;<=>;T< D< @AS> @BÍDE@>

Dolo$ %& S(&)$o*% )% +uillai& /a$$01 2&a 3a&i4%56a7i8&

Su9%56i*a)a:
Pai$ I$ &ui((ai$ )a**+ Sy$d*/012 3$ 4$d1*156i0a61d 7a$i8156a6i/$9
Muan Sala5arD NOC3@ P(9*r4( Kñ*5D NO@ Iri24ó9al E23in(5aD NOE Kli8ia N(r(8:(D NOE

Res$me&
El S$n&r()* &* +uillain/0arr1 *2 una 3(lin*ur(3a4$a &*2)i*lini5an4* a6u&a 7u* 2* 3r*2*n4a 8l$ni8a)*n4* 8(n
&*9ili&a& mus$ul&r ( )r&s)*r+*s &u)*+ómi$*s d/ 0*rm& )12i$&3 mi/+)r&s 4u/ l*s s1+)*m&s s/+si)i5*s su/l/+ 2&s&r d/s&2/r$i6id*s7 8/
d/s$ri6/ la :i24(ria 8l$ni8a &* un 3a8i*n4* )a28ulin( 8(n 8ua&ri3ar*2ia ;l<88i&a a6u&a = 4ra24(rn(2 2*n2i4i>(2 4i3( 3ar*24*2ia2 =
al(&inia 7u* &i;i8ul4ar(n *l &ia6nó24i8( &uran4* 2u a9(r&a@* ini8ial. Bu*6( &*l a9(r&a@* &ia6nó24i8( 8()3l*4( 2* 8(n;ir)ó la
3r*2*n8ia &*l S$n&r()* &* +uillain/0arr1. C*2* a 7u* l(2 2$n4()a2 2*n2i4i>(2 &i;i8ul4ar(n *l &ia6nó24i8( &uran4* *l in6r*2(D *2
i)3(r4an4* d/s)&$&r 4u/ /l d*l*r /s u+& m&+i0/s)&$ió+ 0r/$u/+)/ d/ /s)/ )r&s)*r+*3 si/+d* su6/s)im&d* /+ +um/r*s*s 2&$i/+)/s7
Pala$ra& cla()* S$n&r()* &* +uilla$n/0arr1D &(l(rD al(&iniaD a4$3i8(.

A(s)*+c)
+uillain/0arr1 2=n&r()* i2 an a8u4* &*)=*lina4in6 3(l=n*ur(3a4:= 4:a4 3r*2*n42 8lini8all= Ei4: )u28ular E*aFn*22 an& au9
4(n()i8 &i2(r&*r2 in i42 4=3i8al ;(r)D E:il* 4:* 2*n2(r= 2=)34()2 u2uall= 6( unn(4i8*&. G* &*28ri9* 4:* 8lini8al :i24(r= (; a )al*
3a4i*n4 Ei4: a8u4* fla88i& 7ua&ri3ar*2i2 an& 2*n2(r= &i2(r&*r2 2u8: a2 3ar*24:*2ia an& all(&=nia 4:a4 :in&*r &ia6n(2i2 Ei4:in 4:*
ini4ial a33r(a8:. I()3l*4* &ia6n(24i8 E(rF u3 8(nfir)*& 4:* 3r*2*n8* (; +uillain/0arr1 2=n&r()*. Kl4:(u6: 4:* 2*n2(r= 2=)34()2
$*+0us/d ):/ di&;+*sis duri+; &dmissi*+3 i) is im2*r)&+) )* :i;:li;:) ):&) 2&i+ is & 0r/4u/+) m&+i0/s)&)i*+ *0 ):is dis*rd/r3 6/i+;
u+d/r/s)im&)/d i+ m&+( 2&)i/+)s7
+)y-or/&L +uilla$n/0arr1 2$n&r()*D 3ainD all(&=niaD a4=3i8al

o
</57 =$u&)7 >/ur*l7 V*l7 @A3 > @3 @BCD

I&)*o/$cc01& 0/s)&$i*+/s su/l/+ $urs&r d/ 0*rm& &;ud& $*+ u+ +&dir /+

El S$n&r()* &* +uilla$n 0arr1 RS+0S *2 un 4ra29
)*r+* +/ur*ló;i$* /+m&r$&d* /+ /l ;ru2* d/ l&s
+/ur*9 2&)1&s &;ud&s 4u/ s/ su/l/ 2r/s/+)&r $*m* u+&
2*li+/ur*9 3a4$a &*2)i*lini5an4* &* (ri6*n au4(in)un*D *n
r*23u*24a a un 3r(8*2( in;*88i(2(D 7u* 8()3r()*4*
*T4*n2a)*n4* al 2i24*)a n*r>i(2( 3*ri;1ri8(U 2u
in8i&*n8ia 2*6ún &i>*r2(2
*24u&i(2 *2 9a@a Ra3r(Ti)a&a)*n4* WDXY/Z 8a2(2 anual*2
2*r CBB7BBB :&6i)&+)/sF3 si+ /m6&r;* su $*m2*r)&mi/+)*
/2id/mi*ló;i$* /s mu( 5&ri&6l/ d/6id* & 4u/ su/l/ $urs&r
*n 9r(4*2 a2(8ia&(2 a *3i&*)ia2 in;*88i(2a2D l( 8ual &ifi9
$ul)& su /5&lu&$ió+ /2id/mi*ló;i$&7C3@
El S+0 2* )anifi*24a 4$3i8a)*n4* &*2&* *l 3un4( &*
>i24a 8l$ni8( 8(n 4ra24(rn(2 2()<4i8(2 )(4(r*2D 7u* >ar$an
d/sd/ l& d/6ilid&d l/5/ /+ mi/m6r*s i+0/ri*r/s :&s)&
l& 8ua&ri3l*@$a fl<8i&a 8(n 3ar<li2i2 r*23ira4(riaU *24a2
)ani9
@9E s/m&+&s7E K&i8i(nal a *24a 2in4()a4(l(6$a 3u*&*n
(8u9 rrir )r&s)*r+*s dis&u)*+ómi$*s3 r/s2*+s&6l/s d/
u+& &l)& m*r)&lid&d )/m2r&+&3 ( )r&s)*r+*s s/+si)i5*s
0r/$u/+)/9 m/+)/ i+0r&5&l*r&d*s7[
K 8(n4inua8ión 2* &*28ri9* *l 8a2( 8l$ni8( &* un
3a8i*n4* 8(n 8ua&ri3ar*2ia fl<88i&a a6u&aD in6r*2a&( *n *l
2*r>i8i( &* N*&i8ina \n4*rna &*l ](23i4al +*n*ral &*l Sur
^Or. C*&r( \4ur9*D_ 7ui*n a&*)<2 3r*2*n4ó 4ra24(rn(2
2*n9 2i4i>(2 7u* &ifi8ul4ar(n *l &ia6n(24i8( ini8ial)*n4*D
3*r( &uran4* 2u *>(lu8ión in4ra:(23i4alaria 2* 8(nfir)ó
la 3r*9 2*n8ia &* un S+0.
