respiratory depression
28
ETOMIDATE
•intravenous anesthetic with hypnotic.
•carboxylated imidazole derivative.
•Pain on injection (Maximum)
•potent cerebral vasoconstrictor.
•produces minimal changes in heart rate and cardiac output.
Minimal effect on respiration
i.
causes adrenocortical suppression by producing a dose-dependent
inhibition of 11β-hydroxylase.
BARBITURATEs
Derived from barbituric acid
grouped into thiobarbiturates, substituted with a sulfur
•
to general anesthesia.
do not have analgesic properties
•
Monitoring of Anesthesia
Respiratory system monitoring
Pulse oximetry noninvasive, in vivo, and continuous assessment of
TIME CAPNOGRAM
Increased upslope of phase III, as may occur during bronchospasm (asthma, chronic
obstructive pulmonary disease), or partially obstructed endotracheal tube/breathing circuit.
Cardiogenic oscillations at the end of exhalation as flow decreases to zero and the beating
heart causes emptying of different lung regions and back-and-forth motion between exhaled
and fresh gas
I Reference :
Miller’s Anesthesia 9th Ed,Pg : 1311
31
Curare notch
t
Clefts during phase III indicating spontaneous breathing efforts during controlled
mechanical ventilation
'
NEET 20
Esophageal intubation
Rebreathing of CO2, as may occur with faulty expiratory valve or exhausted absorber
system. Inspiratory CO2 is consistently above 0
Faulty inspiratory valve, resulting in a slower downslope, which extends into the
inhalation phase (phase 0) as CO2 in the inspiratory limb is rebreathed.
Reference :
Miller’s Anesthesia 9th Ed,Pg : 1311
32
sudden shortening of the duration of phase III during controlled mechanical ventilation,
suggesting the abrupt onset of a ruptured or leaking endotracheal tube cuff.
Dual plateau in phase III, suggesting the presence of a leak in a sidestream sample line.
Early portion of phase III abnormally low due to dilution of exhaled gas with ambient air.
The sharp increase in CO2 at the end of phase III reflects a diminished leak resulting from
the increased circuit pressure at the onset of inspiration.
Reference :
Miller’s Anesthesia 9th Ed,Pg : 1311
33
VOLUME CAPNOGRAM
volume capnogram is a graphic display of CO2 concentration or partial pressure versus
: exhaled volume.
The inspiratory phase is not defined in a volume capnogram.
It is partitioned into three distinct phases (I, II, and III) corresponding to anatomic dead
space, transitional, and alveolar gas samples
Anatomic dead space (phase I, red)
Transitional (phase II, blue)
Alveolar gas (phase III, green)
Total tidal volume (VT)
Airway dead space volume (VDaw)
Effective alveolar tidal volume (VTalv)
FETCO2, Fraction of end-tidal CO2
Reference :
Miller’s Anesthesia 9th Ed,Pg : 1312
34
Transient rise in CO2 indicated acute increase in CO2 delivery to the lungs, as may
occur during release of a tourniquet or administration of a bicarbonate bolus
Rise in both the baseline and end-tidal CO2,consistent with a contaminated sample cell
Gradual rise in baseline and end-tidal CO2, consistent with rebreathing. PCO2, Partial
pressure of CO2
Reference :
Miller’s Anesthesia 9th Ed,Pg : 1312
36
Hypovolemia, light
Sinus tachycardia anesthesia, hypoxia,
hypercarbia
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg:349
37
Hypercalcemia Shortened QT
interval,
possible J wave
Korotkoff method
•
Auscultate over antecubital fossa,
inflate cuff, slowly deflate, noting first
auscultation sounds and last sounds.
Gives diastolic as well as systolic
: pressure
Needs stethoscope, quiet environment
A, The CNAP Monitor 500 with arm and finger blood pressure cuffs.
B, The CNAP monitor double finger cuff and transducer.
Invasive blood pressure (IBP)
•
Connect intra-arterial catheter to transducer intra-arterial catheter to
Adv : Wide range of pressure, measures a mean pressure, transducer
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg: 353,354
Anesthesia Equipment Principles and Applications 2nd Ed. Pg 279,280
41
• The mean central venous pressure (CVP) value can be used to assess right-sided heart
filling pressure.
