Pre-Feasibility Report for Proposed Pharmaceutical Manufacturing Unit

PRE-FEASIBILITY REPORT
of
Proposed Manufacturing Unit of Pharmaceuticals Intermediates
and Specialty Chemicals
for
M/s. Navitus Chemicals Private Limited
At
Plot No. A-24/100 & A-24/105,

MIDC Umred, Nagpur-441203
Submitted to
State Expert Appraisal Committee (SEAC-I), Maharashtra
Environmental Consultant Submitted by
Building Environment (India) Pvt. Ltd Navitus Chemicals Pvt Ltd

Dakshina Building, Office No-401,4th Floor, Plot No. A-24/100 & A-24/105,Umred
Industrial Area, Dist. Nagpur,
Beside Raigard Bhavan, Sakal Bhavan Rd,
Maharashtra, India
Sector 11, CBD Belapur,
Navi Mumbai, Maharashtra 400614
Telefax: 022 4123 7073/2757 8554
Web: www.beipl.co.in
September 2020
Proposed Manufacturing Unit of Pharmaceuticals Intermediates and Specialty Chemicals 2020
TABLE OF CONTENTS
Executive Summary ...................................................................................................................... 6

1. Introduction of the project/Background information ....................................................... 8
1.1 Identification of project and project proponent ................................................................ 8
1.2 Brief description of nature of the project ....................................................................... 10
1.3 Need for the project and its importance to the country and our region .......................... 14
1.4 Demand-Supply Gap ...................................................................................................... 15
1.5 Imports vs Indigenous production .................................................................................. 15
1.6 Export Possibility ........................................................................................................... 15
1.7 Domestic/export Markets ............................................................................................... 15
1.8 Employment Generation (Direct and Indirect) due to the project .................................. 16
2. Project Description ............................................................................................................. 16
2.1 Type of project including interlinked and independent projects, if any......................... 16
2.2 Project Location ............................................................................................................. 16
2.3 Details of alternate sites ................................................................................................. 22
2.4 Size or magnitude of operation ...................................................................................... 22
2.5 Project description with process details ......................................................................... 24
2.6 Raw material required along with estimated quantity .................................................... 52
2.7 List of Plant Machinery .................................................................................................. 60
2.8 Resource optimization .................................................................................................... 60
2.9 Availability of water its source, Energy/ power requirement and source ...................... 60
2.10 Quantity of wastes to be generated (liquid and solid) and scheme for their
Management/disposal ............................................................................................................... 63
2.11 Schematic representations of the feasibility drawing which give information of EIA
purpose 63
3. Site Analysis......................................................................................................................... 65
3.1 Connectivity ................................................................................................................... 65
3.2 Land Form, Land use and Landownership ..................................................................... 65
3.3 Topography .................................................................................................................... 65
3.4 Existing land use pattern ................................................................................................ 65
3.5 Existing Infrastructure .................................................................................................... 65
3.6 Soil classification ........................................................................................................... 65
1
BE/PFR Navitus/020/04Rev no. 00
3.7 Climatic data from secondary sources ........................................................................... 66

3.8 Social Infrastructure ....................................................................................................... 67
4. Planning Brief...................................................................................................................... 68
4.1 Planning Concept ........................................................................................................... 68
4.2 Population Projection ..................................................................................................... 68
4.3 Land use planning .......................................................................................................... 68
4.4 Assessment of Infrastructure Demand (Physical &Social) ............................................ 69
4.5 Amenities/Facilities ........................................................................................................ 69
5. Proposed Infrastructure ..................................................................................................... 70
5.1 Industrial Area (Processing Area) .................................................................................. 70
5.2 Residential Area (Non Processing Area) ....................................................................... 70
5.3 Green Belt ...................................................................................................................... 70
5.4 Social Infrastructure ....................................................................................................... 70
5.5 Connectivity ................................................................................................................... 70
5.6 Drinking Water Management ......................................................................................... 70
5.7 Sewerage System............................................................................................................ 70
5.8 Industrial Waste Management ........................................................................................ 74
5.9 Solid Waste Management............................................................................................... 74
5.10 Power Requirement & Supply /source ....................................................................... 75
6. Rehabilitation and Resettlement (R&R) Plan .................................................................. 77
7. Project Schedule & Cost Estimates ................................................................................... 77
8. Analysis of proposal (Final Recommendations) ............................................................... 77
LIST OF FIGURES
Figure 2-1: Site Photographs ..................................................................................................... 18

Figure 2-2: Project location........................................................................................................ 19
Figure 2-3: Site layout ................................................................................................................ 20
Figure 2-4: Geographical coordinates of the project site ........................................................ 21
Figure 2-5: Water Balance Chart .............................................................................................. 62
Figure 3-1: Wind Rose Diagram ................................................................................................ 66
Figure 5-1: Flow Scheme for STP.............................................................................................. 73
2
Figure 5-2: Process Flow Diagram for 20 KLPD ZLD Plant.................................................. 76
LIST OF FIGURES
Table 0-1: Salient feature of the project ..................................................................................... 6

Table 1-1: Role and Responsibility of Core Team Members .................................................... 9
Table 1-2: Profile of Core Team Members ................................................................................. 9
Table 1-3: List of products ......................................................................................................... 11
Table 2-1: Physical and Social Infrastructure around the Project Site ................................. 21
Table 2-2: Production capacity .................................................................................................. 22
Table 2-3: Raw material details ................................................................................................. 52
Table 2-4: Water Budget ............................................................................................................ 61
Table 2-5: Hazardous waste quantification and disposal........................................................ 63
Table 2-6: Details of non-Hazardous waste .............................................................................. 63
Table 3-1: Details of Land use of the Lease Area .................................................................... 65
Table 3-2: Social Infrastructure in the Project Area ............................................................... 67
Table 4-1: Project Timeline........................................................................................................ 68
Table 4-2: Area details................................................................................................................ 68
Table 5-1: Influent and Effluent Characteristics of STP ........................................................ 72
Table 7-1: Project Cost ............................................................................................................... 77
3
ABBREVIATIONS
API Active Pharmaceutical Ingredient
CER Corporate Environmental Responsibility
CHWTSDF Common Hazardous Waste Treatment, Storage and Disposal Facility
CMD Cubic Meter per Day
CSR Corporate Social Responsibility
ETP Effluent Treatment Plant
INR Indian Rupee
MIDC Maharashtra Industrial Development Corporation
MSEDCL Maharashtra State Electricity Distribution Company Limited
SH State Highway
NH National Highway
R&D Research and development
NCPL Navitus Chemicals Private Limited
MTPA Metric Tonnes Per Annum
4
LIST OF ANNEXURES
Annexure 1 - Master Layout
Annexure 2 - PNID Diagrams of all the products
Annexure 3 - Equipment list
Annexure 4 - Possession Receipt
Annexure 5 - Contour Plan
Annexure 6 - Toposheet Map
Annexure 7 - Acknowledgment of CER activities submitted to Collector, Nagpur District
5
Executive Summary
M/s. Navitus Chemicals Private Limited (henceforth referred as “NCPL” in this report) has been
conceptualized to manufacture an array of divergent path-breaking intermediates valued in
domain of Communicable diseases vertical as well as non-Communicable diseases vertical. The
proposed manufacturing facility is located at plot No. A-24/100 & A-24/105, Umred Industrial
Area, Dist. Nagpur, Maharashtra has a plot area of 7981 sq.m. As per EIA notification 2006, its
amendments and S.O. 1223 (E), dated 27th March 2020, the aforesaid project falls under 5f
Category B2.The industry has proposed 26 products with proposed annual capacity of 1850
MTPA. NCPL will not limit itself only in pharmaceuticals sector but also manufacture Speciality
chemicals. In these sectors there is a huge demand for intermediates, which at present is fulfilled
by China. NCPL proposes manufacturing of Oxirane and intermediates used in manufacturing of
drugs important in COVID-19 treatment in immediate pipeline. Oxirane is used in manufacturing
of Lumefantrine intermediate. 4,7-Dichloroquinoline is a starting material of Chloroquine &
Hydroxychloroquine, 5-Chloro-2-Pentanone is a side chain material of Chloroquine &
Hydroxychloroquine and 6-Bromo-3-hydroxy pyrazine-2-carboxamide, an important starting
material of Favipiravir-Antiviral currently used in the treatment of COVID-19.
Salient feature of the project
The salient features of the project are presented in Table 0-1.

Table 0-1: Salient feature of the project
Sr. No. Parameters Description
Proposed manufacturing unit of
pharmaceuticals (API intermediates) and
1. Name of the project
specialty chemicals
2. Nature of the project New
3. Project Proponent Mr. Shyam Nanaji Titirmare
4. Plot Area 7981 sq.m.
5. Capacity of the project 1850 MTPA
6. Category of the project 5 (f)-B2
Plot No. A-24/100 & A-24/105,Umred
Industrial Area, Dist. Nagpur, Maharashtra,
7. Location of the project
India
Requirement: 66.66 KLD,
8. Total water requirement and source Source: Maharashtra Industrial Development
Corporation (MIDC)
6
Connected Load- 600 kVA and Demand

9. Power requirement and source Load- 400 kVA
Source: MSEDCL
D.G. set capacity – 300 kVA x1No.
10. Fuel requirement and type High Speed Diesel (HSD)– 200 Liters/day
(Will be used only for critical reactions in
case of MSEB power cut)
Briquette consumption for hot water
generator: 6.0 tons/day
11. Man power requirement Construction Phase –50Nos.
Operation Phase –100Nos.
Nearest Railway Station / Airport Umred Railway Station- 2.38 km(Aerial
12. Distance),
along with distance in km
Nagpur Airport- 39.41 km (Aerial Distance)
Nearest Town, city, District
13. Headquarters along with distance in Umred – 1.32 km
km
Ecological Sensitive Areas (Wild
life Sanctuaries, National Parks, Umred Karhandla Wildlife Sanctuary 8.41
14.
Biosphere Reserves, Reserve/ km in East direction
Protected Forest etc.)
15. Historical Places None within 10 km of the site
16. Nearest Forest Chichala Reserve Forest 6.6 km (in South
East)
Ranbori Reserve Forest 7.7 (in South East
direction)
Muniya Reserve Forest 7.6 km (in South
west)
7
1. Introduction of the project/Background information
Navitus Chemicals Private Ltd. (NCPL) has been conceptualized to manufacture an array of
divergent path-breaking intermediates valued in domain of Communicable diseases vertical as
well as non-Communicable diseases vertical.
The communicable diseases are major public health problem in the country. To control and
eliminate various communicable diseases specific national health programmes are being
implemented in the country. The National Vector Borne Disease Control Programme
(NVBDCP) is being implemented for control of Malaria, Dengue, Chikungunya and Japanese
Encephalitis (JE) and elimination of Kala-azar and Lymphatic Filariasis. Around 1 million cases
of malaria are being reported annually through public health system. 25,000-75,000 confirmed
dengue cases are being reported under NVBDCP annually in the country with case fatality ratio
of < 0.5%. Among the six diseases, Malaria, Kala-azar and Filaria have specific drug for
treatment. Even after achieving elimination of Kala-azar and filaria, drugs for these diseases will
continuously be required till eradication is being achieved. Malaria is outbreak- prone disease
and continuous availability of drug is to be ensured. There should be mechanism for sustenance
of production and uninterrupted supply of quality drugs. Outside India all African nations are
major consumers of anti-Malarial drugs.
7-Ethyl tryptophol is the starting material used in the manufacturing of Etodolac, which is used
as anti-inflammatory. 4-n- butyl resorcinol is an important compound used in skin whitening
creams. To name a few companies like Lupin, IPCA, Emcure are manufacturing Etodolac. These
companies are totally dependent on Chinese suppliers for 7-Ethyl tryptophol. The aim of the
company is to replace these Chinese suppliers by providing quality material at competitive price.
NCPL will not limit itself only in pharmaceuticals sector but also manufacture speciality
chemicals. In these sectors there is a huge demand for intermediates, which at present is fulfilled
by China. NCPL proposes manufacturing of Oxirane and intermediates used in manufacturing of
drugs important in COVID-19 treatment in immediate pipeline. Oxirane is used in Lumefantrine
intermediate.4,7-Dichloroquinoline is a starting material of Chloroquine & Hydroxychloroquine,
5-Chloro-2-Pentanone is a side chain material of Chloroquine & Hydroxychloroquine and 6-
Bromo-3-hydroxy pyrazine-2-carboxamide, an important starting material of Favipiravir-
Antiviral currently used in the trials for the treatment of COVID-19.
1.1 Identification of project and project proponent

