A station was built at Obertürkheim with the establishment of the 

Central
Railway (German: Zentralbahn) of Württemberg from Stuttgart to Esslingen. At its opening, on 7
November 1845, it became the third station of the Royal Württemberg State Railways (Königlich
Württembergische Staats-Eisenbahnen). Earth had to be brought in from Ailenberg (hill) in order to
strengthen the foundation of the one-story entrance building. The building was later increased by
another floor. In addition, a left and a right wing were added. The first floor was occupied by the
station master and on the ground floor next to the waiting room, from 1855 to 1899, there was a post
and telegraph office, which served the communities of Obertürkheim, Uhlbach and Hedelfingen.
In 1852, the State Railways duplicated the section of the Eastern
Railway between Cannstatt and Plochingen. With the beginning of industrialisation in the wine
community, the station gained a freight shed with a loading ramp in 1868.
From 24 May 1912, it became a tram terminus with the opening of the single line of the Esslingen
tramway by the Eslingen Municipal Tramway Company (Eßlinger Städtische Straßenbahn, ESS).
This ran from the station forecourt to Oberesslingen.
Increasing traffic made an enlargement of the station inevitable. The station building was no longer
adequate. For the design of the new building the State Railways commissioned architect Martin
Mayer, who also designed the new Bad Cannstatt station building, completed in 1915. Construction
began in 1914, making it, along with the station buildings in Cannstatt and Mettingen, one of the last
buildings built by the State Railways. The two-storey sandstone building is characterised by the
lattice windows and green shutters on the platform side. The facade on the forecourt side with its two
corner projections is very monumental. The intervening three round windows on the upper floor are
similar to those at Cannstatt station. On the hip roof there are several dormers. Work was delayed
by the First World War and the building was not completed until August 1918. The previous building,
which was nearby, was maintained until 1929.
On 15 February 1919, the Stuttgart Tramway (Stuttgarter Straßenbahnen) extended its suburban
network to Obertürkheim station forecourt, which operated as tram line 26 from Oberesslingen to
Schlossplatz (palace square) in central Stuttgart.
On 1 April 1922, Obertürkheim was incorporated into Stuttgart and, on 1 December 1927, the station
was renamed Stuttgart-Obertürkheim as a result.
On 14 October 1931, Deutsche Reichsbahn finished rebuilding the line from Cannstatt to Esslingen
with four tracks. With the electrification of the Eastern Railway, Stuttgart suburban services began
operating to Esslingen on 15 May 1933. Traffic on tram line 26 declined as a result. From 10 July
1944, the Esslingen trolleybus service replaced trams between Obertürkheim and Oberesslingen. Its
line (currently numbered 101) has since connected Obertürkheim station with Lerchenäckern in
Oberesslingen.
In 1994, the Stuttgart tram line 26 was converted to standard gauge as Stadtbahn line 4, but it was
cut back to end at Untertürkheim station. It has never been extended to Obertürkheim. Likewise an
extension of the trolley bus from Untertürkheim has received no encouragement.