Journal of Xidian University ISSN No:1001-2400

Change of Corona Nucleic Acid for Human Disease Suffering

E. Rajasekaran*1, R. Indupriya**2 and R. Meenal$3
*
V.S.B. Engineering College, Karur–639111, Tamil Nadu, India.
**
Kazan Federal University, Kazan, Tatarstan-420012, Russia.
$
Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore–641114, Tamil Nadu, India.
1ersekaran@gmail.com

2indupriyarsekaran@gmail.com

3meenasekar5@gmail.com

Abstract— Corona, one of the life threatening disease causing RNA virus posing danger to human life. It is attracted that the virus
enters with adequate components of survival and growth. Accordingly the analysis was carried out using our well characterized
CARd program to meet the requirements of additional value to cure the disease and other alteration. All our results imply that
carbon is the prime force of interaction in deciding the viral spread and survival. Any deviation from this principle of carbon value is
going to be arrest of entire system of operation in the vicinity of cell function. Alteration sites were reported adequately and other
incorporation of alteration to meet out the other system of disease causing profile for carbon value is briefed. Overall the viral one is
carbon rich when compared to human one which is observed here in corona virus. Corona viral disease may perform some of the
alteration in the system that might be beneficial to the course of interaction in due course. In the event of alteration, picking up the
right one to choose for next level of operation is addressed here. Over and above alteration may be part of the end of disorder over the
new one. Conclusion is that Corona virus can be part of the new development of operation where alteration is required to outperform
the diseased one.

Keywords— Coronavirus; ICOD; carbon value; protein modelling; protein analysis; viral protein; carbon domain;

I. INTRODUCTION
One of the most challenging activities in the world currently is to alleviate the corona effect in human
system [1]. According to latest news today is outbreak in Europe demanding more control over the disease
caused by Corona virus. The ill effect of protein caused by this virus seems to be more worry some than
the core issue of protein disorders in human nature. According to nature of law, any protein to follow
functional role will have adequate amount of carbon in its core to stability and all [2-9]. According to the
rule of law, inadequate carbon distribution leads to function of the protein. Familiar proteins do take
necessary berth both at core issue and function of it. Otherwise it is going to be in the garbage in the
system of operation. Well protein of viral one are not so in amenable to this system under maintenance
[10-12]. Well characterized one lead to functional role. One can think any deviation from this law of
nature in dealing carbon rule for maintenance and function will be sorted out in due course of action.
Accordingly, all amino acids in the protein for functional role will do the characterization everywhere in
core issue of carbon value. Well, carbon in this viral one leads to malfunction of the system to operate and
destroy the whole setup. One might be able control this for some extent. Otherwise damage the system
from functioning. According to rule based analysis, all amino acids in viral one may not have to follow but
varying. Infact the thymine in DNA alters sufficiently the carbon according to nature of law [13-16].
References [17, 18] found the role of DNA in modeling of atomic level understanding.
With advent of new concept of carbon mode analysis any protein with deviation from this rule will be
able to identify clearly. CARd analysis deals this concept of carbon distribution based on carbon fractional
value in core of protein from sequence alone [19]. Whereas other modelling may be requiring all other
parameters to define the system in 3D model of calculations. When in need other physical parameters are
required to deal with deviation study of operation. Here our program requires only the sequence to identify
alteration site or active one. Very many sequences are analysed according to rule based analysis for carbon
value[20-26]. In this context, variations in carbon value of operation in viral proteins are to be considered
here on Corona viral one. Best solutions to solve the viral problem and long standing protein of disorders
in disease happening are to be focus of this work.

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II. METHODOLOGY
Amino acid sequences (NC_034972) of the following are taken from NCBI database [27].

S.No. Protein (reference) No. of AA

1 Polyprotein 3974
(YP_009380519.1)
2 Spike protein 1126
(YP_009380521.1)
3 ORF3 214
(YP_009380522.1)
4 Envelope protein 78
(YP_009380523.1)
5 Membrane protein 248
(YP_009380524.1)
6 ORF6 166
(YP_009380525.1)
7 Nucleocapsid protein 389
(YP_009380526.1)
8 ORF8 105
(YP_009380527.1)