The proposed manufacturing facility is located at plot No. A-24/100 & A-24/105, Umred
Industrial Area, Dist. Nagpur, Maharashtra has a plot area of 7981 sq.m. The industry has
proposed 26 products as listed in Table 1-3 which will be manufactured on the need basis. The
production capacity of the products is planned to be 1850 MTPA. Only 3 products will be
manufactured at a time. The product Oxirane will be manufactured throughout the year with
8
production capacity of 288 MTPA. The list of products and annual production capacity are listed
in Table 2-2.
The core team consists of NCPL consists of Mr. Shailesh Dhabekar, Mr. Girish Lad, Mr. Sameer
Bhalerao and Mr. Shyam Titirmare. The team has vast experience in chemical industry. Their
roles and responsibilities and profiles are presented in Table 1-1 and Table 1-2 below.
Table 1-1: Role and Responsibility of Core Team Members
Sr. No Name Designation Responsibility
1. Shailesh Dhabekar Director 1 Liasoning & negotiation with manufacturers and
vendors
Finance Management
Human Resource Management.
2. Girish Lad Director 2 Marketing and Supply chain management
3. Sameer Bhalerao Director 3 Product Management
Scientific Communication.
Human Resource Management.
4. ShyamTitirmare Director 4 Technical Planning & Execution of project related
policies.
Trouble shooting in day to day activities.
Key point of communication between management &
employees.
Table 1-2: Profile of Core Team Members
Profile of Core Team Members
Shailesh Dhabekar- Director 1
 Qualification - Science Graduate

 Experience - 18 years in pharmaceutical industry
 Worked with Sun Pharmaceutical Ltd for 6 years at various positions.
 Worked with Allergan India Ltd, a US based company global leader in ophthalmic segment for 3
years.
 Since 2012 started own venture viz. White & Trust Pharmaceutical (India) Pvt. Ltd. Currently
having a turnover of 10Cr with a team of 70 people working in 9 different states of India.
Girish Lad - Director 2

 Experience - 19 Years in pharmaceutical industry
 Worked with Sun Pharmaceutical Ind. Ltd for 4 Years at various positions.
 Worked with Ajanta Pharma Ltd, as Area Manager for 4 years.
9
Sameer Bhalerao - Director 3

 Experience- 19 years in pharmaceutical industry
 Worked with Sun Pharmaceutical Ind. Ltd for 4 Years
 Worked with Allergan India Ltd, a US based company global leader in ophthalmic segment, for 4
years
 Worked with Novartis Healthcare Pvt. Ltd. For 1 year as Key Account Manager (KAM) for
Speciality Division (Retina)
 Worked with Natco Pharma Ltd, for 2 years as Area Business Development Manager in Oncology
Division.
Shyam Titirmare – Director-4, Project Head
 Qualification M.Sc (Organic Chemistry from Dept of Chemistry, Nagpur University)

 Experience 25 years in Chemical industry (Agro& Pharma), Have 8 patents & publications in OPRD
 Worked for Gharda Chemicals, Torrent Pharma, Emcure Pharma & Row 2 Technologies.
 Have worked on more than 15 DMF projects (for US market) & 6 COS project (for European
market)
 Commercialised number of DMF & domestic projects
 Technology transfer from Lab to Plant scale
 Have run plant for 2 years producing pharma intermediates.
Address and Email address for correspondence:

Name: Mr. Shyam Nanaji Titirmare Designation: Director
Telephone: 9370559385; email: shyamt2123@gmail.com
Address: D-19 Mamta Society near H B Estate Sonegaon, Maharashtra-440025
Telephone No.: 9370559385 Email: shyamt2123@gmail.com
1.2 Brief description of nature of the project

NCPL proposes to manufacture 26 products listed in Table 1-3 below at Umred Industrial Area.
The annual production capacity of the proposed expansion is estimated to be 1850 Metric tons
per annum (MTPA). The proposed intermediates will be used in manufacture drugs of
Communicable diseases vertical as well as non-Communicable diseases vertical and it will also
manufacture specialty chemicals.
10
Table 1-3: List of products
Sr. No. List of Products CAS No. Structure Use

1. (2,7-Dichloro-9H- [53221-14-0] Lumefantrine
fluoren-4-yl) - intermediate
Oxirane
2. 7-Ethyl trytophol [41340-35-7] Etodolac starting

material
3. 4,7- [86-98-6] Starting material of

Dichloroquinoline Chloroquine &
Hydroxychloroquin
e
4. 5-Chloro-2- [5891-21-4] Side chain material

Pentanone of Chloroquine &
Hydroxychloroquin
e
5. 4-n-butyl resorcinol [18979-61-8] De-pigmenting
agent used in
cosmetics
6. Cetylethyldimonium [3006-10-8] Surfactant used in

ethosulphate Hand sanitizers.
7. (2S,3S)-1,2-Epoxy- [98737-29-2] Darunavir

3-(Boc-amino)-4- intermediate
phenylbutane
11

8. (2R, 3S)-1,2-Epoxy- [98760-08-8] Atazanavir
3-(Boc-amino)-4- Intermediate
phenylbutane
9. tert-Butyl (2S,3R)- [191226-98-9] Darunavir

3-hydroxy-4-(N- intermediate
isobutyl-4-
nitrophenylsulfona
mido)-1-
phenylbutan-2-
ylcarbamate (BOC-
nitro)
10. 2-Carboxy [119-67-5] Hydralazine
benzaldehyde starting material
11. 4-(2- [56718-71-9] Metaprolol

Methoxyethyl)phen Starting material
ol
12. Cyclen [294-090-6] Intermediate of

DOTA(MRI
contrast agent)
13. 7-Chloroquinaldine [4965-33-7] Montelukast

starting material
14. 2-(3-chloropropyl)- [88128-57-8] Used in

2,5,5-trimethyl-1,3- Novoldiamine
dioxane
12

15. N-[2-[4- [119018-29-0] Glimepiride
(Aminosulfony)phe intermediate
nyl] ethyl]-3-ethyl-
2,5-dihydro-4-
methyl-2-oxo-1H-
pyrrole-1-
carboxamide
16. (S)-2- [22795-99-9] Levosulpiride
(Aminomethyl)-1- intermediate
ethylpyrrolidine
17. 2-Cyano phenol [611-20-1] Azoxystorbin

starting material
18. 2-Cyclohexen-1-one [930-68-7] Carprofen starting

material
19. 4-Methoxy [19501-58-7] Cox-2 inhibitor

phenylhydrazine starting material
HCl
20. 2-Amino-6-methoxy [1747-60-0] Used in Schiff

benzothiazole bases
21. 8-Nitroquinaldine [881-07-2] Speciality chemical
13

22. 4-Hydroxy [52602-39-8] Carvedilol starting
carbazole material
23. Tyramine HCl [60-19-5] Benzfibrate starting

material
24. 6-Bromo-3-hydroxy [259793-88-9] Favipiravir

pyrazine-2- intermediate. Used
carboxamide in Covid-19
treatment
25. 5-Sulfamoyl-2,4- [2736-23-4] Intermediate of

dichlorobenzoic Furosemide (Used
acid to treat fluid build)
26. 4-Chloro [104-88-1] Used in

benzaldehyde Lumefantrine. Anti-
malarial drug
1.3 Need for the project and its importance to the country and our region
Considering current market situation and demand amid COVID-19, NCPL proposes
manufacturing of following products along with Oxirane (used in Lumefantrine intermediate) in
immediate pipeline:
a. 4,7-Dichloroquinoline- Starting material of Chloroquine & Hydroxychloroquine, 5-

Chloro-2-Pentanone- Side chain material of Chloroquine & Hydroxychloroquine.
b. 6-Bromo-3-hydroxy pyrazine-2-carboxamide- Important starting material of Favipiravir-
Anti viral currently used in the trials for the treatment of COVID-19.
14
The company shall leverage the following advantages of the products:

1. Reduced production costs with improvement in the supply chain management as API will
be manufactured in India.
2. Guaranteed higher yields with costs in line with Chinese products.
3. Reduction in imports from China gives foreign currency benefit.
4. Reduction in stock holding and waiting time of API manufacturer in India
5. Process scalability to meet market requirement.
6. Small but important contribution to make India self-reliant in the field of API.
7. Generate foreign currency through export market.
1.4 Demand-Supply Gap

Malaria is outbreak- prone disease and continuous availability of drug is to be ensured. There
should be mechanism for sustenance of production and uninterrupted supply of quality drugs. 7-
Ethyl tryptophol is the starting material used in the manufacturing of Etodolac, which is used as
anti-inflammatory. 4-n- butyl resorcinol is an important compound used in skin whitening
creams. To name a few companies like Lupin, IPCA, Emcure are manufacturing Etodolac in
India. These companies are totally dependent on Chinese suppliers for 7-Ethyl tryptophol &
covid related drugs.
1.5 Imports vs Indigenous production

The proposed products have huge demand in pharmaceutical industry, cosmetic and other
industries. At present, this huge demand for intermediates is fulfilled by China. The proposed
production unit will help to reduce reliance on import of the bulk drugs and intermediates from
China. Demand for Oxirane in India is 50 tons per month whereas the indigenous production is
less than 5.0 ton per month. Companies like Cadila & Glenmark are making Covid products for
which they are dependent on Chinese suppliers.
1.6 Export Possibility

The proposed products are having demand in Indian as well as International market. There will
be the possibility of export of drugs to African nations as these countries are major consumers of
anti-Malarial drugs.
1.7 Domestic/export Markets

The proposed manufacturing of products shall cater to the needs of domestic market by
supplying intermediates and there is potential for exports.
15
1.8 Employment Generation (Direct and Indirect) due to the project

The proposed project will hire local skilled and semi-skilled workers during construction phase
as well as operation phase. During the construction phase, total 50-70 construction workers will
be employed and during the operation phase, total 80-100 personnel will be employed consisting
of technical staff, general staff for administrative work and other ancillary services.
2. Project Description
2.1 Type of project including interlinked and independent projects, if any
The proposed project is a new project it does not include any interlinked and interdependent
projects.
2.2 Project Location

The proposed manufacturing unit is located in Umred Industrial Area at Plot No. A-24/100 and
A-24/105 in Nagpur district of Maharashtra State. The Site photographs are shown in Figure 2-1
below. The location on Google Earth image and project boundary is shown in Figure 2-2 below.
The site layout is presented in Figure 2-3 and is attached as Annexure-I. The geographical
coordinates of the site are presented in Figure 2-4. The Physical and social infrastructure around
the project site is presented in Table 2-1.
16
17
Figure 2-1: Site Photographs
18
Nagpur
Figure 2-2: Project location
19
Figure 2-3: Site layout
20
dinates of the project site
Figure 2-4: Geographical coordinates of the project site
Table 2-1: Physical and Social Infrastructure around the Project Site
Sr. No. Particulars Details (Aerial distance)
1. Project Location Umred Industrial Area
2. Nearest Highway SH 258- Wardha- Samudrapur-Umred Highway - 0.31 km
NH 247 - 1.67 km
3. Nearest city/town Umred
4. Nearest Fire Station Umred Fire Station -3.3 km
5. Nearest Airport Nagpur Airport – 39.41 km
6. Nearest Railway Umred Railway Station- 2.38 km
Station
7. Water body Hirvatalav - 2.40 km NE
Pandherbodi Talav- 3.67 km SW
Makardhokda Dam and Reservoir - 11.08 km NW
21

8. School /Colleges Mahatma Jyotirao Phule Sharirk Shikshan Mahavidyalay
0.63 km
Om Polytechnic 0.47 km
9. Hospital Sub-district hospital Umred 2.83 km
Rural Charitable Trust Hospital 1.62 km
10. National parks / Umred Karhandla Wildlife Sanctuary - 6.72 km NE
Wildlife Sanctuaries
11. Reserved / Protected Chichala Reserve Forest 6.6 km (in South East)
Forests Ranbori Reserve Forest 7.7 (in South East direction)
Muniya Reserve Forest 7.6 km (in South west)
2.3 Details of alternate sites

The site is located in notified Industrial Area. The land use of the site is already developed for
industrial purpose. The required infrastructure like roads, water and electricity supply is already
available. The site is connected to highways SH 258Wardha- Samudrapur-Umred Highway and
National Highway NH 247 to facilitate transportation of equipment, raw materials and products.
There are no sensitive establishments in the immediate vicinity of the site. Hence, considering all
the benefits like availability of land and existing infrastructure, feasibility of operations the
alternative sites were not examined.
2.4 Size or magnitude of operation