•
a wave - reflects atrial contraction against the closed tricuspid valve
• v wave - occurs during atrial filling
• c wave - reflects tricuspid bulging as the ventricle contracts
• x descent - corresponds to atrial relaxation
• y descent - reflects atrial emptying
Note as the catheter is advanced from the right ventricle into the pulmonary artery the diastolic
pressure is cut off and rises to the PA diastolic, which is only slightly higher than the pulmonary
artery wedge pressure. PA, Pulmonary artery;PCWP,pulmonary capillary wedge pressure.
42
19
•
Cerebral Perfusion Pressure = MAP - ICP Which among the following is most
•
2 methods for ICP monitoring are : commonly used for assessing depth of
i)ventriculostomy catheter anesthesia ?
ii)fiberoptic pressure transducer
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg: 357
43
ventriculostomy catheter
inserted percutaneously into a lateral
•
Cerebral Oximetry
•oxygenation of a portion of the brain (i.e.,
portion of the cerebral cortex) can be
monitored with a reflectance oximeter.
Parameter is called regional oxygen
Normal Electroencephalogram
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg: 357
44
Neuromuscular Monitoring
Neuromuscular Blockade Monitor
• most common method to follow the effects of a nondepolarizing neuromuscular blocking
drug is to use a “twitch monitor” and follow a train-of-four (TOF) count.
• TOF stimulation (four electrical stimulations at 2 Hz delivered every 0.5 second) is based
on the concept that ACh is depleted by successive stimulations.
• In the presence of effects produced at the NMJ by nondepolarizing NMBDs, the height of the
fourth twitch is lower than that of the first twitch, thereby allowing calculation of a TOF
ratio (fade).
Recovery of the TOF ratio to greater than 0.7 correlates with complete return to control
: height of a single twitch response.
In the presence of effects produced at the NMJ by SCh(Depolrizing NMBD), the TOF ratio
remains near 1.0 because the height of all four twitch responses is decreased by a similar
amount (phase I blockade).A TOF ratio of less than 0.3 in the presence of SCh reflects
phase II blockade.
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg: 222
48
Flowmeters
•upper end of the bobbin or the equator of the ball indicates the gas flow in milliliters or
liters per minute.
•oxygen flowmeter should be the last in the sequence of flowmeters.
For emergency purposes, provision is made for delivery of a large volume of oxygen
•(35 to 75 L/min) to the outlet port through an oxygen flush valve that bypasses the
flowmeters and manifold.
VAPORIZERS
Volatile anesthetics are liquids at room temperature and atmospheric pressure.
•
:
container, referred to as a vaporizer.
Commonly, two to three anesthetic-specific vaporizers are present on the
anesthesia machine.
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg: 224
49
All the circuits except for Mapleson E use a bag as an additional reservoir.
•
The Mapleson A, B, and C systems are rarely used today, but the D, E, and F
•
a.k.a the “Magill circuit,” has a spring-loaded pop-off valve located near the facemask.
: It is the only Mapleson circuit where fresh gas flow enters from the end of the circuit
opposite the patient (in this case, near the reservoir bag).
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg: 226
50
Mapleson b and c
• In the B and C systems, both the pop-off valve and fresh gas inlet tubing are located near
the patient.
The Mapleson C is known as the “Waters to-and-fro” circuit and lacks a corrugated tube.
: The reservoir tubing and breathing bag serve as a blind limb where fresh gas, dead space
gas, and alveolar gas can collect.
MAPLESON d, e and f
Mapleson D, E, and F, or “T-piece” group, fresh gas enters near the patient, and excess
:
•
gas is vented off at the opposite end of the circuit.
Mapleson E (also known as “Ayre’s T-piece”).
The Mapleson F system :
- commonly used for controlled ventilation during transport of tracheally intubated
patients.
- ideal for pediatric anesthesia.
- may be used for both spontaneous and controlled ventilation.