CARd analysis on Corona viral proteins are carried out using built-in function written in PERL
programming language. Well all the sequences are subjected to carbon distribution at different sequence
length. For example lengths from 4 to 45 amino levels are considered. In each state of carbon value taken
in COD are grouped to get meaningful average contribution coming from different lengths at a given
amino acid position. These grouped and averaged values are considered for validation of carbon high,
COD or hydrophilic regions as shown in figures. When carbon value exceeds the optimal value of 0.3144
then considered as carbon high stretch and marked as nonCOD residue. Overall performance of this COD
of all amino acids is again calculated with meaningful representation of COD and hydrophilic values. Well
all these are carried out using single program written for this purpose. CODSEQ.pl does the wonder of
these findings and marking all COD and nonCOD amino acids overall. Over and above all these
representation can be studied further with amino acid neighbor role in grouping the amino acids to COD
and nonCOD. All details are provided with output of all representations meaning different length.
Calculating these amino acids in the role played by neighbors is significant part of the mutational study for
further alleviation of human disorders. Otherwise it is going to be easier than any other protein modeling
for mutational work that leads to disease control and alteration.
Another attempt to alter sequence that neutralize disorders are captured via figuring out the number of
nonCOD amino acids (CFHPWY) at a stretch (4/5) are considered here and accordingly alteration can be
performed for neutralizing carbon value with COD principle of adequacy pattern. According to
neutralization value the alteration needs to be part accounting carbon value to neutral value say 0.3144.
Otherwise making the alteration need not be done at all merely based on other principle of hydrophobic,
hydrophilic, charge and all. According to amino acid with neat profile of carbon value in stable stretch, it
follows the principle of adequacy value that account a lot for satisfying ICOD values in 3D structure [4].
Over and above these finding are calculated with each of these corona viral proteins for alteration and are
included in the result one. For all active proteins it is found out to be some of these nonCOD stretch.
Otherwise other membrane or envelope proteins need not possess these. Well all of these are carried out to
all Corona viral protein and discussed. Even though one can get overall pattern of carbon value from all

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levels of carbon score, appropriate one is 5 amino acids level. Accordingly the pattern identified in this
core calculation may influence up to 9 amino acids. Identified levels are up to 45 amino acids and
averaged. Accurate enough to discuss the role played by neighbour in control of carbon force. Alteration
can be accordingly and good enough for mutational study. According to nature of law carbon adequacy is
met with fellow neighbours of even at distance of 22 amino acids. Otherwise it is not considered at all in
the neighbour role. Frankly pattern representation explains all this carbon value provided adequacy is met
with neighbour. All phenomena happened in the protein in its structure and action is applied from carbon
point of view which explains neatly in the context of carbon profile with adequacy principle attained via
carbon value. According to rule of law governed by carbon profile in the protein sequences it is mandatory
to have 0.3144 carbon fraction at the core of the protein to stabilize each amino acid involved in it [28].
Also noticed that all atoms involved in it are in altered bond length. Otherwise going on in accordance
with aromatic flat surface delocalization principle and flat in circular fashion. Adjustments are carried in
the amino acids to meet this carbon profile. Accordingly these nearer amino acids adjusted its atomic
distribution in the vicinity of COD and all. Overall it is mandatory to have protein with adequacy principle
for any self saturation and inactiveness. Otherwise going to be active accordingly. Alteration of these
amino acids involved are crucial for activity and all. Adjustments are to be carried out using carbon value
rather than merely other forces of attraction coming from van der Waals or electrostatic one. One should
carefully design these principled proteins for any meaningful application and all. According to rule of law
governed by adequacy principle, any other amino acids that are non-obedient of this driving force may
attract external one to convince the profile of carbon value. Alteration needs to be satisfied all profile
governed by carbon value here in accordance to the neat production at amino acids level interaction.
Overall performance can be tested with existing one at the amino acid level [29-31]. Otherwise arranging
these amino acids for certain applications needed to be trained and certain function of all.
III. RESLTS ANALYSIS

Fig 1: COD value for polyprotein of Corona virus shown for each amino acid position. Note that the values are in the range from 0.29 to 0.40. Mostly carbon
rich portions are allowing the polyprotein to acquire hydrophilic atoms to satisfy them. May be allowing to hydrophilic part of carbohydrate to interact or so.

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Fig 2: COD value for spike protein of Corona virus shown for each amino acid position. Adequacy is met but also carbon high portions causing to look for
satisfaction with hydrophilic molecules. It may be interacting with layer of the biomolecular elements having atoms of hydrophilic in nature.