The proposed project is expected to manufacture 1850 MTPA. The production capacity of the
products is listed in Table 2-2 below:
Table 2-2: Production capacity
Annual production Waste qty
Sr. No. List of Products
capacity tons/month
1. (2,7-Dichloro-9H-fluoren-4-yl) - Oxirane 288 4.71
2. 7-Ethyl trytophol 120 1.87
3. 4,7-Dichloroquinoline 120 2.47
4. 5-Chloro-2-Pentanone 72 0.74
5. 4-n-butyl resorcinol 12.0 0.11
6. Cetyl ethyldimonium ethosulphate 36 0.3
22

capacity tons/month
7. (2S,3S)-1,2-Epoxy-3-(Boc-amino)-4- 48 0.38
phenylbutane
8. (2R, 3S)-1,2-Epoxy-3-(Boc-amino)-4- 48 0.4

phenylbutane
tert-Butyl (2S,3R)-3-hydroxy-4-(N- 60 0.35
9. isobutyl-4-nitrophenyl sulfonamido)-1-
phenylbutan-2-ylcarbamate (BOC- nitro)
10. 2-Carboxy benzaldehyde 36 0.36
11. 4-(2-Methoxyethyl)phenol 180 1.99
12. Cyclen 6.0 0.035
13. 7-Chloroquinaldine 60 1.88
2-(3-chloropropyl)-2,5,5-trimethyl-1,3- 24 0.176
14.
dioxane
N-[2-[4-(Aminosulfonyl)phenyl] ethyl]-3- 36 0.5

15. ethyl-2,5-dihydro-4-methyl-2-oxo-1H-
pyrrole-1-carboxamide
16. (S)-2-(Aminomethyl)-1-ethylpyrrolidine 36 0.38
17. 2-Cyano phenol 180 3.47
18. 2-Cyclohexen-1-one 120 1.93
19. 4-Methoxy phenylhydrazine HCl 36 0.33

180 1.2
20. 2-Amino-6-methoxy benzothiazole
120 3.1
21. 8-Nitroquinaldine
22. 4-Hydroxy carbazole 120 0.93
23. 60 0.24
Tyramine HCl
6-Bromo-3-hydroxy pyrazine-2- 36 0.83
24.
carboxamide
23

capacity tons/month
25. 5-Sulfamoyl-2,4-dichlorobenzoic acid 60 0.84
26. 4-Chloro benzaldehyde 300 4.17
2.5 Project description with process details
1) 2-(2,7-dichloro-9-H-fluoren-4-yl)oxirane:
a. Brief Process
Fluorene is chlorinated using Chlorine gas & a catalyst. DMF is used as solvent. The obtained
2,7-Dichlorofluorene is reacted with Chloroacetyl chloride in presence of Aluminum chloride.
The acetylated product is then reduced with Sodium borohydride & treated with sodium
hydroxide to get the product. Final material is isolated from Methanol.
b. Route of Synthesis
c. Mole Balance -Stage-I:

Input No. of moles Input wt Output No. of moles Output wt
Fluorene 1 166 2,7-Dichlorofluorene 1 235
Chlorine 2 142 Hydrogen chloride 2 73
Total 308 Total 308
d. P&ID Diagram Stage-I:
24
P&ID of other products is attached as Annexure-I

e. Material Balance Stage-I:
Input kg Output Kg
Flourene 700 2,7-Dichlorofluorene 893
Chlorine 599 Ammonium chloride 450
DMF 1323 Organic waste 66.15
Catalyst 50 Recovered DMF 1273 (96.22%)
Ammonia 144 Process and handling loss 133.85
Total 2816 Total 2816
f. Mole Balance Stage-II:
No. of No. of Output
Input moles Input wt Output moles wt
2,7- 2-(2,7-dichloro-9-H-
Dichlorofluorene 1 235 fluoren-4-yl) oxirane 1 277
CAC 1 113 HCl 1 36.5
Hydrogen from
NaBH4 1 2 NaCl 1 58.5
NaOH 1 40 Water 1 18
Total 390 Total 390
25
g. P&ID Diagram Stage-II:
h. Material Balance Stage-II:

Input kg Output Kg
2-(2,7-dichloro-9-H-
2,7-Dichlorofluorene 893.0 fluoren-4-yl)oxirane 968
Methylene Dichloride 6700.0 Recovered MDC 6394 (95.43%)
Catalyst 557.0 Recovered Catalyst 557
CAC 450.0 Organic waste 124.6
Sodium Borohydride 71.0 Recovered Methanol 3266 (96.06%)
NaOH 306.0 Effluent 21910
Methanol 3400.0 Handling and Process loss 169.4
Sodium Bicarbonate 12.0
Water 21000
Total 33389.0 Total 33389.0
26
2) 7-Ethyl trytophol:
a. Brief Process:
2-Ethyl aniline is diazotized with Sodium nitrite & HCl in aqueous medium. The diazotized mass
is then reduced to get 2-Ethyl phenyl hydrazine HCl. This product is then treated with 2-3-
Dihydrofuran to get 7-Ethyl trytophol.
c. Mole Balance
No. of Input No. of Output
Input moles wt Output moles wt
7-Ethyl Phenyl Hydrazine
HCl 1 172.5 7-Ethyl tryptophol 1 189
Ammonium
2,3 - Dihydrofuran 1 70 Chloride 53.5
Total 242.5 Total 242.5
27
d. Material Balance
Input kg Output kg
2-Ethyl aniline 500.0 7-Ethyl tryptophol 652
Toluene 1200.0 Recovered Toluene 1158 (96.5%)
HCl 1000.0 Organic waste 122
NaNO2 308.0 Effluent 3172
Reducing agent 563.0 Handling and Process loss 274
2,3-Dihydrofuran 300.0
Catalyst 7.0
Water 1500.0
3) 4,7-Dichloroquinoline:
a. Brief Process:
3-Chloroaniline is heated with Methyl methoxy-methlyene malonate to get intermediate which is
further heated & treated with Sodium hydroxide to get Sodium salt of 7-Chloro-4-hydroxy-3-
quinoline carboxylic acid. This salt is heated for de-carboxylation to get 7-Chloro-3-hydroxy
quinoline. The hydroxyl group is converted to Chloro by using Phosphorus oxychloride to get
4,7-Dichloroquinoline.
28
c. Mole Balance
m-Chloroaniline 4,7-Dichloro
1 127.5 quinoline 1 198
Methyl methoxy
methylene malonate 1 174 Methanol 3 96
Phosphorus Oxychloride 1 51 Carbon dioxide 1 44
Sodium
HCl 2 73 phosphate 1 54
Sodium
Sodium hydroxide 3 120 Chloride 2 117
water 2 36
Total 545.5 Total 545
d. Material Balance
Input kg Output Kg
m-Chloroaniline 500.00 4,7-Dichloro quinoline 699
Methyl methoxy methylene malonate 716.00 Organic waste 92
Diphenyl ether 1500.00 Carbon dioxide evolved 172.55
Caustic solution 50 % 790.00 Recovered Methanol 376
Conc HCl 35 % 900.00 1476
Recovered Diphenyl ether (98%)
POCl3 300.00 Aq. layer to ETP 4678
Water 3000.00 1168
Recovered MCB (97%)
MCB 1200.00 Handling and Process loss 244.45
4) 5-Chloro-2-pentanone:
a. Brief Process:
2-Acetyl butyrolactone is heated in presence of Hydrochloric acid. Carbon dioxide gas is
evolved during heating to give 5-Chloro-2-pentanone.
29
c. Mole Balance
Input Output
Input No. of moles wt Output No. of moles wt
2-Acetyl 1 128 5-Chloro-2- 1 120.5
butyrolactone pentanone
Hydrochloric acid 1 36.5 Carbon dioxide 1 44
d. Material Balance
Input kg Output kg
2-Acetyl butyrolactone 750.00 5-Chloro-2-pentanone 628.5
Conc. HCl 35% 600.00 Organic waste 77
Carbon dioxide evolved 257.8
Effluent to ETP 370
Handling and process loss 16.7
5) 4-n-Butyl resorcinol:
a. Brief Process
Resorcinol is reacted with Butyryl chloride in presence of a catalyst to get acylated product. This
product is then reduced using Hydrazine hydrate to get 4-n-Butyl resorcinol.
30
c. Mole Balance
4-n-butyl
Resorcinol 1 110 resorcinol 1 166
n-Butyryl
chloride 1 106.5 HCl 1 36.5
Hydrazine 1 32 Nitrogen 1 28
Water 1 18
d. Material Balance
Input kg Output kg
Resorcinol 200.00 4-n-butyl resorcinol 275
MDC 1200.00 Recovered MDC 1153 (96%)
n-Butyryl chloride 200.00 Recovered catalyst 50
Catalyst 50.00 Evaporator feed 901
Water 600.00 Organic waste 30
80 % Hydrazine 77.00 Handling and Process loss 68
Caustic lye 150.00
6) Cetyl ethyldimonium ethosulphate:
a. Brief Process
Cetyl alcohol is sulphonated by using p-Toluene sulphonyl chloride. This intermediate is reacted
with Di-methylamine to get Cetyl di-methylamine. Finally diethyl sulphate is reacted with Cetyl
di-methylamine to get Cetyl ethyldimonium ethosulphate.
31
c. Mole Balance
Input No. of Output
Input No. of moles wt Output moles wt
Cetyl ethyl dimonium
Cetyl alcohol 1 242.5 ethosulphate 1 423.7
p-Toluene p-Toluene Sulfonic acid
Sulfonyl Chloride 1 190.50 dimethyl amine salt 1 217
Dimethyl amine 2 90 HCl 1 36.5
Diethyl Sulphate 1 154
Total 677 Total 677
d. Material Balance
Input kg Output kg
Cetyl alcohol 300.0 Cetyl ethyl dimonium ethosulphate 483
1148
MDC 1200.0 Recovered MDC (95.67%)
p-Toluene sulfonyl chloride 250.0 Recovered IPA 1168 (97.3%)
Sodium bicarbonate 115.0 Evaporator feed 1280
Catalyst 15.0 Handling and process loss 191
Diethyl sulphate 190.0
IPA 1200.0
Dimethyl amine 40 % 153.0
7) (2S, 3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane:
a. Brief Process:
Chloroketone is reacted with Sodium borohydride in presence of a catalyst to get Chloro alcohol
which is further cyclised using Sodium hydroxide to get (2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-
phenylbutane.
32
b. Mole Balance
(3S)-3-(tertbutoxy (2S,3S)-1,2-epoxy-
carbonyl)-amino-1- 3-(BOC-amino)4-
chloro-4-phenyl butane 1 297.5 Phenyl butane 1 263
Hydrogen
(from NaBH4) 1 2 NaCl 1 58.5
c. Material Balance
Input kg Output Kg
Chloroketone 500.00 (2S,3S)-1,2-epoxy-3-(BOC- 406
amino)4-Phenyl butane
NaBH4 31.70 Recovered MDC 2401
(96.04%)
MDC 2500.00 Recovered Methanol 1357.9
(96.99%)
NaOH 50 % 135.00 Recovered catalyst S 1.50
Methanol 1400.00 Evaporator feed 732
Catalyst S 1.50 Process and Handling loss 231.8
8) (2R, 3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane:
a. Brief Process
Chloroketone is reacted with Sodium borohydride in presence of a catalyst to get Chloro alcohol
which is further cyclised using Sodium hydroxide to get (2R,3S)-1,2-Epoxy-3-(Boc-amino)-4-
phenylbutane.
33
c. Mole Balance
(3S)-3-(tertbutoxy (2R,3S)-1,2-epoxy-3-
carbonyl)-amino-1- (BOC-amino) 4-
chloro-4-phenyl butane 1 297.5 Phenyl butane 1 263
Hydrogen
(from NaBH4) 1 2 NaCl 1 58.5
d. Material Balance
Input kg Output Kg
Chloroketone 500.00 (2R, 3S)-1,2-Epoxy-3-(Boc-
amino)-4-phenylbutane 404
NaBH4 31.70 1361
Recovered IPA (97.21%)
MDC 2500.00 2397
Recovered MDC (95.88%)
NaOH 50 % 135.00 Recovered Catalyst 1.5
IPA 1400.00 Evaporator feed 726
Catalyst R 1.50 Process and Handling loss 241.7
9) tert-Butyl (2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-
ylcarbamate(BOC-nitro):
a. Brief Process
BOC-Amino alcohol is reacted with p-Nitrobenzene sulphonyl chloride using MDC as solvent &
Sodium bicarbonate as base to get the product.
34
c. Mole Balance
BOC-Amine 1 336 BOC-nitro 1 521
p-Nitrobenzene Hydrogen
1 221.5 1 36.5
sulfonyl chloride chloride
Total input 557.5 Total Output 557.5
d. Material Balance
Input kg Output Kg
Boc-Amine 400.00 BOC-nitro 590
p-NO2 benzene sulfonyl chloride 255.00 Recovered MDC 2880 (96.6%)
Sodium Carbonate 130.00 Recovered Methanol 1149 (95.75%)
MDC 3000.00 Effluent 1166
Methanol 1200.00 Handling and Process loss 159
Total 5985.00 Total 5985.00
10) 2-Carboxy benzaldehyde:
a. Brief Process
Phthalide is reacted with Dichloro hydantoin in presence of a catalyst & then it is hydrolyzed
with water to get 2-Carboxy benzaldehyde.
c. Mole Balance
Phthalide 1 134 2-Carboxy benzaldehyde 1 150
Water 1 18 Hydrogen Bromide 1 81
DBDMH 0.5 143 DMH 0.5 64
Total 295 Total 295
35
d. Material Balance
Input Kg Output Kg
Phthalide 800.00 2-Carboxy benzaldehyde 806
1,3-Dibromo,5-5 dimethyl hydantoin 900.00 Recovered MCB 3125 (97.66%)
MCB 3200.00 Evaporator feed 3150
Catalyst 4.00 Organic waste 95
Water 2500.00 Handling and Process loss 228
11) 4-(2-Methoxyethyl) phenol:

a. Brief Process
2-Phenylethyl methyl ether is reacted with acetyl chloride in presence of a catalyst. The acylated
product is further treated with Hydrogen peroxide & then heated with Methanol for trans-
esterification to get 4-(2-Methoxyethyl) phenol.
36
c. Mole Balance
2-Phenylethyl methyl 4-(2-methoxy-
ether 1 136 ethyl)phenol 1 152
Acetyl chloride 1 78.5 Methyl acetate 1 74
Methanol 1 32 Hydrogen chloride gas 1 36.5
Hydrogen Peroxide 1 34 water 1 18
d. Material Balance
Input Kg Output Kg
2-Phenylethyl methyl ether 1250.0 4-(2-methoxy-ethyl)phenol 1240
Acetyl chloride 758.0 2866
MDC 3000.0 Recovered catalyst 125
Catalyst 125.0 Effluent 5848
H2O2 50 % 656.0 Organic waste 165
Methanol 400.0 Handling and Process loss 218
Caustic lye 50 % 773.0
12) Cyclen:
a. Brief Process:
Triethylene tetramine is reacted with Glyoxal to get imine as intermediate. In-situ this imine is
reduced with Sodium borohydride to get Cyclen.
c. Mole Balance
Triethylene tetramine 1 146 Cyclene 1 172
Glyoxal 1 58 Water 2 18
Hydrogen from NaBH4 1 4
Total 208 Total 208
37
d. Material Balance
Input Kg Output Kg
Triethylene tetramine 200.00 Cyclene 219
40 % Glyoxal 220.00 Organic waste 16
Sodium borohydride 26.30 Recovered MCB 487 (97.4%)
MCB 500.00 Water from Glyoxal &
reaction 297
Water 100.00 Handling and Process loss 27.3
13) 4-Hydroxy carbazole:

a. Brief Process:
Phenyl hydrazine Hydrochloride is reacted with 1,3-Cyclohexanedione in presence of a catalyst.
Dehydration & Cyclization occurs during this process to give 4-Hydroxy carbazole.
c. Mole Balance
Phenyl hydrazine 4-Hydroxy
hydrochloride 1 144.5 carbazole 1 183
Ammonium
1,3-Cyclohexanedione 1 112 Chloride 1 53.5
Water 1 18
Hydrogen
(absorbed by
aromatizing agent) 1 2
38
d. Material Balance
Input kg Output Kg
Phenyl hydrazine HCl 600.00 4-Hydroxy Carbazole 691.5
1,3-Cyclohexanedione 480.00 Recovered n-Butanol 1228.8 (96%)
n-Butanol 1280.00 Effluent 1526
Catalyst 30.00 Organic waste 64
Water 1200.00 Handling and Process loss 79.7
14) 7-Chloroquinaldine:
a. Brief Process:
3-Chloroaniline & paraldehyde are reacted under reflux conditions in presence of Hydrochloric
acid & n-Butanol. Aqueous layer is separated & Sodium hydroxide is added to isolate 7-
Chloroquinaldine.
c. Mole Balance
3-
Chloroaniline 1 127.50 7-Chloroquinaldine 1 177.5
Paraldehyde 0.66 88 Water 3 54
HCl 1 36.5 NaCl 1 58.5
Hydrogen (absorbed
NaOH 1 40 by aromatizing agent) 1 2
Total 292 Total 292
39
d. Material Balance
Input kg Output Kg
3-Chloroaniline 700 7-Chloroquinaldine 782
Paraldehyde 760 Recovered n-Butanol 576 (96%)
n-Butanol 600.00 Evaporator feed 2696
Con HCl 800.00 Organic waste 210
Caustic lye 560.00
15) 2-(3-chloropropyl)-2,5,5-trimethyl-1,3-dioxane:
a. Brief Process:
5-Chloro pentanone & Neopentyl glycol are reacted in presence of a catalyst &Toluene as
solvent. Water is removed to get the product.
c. Mole Balance
2-(3-chloropropyl)-
5-Chloro-2- 2,5,5-
pentanone 1 120.5 trimethyl-1,3-dioxane 1 202.5
Neopentyl glycol 1 104 Water 1 18
d. Material Balance
Input kg Output kg
5-Chloro-2-pentanone 2-(3-chloropropyl)-2,5,5-
250.00 400
trimethyl-1,3-dioxane
Toluene 500.00 Organic waste 35
Neopentyl glycol 482
225.00
Recovered Toluene (96.4%)
Catalyst Water generated goes to
2.50 37
evaporator
Handling and Process loss 23.5
40
16) N-[2-[4-(Aminosulfonyl) phenyl] ethyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrole-1-

carboxamide:
a. Brief Process:
3-Ethyl-4-methyl-2-oxo-pyrroline is reacted with 2-Phenyl ethyl isocyanate to give addition
product. This product is reacted with Chlorosulphonic acid to give sulphonyl chloride
intermediate which is treated with ammonia to get N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-3-
ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrole-1-carboxamide.
c. Mole Balance
3-Ethyl-4- N-{2-[4-(aminosulfonyl)
methyl-2-oxo- phenyl]ethyl}-3-ethy;-4-
1 125.00 1 351
pyrroline methyl-2-oxo-2,5-dihydro-
1H-pyrrole-1-carboxamide
2-Phenyl ethyl
1 147.00 1 18
isocyanate Water
Chlorosulphonic
1 116.50 1 36.5
acid HCl
Ammonia 1 17
41
d. Material Balance
Input kg Output Kg
3-Ethyl-4-methyl-2-oxo- 200.00 N-[2-[4-(Aminosulfonyl) phenyl]
pyrroline ethyl]-3-ethyl-2,5-dihydro-4-
methyl-2-oxo-1H-pyrrole-1-
carboxamide 615
2-Phenyl ethyl isocyanate 245.00 Organic waste 103
Chlorosulphonic acid 410.00 774
Ammonia 25 % solution 550.00 1922
IPA 800.00 Evaporator feed 2532
MDC 2000.00 Handling and process loss 59
Water 1800.00
Total 6005.00 Total 6005.00
17) (S)-2-(Aminomethyl)-1-ethylpyrrolidine:
a. Brief Process
L-Proline is reacted with Diethyl sulphate in presence of a base to get N-Ethyl –L-proline ethyl
ester. This ester is then reduced to alcohol by using Sodium borohydride. The alcohol product is
treated with Methane sulphonyl chloride & then with ammonia to get (S)-2-(Aminomethyl)-1-
ethylpyrrolidine.
42
c. Mole Balance
No. of Output
Input No. of moles Input wt Output moles wt
(S)-2-Aminomethyl-1-
L-Proline 1 115 ethylpyrrolidine 1 128
Diethyl Sulfate 1 154 Ethanol 1 46
Ammonia 1 17 Sodium Sulphate 1 142
Hydrogen (from
reducing agent) 2 4 Water 3 54
NaOH 2 80
Total 370 Total 370
d. Material Balance
Input kg Output Kg
L-Proline 300.0 (S)-2-Aminomethyl-1-ethylpyrrolidine 297
Diethyl sulphate 202.0 Organic waste 38.4
Water 1600.0 Effluent 1966
Caustic lye 210.0 In-organic salts 272
NaBH4 48.6 Handling and process loss 9.2
NH3 25 % 222.0
18) 2-Cyano phenol:
a. Brief Process:
Salicylic acid is converted to its ammonium salt by using Ammonia & Diphenyl ether as solvent.
Catalyst is added & mass is heated. Dehydration takes place to get 2-Cyano phenol.
c. Mole Balance
Salicylic acid 1 138 2-Cyano phenol 1 119
Ammonia 1 17 Water 2 18
Total 155 Total 155
43
d. Material Balance
Input kg Output kg
Salicylic acid 1250.00 2-Cyano phenol 1004.00
Ammonia 155.00 Organic waste 232.00
Diphenyl ether 4000.00 Recovered Diphenyl ether 3880 (97%)
Catalyst 125.00 Water generated sent to evaporator 326
Handling and process loss 88
Total 5530.00 Total 5530.00
19) 2-Cyclohexen-1-one:
a. Brief Process:
Cyclohexanone is reacted with 1,3-Dibromo-5,5-di-methyl hydantoin(DBDMH) in presence of
Monoethylene glycol. The intermediate obtained is treated with alkali & further deprotection of
ethylene glycol is carried out to get 2-Cyclohexen-1-one.
44
c. Mole Balance
No. of
Input moles Input wt Output No. of moles Output wt
2-Cyclohexen-
Cyclohexanone 1 98 1-one 1 96
DBDMH 0.5 143 DMH 0.5 64
Sodium
Hydroxide 1 40 NaBr 1 103
MEG 1 62 Water 1 18
MEG 1 62
Total 343 Total 343
d. Material Balance
Input Kg Output Kg
Cyclohexanone 1250.0 2-Cyclohexen-1-one 1028.0
DBDMH 1850.0 Organic waste 198.0
MEG 800.0 Recovered DBDMH 828.0
PTSA 60.0 Recovered MEG 776.0 (97%)
Caustic lye 50 % 1024.0 Recovered Ethyl acetate 816.0 (96%)
Ethyl acetate 850.0 Evaporator feed 5110.0
Total 9034.0 Total 9034.00
20) 4-Methoxy phenylhydrazine HCl:

a. Brief Process:
4-Methoxy aniline is diazotized by using Sodium nitrite & Hydrochloric acid. They diazo
solution is treated with reducing agent to get 4-Methoxy phenylhydrazine HCl.
45
c. Mole Balance
4-methoxy 4-Methoxy
Aniline 1 123 phenylhydrazine HCl 1 174.5
NaNO2 1 69 NaCl 1 58.5
HCl 1 36.5 Water 2 36
Hydrogen from
reducing agent 2 4
Total 269 Total 269
d. Material Balance
Input Kg Output kg
4-Methoxy aniline 400.0 4-Methoxy phenylhydrazine HCl 516
NaNO2 231.0 Organic waste 58
HCl 800.0 Recovered Butanol 781 (97.63%)
Butanol 800.0 Effluent to ETP 4046
Reducing agent 425.0
21) 2-Amino-6-methoxy benzothiazole:

a. Brief Process:
4-Methoxy aniline is reacted with Ammonium thiocyanate. The intermediate formed is
chlorinated by Chlorine gas & in-situ cyclised to get 2-Amino-6-methoxy benzothiazole.
46
c. Mole Balance
2-Amino-6-Methoxy
4-methoxy Aniline 1 123 benzothiazole 1 180
Ammonium
thiocyanate 1 76.1 Ammonium Chloride 1 53.5
Chlorine 1 70.9 Hydrogen chloride 1 36.5
Total 270 Total 270
d. Material Balance
Input kg Output Kg
p-Anisidine 600.0 2-Amino-6-methoxy benzothiazole 816
Sodium thiocyanate 415.0 Organic waste 65.5
MDC 4000.0 3840.0
Recovered MDC (96%)
Chlorine 347.0 Evaporator feed 3722
NH3 25 % 335.0 Handling and Process loss 253.5
H2O 3000.0
22) Tyramine HCl:
a. Brief Process
Tyramine free base is taken in Isopropyl alcohol. HCl is added to the reaction mass to get
Tyramine HCl.
c. Mole Balance
Tyramine 1 137 Tyramine HCl 1 173.5
HCl 1 36.5
47
d. Material Balance
Input kg Output kg
Tyramine 600.00 Tyramine Hydrochloride 737.5
1958
HCl 165.00 Recovered IPA (97.9%)
IPA 2000.00 Organic waste 34.5
Handling and Process loss 35
Total Input 2765 Total output 2765
23) 8-Nitroquinaldine:
a. Brief Process:
2-Nitroaniline is reacted with Paraldehyde in presence of a Hydrochloric acid& a catalyst. To
isolate the product the acidity is neutralized with caustic solution.
c. Mole Balance
2-Nitro aniline 1 138 8-Nitroquinaldine 1 188
Paraldehyde 0.66 132 Water 3 56
HCl 1 36.5 Sodium Chloride 1 58.5
NaOH 1 40
d. Material Balance
Input kg Output kg
2-Nitro aniline 500.0 8-Nitroquinaldine 501.0
Paraldehyde 458.0 Organic waste 157.0
35 % HCl 800.0 Recovered MCB 486.0 (97.2%)
Water 1400.0 Evaporator feed 2304.0
Water recovered during
Catalyst 50.0 241.0
drying of the product
Caustic lye 50 % 490.0 Inorganic salts 336.0
MCB 500.0 Handling and Process loss 170
48
24) 6-Bromo-3-hydroxy pyrazine-2-carboxamide