2+so 234&0co
Ca8i*n4* )a28ulin( &* YZ añ(2D na4ural = 3r(8*&*n4*
&* la 8iu&a& &* Nara8ai9(D 2in an4*8*&*n4*2 3a4(ló6i8(2D

2Oqnfq_l_ cd Onrfq_cn cd Ldcibim_ Hmsdqm_ Gnrois_k Fdmdq_k cdk Rtq zCq- Odcqn
Bnqqdronmcdmbi_9
Hstqad–- Tmiudqric_c cdk Ytki_- L_q_b_ian+ Udmdytdk_-
It_m R_k_y_q+ LC
3Bdmsqn cd Hmudrsif_binmdr Dmcnbqimn Lds_aókib_r zCq- Eákiw Fóldy–-
Oqnfq_l_ cd Onrfq_cn cd Ldcibim_ Hmsdqm_ Gnrois_k Fdmdq_k cdk Rtq Cq-
Tmiudqric_c cdk Ytki_- L_q_b_ian+ Udmdytdk_-
Odcqn Hstqad-
4Gnrois_k Fdmdq_k Oqnuimbi_k J_s_btmf_+ Limirsdqin cd R_ktc Oóakib_- Bnsno_wi+
Tmiudqric_c cdk Ytki_- L_q_b_ian+ Udmdytdk_-
Dbt_cnq-
D,l_ik9 It_miru07?gnsl_ik-bnl

Vol$ h&' (o h' h)*+ , Re/0123 45632o70383 9e (e67olo:;3 *)<

4ui/+ $*+sul)& 2*r 2r/s/+)&r $u&dr* $l1+i$* d/ A d1&s d/ B[/BY = BY/Sb *n r*la9
*>(lu8ión 8ara84*ri5a&( 3(r &i2)inu8ión &* la ;u*r5a $ió+ & $&m6i*s d/ dis$*2&)1& d/;/+/r&)i5& $*+ 2r*mi+/+$i&
)u29 8ular *n la2 [ *T4r*)i&a&*2D &* ;(r)a 3r(6r*2i>a =
&* 3r*9 &()ini( *n )i*)9r(2 2u3*ri(r*2 a8()3aña&( &*
3ar*24*9 si&s ( d*l*r d/ m*d/r&d& i+)/+sid&d3 )i2* l&+
$i+&+)/3 d/ 2r/d*mi+i* /+ :*m6r*s ( musl*s 4u/ $/d1&
2&r$i&lm/+)/ 8(n anal612i8(2 4i3( K\`ESD )(4i>(2 3(r
l(2 8ual*2 *2 i+;r/s&d* /+ +u/s)r& i+s)i)u$ió+7
Kl in4*rr(6a4(ri( n( r*;*r$a nin6ún
an4*8*&*n4* d/ im2*r)&+$i&3 +i $u&dr*s $l1+i$*s
;ri2&l/s * /+)/r&l/s r/$i/+)/s3 +i 2ródr*m*s3 +i
)r&um&)ism*s7 8u *$u2&$ió+
*ra 8(n&u84(r &* >*:$8ul(2 3*2a&(2 = *n 2u *Ta)*n ;un9
8i(nal 2(l( r*3(r4a9a 31r&i&a &* 3*2( &*
a3r(Ti)a&a)*n4* a F6 *n b )*2D n( a2(8ia&( a r16i)*n
&i*414i8(.
Kl *Ta)*n 8l$ni8(D la 3r*2ión ar4*rial ;u* baWcdW
))]6D ;r*8u*n8ia 8ar&$a8aL eW la4i&(2 3(r )inu4(D
;r*9 8u*n8ia r*23ira4(riaL bd r*23ira8i(n*2 3(r )inu4(D
2a4ura9 8ión fZL eXgD 4*)3*ra4uraL aXhIU 2u2 8(n&i8i(n*2
8l$ni8a2
*ran r*6ular*2D 8ar&i(3ul)(nar 2in :alla56(2
r*l*>an4*2D
*n a9&()*n 2* *n8(n4ra9a 3lan(D P]K RiSD 9lan&(D
&*3r*9 si6l/3 l/5/m/+)/ d*l*r*s* & l& 2&l2&$ió+ d/
:i2*;&s)ri*3 si+ si;+*s d/ irri)&$ió+3 si+ 5is$/r*m/;&li&s7
>/ur*ló;i$&9
)*n4*L I(n28i*n4*D (ri*n4a&( *n 4i*)3(D *23a8i( 3*r2(naD
l*n6ua@* 8(:*r*n4*D @ui8i( = 3*n2a)i*n4( 3r*2*r>a&(D n(
a;a2iaD n( a3raTiaD n( a6n(2iaD CIL \n&*)n*2D jNL
0ra9 7uial \\\ck l IruralL \\\ck R&* 3r*&()ini( *n
)u28ula4ura 3r(Ti)alSD P*fl*@(2 (24*(4*n&in(2(2L
:i3(rr*fl*Tia *n [
)i*)9r(2D 2*n2i9ili&a&L al(&inia *n [ )i*)9r(2D
&i2)*9 4r$aD &ia&(8(8in*8iaD 4aTia n( >al(ra9l*D 2in 2i6n(2
)*n$n9 6*(2D ni r*fl*@(2 3a4(ló6i8(2D +la26(E bYcbY.