- Disadvantages :
(1) the need for high fresh gas
inflow to prevent rebreathing,
(2) the possibility of high airway
pressure and barotrauma should
the overflow valve become occluded.
(3) the lack of humidification.
NEET 18
- A > DFE > CB during spontaneous ventilation Most effective circuit used for anesthesia
- DFE > BC > A during controlled ventilation. under spontaneous breathing ?
Bain System
is a coaxial version of the Mapleson D system in which the fresh gas supply tube
•
Schematic diagram of the Bain system showing fresh gas flow (FGF)
entering a narrow tube within the larger corrugated expiratory limb (A).
The only valve in the system (B) is an adjustable pressure-limiting
(overflow) valve located near the FGF inlet and reservoir bag (C).
Circle System
• prevents rebreathing of CO2 by chemical
neutralization of carbon dioxide with carbon
dioxide absorbents.
anesthesia machine ventilator (V)
Soda Lime
Heliox
Is mixture of 21 % oxygen and 79% helium
Entonox
• Is 50 :50 mixture of nitrous oxide and oxygen.
Compressed in cylinders at 13,700 kPa
: PISS -7
Orange in colour.
PISS - 3,6
•
\
54
Anesthesia Equipments
Guedel's oropharyngeal airway
•
Aim of airway- prevent the tongue fall.
• Most commonly used is Guedels airway.
• Airways are available in many sizes.
•
The appropriate length is the distance
between tip of nose and tragus plus 1 cm.
Waters Airway
•Metal airway with flattened anatomically
curved tube and holes at side and on top at
end of tube.
•has a side port or “nipple” to deliver air or
oxygen via tubing.
Reference:
Short Textbook of Anesthesia by Ajay Yadav 6th Ed 32
56
Nasopharyngeal airway
•
Was introduced by Hans Karl Wendl
•Are made from soft, flexible materials
•Tolerated better in awake patients than are oropharyngeal airways.
•
Appropriate sizing determined by measuring the distance from the
patient’s bony mandible or nostril to the meatus of the ear.
FACEMASKS
used to ventilate the patient without intubation.
•
Reservoir bag
•
Is a device used to assist in the delivery of oxygen therapy.
•
An NRB requires that the patient can breathe unassisted, but unlike low-flow nasal
cannulae, the NRB allows for the delivery of higher concentrations of oxygen.
•
Utilized for patients with physical trauma, chronic airway limitation, cluster headache,
smoke inhalation, and carbon monoxide poisoning, or any other patients who require high-
concentration oxygen, but do not require breathing assistance.
The flow rate and approximate for different FiO2 oxygen delivery devices
Oxygen delivery devices Flow rate (litre/min) Approximate FiO2
Nasal cannula 1-6 0.24-0.44
Simple face mask 5-8 0.40-0.60
Partial rebreathing mask 6-10 0.60-0.80
Non rebreathing mask 10-15 0.90-1.00
Venturi mask 2-15 0.24-0.60
ap le.g
• is an open breathing system for delivering
•
Was used for the drop method of an anesthetic.
anesthesia.
Mask headstrap
Endotracheal Tubes
• An endotracheal tube is a specific type of tracheal tube that is nearly always inserted
through the mouth (orotracheal) or nose (nasotracheal).
Reference:
Anesthesia Equipment Principles and Applications 2nd Ed. Pg :332
59
'
NEET 18
Murphy’s eye is
seen in which
device ?
•
Murphy eye provides an alternate gas passage way should this type of occlusion
at the tip occur.
Cuff design
•Most endotracheal tubes for use in adults
have a tracheal cuff near their distal end.
•Cuff-less ETTs are also available, and a
more commonly used in pediatric patients.
•
two types of endotracheal tube cuffs in
use, high volume-low pressure cuffs and
low volume- high pressure cuffs.
• The cuff is inflated through a spring-loaded valve with a Luer lock connector.
•
Attached to the valve is a pilot balloon which allows for (rough) tactile and visual
• confirmation of cuff inflation after intubation or deflation just before extubation.