a. Brief Process:
2-Aminopropanediamide is reacted with aqueous solution of Glyoxal in presence of alkali to get
the Pyrazine derivative which is then reacted with Bromine to get the product.
c. Mole Balance
2-Amino 1 117 6-Bromo-3-hydroxy- 1 218
propanediamid pyrazine-2-carboxamide
e
Glyoxal 1 58 Hydrogen bromide 1 80.9
Bromine 1 159.8 Water 2 36
Total input 334.8 Total Output 334.9
d. Material Balance
Input kg Output kg
2-Amino propane diamide 200.0 6-Bromo-3-hydroxy
pyrazine-2-carboxamide 302.0
40 % Glyoxal 250.0 Organic waste 84.0
Caustic lye 50 % 140.0 Recovered Acetonitrile 867.0 (96.33%)
Bromine 275.0 Evaporator feed 1596.0
Acetonitrile 900.0 Handling and Process
loss 116
Water 1200.0
49
25) 5-Sulfamoyl-2,4-dichlorobenzoic acid

a. Brief Process
2,4-Dichloro benzoic acid is dissolved in MDC. To this solution is added Chlorosulphonic acid
to get sulphonyl chloride intermediate which is treated with Ammonia to get the product
c. Mole Balance
2,4- dichloro 1 191 5-Sulfamoyl-2,4- 1 270
benzoic acid dichlorobenzoic acid
Chlorosulfuric 1 233 HCl 1 36.5
acid
Ammonia 2 17 H2SO4 1 98
Ammonium Chloride 1 53.5
Total input 458 Total Output 458
50
d. Material Balance
Input kg Output Kg
2,4-Dichloro benzoic acid 5-Sulfamoyl-2,4-Dichloro
500.0 615.0
benzoic acid
Chlorosulphonic acid 645.0 Organic waste 103.0
MDC 2500.0 Recovered MDC 2389.0 (95.56%)
Ammonia 1952.0
800.0
IPA 2000.0 Evaporator feed 2458.0
26) 4-Chloro benzaldehyde
a. Brief Process
4-Chloro toluene is side chain chlorinated in presence of a catalyst. The side chain chlorinated
product is hydrolyzed & extracted in Chlorobenzene & distilled to get pure product
c. Mole Balance
p-chloro p-chloro
Toluene 1 126.5 benzaldehyde 1 140.5
Water 2 36 HCl 4 146
Chlorine 2 142 water 1 18
51
d. Material Balance
Input kg Output Kg
p-Chlorotoluene 1250.0 4-Chloro benzaldehyde 1638
Chlorine gas 1420.0 HCl gas 730.0
Catalyst 30.0 Recovered MCB 1168 (97.33%)
H2SO4 1000.0 Effluent 5022
Water 4000.0 Organic waste 342.0
MCB 1200.0
Material balance:
The data submitted is from lab batches. The project proponent is confident of achieving better
recoveries of solvents in plant, as the processes are in closed loop & reactors will be equipped
with primary & secondary condensers. Low boiling solvents recovery will have secondary
condensers with -8°C brine solutions which will help to improve recovery percentage resulting
in better material balance.
2.6 Raw material required along with estimated quantity

The raw materials required in the manufacturing of the proposed products are presented in Table
2-3. All the raw materials will be procured from domestic market.
Table 2-3: Raw material details
One-time storage Mode of
Sr. No. Raw Materials Form & packing
within plant transport
1. Oxirane
Solid packed in 25 Road
a. Fluorene 10.0 ton
Kg bags
Liquid. 200 lts Road
b. Dimethyl formamide 6.0 ton
drums
Road
c. Chlorine 5.0 tonners Gas. Tonner
Road
d. Ammonia 250 Kg (5 cylinders) Gas. Cylinder
Road
e. Methanol 8.0 ton Liquid. Tanker
Road
f. Methylene chloride 13.5 ton Liquid. Tanker
Liquid. 40 Kg Road
g. Chloroacetyl chloride 5.0 tons
Carbouy
Solid. 25 Kg bags Road
1.0 ton
h. Sodium borohydride placed in 200 Kg
drum
Road
i. Sodium hydroxide 2.0 ton Solid. 50 Kg bags
52

Road
j. Sodium bicarbonate 1.0 ton Solid. 50 Kg bags
Road
k. Aluminium chloride 4.0 ton Solid. 25 Kg bags
2. (2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane
(3S)-3-(tert- Solid. packed in 25 Road
1.0 ton
butoxycarbonyl) amino- Kg bags
a.
1-chloro-4-
phenylbutane
b. Methylene dichloride Liquid. Tanker Road
c. Sodium borohydride placed in 200 Kg
drum
d. Sodium hydroxide Solid. 50 Kg bags Road
e. Methanol Liquid. Tanker Road

Solid. 5 Kg carbouy Road
f. Catalyst S 50 Kg
3. (2R,3S)-3-(tert-Butoxycarbonyl)amino-1,2-epoxy-4-phenylbutane
(3S)-3-(tert- Solid packed in 25 Road
1.0 ton
butoxycarbonyl) amino- Kg bags
a.
1-chloro-4-
phenylbutane
c. Sodium borohydride placed in 200 Kg
drum
d. Sodium hydroxide Solid. 50 Kg bags Road
e. IPA Liquid. Tanker Road

Solid. 5 Kg carbouy Road
f. Catalyst R 50 Kg
4. tert-Butyl (2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-
phenylbutan-2-ylcarbamate
Tert-Butyl[(1S,2R)-1- Solid packed in 25 Road
1.0 ton
benzyl-2-hydroxy- Kg bags
a. 3(isobutyl amino)
propyl]carbamate (BOC
amine)
53

p-Nitrobenzene sulfonyl 0.5 ton
c. placed in 200 Kg
chloride
drum
d. Sodium bicarbonate Solid. 50 Kg bags Road
e. Methanol Liquid. Tanker Road
5. 7-Ethyl trytophol
Liquid. 200 Kg Road
a. 2-Ethyl aniline 2.0 ton
drums
Liquid. Tanker Road
b. Conc. HCl 11.5 ton
c. Sodium nitrite 0.5 ton
d. Reducing agent 2.0 ton
Liquid, 200 Kg Road
e. 2,3-Dihydro furan 2.0 ton
drums
f. Toluene 5.0 ton Liquid. Tanker Road
6. 2-Carboxy benzaldehyde
a. Phthalide 1.0 ton
b. Dibromohydantoin 2.0 ton
Liquid. Tanker Road
c. Chlorobenzene 5.0 ton
d. Sodium bicarbonate Solid. 50 Kg bags Road
7. 4-Hydroxy carbazole
Phenyl hydrazine Solid. 50 Kg bags Road
a. 2.0 ton
Hydrochloride
b. Cyclohexane-1,3-dione 2.0 ton
Liquid. Tanker Road
c. n-Butanol 5.0 ton
d. Aromatizing agent 1.0 ton
8. 4,7-Dichloroquinoline
Liquid. 200 Kg Road
a. 3-Chloroaniline 3.0 ton
drum
Methyl methoxy Liquid. 200 Kg Road
b. 3.0 ton
methylene malonate drum
54

Liquid. 200 Kg Road
c. Di-phenyl ether 5.0 ton
drum
d. Sodium hydroxide
Liquid. Tanker Road
e. HCl
Liquid. 40 Kg Road
f. Phosporus oxychloride 1.0 ton
carbouy
9. 4-Methoxy phenylhydrazine HCl
Solid. 40 Kg drum Road
a. 4-Methoxy aniline 2.0 ton
b. HCl Liquid. Tanker Road
c. Sodium nitrite Solid. 25 Kg bags Road
d. Reducing agent Solid. 50 Kg bags Road
10. 2-Cyano phenol

Solid. 25 Kg bag Road
a. Salicylic acid 3.0 ton
b. Urea 1.0 ton
c. Dehydrating agent 1.0 ton
Liquid. 200 Kg Road
d. Diphenyl ether
drums
11. 2-Amino-6-methoxy benzothiazole
Solid. 40 Kg drum Road
a. 4-Methoxy aniline 2.0 ton
b. Ammonium thiocyanate 2.0 ton
Gas. Tonner Road
c. Chlorine
Liquid. Tanker Road
d. Monochlorobenzene
Liquid. Tanker Road
e. Sulphuric acid 5.0 ton
12. 5-Chloro-2-pentanone
Liquid. 200 Kg Road
a. 2-Acetylbutyrolactone 3.0 ton
drum
b. Conc HCl Liquid. Tanker Road
13. 4-(2-Methoxyethyl)phenol
55

2-Phenyl ethyl methyl Liquid. 200 Kg Road
a. 3.0 ton
ether drum
Liquid. 40 Kg Road
b. Acetyl chloride 1.0 ton
carbouy
c. Catalyst 1.0 ton
Liquid. Tanker Road
d. Methylene dichloride
Liquid. 200 Kg Road
e. Hydrogen peroxide 1.0 ton
drum
f. 50 % Caustic solution Liquid. Tanker Road
g. HCl Liquid. Tanker Road
14. Cyclen
Liquid. 200 Kg Road
a. Triethylenetetramine 0.5 ton
drum
Liquid. Tanker Road
b. N-Butanol
Liquid. 200 Kg Road
c. Glyoxal 0.5 ton
drum
0.5 ton
d. Sodium borohydride placed in 200 Kg
drum
15. 2-Cyclohexen-1-one
Liquid. 200 Kg Road
a. Cyclohexanone 5.0 ton
drum
Liquid. Tanker Road
b. Ethyl acetate 5.0 ton
Liquid. 200 Kg Road
c. Monoethylene glycol 3.0 ton
drum
p-Toluene sulphonic 0.5 ton
d. placed in 200 Kg
acid
drum
Solid. 25 kg card- Road
e. DBDMH 5.0 ton
board drum
f. 50 % caustic lye Liquid. Tanker Road
16. 7-Chloroquinaldine
Liquid. 200 Kg Road
a. 3-Chloroaniline 2.0 ton
drum
Liquid. Tanker Road
b. Conc. HCl
56

Liquid. 200 Kg Road
c. Paraldehyde 1.0 ton
drum
2.0 ton
d. Aromatizing agent placed in 200 Kg
drum
e. N-Butanol Liquid. Tanker Road
17. 8-Nitroquinaldine
a. 2-Nitroaniline 3.0 ton
Liquid. Tanker Road
b. Conc HCl
2.o ton Liquid. 200 Kg Road

c. Paraldehyde
drum
2.0 ton
d. Aromatizing agent placed in 200 Kg
drum
Liquid. Tanker Road
e. Monochloro benzene 5.0 ton
18. N-Ethyl-L-prolinamide
a. L-Proline 2.0 ton
Liquid. 40 Kg Road
b. Diethyl sulphate 2.0 ton
Carbouy
Liquid. Tanker Road
c. Caustic lye
200 Lts drum Road
d. Ammonia solution 2.0 ton
Liquid. Tanker Road
e. N-Butanol
2.0 ton
f. Reducing agent placed in 200 Kg
drum
19. Tyramine HCl
a. Tyramine 2.0 ton
Gas. Cylinder Road
b. HCl 0.5 ton
Liquid. Tanker Road
c. IPA 5.0 ton
20. 5-Sulfamoyl-2, 4-Dichloro benzoic acid

2,4-Dichloro benzoic Solid. 25 Kg bags Road
a. 2.0 ton
acid
57

Liquid. 40 Kg Road
b. Chlorosulfonic acid 2.5 ton
Carbouy
Liquid. 200 Kg Road
c. Ammonia solution
drum
d. Methanol Liquid. Tanker Road
21. 6-Bromo—hydroxy pyrazine -2-carboxamide

a. 2-Amino propandiamide 2.0 ton
Liquid. 200Kg Road
b. 40 % Glyoxal 2.0 ton
drum
Liquid. 3 Kg Road
2.0 ton
c. Bromine bottles in wooden
box
Liquid. Tanker Road
d. Caustic lye
Liquid. Tanker Road
e. Acetonitrile 5.0 ton
22. N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethy;-4-methyl-2-oxo-2,5-dihydro-1H-
pyrrole-1-carboxamide
3-Ethyl-4-Methyl-2- Solid. 25 Kg bags Road
a. 1.5 ton
oxo-pyrroline
2-Phenyl ethyl Liquid. 40 Kg Road
b. 1.5 ton
isocyanate carbouy
Liquid. 40 Kg Road
c. Chlorosulfonic acid 2.0 ton
Carbouy
Liquid. 200 Kg Road
d. Ammonia solution
drum
e. MDC Liquid. Tanker Road
f. IPA Liquid. Tanker Road
23. 4-n-Butyl –resorcinol