En l(2 *T<)*n*2 3ara8l$ni8(2 r*ali5a&(2 &uran4* 2u
in6r*2( 2* r*3(r4anD 8u*n4a 9lan8aL d[WW 81lula2c))a
Rn*u4rófil(2L X[DmgD lin;(8i4(2L beDmgSD :*)
(6l(9inaL bZDb 6rc&lD :*)a4(8ri4(L [WDagD 3la7u*4a2L
aZ[WWW 81lula2c
))aD 6li8*)iaL bbY )6c&lD ur*aL Zd )6c&lD 8r*a4ininaL WDd
)6c&lD 2(&i(L bam )6c&lD 3(4a2i(L [DZ )6c&lD 8l(r(L eeDa
)6c&lD 8al8i( 4(4alL dDe )6c&lD )a6n*2i(L ZDZ )6c&l. En *l
*24u&i( *l*84r(8ar&i(6r<fi8( = 4()(6ra;$a 8*r*9ral n(
3r*9 2*n4a9a :alla56(2 3a4(ló6i8(2. En >i24a &* l(2
:alla56(2 8l$ni8(2 2* &*8i&* in6r*2ar 8(n l(2 &ia6nó24i8(2
2in&r()<9 4i8(2L S$n&r()* &* 8()3r*2ión ra&i8ular
*T4ra)*&ular >2. Ni(3a4$a \nfla)a4(riaU 8(n 3lan &*
r*ali5a8ión &* nu*>(2
/s)udi*s 2&r&$l1+i$*s 2&r& 2r/$is&r /l *ri;/+ d/ l*s
s1+9 4()a2 = 2* in&i8an anal612i8(2 4i3( K\`ES )<2
n*ur()(9 &ula&(r*2 4i3( 3r*6a9alina XY )6 fO.
Ouran4* 2u *24an8ia in4ra:(23i4alariaD 2* r*ali5a
r*2(9 nan8ia )a6n14i8a &* 8(lu)na lu)9(/2a8ra 7u*
r*3(r4aL
$u/r2*s 5/r)/6r&l/s $*+ 2r/s/r5&$ió+ d/ &l)ur& /
i+)/+sid&d &* 2*ñalD (92*r><n&(2* 8a)9i(2 N(&i8 4i3( \\
*n 3la4ill( in;*ri(r &* BaD 2u3*ri(r &* B[D in;*ri(r &* BYD
= 2u3*ri(r &* Sb. K2i)i2)( i)3r*2i(na :*)an6i()a
8u*r3( >*r4*9ral nbZ. Oi2)inu8ión *n la in4*n2i&a& &*
2*ñal &* l(2 &i28(2 in4*r>*r4*9ral*2 lu)9ar*2 Ba/B[D
 3(24*ri(r &* l(2 <nul(2 fi9r(2(2 *n l(2 Z 3ri)*r(2 =
3r(4ru9 2ión 3(24*r(8*n4ral a ni>*l BY/SbD 8(n &i<)*4r(2
&*l 8anal
*23inal &* a)3li4u& 3r*2*r>a&a al i6ual 7u* l(2 ;
(r<)*n*2 &* *)*r6*n8ia &* ra$5 n*r>i(2a = 8(n(
)*&ular n(r)al.
C*2* a l(2 :alla56(2 i)a6*n(ló6i8(2 2* r*ali5a
*l*89 4r()i(6ra;$a &* l(2 )i*)9r(2 7u* r*3(r4aL
3r(l(n6a&a2 l&)/+$i&s )/rmi+&l/s m*)*r&s3
5/l*$id&d/s )r*+$ul&r/s m*)*r&s m&r$&d&m/+)/ l/+)&s
( 5/l*$id&d/s s/+si)i5&s l*n4a2. Ba 9a@a a)3li4u& &*
r*23u*24a2 *>(8a&a2 in&i8a9aL
`*ur(3a4$a 3*ri;1ri8a )iT4a 8(n 3r*&()ini(
&*2)i*li9 ni5an4*. En >i24a &* l(2 :alla56(2
n*ur(fi2i(ló6i8(2 = *l 8ur2( in4ra:(23i4alari( &* bY &$a2
&* *>(lu8iónD 2* 3r*3ara 3ara la r*ali5a8ión &* 3un8ión
lu)9ar = 3la2)a;1r*2i2.