Fig 3: COD value for ORF3 protein of Corona virus shown for each amino acid position. Arrangements are allowed to code for hydrophilic molecule of
intervening portions of other molecular system. Otherwise all are in high carbon mode, available for association and not self satisfied here.

Fig 4: COD value for envelope protein of Corona virus shown for each amino acid position. Arranged are carbon high, hydrophobic followed by carbon high
regions. Accordingly the hydrophilic mediations are missing. Full of carbon high lengths, alleviating protein to mould themselves with macromolecule of
hydrophilic part of other system of interest naturally.

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Fig 5: COD value for membrane protein of Corona virus shown for each amino acid position. Once again carbon high portions and some extent of COD
position which are self satisfying. Hydrophilic may satisfy the hydrophobic nature of the protein on folding.

Fig 6: COD value for ORF6 protein of Corona virus shown for each amino acid position. Overall it is carbon high sequence. One may think of reducing it to
optimum level for effective treatment of all genome based diseases.

Fig 7: COD value for nucleocapsid protein of Corona virus shown for each amino acid position. Note that hydrophilic portions are more in this protein. May be
looking for carbon high portions to satisfy them. Allowing nucleocapsid it may either form hydrophobic or hydrophilic core for stable one.

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Fig 8: COD value for ORF8 protein of Corona virus shown for each amino acid position. Hardly any COD portion leading to instability. Otherwise hydrophilic
parts are satisfying hydrophobic portions. Overall not many changes in amphipathic form.

Polyprotein, one of the largest in series having so many nonCOD targets including 275FQYCC279,
460RYFHCK465, 545YAFFY549, 552GYYFPL557, 773HHLWY777, 1222GFFCYT1227,
1426FCNFYCYVY1434, 1584PHFKF1588, 1605GFCHFVYF1612, 1725HYTFY1729,
1863WFYAF1867, 1873FFYICY1878, 1944FFIFYH1949, 2068HQFFC2072, 2120FYYLH2124,
2368KCCYYM2373, 2429FPEWH2433, 2526HVYCF2530, 2624FFSFF2628, 3009FCYLH3013,
3166LFFFFV3171, 3364FCAYY3368, 3388YYDYC3392 and 3893CCLYC3897. It also has many carbon
rich regions in it to have accommodated for hydrophilic one including 14-21, 27-67, 89-129, 132-157,
207-230, 250-260, 267-296, 306-324, 328-335, 361-393, 407-427, 477-483, 519-527, 540-604, 613-625,
635-675, 697-712, 725-734, 742-759, 761-785, 793-803, 831-836, 851-862, 889-908, 929-944, 946-965,
989-1010, 1059-1066, 1080-1084, 1101-1126, 1133-1148, 1188-1209, 1215-1225, 1232-1262, 1278-1282,
1297-1308, 1362-1366, 1384-1393, 1405-1459, 1522-1555, 1583-1614, 1715-1732, 1735-1741, 1761-
1766, 1778-1822, 1856-2021, 2063-2071, 2081-2085, 2104-2143, 2153-2159, 2201-2218, 2261-2266,
2302-2308, 2329-2337, 2357-2445, 2474-2496, 2525-2579, 2596-2629, 2652-2665, 2672-2676, 2683-
2736, 2758-2774, 2795-2826, 2836-2846, 2870-2889, 2922-2932, 2942-2975, 3003-3013, 3023-3035,
3053-3069, 3075-3090, 3117-3139, 3159-3191, 3196-3400, 3412-3417, 3464-3470, 3492-3514, 3524-
3537, 3567-3571, 3634-3638, 3653-3657, 3667-3673, 3699-3705, 3743-3769, 3772-3781, 3786-3797,
3841-3847 and 3926-3930. At the same time hydrophilics are limited by some extent which are 348-355,
395-404, 605-611, 807-813, 1017-1026, 1053-1057, 1227-1231, 1269-1275, 1340-1349, 1486-1491, 1667-
1673, 1828-1843, 2028-2036, 2057-2061, 2094-2101, 2162-2167, 2225-2232, 2267-2273, 2321-2326,
2348-2352, 3070-3074, 3101-3105, 3153-3158, 3429-3433, 3545-3552, 3575-3580, 3592-3603, 3614-
3618, 3724-3736, 3799-3805, 3863-3869, 3909-3913 and 3949-3954. Include very many COD regions
that and all self sufficient in and stable one. These are 8-13, 68-72, 162-173, 176-182, 185-200, 202-206,
231-243, 297-305, 336-347, 356-360, 428-432, 435-440, 463-472, 484-497, 528-536, 676-696, 713-721,
786-792, 818-830, 837-850, 863-882, 909-918, 966-988, 1039-1046, 1048-1052, 1067-1079, 1149-1157,
1160-1184, 1210-1214, 1283-1290, 1319-1327, 1330-1339, 1350-1358, 1367-1383, 1397-1404, 1460-
1469, 1471-1479, 1497-1521, 1556-1563, 1572-1582, 1626-1631, 1635-1666, 1682-1687, 1691-1696,
1700-1705, 1742-1750, 1753-1760, 1767-1777, 1851-1855, 2022-2027, 2040-2048, 2072-2080, 2086-
2093, 2144-2152, 2168-2172, 2177-2200, 2219-2224, 2274-2278, 2288-2294, 2338-2347, 2446-2461,
2463-2470, 2500-2504, 2513-2524, 2590-2595, 2630-2651, 2666-2671, 2677-2682, 2737-2748, 2752-
2757, 2781-2794, 2856-2863, 2890-2895, 2905-2909, 2933-2941, 3014-3022, 3036-3045, 3048-3052,
3106-3116, 3140-3145, 3401-3411, 3418-3428, 3446-3453, 3482-3491, 3515-3523, 3584-3588, 3604-
3613, 3619-3633, 3647-3652, 3662-3666, 3674-3698, 3706-3723, 3819-3823, 3828-3835, 3852-3860,
3870-3884, 3903-3908, 3917-3925, 3931-3938, 3943-3948. 3955-3960 and 3964-3971.