Solid, 25 Kg bags Road
a. Resorcinol 1.0 ton
Liquid, 40 Kg Road
b. Butryl chloride 1.0 ton
carbouy
Soild, 25 Kg bag Road
c. Catalyst 0.25 ton
Liquid. 200 Kg Road
d. Hydrazine 80% 1.0 ton
drum
e. MDC Liquid. Tanker Road
f. Caustic lye Liquid. Tanker Road
58

24. Cetyl ethyl dimonium ethosulphate
a. Cetyl alcohol 1.5 ton
p-Toluene sulphonyl Liquid. 40 Kg Road
b. 1.5 ton
chloride carbouy
Liquid. 25 Kg Road
c. Catalyst 0.2 ton
Carbouy
Solid . 25 Kg bags Road
d. Sodium bicarbonate
Liquid. 200 Kg Road
e. Dimethyl amine 1.0 ton
drums
Liquid. 40 Kg Road
f. Diethyl sulphate 1.0 ton
carbouy
25. 2-(3-chloropropyl)-2,5,5-trimethyl-1,3-dioxane
a. 5-Chloro-2-pentanone -
3.0 ton Liquid. 200 Kg drum
Neo pentyl glycol Road
b. 1.0 ton Solid. 50 Kg bag
Catalyst Road
c. 250 Kg 25 Kg drum
Toluene
d. Liquid. Tanker Road
26. 4-Chloro benzaldehyde

a. p-Chlorotoluene 5.0 tons Liquid. 200 Kg drums Road
b. Chlorine gas Gas. Tonner Road
Catalyst Road
c. 25 Kg drum
d. Sulphuric acid Liquid. Tanker Road
e. MCB Liquid. Tanker Road
59
2.7 List of Plant Machinery

Project Proponent has proposed 7 numbers of Glass lined reactors, 10 numbers of Stainless Steel
Reactors and two cooling towers 500 Tr and 100 Tr capacity. Detailed equipment list with
material of Construction and capacity is presented in Annexure -III.
2.8 Resource optimization

The manufacturing process optimization shall be carried out to reduce or eliminate resource
wastage. Following measures are proposed to reduce waste.
 Use of solvent recovery system, reuse the solvent and minimize the solvent loss. Secondary
condensers with -8°C brine solution for low boiling solvents recovery
 Installation of Multiple-effect evaporator (MEE) and reuse of condensate.
 Reduce evaporation losses by using efficient cooling towers
 Recovery of by products from waste stream generated.
 Use of Energy efficient lighting system
 Installation of solar panels
2.9 Availability of water its source, Energy/ power requirement and source
During operation of proposed project 66.66 KLD of water will be required for industrial &
domestic purpose. It will be supplied by MIDC pipeline. The total power requirement in the form
of connected load is 600 kVA and demand load of 400 kVA. It will be supplied by MSEDCL.
Solar panels of 20 kVA will be installed which will be used for lights in the entire premises. 300
kVA capacity of DG set will be installed at the site which will be used to run critical processes &
emergency lights. D.G set will be used backup source in case of power failure. Fuel used for
D.G. set will be High speed Diesel with requirement of 200 Liters/day. Detailed water budget is
presented in Table 2-4.
60
Table 2-4: Water Budget

Details of Water Budget
Particulars/ Waste
Fresh Recycled Loss
Water Water
(KLD) (KLD) (KLD)
Requirement (KLD) Remark
Sewage will be treated in STP.
Domestic 4 0 0.2 3.8 3.8KL will be used for
gardening
5.962 KL goes for aluminates
recovery to registered vendor
Products from Oxirane manufacturing.
25 19.038 5.962 19.038
manufacturing 19.038 KL recovered from
MEE will be directly used in
next batch
2.9KL will be cooling tower
makeup considering 20%
evaporation losses. Once the
Cooling tower 14.5 11.6 1.9 1 TDS crosses 500, the water
will be used for gardening.
1KL per day blow day will be
used for gardening
Hot water System is similar to Thermic
10* 0 10 0
Generator fluid. No losses
Total requirement is 13.16KL
out of which 4.8KL will be
Gardening 13.16 4.8 13.16 0 treated water from STP
(3.8KL) and water blowdown
from Cooling tower (1KL)
Total Water
66.66 35.438 31.225 23.838
requirement
*Once in a lifetime
61
Figure 2-5: Water Balance Chart
62
2.10 Quantity of wastes to be generated (liquid and solid) and scheme for their
Management/disposal
In operation phase generated solid waste will be segregated. Details of hazardous & non-
hazardous are presented in Table 2-5 and Table 2-6. Hazardous waste is sent to Butibori
CHWTSDF and non-hazardous waste is disposed-off through authorized vendor/
recycler/reprocessor. The liquid waste and trade effluent within the plant will be collected by a
pipe network and treated in ZLD plant. Domestic Sewage waste will be treated in 5 KLD
Sewage Treatment Plant (STP). 0.54 kg per day of treated sludge will be generated from STP.
Table 2-5: Hazardous waste quantification and disposal
Hazardous waste Category Proposed Disposal
(kg/month)
Process waste/Residue 28.1 8100 CHWTSDF
ETP Sludge 35.3 200 CHWTSDF
Discarded drums/Bags 100 CHWTSDF or sale to
33.1
Authorized Recycler
Salts from MEE 37.3 15075 CHWTSDF
Liners 33.1 100 CHWTSDF
Quantification of industrial dry waste like wooden pallets, Glass scrap, Plastic, Paper corrugated
box, Cartons that will be generated in the project is presented in Table 2-6: Details of non-
Hazardous waste. E-Waste of 500 kg/annum will be generated and it will be disposed through
authorized e-waste recyclers. Total excavation material will be about 500 cu.m. It will be used in
refilling.
Table 2-6: Details of non-Hazardous waste
Non-Hazardous waste Proposed (kg/month) Treatment

Glass scrap 20 Sale to Authorized recycler
Plastic 20 Sale to Authorized recycler
Plastic Drums 100Nos. Sale to Authorized recycler
Paper/ Corrugated box 50 Sale to Authorized recycler
e-Waste 500 kg/annum Sale to Authorized recycler
2.11 Schematic representations of the feasibility drawing which give information of

EIA purpose
Considering the products (bulk drugs and intermediates) & project location (located in notified
industrial area, Umred Industrial area, Navi Mumbai, Maharashtra. The proposed project falls
under Category 5 (f) “B” of the Schedule-I of EIA Notification SO 1533. As per the provision of
the S.O. 1533, it is necessary to get Environmental Clearance by applying to MoEF along with
the Environmental Impacts Assessment Study Report for the proposed project prior to
63
commissioning of the project activities. However, as per notification S.O. 1223 (E), dated 27th
March 2020, MoEF has directed expeditious disposal of proposal relating to Active
Pharmaceutical Ingredients (API) as Category B2 in light of present situation arising from
COVID-19 outbreak. This OM is valid till 30th September 2020. The proposed project shall be
appraised as Category „B2‟ project.
64
3. Site Analysis
3.1 Connectivity
The proposed project site is connected to Nagpur through road and rail linkages. National
Highway NH 247 is at a distance of 1.67 km from project site whereas, SH-258 (Wardha-
Samudrapur-Umred Highway) is at about 300 meters from the project site. Umred has
connectivity to Nagpur district via rail line, which further extends to Bhivapur and Nagbhid. The
nearest airport, Nagpur Airport is about 39.4 km from the project site. The nearest railway
station is Umred situated at2.38 km from the project site.
3.2 Land Form, Land use and Landownership

The project site is within the lease area of M.I.D.C. with a plot area of 7981 sq.m. The details of
the land are given in Table 3-1 below. (Possession receipt is attached as Annexure IV)
Table 3-1: Details of Land use of the Lease Area
Plot No. Area Type of Land Ownership of the land
A-24/100 and A-24/105 7981 sq.mt Private M/s. Navitus Chemicals Pvt. Ltd.
3.3 Topography
The slope of the project site is from north to South direction. The highest and lowest contours
are98.500 m and 96.750 m respectively and the difference is 1.750 m. Contour map is attached
as Annexure-V. The Toposheet map of 1:50,000 scale is attached as Annexure – VI.
3.4 Existing land use pattern

The project site is located in notified industrial area; the land use of the project site is industrial.
3.5 Existing Infrastructure

Umred Industrial Area has internal roads with streetlights, electricity supply and water supply
distribution network. (Source: MIDC, Government of Maharashtra). The project site has access
road width 20 m. The State Highway SH 258 Wardha- Samudrapur-Umred Highway and
National Highway MSH 9-Changrapur-Mul-Nagbhir-Nagpur Highway are at 0.31 km and 0.95
km respectively from the project site.
3.6 Soil classification

Deep black soil type is predominantly found in the Umred Tehsil. (Source: NBSS & LUP,
65
Nagpur).
3.7 Climatic data from secondary sources

The climate of Nagpur can be broadly divided into three important seasons of summer, winter
and monsoon. Almost throughout the summer (March-June), the maximum temperature remains
beyond 40 degree Celsius. Sometimes it may be as high as 48 degree Celsius. Monsoons (July-
September) take its charge in the month of June. It showers maximum in the months of July and
August. The minimum temperature recorded around 12 degree Celsius in winters (October-
January) and sometimes even dips down below that level in the month of February. Nagpur city
experiences a low pressure in the end of May month resulting in the wind blowing at a speed of 6
m/s or more and for the rest part of the year; the speed remains 2 to 3 m/s.
Annual wind rose prepared from daily surface wind data recorded for 1971 to 2000 at Nagpur
(Sonegaon) indicates that the most frequently occuring direction is from west (W) followed by
winds from east (E) and northwest (NW). The frequency of winds from west (W), east (E),
northwest (NW), southwest (SW) and northeast (NE) are 8%, 8%, 8%, 7% and 7% respectively.
Annual strongest wind, those greater than 11mps come from west W) direction. Annual wind
rose for Nagpur (Sonegaon) is shown in Figure 3-1:
Figure 3-1: Wind Rose Diagram

*Source of wind rose: IMD, Atlas of wind roses 1971-2000, Volume-II
66
Temperature
The temperature generally rises from the beginning of March till June, which is the hottest
month of the year with mean minimum and maximum temperatures of 20.3oC and 36.7oC
respectively. With the onset of monsoons by the end of June, temperature begins to fall. The
drop in day temperature is much more than the drop in night temperature. The night temperature
falls rapidly after the withdrawal of monsoons by mid-September. The month of December is
coolest month with the mean maximum and minimum temperatures being 28.3 oC and 12.1oC
respectively. Sky is generally clear with light surface winds blow from North or North-easterly
direction. The normal minimum temperature is 12.0°C to 14.0°C with slight rise in the mean
daily minimum temperature. The mean maximum temperature is around 29.0°C.
Humidity
Except during monsoon months is generally low throughout the year. During summer season,
humidity is lowest (20.7%). During monsoon months, it goes as high as 80- 90%. The highest
level of humidity (88%) is observed in the month of August.
Rainfall
At Nagpur, the annual rainfall is 1250.7 mm. About 60 to 70 % of the annual rainfall is reviewed
in the monsoon months. The rain in Nagpur is heavily dominated by the south-westerly monsoon
winds. Precipitation in form of rain is received during monsoon months. The number of rainy
days in a year is about 56.9 at Nagpur.
3.8 Social Infrastructure

It has a Post office, Telex - Fax - ISD/STD facility, city transport, fire station, hotels, banks and
hospitals. Educational institutes are located in nearby areas. Social infrastructure in the project
area is presented in Table 3-2.
Table 3-2: Social Infrastructure in the Project Area
SH 258- Wardha- Samudrapur-Umred Highway - 0.31 km
1. Nearest Highway
NH 247 - 1.67 km
2. Nearest Fire Station Umred Fire Station -3.3 km
3. Nearest Airport Nagpur Airport – 39.41 km
Nearest Railway
4. Umred Railway Station- 2.38 km
Station
Mahatma Jyotirao Phule SharirkShikshanMahavidyalay0.63 km
5. School /Colleges
Om Polytechnic 0.47 km
6. Post Office Umred Post office – 1.66 km
7. Bus stop Umred bypass bus stop – 0.99 km
Sub-district hospital Umred 2.83 km
8. Hospital
Rural Charitable Trust Hospital 1.62 km
67
4. Planning Brief
4.1 Planning Concept

The proposed project is estimated to manufacture 1850 MTPA of pharmaceutical
intermediates and speciality chemicals. Project timeline is given in Table 4-1 below.
Table 4-1: Project Timeline
Particulars Duration Scope Stage
Land Acquisition & Other 8 months New Firm Complete
Environmental Clearance 3 months New Firm In process
Facility Build up & Commissioning 5 months New Firm
Pre-Production 1 month New Firm
Total 17 months
4.2 Population Projection

The proposed project will hire local skilled and semi-skilled workers during construction phase
as well as operation phase. During the construction phase, total 50 construction workers will be
employed and during the operation phase, total 80 personnel will be employed. No population
influx is anticipated from the proposed project.
4.3 Land use planning