G*s r/sul)&d*s d/ $i)*4u1mi$& d/ l14uid*
$/0&l*rr&9 7u$&*( )(24rar(n &*2&* *l 3un4( &* >i24a
)a8r(28ó3i8(L K23*84(L Ilar( / I(l(rL \n8(l(r( /
I(<6ul(L `( 3r*2*n4*
- 3]L XDY / O*n2i&a&L bWbY = )i8r(28ó3i8(L ]*)a4$*2L `(
2* (92*r>ar(n / B*u8(8i4(2L `( 2* (92*r>ar(n / +lu8(2aL
mX / BO]L ba / Cr(4*$na2L eaU 8()3a4i9l*2 8(n
&i2(8ia9 8ión al9ú)in(/8i4(ló6i8a. nra2 *24(2 :alla56(2
2* )(&i9 fi8an l(2 &ia6nó24i8(2 a 3(lirra&i8ul(3a4$a
&*2)i*lini9 5an4* a6u&aL 2$n&r()* &* +uillain/0arr1
= &i28(3a4$a d/;/+/r&)i5& d/ GE & 8C7
El 3a8i*n4* ;u* 2()*4i&( a [ 2*2i(n*2 &*
3la2)a;19 r/sis i+)/rdi&ri&s3 d/ &$u/rd* & dis2*+i6ilid&d
i+s)i)u$i*+&l3 si+ $*m2li$&$i*+/s dur&+)/ l&s mism&s7
*)= Re/0123 45632o70383 9e (e67olo:;3 , Vol$ h&' (o h' h)*+
Hr&s @C d1&s d/
*>(lu8ión in4ra:(23i4alariaD la ;u*r5a )u28ular ;u* )*@(9
r&+d* 2r*;r/si5&m/+)/3 /+ mi/m6r*s su2/ri*r/s ( lu/;*
mi/m6r*s i+0/ri*r/s3 :&s)& i+i$i&r d/&m6ul&$ió+ +* &sis9
4i&aD )i*n4ra2 7u* la al(&inia )*@(ró 3ar8ial)*n4* =
2*
)an*@ó 8(n 3r*6a9alina aWW )6 fO.
50sc$s01&
El S+0 2* )anifi*24a 4$3i8a)*n4* 8()( una 3(lin*u9
r(3a4$a &*2)i*lini5an4* infla)a4(ria a6u&a 8(n a;*84a8ión
3r*&()inan4*)*n4* )(4(raU 2in *)9ar6(D la *T3r*2ión
8l$9
+i$& d/ /s)/ s1+dr*m/ )i/+/ u+ &m2li* /s2/$)r* d/ m&+i9
;*24a8i(n*2 7u* :a 3*r)i4i&( in8lu2( i&*n4ifi8ar >arian4*2
8l$ni8a2 *23*8$fi8a2 8()( la aT(nal )(4(ra a6u&aD aT(nal
2*n2i4i>(/)(4(ra a6u&aD 2$n&r()* &* Nill*r ji2:*r = 8ua9
&r(2 &*li)i4a&(2 a l(2 n*r>i(2 8ran*al*2 8()( la &i3l*@$a
0&$i&l3 )*d* &s*$i&d* 2*si6l/m/+)/ &l )i2* d/ +/r5i* &0/$9
4a&( = a la *T4*n2ión &* *24* 8()3r()i2( *n *l 2i24*)a
n*r9
>i(2( 3*ri;1ri8(.aDY
=+ /s)/ s/+)id*3 l*s s1+)*m&s s/+si)i5*s dur&+)/ /l
$urs* $l1+i$* d/ /s)/ s1+dr*m/ su/l/+ s/r su6/s)im&d*s3 (
+*rm&lm/+)/ /l $l1+i$* /+0*$& su &2r/$i&$ió+ di&;+ós)i$&
( 2r/*$u2&$ió+ 2r*+ós)i$& /+ 6&s/ & l&s m&+i0/s)&$i*+/s
m*)*r&s 4u/ 2u/d/+ $*m2r*m/)/r l& 5id& d/l 2&$i/+)/7 >*
(924an4*D la2 3ri)*ra2 &*28ri38i(n*2 3(r +uilla$n )*n8i(9
+&6&+ l& 2r/s/+$i& d/ d*l*r3m 3(24*ri(r)*n4* *n la &18a&a
d/ l*s DB <*22/r ( 8:&:&+i d/mu/s)r&+ /+ u+& s/ri/ d/
$&s*s l& im2*r)&+$i& d/l d*l*r ( su 2&)ró+ d/ &2&ri$ió+ /+
/s)/ ;ru2* d/ 2&$i/+)/s7A O*2&* *n4(n8*2 nu)*r(2a2 in>*29

=tsnq□%qde( LdsncnjnféZ
EirinoZsnjnféZ LZqsémdy□ds□Zk□’02( Drstcin□oqnrodbsiun□dm□2/□oZbidmsdr□bnm□RFA□Zclisicnr□Z□tmZ□
TmicZc□cd□BticZcnr□Hmsdmriunr□bnloZqZcnr□bnm□04□rtidsnr□bnmsqnk-□
ITaIT 1. Dmr_xnr bkémibnr qdk_binm_cnr _ cnknq dm rémcqnld cd Ftikk_im,A_qqd cdrcd dk otmsn cd uirs_ firino_snkófibn+ bkémibn x
Rdftilidmsn□gZrsZ□07□ldrdr-
DuZktZbióm□rdmrnqiZk□btZmsisZsiuZ
Qtsr□ds□Zk□’04( Drstcin□oqnrodbsiun□dm□21□oZbidmsdr□bnm□RFA□n□rtr□uZqiZmsdr□cdk□
drstcin□FQAOG□Rdftilidmsn□gZrsZ□5□ldrdr-