Reference :https://aam.ucsf.edu
60
Microlaryngoscopy tube
•
is in essence a pediatric-sized standard ETT with an adult length or an adult standard
ETT with a pediatric-sized diameter.
• comes in three sizes, 4.0, 5.0 and 6.0mm.
• The size 5.0mm tube is the most commonly used.
intubation.
USES
•
designed to reduce the risk of traumatic intubation, which is more likely to occur in
(mainly) two situations:
1.Nasal intubation, particularly with a narrow passage, e.g. due to relatively large
turbinates
2.Intubation with a Seldinger technique
62
Armored Tubes
•
both anode or flexometallic,have a reinforced metal or nylon wire wound in a spiral
throughout the shaft of the tube.
resistant to kinking and compression
: used in head, neck and tracheal surgery and in positions in which the neck is flexed.
Preformed Tubes
such as Ring-Adair-Elwyn (RAE) tubes,have a preformed bend and are available for
iboth oral and nasal intubations to prevent the ETT from hindering access to the
surgical field.
They are predominantly used in oromaxillofacial and nasal procedures.
Oral RAE tube with preformed bend ( SOUTH facing) Oral RAE tube in-situ
Nasal RAE tube with preformed bend ( NORTH Facing ) Nasal RAE tube in-situ
63
Gum-elastic bougie
•also called 'introducer', 'gum-elastic bougie' or 'GEB', is a device which allows a
Seldinger-like technique of intubating a patient's airway.
•moderately flexible and can be bent into shape from its straight form.
•
Bougies are commonly about 15F in diameter and 70cm in length.
•
tip of the bougie is angled at 30 degrees and should point anteriorly during
•intubation to facilitate navigation of the device towards an anteriorly located larynx.
Gum-elastic bougie
Aintree catheter
is a blunt-tipped, 19 Fr radio-opaque catheter
Distal tip of Aintree catheter with end hole and two side holes
64
Magill forceps
•help with ET tube placement during nasal
intubation.
The design remains pretty much unchanged.
: breathing unit.
available in a capacity of
-I,200 mL for adults,
-500 mL for children
-250 mL for newborns.
•
100% oxygen can be delivered by AMBU bag by attaching O2 source and O2 reservoir
Laryngoscopes
•
used for visualizing the glottis to facilitate intubation.
McCoy Miller
It has got a movable lip, which can be used
•
• It has a straight blade with
to maneuver the glottis curve at the tip.
Reference:
Short Textbook of Anesthesia by Ajay Yadav 6th Ed 33
66
Magill
straight blade used for neonates.
: Neonatal epiglottis is large, leafy
and more anterior, therefore it need
to be lifted by straight blade to
visualize glottis.
Bullard Laryngoscope
•
the prototypical anatomically shaped
rigid fiberscope.
• Accessories include hollow tracheal
tube stylet, a single-use blade
extender, and an external light
source cable adaptor.
• Pediatric and adult sizes are
available
68
Video Laryngoscopes
video of the real time refracted image of glottis is obtained on a screen.
•
most commonly used and prototype is C-MAC the design of which is based on the
•
Macintosh blade.
69
McGrath Laryngoscope
•
is a portable rigid glottic imaging device that replicates the look and
feel of the direct laryngoscope.
LMA Flexible
•
The tube of LMA is enforced with a
wire making it flexible(nonkinkable
making it useful for head and neck
surgeries.)
Reference:
Short Textbook of Anesthesia by Ajay Yadav 6th Ed 35,36
71
Intubating LMA
• also called as LMA Fastrach
• Up to 8 no. endotracheal tube can be guided through it.
Fastrach
Moreover, it has drain tube which can be used to deflate the stomach
•
Supreme LMA
• Supreme LMA is like proseal LMA
with a bite block to avoid damage
to LMA tube, if the patient bites.
available in adult sizes 3 to 5
I-Gel
The cuff is prefilled with gel avoiding the
•
Peripharyngeal airway(Cobra-PLMA)
It has high volume oval cuff, which seals
•
LMA C-Trach
•
Like video laryngoscopy, the LMA is
attached to screen to visualize the
structures
73
Combitube
a double-lumen airway composed of a
SPINAL ANESTHESIA
• Spinal anesthesia requires a small amount of drug to produce rapid, profound,
reproducible, but finite sensory analgesia. AIIMS 18
'
•
Distal termination of Spinal cord : At what level does the spinal
- infants - L3 cord end in Adults ?