Land is already developed for industrial purpose. Area details are presented in Table 4-2
below:
Table 4-2: Area details
Sr. No. Description Area in Sq.m.
1. Security cabin 01 20
2. UG Tank area (Fire) 60
3. UG Tank area (Domestic) 12
4. Store+ Admin+ Lab 1200
5. Tank farm 105
6. Waste material storage 22.5
7. Drum Yard 67.5
8. Evaporator (MEE) 70
9. Chlorine Shed 25
10. Lift hoist 4
11. Plant 01 541.5
12. Plant 02 541.5
68
13. Chiller room 25

14. STP 17.5
15. ETP area 94.5
16. Utility room 200
17. Security cabin 2 20
18. Transformer room 36
19. Total Ground coverage 1767.98
20. Area under road 2423.87
21. Area under paving 228.35
22. Parking area 595.3
23. Green belt area 2627.5
Total 7980
4.4 Assessment of Infrastructure Demand (Physical &Social)

The project is connected by road to Nagpur city and other regions. All educational, banking,
recreational, medical facilities and other infrastructure are already available in Umred MIDC.
Hence, no additional infrastructure is required.
4.5 Amenities/Facilities
Facilities like rest rooms, parking area, first aid and recreation facilities will be provided in the
proposed project. In addition to this D.G set as power back up will be installed. No other
additional facilities are proposed.
69
5. Proposed Infrastructure
5.1 Industrial Area (Processing Area)

The Processing area which includes Plant facilities, Lab, ETP Area and Utility Services are
shown in Annexure 1 and area details are listed in Table 4-2.
5.2 Residential Area (Non Processing Area)

As the project will be deploying local workers, therefore no infrastructure for their residential
purposes is needed. No labour colony will be constructed at the project site. Workers will
commute from nearby areas.
5.3 Green Belt

An area of 2654.5 sq.m. i.e. one-third (33%) of the total plot area (7980 sq. m) is earmarked for
green belt development. There are existing 4trees at the project site. All the existing trees will be
retained. In addition to these 4 trees, 33 trees will be planted.
5.4 Social Infrastructure

The project site and surrounding area is already developed all required social infrastructure like
transport facilities like road network, bus stop, medical facilities, education infrastructure,
recreational facilities are developed within 5 km radius of the project site. Due to availability of
the required social infrastructure, no additional infrastructure is proposed.CER details - amount
and details.
5.5 Connectivity
The project site is well connected by road and rail to Nagpur city and other localities of Nagpur
district. Due to available internal roads and existing connectivity to other regions of Nagpur
district no additional infrastructure is proposed.
5.6 Drinking Water Management

Domestic water demand is 4 KLD which will be met by water supply from MIDC.
5.7 Sewerage System

During Construction Phase, about 2.9 KLD of sewage will be generated and it will be collected
70
in septic tank/ soak pit. During operation phase, about 3.6 KLD of domestic sewage will be
generated. It will be treated in STP (Capacity 5 CMD) and treated water will be used for
gardening purpose. Details of STP are provided below and influent and effluent characteristics
are presented in Table 5-1.
The Sewage Treatment plant will consist of following units:
 Screen chamber
 Raw Sewage Sump
 MBBR
 Secondary Tube Settler
 Sludge Drying Beds
 Clarified Water Tank
 Pressure Sand Filter
 Activated Carbon Filter
 Treated water Tank
Screen Chamber
Overflow from septic tank comes to Screen Chamber. Screen Chamber is constructed in R.C.C.
at a level of inlet Sewage shall be provided with a screen. This will remove the floating matter
present in the incoming Sewage like plastics, fibers and any other floating material.
Raw Sewage Sump
This tank serves as the holding tank for the incoming Sewage. The overflow of sewage from
septic tank after passing through septic tank is collected in this tank. This will help in loading the
sewage with a consistent flow and will accommodate the variation in flow during the peak
period. From here it is pumped to the MBBR in require steady rate for the biological process and
reaction. This sump would be constructed in RCC.
Moving Bed Bio Reactor
MBBR unit will be equipped with a grid of piping and air diffusers through which compressed
air is passed and distributed throughout the tank in the form of fine bubbles using diffusers. PVC
fill media in the form of Moving bio carriers will also be provided for the immobilization of the
additional bio mass. The PVC Bio carriers increases the contact period of air and water and helps
in maintaining the MLSS in aeration tank. Here fine bubble flexible EPDM membrane diffusers
will aerate Sewage along with Bio carriers In MMBR the organic impurities will get oxidized
with the help of microbial organism in to inorganic form. For the first run of the plant the
microbial culture is brought from outside and as the culture grows then the sludge from the
settler acts as the culture.
Secondary Tube Settler
A Tube Settler shall be provided for the settlement of fully aerated Sewage from MBBR unit.
The Settling Tank shall be provided with Tube Deck. Settled sludge at the bottom of Tube Setter
will be discharged to sludge drying beds as per operational requirements. This Sludge being fully
mineralized is suitable for the sun drying on
71
sludge drying beds and further it will used as manure.

Sludge Drying Beds
In the extended aeration system, the sludge is sufficiently mineralized and does not need any
further treatment before dewatering and deposal. Drying Beds with filtration through sand bed
will be provided where sludge will be dewatered by filtration through sand bed and drying of
dewatered sludge by solar radiation. Sludge Drying Beds will be constructed in brick masonry
with a sand media supported by gravel bed with suitable under drain system.
Clarified Water Tank
Overflow from Secondary Tube Settler i.e. Clarified water will further be collected at the
Clarified water tank for further filtration.
Dual Media Filter
Overflow from tube settler i.e. Clarified water may contain some fine particulate suspended
matter, hence to remove these suspended impurities the clarified water would be pumped
through dual media filter. The media used would be graded quartz sand and Anthracite. Dual
media Filter is fabricated out of FRP Dual media filter will be provided with Suitable media,
piping & Valves for backwashing arrangement.
Activated Carbon Filter
Clear water from Dual media Filter is passed through Activated carbon Filter, where it is passed
through the bed of Activated Carbon. This helps in further improving the quality of outlet water
by removing the residual odour and colour. Activated Carbon filter will be provided with
suitable media, piping & valves for backwashing arrangement.
Treated Water Tank
Output from Activated carbon Filter i.e treated water will further be collected at the Treated
water tank before disposal or reuse in gardening / toilet flushing. But before that it is subjected
for chlorination for de-nitrification. Chlorine solution will be added for disinfection. Chlorine
dose will be adjusted to maintain the residual chlorine concentration of 0.5 to 1 ppm.
Table 5-1: Influent and Effluent Characteristics of STP
Sr. No. Parameter Inlet Characteristics Out-let Characteristics
1. Inlet Flow 3.0 M3 / day 3.0 M3 / day
2. pH 7 to 9 7 to 8
3. BOD 250 -300 mg/ l < 30 mg/ l
4. COD 500 – 600 mg / l < 100 mg / l
5. TSS 300 mg /l < 20 mg /l
72
Figure 5-1: Flow Scheme for STP
73
5.8 Industrial Waste Management

Industrial solid waste will be segregated as hazardous and non-hazardous. The categorization of
hazardous waste as per the Hazardous and Other Wastes (Management and Transboundary
Movement) Rules, 2016, its quantification and modes of disposal are presented in Table 2-5.
Non-hazardous waste will be disposed-off through authorized third party
vendor/recycler/reprocessor. The industrial liquid waste i.e. trade effluent generated will be
collected by a pipe network and treated in ZLD.
ZLD plant is designed as effluent evaporation plant for effluent feed to the system. We have
designed this plant upto complete zero liquid discharge solution.
This is Single effect Evaporation system along with specially designed thermo vapour-
recompression system to concentrate effluent upto maximum extent possible & then treated it in
specially designed patented compact dryer. The condensate generated can be reused for process
operations, cleaning etc. Feed will be passed through evaporator getting higher concentration.
Then concentrated effluent will be dried in dryer using steam as a heating media. Vapors out
from effect 1 will be passed to indirect contact type condenser for further condensation. Cooling
water will be used as a cooling media for condensation. The entire system will be operated under
vacuum. Vacuum will be applied by water ring vacuum pump only when the condensate to be
recovered from the plant. This process is designed as semiautomatic process where system main
parameters will be controlled automatically. The plant capacity has been considered as 20
KLPD. The flow diagram of the treatment process is depicted in Error! Reference source not
ound.. Effluent quantity and characteristics is given below.
After streaming in a separate Cooling Tower
Input
Volume, Ltrs COD Kg of COD
Total effluents 20000 38000 760
Output
Quantity of feed to evaporator
5.9 Solid Waste Management

During Construction Phase, total Municipal waste generated will be 31.5 kg/day of which
Biodegradable waste will be 18.9 kg/day and Non-biodegradable waste will be 12.6 kg/day. The
biodegradable waste and will be handed over to Authorized vendors. During Operation Phase,
total Municipal waste generated will be 40.5 kg/day of which Biodegradable waste will be 24.30
kg/day and Non-biodegradable waste will be 16.2 kg/day. After segregation at source
Biodegradable waste and Non-biodegradable waste will be handed over to Authorized vendors
74
5.10 Power Requirement & Supply /source

The electricity will be sourced from Maharashtra State Electricity Distribution Company Limited
(MSEDCL). The connected load of 600 kVA and demand load of 400 kVA during operation
phase will be required. DG set of 300 kVA capacity will be installed and will only be used as a
back-up power source. During construction phase, power requirement of 10 kVA will be met
through temporary connection.
75
Figure 5-2: Process Flow Diagram for 20 KLPD ZLD Plant
76
6. Rehabilitation and Resettlement (R&R) Plan
The project site is located in notified industrial area and developed by MIDC under Government
of Maharashtra for setting up of industries. It does not involve resettlement and rehabilitation.
7. Project Schedule & Cost Estimates
The manufacturing of proposed products is planned to commence in6 months after obtaining
Environmental Clearance and other necessary authorizations. The capital investment of the
project is INR 1300 Lakhs. The project schedule and project cost are presented in Table 4-1
and Table 7-1 and respectively.
Table 7-1: Project Cost
S No Particulars Amount (In Lakhs)
1. Land acquisition 100
2. Pre-Operative Expenses 55
3. Civil Work 220
4. Machinery* 730
5. QC & PD Lab Equipment 35
6. Commissioning &Pre-operative funds 60
7. EMP (capital cost of pollution 100
control systems)
Total 1300
*ETP cost is included in Plant machinery
8. Analysis of proposal (Final Recommendations)
In light of the ongoing COVID-19 pandemic, the proposed project plans to manufacture three
intermediates which serve as starting material for manufacture of APIs for COVID-19 treatment.
The project is located in notified industrial area. There will be no change in land use. The
proposed project will be equipped with the pollution control facilities to handle the pollution
load generated due to its proposed operations. Zero Liquid Discharge for effluent treatment will
be provided. D.G. set with acoustic enclosure will be installed. The proposed project will create
job opportunities (Direct & Indirect) by employing 80 nos. of personnel and will create
opportunities for ancillary business in the project area. Corporate Environmental Responsibility
(CER) activities like construction of toilets and installing solar panels at Nagar Parishad School
at Umrer are among many activities that will be undertaken based on Office Memorandum No.
F.No. 22-65/2017-IA.III dated 1stMay 2018 on CER by MoEF. Acknowledgment of CER
77
activities submitted to Collector, Nagpur District is attached as Annexure 7. The project will
have tax benefit to the country and foreign exchange savings and Revenue generation for
Government of Maharashtra. Thus, the proposed manufacturing unit shall provide opportunities
for employment creation, import reduction, and saving in foreign currency.
78
ANNEXURE- 1
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
PROPOSED INDUSTRIAL AREA AT

UMRED, NAGPUR.
BELONGING TO : NAVITUS CHEMICAL PVT. LTD.
14.1m [46'-1"]
91.7m [300'-4"]
AREA STATEMENT
COMPOUND WALL
O +2.4m HIGH
O
STP
3.5 x 5 m
PLOT AREA = 7980 SQ.M
G 06 R/W HARVESTING
G 05 G 05 FSI STATEMENT
SECURITY CABIN 01 = 20 SQ.M 0.25%

