Embolization of hypervascular

renal tumors

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Biocompatibles UK Ltd is a
BTG International group company
 Embolization of hypervascular renal tumors in combination therapy

Bead Block embolic agent offers the benefits associated with targeted occlusion of renal vessels and is ideally suited for super-selective arterial embolization.
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Recent studies have demonstrated that super-selective embolization of renal tumors prior to resection or ablation may offer the following benefits:
• Preservation of renal function • Reduced RFA heat sink effect • Reduced probability of bleeding • Eliminate the need to clamp renal vessels

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Preoperative SEA [super-selective arterial embolization] allows us to perform LPN
[laparoscopic partial nephrectomy] without clamping hilum vessels and so avoiding ischemic
damage that is the main limiting step of this procedure for an experienced surgeon.
Simone G et al, J Endourol, 23 (2009): 1473-8.
“ Bead Block + Partial Nephrectomy

• Eliminate the requirement to clamp the

3,4
renal artery during procedure
STE [super-selective transarterial embolization] allowed us to perform a zero-ischemia LPN for tumors with • Avoid risks associated with exceeding the
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moderate nephrometry score and provided excellent functional results with low complications rate and adequate
oncologic results. STE significantly simplifies LPN and combines the advantages of excellent bleeding control
“ warm ischemia time (WIT) threshold 3,4

without any ischemia and thus without time thresholds within which to perform tumor excision.
Simone G et al, J Endourol 25 (2011): 1443-6.

Bead Block + Cryoablation

Hematoma volume after renal cryoablation

“ Although this does not argue that all large renal tumors should undergo pre-embolization, it does suggest
that pre-embolization can reduce post-cryoablation hemorrhage. This also supports the finding that
percutaneous cryoablation of very large renal masses measuring at least 5cm is technically feasible,
“ • Reduce the risk of bleeding and
bleeding-related complications
following renal cryoablation 2
Bead Block™

embolization

Without
18ml (Range 3-57)

357ml (Range 67-1,209)

relatively safe, and appears to be effective in local tumor control at short-term follow-up. embolization
Woodrum DA et al. J Vasc Interv Radiol 21(6) (2010): 930-6.
• Increase the feasibility, safety and ml

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effectiveness of cryoablation of
2 Graph adapted from: Woodrum DA et al, J Vasc Interv Radiol 21(6):93
very large (>5cm) renal tumors

“ The combination of RF ablation and embolization in tumors

larger than 2.5cm in diameter is regarded to be of some advantage.
Devascularization presumably allows the creation of a larger necrotic
Bead Block + Radiofrequency Ablation
volume and less energy is needed to completely destroy the tumor. “
Therefore, the remaining parenchyma is less exposed to possible • Reduce the risk of bleeding and bleeding-
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detrimental effects of heating. related complications following RFA
Hoffman et al. Eur J Radiol 73 (2010): 652-6.

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• Achieve a larger volume of necrosis
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Before Bead Block After Bead Block

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embolization4 embolization4
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Bead Block embolic agent offers:
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• Proven performance for the embolization of hypervascular

tumors and arteriovenous malformations (AVMs)
• Blue-tinted beads, in prefilled, color-coded syringes
for added convenience and safety
• Precisely calibrated sizing for effective and
accurate embolization
• Compressible spherical embolic with 100%
elastic shape recovery for easier delivery
• Confidence of product and clinical support from
Biocompatibles – leaders in embolization technology

Bead Block ordering information References

1. Hoffmann RT, Jakobs TF, Kubisch CH, Trumm C, Weber C, Siebels M,
Label Color and Helmberger TK, Reiser MF. Renal cell carcinoma in patients with a solitary kidney
Volume of Beads Product Code
Nominal Bead Size after nephrectomy treated with radiofrequency ablation: mid term results.
Eur J Radiol. 2010; 73: 652-656.
100-300µm 2ml EB2S103 2. Woodrum DA, Atwell TD, Farrell MA, Andrews JC, Charboneau JW, Callstrom MR.
Role of intraarterial embolization before cryoablation of large renal tumors: a pilot study.
300-500µm 2ml EB2S305 J Vasc Interv Radiol. 2010 Jun; 21(6): 930-6.
3. Simone G, Papalia R, Guaglianone S, Carpanese L, Gallucci M. Zero ischemia
500-700µm 2ml EB2S507 laparoscopic partial nephrectomy after superselective transarterial tumor embolization
for tumors with moderate nephrometry score: long-term results of a single-center
experience. J Endourol. 2011 Sep; 25(9): 1443-6.
700-900µm 2ml EB2S709
4. Simone G, Papalia R, Guaglianone S, Forestiere E, Gallucci M. Preoperative
superselective transarterial embolization in laparoscopic partial nephrectomy:
900-1200µm 2ml EB2S912
technique, oncologic, and functional outcomes. J Endourol. 2009 Sep; 23(9): 1473-8.

2ml Bead Block is suspended in physiological buffered

saline in 20ml syringe and is packed singly.
Important information
Indications:
Bead Block is intended to be used for the embolization of hypervascular
For more information, please contact: tumors and arteriovenous malformations (AVMs).

Biocompatibles UK Limited Phone: +44 (0)1252 732 732 Potential Complications:

1. Undesirable reflux or passage of Bead Block into normal arteries adjacent
Chapman House Fax: +44 (0)1252 732 777 to the targeted lesion or through the lesion into other arteries or arterial beds,
Farnham Business Park E: marketing@biocompatibles.com such as the internal carotid artery, pulmonary, or coronary circulations.
Weydon Lane, 2. Pulmonary embolization.
3. Ischemia at an undesirable location.
Farnham, Surrey, 4. Capillary bed saturation and tissue damage.
GU9 8QL, UK www.biocompatibles.com 5. Ischemic stroke or ischemic infarction.
6. Vessel or lesion rupture and hemorrhage.
7. Neurological deficits including cranial nerve palsies.
8. Vasospasm.
9. Death.
10. Recanalization.
11. Foreign body reactions necessitating medical intervention.
12. Infection necessitating medical intervention.
13. Clot formation at the tip of the catheter and subsequent dislodgement.

Caution:
Federal (USA) law restricts the sale of this device by or on order of a physician.

Bead Block is manufactured by Biocompatibles UK Ltd, Chapman House,

Farnham Business Park, Weydon Lane, Farnham, Surrey, GU9 8QL, UK.
Biocompatibles, Inc. and Biocompatibles UK Ltd are BTG International group
companies. Bead Block is a trademark of Biocompatibles UK Ltd. BTG and
the BTG roundel logo are registered trademarks of BTG International Ltd.
© Copyright 2012 Biocompatibles UK Ltd. IVMPRC11-015 Rev 3 AVM.
ellence in E
Exc m
s
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bo
compatib

liza
tion
™
Bio

Biocompatibles UK Ltd is a
BTG International group company