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One of the active carbon role in the viral proteins are this spike protein with several nonCOD portions
including 13YRCPF17, 54RHWHCG59, 83HPNWWHFA90, 103LFWWHR108, 386CFGYF390,
916MFFHYT921, 1068KWPWYVW1074, 1089LWCCCA1094 and 1097CCGCC1101 present in it. Any
other proteins do have this much of active form. Well poly protein does have this. Lot of variations
observed. One would go on designing this protein to hold lot of other molecules during this process of
interaction with other portion of the cell during infection. And also have very many carbon high stretches
including 9-22, 32-39, 41-55, 64-108, 114-126, 128-133, 157-218, 229-241, 245-294, 297-343, 358-409,
414-434, 445-454, 465-479, 485-489, 528-536, 552-566, 591-604, 616-623, 636-641, 650-698, 708-730,
783-792, 823-832, 859-865, 894-924, 947-951, 958-970, 995-1041, 1049-1089 and .1117-1121. This
many carbon high portions are marginally nullified by hydrophilic stretches (58-63, 500-511, 847-855 and
952-956) which may not be sufficient to neutral one. Overall spike one is high carbon content. CODs are
at 23-27, 140-156, 219-226, 435-444, 512-527, 537-551, 567-576, 581-586, 605-615, 624-629, 645-649,
731-735, 761-778, 798-807, 810-822, 833-837, 840-846, 866-872, 875-885, 925-946, 971-985, 989-994,
1090-1107 and 1111-1116, which again self sufficient neutrally.
ORF3 has one nonCOD (44YSCFF48) stretch with multiple carbon rich stretches (3-13, 25-56, 62-68,
70-149 and 190-211). Sufficiently filling the carbon high portion in two hydrophilic (57-61 and 168-174)
part and CODs are present in three places (14-24, 150-154 and 184-189).
Covers of nuclear RNA came out to be this envelope protein which in turn has no active
nonCOD_CFHPWY stretch. But there are two carbon high portion (2-31 and 56-76) which are flexible
enough to undergo hydrophoic-hydrophilic negotiations. At the same one the hydrophilic one is missing
internally which may have to be met out with incoming moleculae of ingterest. COD is there in single
stretch at 32-47, again self sufficient.
Membrane one is supposely safeguarding the core formed from other interactive elements of other
macromolecular system thus forming no interaction anywhere when in action. That is why this has no
nonCOD_CFHPWY stretch in it. Befittingly carbon high (2-7, 33-137 and 215-231) or hydrophilic (20-30,
146-150, 175-179 and 204-214) one are accordingly distributed to show strength when in action.
Otherwise there are noninteractive COD at 8-19, 138-145, 158-170, 180-186, 191-199 and 232-246 that
and all reviewed from time to time with non compliance with external body of interactive elements which
are there N many time in the process of cell one.
ORF6 protein has an nonCOD portion at 48CFFNW52 for further processing of protein into inactive
form. At the same time there are variety of carbon rich stretches including 2-6, 21-27, 34-76, 83-138 and
153-160 for processing it. There is one hydrophilic stretch at 146-150 balance carbon rich part to some.
Overall one would think that ICOD at 7-16 and 139-145 owing to carbon domain may be silent in all
sense.
Nucleocapsid proteins are supposedly wound to the nuclear RNA which may be having mixer of
nonCOD or COD portions around it. It has about two nonCOD stretches at 70CGYWY74 and
91PPAWYFYFL99. Accordingly the carbon rich portion (34-43, 69-79, 87-118, 254-258, 263-292, 313-
337 and 360-364) of it may be playing the same role as nonCOD one provided flexible enough to wound
the nuclear RNA which in turn there are flatness in it. Otherwise the other carbon richness is taken care by
hydrophilic part of it such as 14-30, 80-86, 119-144, 153-206 and 211-227. Overall, very less amount of
COD in it which in turn looks for partner for satisfaction? COD are 9-13, 50-68, 298-307 and 374-381
ORF8 protein has no nonCOD_CFHPWY stretches which mean that active may not be there but with
carbon rich (29-71 and 90-98) portion it might be associating with hydrophilic part of other macro one.
But it has its own hydrophilic (20-24 and 74-78) part which may interact to nullify the carbon one. CODs
(5-15 and 84-89) are there with null effect in it.