6 m WIDE ROAD
GATE
9.0m [29'-6"]
6 m WIDE ROAD 6 m WIDE ROAD (4.0 x 5.0)
ENTRY
N N
UG RANK (FIRE) = 60 SQ.M 2.63%
6 m WIDE ROAD
7.1m [23'-1"]
((6.0 x 10.0) x 3.5(deep)
TANK FARM
UG TANK (DOMESTIC) = 12 SQ.M 0.52%
P 04
15.3m [49'-11"]
5 x 21m SECURITY ((6.0 x 2.0) x 3.5(deep)
P 05 G 01 CABIN 01
STORE + ADMIN + LAB (G+1) = 1200 SQ.M 15.03%
6 m WIDE ROAD
25.4m [83'-1"]
4 x 5m
3.1m [10']
((40.0 x 15.0) x 2)
M
WASTE MATERIAL STORAGE
TANK FARM = 105 SQ.M 1.31% M
2.5 x 9 m (5.0 x 21.0)
WASTE MATERIAL STORAGE = 22.5 SQ.M 0.28%
18.9m [61'-11"]
DRUM YARD
UG TANK FIRE (2.5 x 9)
6 x 10 x 3.5 m
G 05 7.5 x 9m DRUM YARD = 67.5SQ.M 0.84%
G 07 G 02 (7.5 x 9)
30 M WIDE ROAD
EVAPORATOR (MEE) = 70 SQ.M 0.87%
L L
UG TANK DOMESTIC (10.0 x 7.0)
6 x 2.5 x 3.5 m
54.5m [178'-6"]
CHLORINE SHED = 25 SQ.M 0.31%
(5.0 x 5.0)
7 x 4.5 x 2 m
7 x 4.5 x 2 m
LIFT HOIST = 4 SQ.M 0.05%
ETP 01
ETP 02
EVAPORATOR (2.0 x 2.0)
10 x 7 m
PLANT 01 = 541.5 SQ.M 6.78%
K ((19.0 x 9.5) x3 (G+2) K
ETP 03 PLANT 02 = 541.5 SQ.M 6.78%

STORE + ADMIN +LAB
7 x 4.5 x 2 m
40.0m [131'] P 01
((19.0 x 9.5) x3 (G+2)
15.0m [49'-2"]
CHILLER ROOM = 25 SQ.M 0.31%
LIFT
HOIST P 03 (5.0 x 5.0)
2x2m
STP = 17.5 SQ.M 0.21%
6 m WIDE ROAD
6 m WIDE ROAD
CHLORINE G 07
(3.5 x 5.0)
J J
SHED ETP 01 = 31.5 SQ.M 0.39%
5x5m
((7.0 x 4.5) x2 (deep)
PLANT 02 ETP 02 = 31.5 SQ.M 0.39%
19 x 9.5 m
((7.0 x 4.5) x2 (deep)
P 02 ETP 03 = 31.5 SQ.M 0.39%
6 m WIDE ROAD 6 m WIDE ROAD ((7.0 x 4.5) x2 (deep)
I UTILITY ROOM = 200 SQ.M 2.50% I
G 03
(15.0 x 15.0)
G 03
SECURITY CABIN 02 = 20 SQ.M 0.25%
COMPOUND WALL
115.3m [377'-9"]
+2.4m HIGH
72.3m [236'-8"] (5.0 x 4.0)
TRANSFORMER ROOM = 36 SQ.M 0.45%
6 m WIDE ROAD
(6.0 x 6.0)
H H
G 05
TOTAL F.S.I = 3062 SQ.M 38.37%
TOTAL GROUND COVERAGE = 1767.98 SQ.M 23.15%

PLANT 02 G 03
19 x 9.5 m
AREA UNDER ROAD = 2423.87 SQ.M 31.37%
6 m WIDE ROAD
G AREA UNDER PAVING = 228.35SQ.M 3.86% G
PARKING STATEMENT
AREA UNDER PARKING 01 = 122.36 SQ.M
59.7m [195'-7"]

F F
G 07
TOTAL PARKING AREA = 595.3 SQ.M 7.12%
COMPOUND WALL
+2.4m HIGH
GREEN BELT AREA STATEMENT

COMPOUND WALL
AREA UNDER GREEN BELT 01 = 38.0 SQ.M

6 m WIDE ROAD
+2.4m HIGH
E
G 03 GREEN BELT 02 = 38.2 SQ.M E
GREEN BELT 03 = 274.63 SQ.M

CHILLLER
1.5m [4'-9"]
ROOM 1.5m [4'-11"]
5x5m
6 m WIDE ROAD
D UTILITY ROOM D
15 x 15 m
G 05
1.5m [5']
TOTAL GREEN BELT AREA =2654.5 SQ.M 33.4%
LEGENDS
@ 2.4m FROM GL.
COMPOUND WALL
BUILDING LINE PLOT BOUNDARY

C GREEN AREA C
ROAD
G 04 PAVED AREA U.G STRUCTURE
TRANSFORMER P06
SECURITY ROOM
CABIN 02 6 x 6m REVISION DATE DESCRIPTION SIGN.
9.0m [29'-6"]
5 x 4m
TITLE :- MASTER SITE PLAN
COMPOUND WALL
33.8m [110'-8"]
+2.4m HIGH
PROJECT :- UMRED INDUSTRIAL AREA, DISTT. NAGPUR.
EXIT
B B
CLIENT :- M/s. NAVITUS CHEMICAL PVT. LTD.
DWG No. :- SITE PLAN
20 M WIDE ROAD
A A
Address E-Mail ID
1st Floor, Junipers - Hemant Building, contact@techture.co.in
Plot No. 2, IT Park, South Ambazari Road, Website
Nagpur - 440011, Maharashtra, India www.techture.co.in
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
ANNEXURE- 2
ANNEXURE- 3
Equipment list
Sr. No. Equipment MOC Volume Quantity
Reactors
1 Glass lined MSGLR 3.0 KL 4
5 Stainless steel SSR 7.0 KL 4
Condensor
9 Graphite 15 sqm 3
10 SSR 15 sqm 12
Receiver tank
11 Stirred tank PP 3.0 KL 1
12 Tank HDPE 3.0 KL 5
13 Tank SS 304 3.0 KL 10
14 Tank SS 304 1.0 KL 5
15 Tank SS 304 0.5 KL 6
16 Tank MSGL 7.0 KL 1
17 Tank PP 10 KL 2
18 Tank SS 304 7.0 KL 2
19 Tank SS 304 5.0 KL 2
20 Tankfarm (09) MS 10 KL 8
21 Centrifuge MSRL 48" 2
22 Nutch filter SS 304 2.0 K 2
23 Centrifuge SSR 36" 2
24 ANFD SS 316 5.0 KL 1
25 ANFD SS 316 3.0 KL 1
26 Tray Dryer SS 316 96 tray 1
28 FBD SS 316 100 Kg/Hr 1
29 Pumps 30
30 Ejector system 2
32 Balance 4
33 Boiler 3.0 Ton 1
34 Dowtherm 1.0 Ton 1
35 Cooling tower 500 Tr 1
36 Cooling tower 100 Tr 1
37 Chiller 40 Tr 1
38 Material lift(2 No) 2
39 Evaporator MS Halar 800 Lt/Hr 1
ANNEXURE- 4
ANNEXURE- 5
N 2304780 N 2304780
E 324750
E 324800
E 324850
E 324900
E 324950
E 325000
E 325050
E 324700
DETAIL TOPOGRAPHIC SURVEY PLAN FOR

THE SITE OF
M/s. NAVITUS CHEMICAL PVT. LTD.
TOWARDS AT PLOT No. A-24/100 & A-24/105
UMRED UMRED INDUSTRIAL AREA, DISTT. NAGPUR.
LEGENDS
SYMBOL DESCRIPTION SYMBOL DESCRIPTION
N 2304730 N 2304730
TOWARDS
END
N 2304680 N 2304680
N 2304630 N 2304630
TBM NO:-2 TBM NO ELEVATION LOCATION

RL:-98.893
1) HIGHEST CONTOUR : 98.500 M

2) LOWEST CONTOUR : 96.750 M.
3) CONTOUR INTERVAL : 0.250M.
4) DIFFERENCE : 1.750 M.
DETAILS IN SQM. IN HA. IN ACRE.
NOTES :
1) ALL DIMENSION ARE IN METER
2) GRID SIZE 50m x 50m.
TOWARDS
MIDC AREA
N 2304580 N 2304580 M/s. NAVITUS CHEMICAL PVT. LTD.
UMRED, DISTT. NAGPUR.
imaGIS Engineering
Solutions Pvt. Ltd
UMS 07th june-2020 to 07th june-2020
DETAIL TOPOGRAPHIC SURVEY PLAN FOR

THE SITE OF
M/s. NAVITUS CHEMICAL PVT. LTD.
E 325050
E 324700
AT PLOT No. A-24/100 & A-24/105

E 324750
E 324800
E 324850
E 324900
E 324950
E 325000
UMRED INDUSTRIAL AREA, DISTT. NAGPUR.
TOWARDS
MIDC AREA FINAL DRAWING
N 2304530 N 2304530
1 : 500 IESPL / 20-21 / UMS / TPO 160 17/06/20 02
ANNEXURE- 6
79°18′0.00″ 79°24′0.00″
Survey of India Toposheet Indicating Boundary of the Proposed Navitus Chemicals Pvt. Ltd. and 10km radial distance (Study area)
SOI TOPOSHEET MAP
SOI Toposheet No.

F44T1 SOI Toposheet No.
F44T5
Scale 1:50000
Legend
Navitus Chemicals Pvt. Ltd. Plot Boundary
20°54′0.00″
20°54′0.00″
10km Radial distance (Study Area)
20°48′0.00″
20°48′0.00″
SOI Toposheet No. SOI Toposheet No.

F44T2 F44T6
79°18′0.00″ 79°24′0.00″
ANNEXURE- 7

Pre-Feasibility Report for Proposed Pharmaceutical Manufacturing Unit

Uploaded by

Document Information

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Pre-Feasibility Report for Proposed Pharmaceutical Manufacturing Unit

Uploaded by

Copyright:

Available Formats

PRE-FEASIBILITY REPORT

M/s. Navitus Chemicals Private Limited

Plot No. A-24/100 & A-24/105,

Environmental Consultant Submitted by

Building Environment (India) Pvt. Ltd Navitus Chemicals Pvt Ltd

Executive Summary ...................................................................................................................... 6

3.7 Climatic data from secondary sources ........................................................................... 66

Figure 2-1: Site Photographs ..................................................................................................... 18

Figure 5-2: Process Flow Diagram for 20 KLPD ZLD Plant.................................................. 76

Table 0-1: Salient feature of the project ..................................................................................... 6

API Active Pharmaceutical Ingredient

CER Corporate Environmental Responsibility

CHWTSDF Common Hazardous Waste Treatment, Storage and Disposal Facility

CMD Cubic Meter per Day

CSR Corporate Social Responsibility

ETP Effluent Treatment Plant

INR Indian Rupee

MIDC Maharashtra Industrial Development Corporation

MSEDCL Maharashtra State Electricity Distribution Company Limited

R&D Research and development

NCPL Navitus Chemicals Private Limited

MTPA Metric Tonnes Per Annum

Salient feature of the project

The salient features of the project are presented in Table 0-1.

Connected Load- 600 kVA and Demand

1. Introduction of the project/Background information

1.1 Identification of project and project proponent

 Qualification - Science Graduate

 Qualification - Science Graduate

Sameer Bhalerao - Director 3

 Qualification - Science Graduate

Shyam Titirmare – Director-4, Project Head

 Qualification M.Sc (Organic Chemistry from Dept of Chemistry, Nagpur University)

Address and Email address for correspondence:

1.2 Brief description of nature of the project

Table 1-3: List of products

Sr. No. List of Products CAS No. Structure Use

2. 7-Ethyl trytophol [41340-35-7] Etodolac starting

3. 4,7- [86-98-6] Starting material of

4. 5-Chloro-2- [5891-21-4] Side chain material

6. Cetylethyldimonium [3006-10-8] Surfactant used in

7. (2S,3S)-1,2-Epoxy- [98737-29-2] Darunavir

Sr. No. List of Products CAS No. Structure Use

9. tert-Butyl (2S,3R)- [191226-98-9] Darunavir

11. 4-(2- [56718-71-9] Metaprolol

12. Cyclen [294-090-6] Intermediate of

13. 7-Chloroquinaldine [4965-33-7] Montelukast

14. 2-(3-chloropropyl)- [88128-57-8] Used in

Sr. No. List of Products CAS No. Structure Use

17. 2-Cyano phenol [611-20-1] Azoxystorbin

18. 2-Cyclohexen-1-one [930-68-7] Carprofen starting

19. 4-Methoxy [19501-58-7] Cox-2 inhibitor

20. 2-Amino-6-methoxy [1747-60-0] Used in Schiff

21. 8-Nitroquinaldine [881-07-2] Speciality chemical

Sr. No. List of Products CAS No. Structure Use

23. Tyramine HCl [60-19-5] Benzfibrate starting

24. 6-Bromo-3-hydroxy [259793-88-9] Favipiravir

25. 5-Sulfamoyl-2,4- [2736-23-4] Intermediate of

26. 4-Chloro [104-88-1] Used in

a. 4,7-Dichloroquinoline- Starting material of Chloroquine & Hydroxychloroquine, 5-

The company shall leverage the following advantages of the products:

1.4 Demand-Supply Gap

1.5 Imports vs Indigenous production