CdmricZc□cd□eiaqZr□mdquinrZr□imsqZdoicáqlibZr
BZqZbsdqérsibZr Qtsr□ds□Zk□’00( Drstcin□oqnrodbsiun□dm□045□oZbidmsdr□bnm□RFA□n□rtr□uZqiZmsdr□cdk□
□ bjémibZr drstcin□FQAOG□Rdftilidmsn□gZrsZ□01□ldrdr-
Rd□duZktó□knbZkiyZbióm+□sion□d□imsdmricZc□cdk□cnknq□tsikiyZmcn□
ciedqdmsdr□btdrsinmZqinr
Jimanrgi□ds□Zk□’08( Drstcin□qdsqnrodbsiun□dm□23□oZbidmsdr□bnm□RFA□Zclisicnr□dm□dk□
gnroisZk□fdmdqZk□HiimjZi□SZjdcZ□’Jxnsn+□IZoóm(□ctqZmsd□01□Zñnr-
Rd□duZktó□kZr□bZqZbsdqérsibZr□cdk□cnknq□ctqZmsd□kZ□eZrd□ZftcZ-
LZmdin□ OZmcdx□ds□Zk□’07( Drstcin□ZkdZsnqiyZcn□cnakd□bidfn+□bnmsqnkZcn□eqdmsd□Z□okZbdan□dm□25□
SdqZoátsibn oZbidmsdr□dm□tmZ□TBH□cd□HmciZ:□ciuicicnr□ZkdZsnqiZldmsd□dm□2□
□ rtafqtonr9□fZaZodmsimZ□2//□lf+□bZqaZlZydoimZ□0//□lf□n□
okZ,bdan+□ZclimirsqZcnr□2□udbdr□Zk□céZ□ctqZmsd□6□céZr-
KZ□imsdmricZc□cdk□cnknq□etd□ldcicZ□bnm□kZ□drbZkZ□Zm±knfZ□uirtZk-
Qtsr□ds□Zk□’0/( Drstcin□ZkdZsnqiyZcn+□cnakd□bidfn+□bnmsqnkZcn+□bnloZqZcn□bnm□
okZbdan□dm□112□oZbidmsdr□gnkZmcdrdr□’44"□cd□knr□btZkdr□
qdedqéZ□cnknq(-□Rd□bnloZqn□dk□trn□cd□HmltmnfknatkimZ□*□
LdsikoqdcmirnknmZ□’4//lf□onq□4□céZr(□ur□HmltmnfknatkimZ□*□
OkZbdan-
KZ□deibZbiZ□cdk□ldcibZldmsn□etd□duZktZcZ□onq□dk□onqbdmsZid□cd□
sdq_oátsibn-
oZbidmsdr□ptd□oqdrdmsZqnm□cnknq□Z□kn□kZqfn□cdk□drstcin-□Rim□tsikiyZq□
drbZkZ□oZqZ□rt□ldcibióm-
Vol$ h&' (o h' h)*+ , Re/0123 45632o70383 9e (e67olo:;3 *)>
QdrtjsZcnr.Bnmbjtrióm
Dwirsd□tmZ□ZksdqZbióm□dm□kZr□eiaqZr□mnbibdosiuZr□cd□cnknq□mdtqnoZsibn□dm□
drsZcinr□sZmsn□Zftcnr□bnln□bqómibnr□cdk□RFA-
Dwirsd□ZedbsZbióm□cd□mdquinr□cáqlibnr□lidkimiyZcnr□x□mn□lidkimiyZcnr□bnm□
cdfdmdqZbióm□ZwnmZk□d□imeiksqZcn□lnmnmtbkdZq-□Acdl±r□cd□tmZ□
cirlimtbióm□sdloqZmZ□cd□kZ□cdmricZc□cd□eiaqZr□mdquinrZr□imsqZdoicáqli,
bZr□ptd□rd□lZmsidmd□dm□dk□sidlon+□ptd□rd□qdkZbinmZ□bnm□kZ□imsdmricZc□cdk□
cnknq□dm□kZ□eZrd□ZftcZ□x□oncqéZ□oqdcdbiq□cirbZoZbicZc□cd□kZqfn□okZyn-
Dk□cnknq□rd□qdonqsó□1□rdlZmZr□Zmsdr□cd□kZ□cdaikicZc□ltrbtkZq□dm□25"□cd□
oZbidmsdr+□dm□55"□ctqZmsd□kZ□eZrd□ZftcZ□x□27"□sqZr□tm□Zñn□cdk□btZcqn□
bkémibn-□KZ□imsdmricZc□etd□cd□lncdqZcZ□Z□rdudqZ□x□ZoZqdbió□dm□sncn□dk□
drodbsqn□bkémibn□cdk□RFA-□
Dk□cnknq□rd□qdonqsó□18"□cd□knr□rtidsnr□ctqZmsd□kZ□eZrd□ZftcZ+□ridmcn□dk□
cnknq□ktlaZq□kZ□oqdrdmsZbióm□lZr□eqdbtdmsd+□Zré□bnln□kZ□ZoZqibióm□dm□
oZbidmsdr□ióudmdr-□□Rt□oqdrdmbiZ□qdsqZrZ□dk□sidlon□oZqZ□kkdfZq□Zk□
ciZfmnrsibn□bnqqdbsn□x□oqnknmfZ□kZ□drsZmbiZ□x□qdbtodqZbióm□imsqZgnroisZ,
kZqiZ-□Rim□dlaZqfn+□mn□imektxd□dm□dk□oqnmnrsibn□etmbinmZk-
Dwirsd□tmZ□lZxnq□cirlimtbióm□dm□kZ□drbZkZ□cd□cnknq□dm□dk□rtafqton□ptd□
qdbiaió□fZaZodmsimZ□’2+4,1+4,1+/,1+/,1+/,1+/,1+/(□bnloZqZcn□bnm□dk□ptd□
qdbiaió□bZqaZlZydoimZ□’5+/,5+/,4+/,3+/,3+/,2+4,2+/(□x□okZbdan□
’5+/,5+/,5+/,5+/,5+/,5+/,5+/(□’o;/+/4(-□Aré□bnln□tm□ldmnq□trn□cd□