- adults - the lower border of L1
CSF resides in the subarachnoid (or intrathecal) space between the pia mater and the
: arachnoid mater.
No drug metabolism takes place in the CSF.
Baricity is the ratio of the density of a local anesthetic solution to the density of CSF.
Spinal needles
You are doing the lumbar puncture.Which is the last structure to be encountered :
headache.
A. Ligamentum lavum C. Arachnoid • rounded points and side injection.
B. Dura D. Pia • pencil-point needles of 25 G, 26 G, and
27 G probably represent the optimal
needle choice.
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg: 273
75
Pitkin needle
Whitacre needle
Reference :https://associationofanaesthetists-publications.onlinelibrary.wiley.com
76
18G Pink
19G Ivory
20G Yellow
21G Green
22G Black
23G Blue
24G Violet
25G Orange
26G Brown
27G Grey
EPIDURAL ANESTHESIA
Continuous catheter-based epidural infusions
:
are used for obstetric labor analgesia and to
provide postoperative pain relief for days after
major surgery (e.g., thoracic, abdominal, lower
limb).
Tuohy needles are most commonly used.
Suggested Epidural Insertion Nature of Surgery Sites for Common Surgical Procedures
Tuohy needles
77
A spinal needle and epidural needle are used for the combined
spinal-epidural technique.
Tuohy needle with a “back eye” that permits placement of the spinal needle
directly into the suba- rachnoid space (left panel) and subsequent threading of
the epidural catheter into the epidural space after removal of the spinal needle.
•
Some Types of epidural needles include :
1)The Crawford Needle
2)The Tuohy Needle
3)The Hustead Needle
4)The Weiss Needle
5)The Sprotte Spezial Needle
78
Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg:307
79
Interscalene Block
•
targets the ventral rami of the brachial
plexus (derived from C5, C6, C7, C8, and T1
nerve roots).
•
suited for surgeries that involve the distal
clavicle, shoulder, and upper arm.
• has the potential risk of Horner syndrome,
recurrent laryngeal nerve block, epidural
or subarachnoid injection, vertebral artery
injection and pneumothorax.
Supraclavicular Block
Pneumothorax is the most common
: serious complication.
Advantages are rapid onset and
ability to perform the block with the
arm in any position.
• Bilateral supraclavicular blocks are
not recommended for fear of
bilateral pneumothorax or phrenic
nerve paralysis.
Infraclavicular Block
•
targets the medial, lateral, and posterior
cords of the brachial plexus.
Suitable for surgeries of the arm below the
: shoulder.
Aadvantages are the close proximity of the
brachial plexus to the artery, relatively
consistent anatomy and a stable site for
placement of a continuous peripheral nerve
catheter.
•
BP, Brachial plexus; LC, lateral cord; MC, medial cord; PC, posterior cord;
PMa, pectoralis major muscle; PMi, pectoralis minor muscle; SA, subclavian artery.
Reference :
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Axillary Block
targets the terminal branches of the brachial plexus in the axilla: the median, ulnar,
•
:
cutaneous innervation to the medial half of the arm.
may be used as a supplement to brachial plexus blocks to improve tolerance of an arm
tourniquet or to improve surgical conditions for proximal arm surgery.
÷ The lumbar plexus - first four lumbar nerves (L1-L4).Nerves that arise from the
lumbar plexus include the lateral femoral cutaneous, femoral, and obturator nerves.
• The sacral plexus - first four sacral nerves (S1-S4) and also receives contributions
from L4 and L5. This plexus gives rise to the sciatic nerve.
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:nerve and infrapatellar nerve) as they travel deep to the sartorius muscle in the thigh.
Advantage analgesia for knee surgery, with minimal quadriceps muscle weakness.