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IV. DISCUSSION
Having read all the proteins of Corona virus, it is observed that many portions full of carbon that and all
targets for future applications. Polyprotein for example has several carbon high and nonCOD portions that
are to be followed for target where incoming molecules may bind further on inactivation [32]. Overall it is
advisable to better the research of Corona virus where one require to penetrate useful protein to target any
sufferings in the human one. Whereas is amenable for Corona to enter and alleviate human diseases and
all. Many times it failed to carry on with disease control where as Corona one may do it with ease. One has
to device planned mission of infiltration and alter existing one for cure. Otherwise it is going to be
exhaustive with one and all in the disease prohibition. Overall one would go with carbon based research in
design and alter the diseased one to go out. Better technology needed to be developed in control of all
these human related diseases where alteration required is to be part of it. Over and above this is going to be
the next generation base for alternative workout for suffering. Overall performance needs to be monitored
for betterment and alleviation work. Nonetheless it is remarkable to be part of the revolutionary effort in
magnifying the remedy of all diseases. One can think of change in scenario where carbon alone will decide
to focus to meaningful applications where neither forces of attraction nor other bonded interaction will be
failing.
All the proteins in viral one are possessing very high carbon value whereas in human it is optimized to
lower level. Whereas it is remarkable that proteins are working model for future full work leading to
disease control or the alleviation work. Reference is made here to address the carbon value in deciding
mutation for certain disease control and alteration [24, 33].
V. CONCLUSIONS
Corona viral proteins are analysed for meaningful application in the due course of action in
incorporating appropriate proteins to solve the problems associated with disorders in human sufferings.
Adequacy is the prime force of interaction in the intervening protein sample for stable or active form of
operation in certain biological function. Adequacy is altered for specific role of action in protein that may
or may not have to do a specific task in biology of macromolecular association. Very good agreement in
response to sequence analysis carried out with protein CARd analysis. Value on carbon prime force is
going to be the task to decide several disease control or alteration. Alteration may lead to advanced effect
in disease control that will be permanent for due course of action. Alteration may be permanent or
temporary but with vengeance to disease one. Very well addressed, careful design and alteration is going
to stay for a while that may happen in the future of all time to come. According to rule of law careful
selection of carbon profile alone going to be stack of interaction which will work out for all interaction
within and outside the protein one. Profile analysis leading to these kind mutation profile workout may be
part of the work here in this neat fixing of carbon value adequately in the system of operation. Adequately,
altered one will better perform over the existing one may be part of the development in the due course.
Value addition is the key to success in the formation of forum for additional force of interaction.
Accordingly addressing these issues with adequacy principle may take to the level one rather than
fractional part of it. This kind of alteration might be significant to the system of operation. Very well
addressed here which may be taken to next level of operation in the cell to function.
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