edmsZmikn□bnln□ZmZkfáribn□rtokdldmsZqin-
BtZmcn□rd□imibió□kZ□ZkdZsnqiyZbióm□rd□qdonqsZqnm□knr□riftidmsdr□sionr□cd□
cnknq9□cnknq□cd□droZkcZ□’22"(+□cnknq□imsdqdrbZotkZq□’17"(+□ltrbtkZq.,
bZkZlaqdr□’13"(+□oZqdrsdriZr.cirdrsdriZr□’07"(+
cnknq□qZcibtkZq□’07"(+□nsqnr□’04"(+□cnknq□dm□kZr□ZqsibtkZbinmdr□’4"(□x□
cnknq□uirbdqZk□’4"(-
Dk□drstcin□mn□lnrsqó□tm□dedbsn□rifmieibZsiun□dm□kZ□qdctbbióm□cdk□onqbdmsZid□
cd□oZbidmsdr□bnm□cnknq□dm□dk□fqton□ptd□qdbiaió□ldsikoqdcmirnknmZ+□mi□dm□kZ□
oqdrdmbiZ□mi□dm□kZ□imsdmricZc-
4i6a8i(n*2 :an 8ara84*ri5a&( *l 8()3(r4a)i*n4( &*l &(l(r
( &1fi8i4 2*n2(rial *n *l 3a8i*n4* 8(n S+0U (92*r><n&(2*
/+ dis)i+)*s ;ru2*s /)&ri*s3 0*rm&s d/ 2r/s/+)&$ió+
$l1+i$&3 i)3li8a8i(n*2 *n la 8ali&a& &* >i&a = )an*@(
4*ra31u4i8(.D9CB En un an<li2i2 3r*>i( &*l Ou48: +0S
S4u&= +r(u3
2* *>aluar(n 3r(23*84i>a)*n4* bYm 3a8i*n4*2 8(n
S+0D in8lu=*n&( 2u@*4(2 8(n >arian4*2 8l$ni8a2D a
7ui*n*2 2* l*2 &*4*r)inó la l(8ali5a8iónD in4*n2i&a& =
4i3( &* &(l(r &uran4* un 2*6ui)i*n4( &* b añ(.
E>i&*n8i<n&(2* 7u*
/s)/ /s u+ s1+)*m& $*mú+ /+ l&s di5/rs&s 0*rm&s $l1+i$&s
= 7u* a&*)<2 &* 2u al4a ;r*8u*n8iaD 3u*&* a3ar*8*r 8()(
m&+i0/s)&$ió+ i+i$i&l Ji+$lus* &+)/s d/ l& d/6ilid&d mus9
8ularS = 2u &ura8ión 3u*&* 2*r &* al )*n(2 b añ( r*7ui9
ri/+d* /s2/$i&l &)/+$ió+7CC
=l $&s* $l1+i$* d/s$ri)* d/mu/s)r& l& i+)/r2r/)&9
8ión *rrón*a ini8ial 7u* 3u*&* r*ali5ar2* &* la 3r*2*n8ia
&* &(l(r *n un 3a8i*n4* 7u* 8ur2a 8(n 3ar<li2i2 fl<88i&a
&;ud&3 d&d*s l*s +um/r*s*s di&;+ós)i$*s di0/r/+$i&l/s
7u* 3u*&*n 3lan4*ar2*D *n *24* 8a2( 3a4(l(6$a *T8lu2i>a
&*l )ú28ul( *27u*l14i8( ( &* la )1&ula *23inal.C@ I(n2i9
&*ra8i(n*2 7u* &*9* 4()ar *n 8u*n4a *l )1&i8( &* a4*n9
8ión 3ri)aria ( *l *23*8iali24a 7u* a9(r&* al 2u@*4( a;*89
)&d* d/ m&+/r& )/m2r&+&7
ji2i(3a4(ló6i8a)*n4* *l 3r(8*2( infla)a4(ri( *n
*l S+0 a;*84a 3rin8i3al)*n4* la2 fi9ra2 )i*lini5a&a2
&*
l*s +/r5i*s m*)*r/s ( l&s /0/r/+$i&s &u)*+ómi$&s3 si+
/m6&r;*K r/2*r)/s 2r/5i*s :&+ d/m*s)r&d* u+ $*m2r*9
)i2( &* la2 fi9ra2 3*7u*ña2 a;*r*n4*2 = una &*n2i&a& &*
fi9ra2 n*r>i(2a2 in4ra*3i&1r)i8a2 r*&u8i&aDCE
r/s2*+s&6l/s
+* s*l* d/ l& i+)/+sid&d d/ l*s s1+)*m&s s/+si)i5*s dur&+)/
la ;a2* a6u&a 2in( 4a)9i1n &* la a3ari8ión = 3*r2i24*n8ia
&* un 2$n&r()* &* &(l(r n*ur(3<4i8( a lar6( 3la5(.b[ C(r
2u 2&r)/3 <u)s /) &l7bY :&+ d/m*s)r&d* /+ u+ /s)udi*
2r*s2/$9 4i>( *n aZ 3a8i*n4*2 8(n S+0D 7u* 4an4( l(2
n*r>i(2 8u4<9 n*(2 )i*lini5a&(2 8()( n( )i*lini5a&(2 2*
*n8(n4ra9an &i;u2a)*n4* a;*84a&(2 *n 3a8i*n4*2 8(n S+0
8l<2i8( = 2u2
>arian4*2D a&*)<2 la &*n2i&a& &* fi9ra2 n*r>i(2a2
in4ra*9 3i&1r)i8a2 3r*2*n4a9a una &i2)inu8ión 3r(6r*2i>a
8(rr*9 la8i(n<n&(2* &* i6ual )an*ra 8(n la 2*>*ri&a& &*l
&(l(r a6u&( = la 3r*&i88ión &* &i28a3a8i&a& a lar6( 3la5(.