FA, Femoral artery;SM, sartorius muscle; SN, saphenous nerve; VM, vastus medialis muscle.
Reference :
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Reference :
Basics of Anesthesia by Manuela C.Pardo,Ronald D. Miller. Pg:307
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Ankle Block
•
All five peripheral nerves that supply the foot can be
blocked (ankle block) at the level of the malleoli.
i. tibial nerve
ii.sural nerve
iii.saphenous nerve
iv.deep peroneal nerve
v.superficial peroneal nerve
•
Because the foot does not have a generous blood
supply, systemic toxicity after an ankle block is rare.
: nerves.
beneficial for thoracic and upper abdominal
surgery, as well as following chest wall trauma.
there is a potential risk of a pneumothorax.
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:
used for surgical procedures with minimal postoperative pain and duration of 2 hours or
less.
Contraindications :
- sickle cell disease,
- ischemic vascular disease
- infection in the extremity.
Commonly used local anesthetic solutions for intravenous regional anesthesia are 0.5%
•
also called the dorsal decubitus position, is the most common position for surgery.
: One or both arms can be abducted or adducted alongside the patient. Arm abduction
should be limited to less than 90 degrees in order to prevent brachial plexus injury
from the head of the humerus pushing into the axilla.
• should pad all bony prominences as well as stopcocks or intravenous lines that may
exert pressure on the skin during the operation
Variations of the Supine Position
Lawn-chair position
flexes the hips and knees slightly, which reduces stress on the back, hips, and knees.
:This modified supine position is often better tolerated by patients who are awake or
undergoing monitored anesthesia care.
facilitates venous drainage from the lower extremities
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frog-leg position
the hips and knees are f lexed and the hips are externally rotated with the soles of the
:feet facing each other, facilitates procedures to the perineum, medial thighs, genitalia,
and rectum.
The knees must be supported in order to minimize stress or dislocation of the hips.
Lateral Decubitus
•
the patient lies on the non- operative side in order to facilitate surgery in the thorax,
retroperitoneum, or hip.
Neither arm should be abducted more than 90 degrees in order to prevent injury to the
Trendelenburg position
•commonly used today to increase venous return during hypotension, improve exposure
during abdominal and laparoscopic surgery, and prevent air emboli during central line
placement.
•It is part of the initial resuscitative efforts to treat hypovolemia.
•Intraocular pressure and intracranial pressure (ICP) can increase.
•Nonsliding mattresses are recommended to prevent the patient from sliding cephalad.
Endotracheal intubation is strongly recommended over supraglottic airways because of
:
the risk of pulmonary aspiration of gastric contents.
reverse Trendelenburg position
Tilts the supine patient upward so that the head is higher than any other part of the body.
•
Most often used to facilitate upper abdominal surgery.
Patients who are hypovolemic, are at risk for hypotension due to decreased venous return.
reverse
Trendelenburg
position
Trendelenburg
position
Jackknife position
Also called the Kraske position.
: Patient's abdomen lies flat on
the bed.
•
The bed is scissored so the hip
is lifted and the legs and head
are low.
Reference :
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Lithotomy
frequently used during gynecologic, rectal, and urologic surgeries.
i
lithotomy position causes some physiologic changes :
1. transient increase in cardiac output
2. decreased tidal volume.
Lower extremity compartment syndrome is a rare but devastating complication
associated with the lithotomy position.
i
a.k.a Tredelenburg position with legs apart or head down Lithotomy.
It is defined as supine position of the body with hips flexed at 15 ̊ as the basic angle and
with a 30 ̊ head-down tilt.
The key difference between lithotomy and Lloyd-Davies is the degree of hip and knee
flexion.
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SITTING
patient’s head and also the operative field are located above the level of the heart.
: excellent surgical exposure for some cervical spine and neurosurgical procedures,
particularly of the posterior fossa and superior cervical spine.
Sitting position with Mayfield head pins
•
The patient is typically semirecumbent rather
than sitting as the legs are kept as high as
possible to promote venous return.
• Arms must be supported to prevent shoulder
traction.