>* *6s)&+)/3 :&s)& &:*r& +* s/ $*+*$/+ l*s m/$&9
+ism*s m*l/$ul&r/s su6(&$/+)/s d/ l& &0/$)&$ió+ d/ /s)/
6ru3( &* fi9ra2 n*r>i(2a2 n(8i8*34i>a2 = la2 4*(r$a2 3lan9
)/&d&s i+5*lu$r&+ l& li6/r&$ió+ d/ $i)*$i+&s (
6i*m&r$&9 &(r*2 &* &añ( aT(nal.bm =+ $u&+)* &l
)r&)&mi/+)* 0&rm&9 8(ló6i8(D 2(n 3(8(2 l(2 *n2a=(2
8l$ni8(2 al*a4(ri5a&(2 r*ali5a&(2 3ara la *>alua8ión &*l
u2( &* anal612i8(2 *n *l 3a8i*n4* 8(n S+0 7u*
*T3*ri)*n4a &(l(rD 2i*n&( un a9(r9 &a@* 8()3l*@( &a&a la
>aria9ili&a& &* *24* 2$n4()a = la2 8ara84*r$24i8a2
n(8i8*34i>a2 ( n*ur(3<4i8a2 8(n la2 8ual*2 2u/d/
2r/s/+)&r7CA
=+ /s)/ s/+)id*3 2/s/ & $i/r)&s $*+sid/r&$i*+/s m/)*9
&(ló6i8a2 l(2 :alla56(2 )<2 ;a>(ra9l*2 *n *l )an*@( &*l
&(l(r 2* :an (94*ni&( 8(n ;<r)a8(2 8()( 6a9a3*n4ina =
8ar9a)a5*3ina *23*8ial)*n4* 8(n *l 3ri)*r(D *l 8ual :a
d/m*s)r&d* u+& m&(*r /0/$)i5id&d /+ l& dismi+u$ió+ d/l
&(l(r = &*l u2( &* (4r(2 ;<r)a8(2 a&=u>an4*2 8()(
;*n9
)&+il*7CD C(r 2u 3ar4*D la u4ili5a8ión &* )*4il3r*&ni2(l(na
+* :& m*s)r&d* /0/$)*s 2*si)i5*s /+ l& r/du$$ió+ d/ d*l*r
* s1+)*m&s s/+si)i5*s7CB O* 8ual7ui*r )an*raD la *>i&*n8ia
/s 2*$* $*+sis)/+)/ ( s/ r/4ui/r/+ +u/5*s /s)udi*s
$*+ m&(*r $&+)id&d d/ 2&$i/+)/s3 2/ri*d*s d/
s/;uimi/+)*
)<2 3r(l(n6a&(2D = *n2a=( &* 6ru3(2 ;ar)a8(ló6i8(2
8a9*5a a 8a9*5a 7u* 3*r)i4an i&*n4ifi8ar la2 (38i(n*2
4*ra9 31u4i8a2 )<2 a&*8ua&a2 2*6ún la2 8ara84*r$24i8a2 &*l
&(l(r
*T:i9i&a2. Ba na9la b r*2u)* l(2 *24u&i(2 8l$ni8(2 8(n
:alla56(2 fi2i(3a4(ló6i8(2D 8l$ni8(2 = 4*ra31u4i8(2 r*la8i(9
na&(2 al &(l(r *n S+0.
=+ $*+$lusió+3 l& 2r/s/+$i& d/ s1+)*m&s s/+si)i5*s
*23*8$fi8a)*n4* &(l(r *n l(2 3a8i*n4*2 8(n S+0 *2 ;r*9
$u/+)/3 si/+d* su6di&;+*s)i$&d* * i+0r&5&l*r&d*
d/6id* & d/s$*+*$imi/+)* /+ sus $&r&$)/r1s)i$&s *
$r*+*l*;1&3 & la i)3(2i9ili&a& 3ara 2*r *T3r*2a&( *n
a7u*ll(2 3a8i*n4*2 2()*4i&(2 a >*n4ila8ión )*8<ni8a ( al
&ia6nó24i8( *rrón*( d/ *)r&s /+)id&d/s $l1+i$&s d/+)r*
d/l &m2li* ;ru2* d/ 2&)*l*;1&s di0/r/+$i&l/s &+)/ u+
$u&dr* $l1+i$* d/ d/6i9 lid&d mus$ul&r &;ud& /+ /l
&dul)*3 )&l $*m* *$urrió /+
/l $&s* $l1+i$* d/s$ri)* ( /+ r/2*r)/s 2r/5i*s7CL C(r
*n&*D r*2ul4a n*8*2ari( in24ruir al )1&i8( &* a4*n8ión
3ri)aria
*n la i&*n4ifi8a8ión 4*)3rana &* *24a 2in4()a4(l(6$a 3ara
9rin&ar un a&*8ua&( )an*@( 4*ra31u4i8(.
Re6e*e&c0+s
C7 C1r*5 MI. S$n&r()* &* +üillain 0arr1 RS+0S
K84ua9 li5a8ión. K84a `*ur(l I(l()9
ZWWmUZZLZWb/ZWd.
@7 Ia(/B(r)*au kND 0laF* KD N(n2 SD Ba24*r* SD
P(8:* ID kan:()E*6*n MD *4 al. +uillain/0arr1
S=n&r()* (u49r*aF a22(8ia4*& Ei4: piFa
>iru2 in;*84i(n in jr*n8: C(l=n*2iaL a 8a2*/8(n4r(l
24u&=. Ban8*4. ZWbmUadXRbWWZXSLbYab/bYae.
E7 B*24a=(/fqjarrill pD ]*rnan&*5/I<8*r*2 MB. Kn<9
li2i2 &*l 8()3(r4a)i*n4( &*l 2=n&r()* &* +uillain/
0arr1. I(n2*n2(2 = &i28r*3an8ia2. PEk `ErPfB
ZWWdU [mL ZaW/X.
[. S*)3r(ni ND +i92(n +D su=3*r BD na) C. rnu2ual
2*n2(r= >arian4 (; +uillain/0arr1 2$n&r()*.
0NM Ia2* P*3(r42 ZWbXU 3iiL 98r/ZWbm/ZbdeaY.
Y. Oi&i&5* N`. Ilini8al >arian42 (; +uillain/0arr*
2=n&r()*L 2()* a23*842 (; &i;;*r*n4ial
&ia6n(2i2.
+*(r6ian N*& `*E2. ZWWeURbmmSL[d/Yb.
m. +uillain +D 0arr1 MKD S4r(:l K.
tPa&i8ul(n*uri4i2 s(+dr*m/ Mi): :
(2/r&l6umi+*sis *0 $/r/6r*s2i+&l flui& Ei4:(u4
8*llular r*a84i(n. `(4*2 (n 8lini8al
;*a4ur*2 an& 6ra3:2 (; 4*n&(n r*fl*T*2. bebmu.
Knn. N*&. \n4*rn* RCari2S beeeUbYWLZ[/aZ.
A7 P(33*r K]D S:a:ani 0n. Cain in
+uillainl0arr1 2=n&r()*. Kr8:. `*ur(l. bed[U[bL
Ybb/Yb[.
*)6 Re/0123 45632o70383 9e (e67olo:;3 , Vol$ h&' (o h' h)*+
D7 s(rin4:*n9*r6 PD S8:*22l MD sir28:n*r M. bY. Pu42 BD >an O((rn CKD B()9ar&i PD *4 al.
Ilini8al 3r*2*n4a4i(n an& 8(ur2* (; 8:il&:((& rn)=*9 lina4*& an& )=*lina4*& 2Fin n*r>*
+uillainl 0arr1 2=n&r()*L a 3r(23*84i>* &a)a6* in +ui9 llainl0arr1 2=n&r()*L
)ul4i8*n4r* 24u&=. I(rr*la4i(n Ei4: 3ain an& r*8(>*r=. Cain
`*ur(3*&ia4ri82 ZWWXU adL bW/bX. ZWbZUbYaLaeel[We.
L7 Pu42 BD Pi8( PD >an s(nin62>*l& P *4 al. Cain bm. 0in&*r KD 0ar(n P. Si5* )a44*r2 / 2)all fi9*r n*u9
a88()3ani*2 3ur* )(4(r +uillainl0arr1 2=n&r()*. r(3a4:= in 4:* +uillain/0arr1 2=n&r()*. Cain.
M. C*ri3:*r. `*r>. S=24. ZWWdU baL aWYlaWm. ZWbWUbYbRbSLe/bW.
CB7 Pu42 BD >an s(nin62>*l& PD Ma8(92 0ID >an O((rn CA7 C*ña BD N(r*n( I0D +u4i1rr*5/Ál>ar*5 KN.
CK. O*4*r)ina4i(n (; 3ain an& r*23(n2* 4( )*4:=l9 Nan*@( &*l &(l(r *n *l 2$n&r()* &* +uillain/0arr1.
3r*&ni2(l(n* in +uillainl0arr1 2=n&r()*. M. P*>i2ión 2i24*)<4i8a. `*ur(l(6$a.
`*ur(l. ZWWXU ZY[L babd/baZZ. ZWbYUaWRXSL[aa/[ad.
CC7 Pu42 BD Or*n4:*n MD M(n6*n MBD *4 al. Cain in CD7 Can&*= IsD Pa5a ND nri3a4:i ND `a>Far OkD
+ui9 llain/0arr* 2=n&r()*L a l(n6/4*r) ;(ll(E/u3 su)ar KD Sin6: rsD *4 al. n:* 8()3ara4i>*
24u&=. *>alua4i(n (; 6a9a3*n4in an& 8ar9a)a5*3in* ;(r
`*ur(l(6=. ZWbWUXYRbmSLb[ae/[X. 3ain )ana6*9
C@7 va&a> KsD 0:a44arai CD Kr=al 0D *4 al. K8u4* fla88i& )*n4 in +uillain/0arr* 2=n&r()* 3a4i*n42 in 4:*
3aral=2i2L Kn a33r(a8: 4( &ia6n(2i2. ]*al4: P*nai29 in4*n2i>* 8ar* uni4. Kn*24: Knal6.ZWWYUbWbLZZW/Y.
2an8* ZWbYUbaRZSL bm[/bme. CL7 sin9(2:i ND \n(u* ND s(@i)a vD *4 al. Cain in 4:*
CE7 Nar4in*5 kD jl*48:*r OD Nar4in jD frliF(E2Fi a8u4* 3:a2* (; +uillainl0arr1 2=n&r()*. `*ur(9
OD S:ar2:ar nD I:au>in ND 0(u:a22ira OD K44al l(6= an& Ilini8al `*ur(28i*n8*U ZWb[UZRZSL YWlYa.
`. S)all fi9r* i)3air)*n4 3r*&i842 n*ur(3a4:i8 3ain
in
+uillainl0arr1 2=n&r()*. Cain ZWbWUbYbLYalmW.
b[. Can IBD n2*n6 nMD Bin v]D I:ian6 NID Bin GND
]2i*: Sn. Iu4an*(u2 inn*r>a4i(n in +uillainl0arr1
2=n&r()*L 3a4:(l(6= an& 8lini8al 8(rr*la4i(n2.
0rain ZWWaUbZmLadmleX.

Vol$ h&' (o h' h)*+ , Re/0123 45632o70383 9e (e67olo:;3 *)&