•
head holder support is preferably attached to
the back section rather than the thigh section
of the table so that the patient’s back may be
adjusted or lowered emergently without first
detaching the head holder.
;:
Hypoperfusion of the brain.
Macroglossia can also occur with
excessive neck flexion.
Currently TEE is the gold standard for
detection of intracardiac shunts.
91
Prone position
a.k.a ventral decubitus position.
: used primarily for surgical access to the posterior fossa of the skull, the posterior
spine, the buttocks and perirectal area, and the lower extremities.
•
Prone position with Wilson frame.
Arms are abducted less than 90 degrees whenever possible.
: Pressure points are padded, and chest and abdomen are supported away from the bed to
minimize abdominal pressure and preserve pulmonary compliance.
•
Foam head pillow has cutouts for eyes and nose and a slot to permit the endotracheal
tube to exit.
•
Is a risk factor for perioperative visual loss (POVL)
Sims' position
•
Is a variation of the left lateral position.
•
The patient is usually awake and helps
with the positioning.
• The patient will roll to his or her left
side. Keeping the left leg straight, the
patient will slide the left hip back and
bend the right leg. This position allows _IeI_-
access to the anus.
Fowlers position
Begins with patient in supine position.
•
Semi-Fowlers position
Lower torso is in supine position and the upper torso is bent at a nearly 85 degree position.
•
F luid Management
PERIOPERATIVE FLUID BALANCE
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Ringer lactate
•
Composition :
i) Na (mEq/L) - 130
ii)K (mEq/L) (g/L) - 4
iii)Glucose (g/L) - 0
iv)Osm - 273
v) pH - 6.5
vi)Other -(Lactate 28 mEq/L)
Plasma-Lyte A
• Composition :
i) Na (mEq/L) - 140
ii)K (mEq/L) (g/L) - 5
iii)Glucose (g/L) - 0
iv)Osm - 295
v) pH - 7.4
Normosol
•Composition :
i) Na (mEq/L) - 140
ii)K (mEq/L) (g/L) - 5
iii)Glucose (g/L) - 0
iv)Osm - 294
v) pH - 6.6
vi)Other - Mg 3 mEq/L,
Acetate 27 mEq/L,
Gluconate 23 mEq/L
95
Normal Saline
Normal saline (0.9% NaCl) is hypertonic with
Hypertonic Saline
•
Generally used in specific situations such as
control of intracranial hypertension or the
need for rapid intravascular resuscitation.
•
The sodium concentrations range from 250 to
1200 mEq/L.
•Patients predisposed to tissue edema might
benefit from use of a hypertonic solution.
•
However, the half-life of hypertonic solutions
is similar to that of isotonic solu tions.
Reference :
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Colloids
•
Colloid solutions, albumin, and starches contain large molecular weight substances.
The synthetic starches have little to no risk of infection, but allergic reactions can occur.
Albumin
supplied as a 5% or 25% solution.
:
The initial volume of distribution is equivalent to the
plasma volume, and it remains in the intravascular
space for a longer duration than crystalloids.
Composition :
i) Na (mEq/L) - 145 ± 15
ii)K (mEq/L) (g/L) - <2.5
iii)Glucose (g/L) - 0
iv)Osm - 330
v) pH - 7.4
97
Dextran
• The two used medically are dextran 40 (40 kDa) and
dextran 70 (70 kDa).
synthesized from sucrose by lactic acid bacteria,
:
such as Leuconostoc mesenteroides and
Streptococcus mutans.
used as antithrombotics to reduce blood viscosity,
and as intravascular volume expanders in
hypovolemia.
Side effects :
- anaphylactic or anaphylactoid reactions
- increased bleeding times
•
Composition :
- noncardiogenic pulmonary edema(rare) i)Osm - 255
ii)pH - 4.0
Hydroxyethyl Starch
nonionic starch derivatives and were one of the
:
most frequently used intravascular volume
expanders.
HES interferes with von Willebrand, factor VIII,
and platelet function.
most common complication associated with HES
•
administration is pruritus.
Composition :
•
i) Na (mEq/L) - 154
ii)K (mEq/L) (g/L) - 0
iii)Glucose (g/L) - 0
iv)Osm - 310
v) pH - 5.9
Sub-Tenon block
•
Local anesthetic is infused via a cannula into the potential space between
Capsule of Tenon and the sclera, ultimately arriving at the optic nerve.
Reference :
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:
during the first stage of labor.
•
Blocks transmission of pain impulses at the
paracervical ganglion.
Complications from systemic absorption
can occur as well as the possibility of direct
fetal trauma or injection.
Paracervical block is associated fetal
bradycardia.
Pudendal Block
is infrequently used to provide pain relief during
Reference :
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•
Options for Lung Isolation
- facilitate selective ventilation of one lung.
- These include DLTs , bronchial blockers (BBs) placed through a single-lumen endo-
tracheal tube (SLT) and a single-lumen tube (standard endotracheal tube or
endobronchial tube) placed directly into a bronchus.
Double Lumen Endobronchial Tubes
•
Absolute indications for use :
- Surgical exposure in video-assisted
thoracoscopic surgery (VATS)
- Single lung lavage: Treatment for pulmonary
alveolar proteinosis or cystic fibrosis
101
Mechanical Ventilation
•performed entirely via positive-pressure ventilation
:degree.
So, if tidal volume is set at 500 mL, then all breaths (i.e., mandatory and
spontaneous) will receive a tidal volume of 500 mL.
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Pressure Support
PS mode is used only with spontaneously breathing patients, as all breaths are
:
triggered by patient effort.
The driving pressure (ΔP), positive end-expiratory pressure (PEEP), and fraction
of inspired oxygen (F io2) are the only variables set in this mode.
Inspiratory flows are based on patient demand. The ventilator ends inspiration when
the flow rate has decreased to a predetermined level (usually 25% of the peak flow
rate).
There is no backup respiratory rate in PS mode unless it is combined with SIMV.
Nasal Cannulas
Nasal Mask
Simple Oxygen Mask Masks with Gas Reservoirs
gas reservoirs
104
÷
can decrease airway inflammation,maintain
mucociliary function ,mucous clearance and
reduce the caloric expenditure in acute
respiratory failure.
Can deliver between 60 -70 L /min
Can generate PEEP betweeen 4-6 mm Hg
• Decrease Alveolar dead space
•
Disadvantage : less effective in Oxygenation
A- 1114519
Bi PAP CPAP
CPAP
•
Bi level Positive Airway Pressure
• Constant Positive Airway Pressure
Most basic level of support and provides constant fixed positive pressure
'
AIIMS 17
Calculate GCS ?
108
Miscellaneous
CPR - Cardiopulmonary Resuscitation
AHA Chains of Survival for Adult IHCA and OHCA
(In Hospital )
(Out of Hospital)
'
AIIMS 17
Correct Sequence of
BLS Algorithm ?
Reference : https://www.ahajournals.org
109
AIIMS 20
Alternative drug for cardiac arrest if epinephrine is not effective ? Effective CPR includes?
110
:
- We recommend that laypersons initiate CPR for presumed cardiac arrest because
the risk of harm to the patient is low if the patient is not in cardiac arrest.
:
- It may be reasonable to use audiovisual feedback devices during CPR for real-time
optimization of CPR performance.
Physiologic Monitoring of CPR Quality
- use physiologic parameters such as arterial blood pressure or ETCO2 when
feasible to monitor and optimize CPR Quality.
Double Sequential Defibrillation Not Supported
:
IV Access Preferred Over IO
- IO access may be considered if attempts at IV access are unsuccessful or
not feasible.
Post–Cardiac Arrest Care and Neuroprognostication
A- 1114519
Reference :
https://www.ambulance.qld.gov.au/docs/clinical/cpp/CPP_Manual%20inline%20stabilisation.pdf
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:
hand to lift the jaw upward and outward so that
the lower central incisors are anterior to the
upper central incisors.
In children with traumatic injuries,the cervical
spine must be maintained in a neutral position
during this maneuver