PARACETAB

300 mg / tablet
ANTIPYRETIC/ANALGESIC
Dosage Information
Adults: 1 tablet every 4 to 6 hours. Max dose: 4 grams.
Children: 10 to 15 mg/kg every 4 to 6 hours.

Indication/s
It is used to treat headache, muscle aches, arthritis, backache, toothaches, colds, and fevers

Administration
May be taken with or without food.

Contraindications
Hypersensitivity. Severe hepatic impairment or active liver disease (IV)

Special Precautions
Patient with known G6PD deficiency, alcohol dependence, chronic malnutrition or dehydration,
weight <50 kg; severe hypovolaemia (IV). Renal and hepatic impairment. Children. Pregnancy and
lactation.

Adverse Reactions
Significant: Thrombocytopenia, leucopenia, neutropenia, pancytopenia, methaemoglobinaemia,
agranulocytosis, angioedema, rarely, hypotension and tachycardia.
Gastrointestinal disorders: Nausea, vomiting, constipation.
Skin and subcutaneous tissue disorders: Erythema, flushing, pruritus.
Potentially Fatal: Hepatotoxicity, acute renal tubular necrosis. Rarely, hypersensitivity reactions such
as acute generalised exanthematous pustulosis (AGEP), Stevens-Johnson syndrome (SJS), toxic
epidermal necrolysis (TEN).

Drug Interactions
Decreased absorption with colestyramine. Decreased serum concentrations with rifampicin and some
anticonvulsants (e.g. phenytoin, phenobarbital, carbamazepine, primidone). Enhances the
anticoagulant effect of warfarin and other coumarins with prolonged use. Increased absorption with
metoclopramide and domperidone. Increased serum concentration with probenecid. May increase
serum concentration of chloramphenicol.

Pregnancy Category (US FDA)

PO/Rectal: B

Storage and condition

Store at room temperature 15 to 30 degrees Celsius. Keep out of reach of children.
MANUFACTURED BY:
Thisavros Pharmaceuticals Inc.
Brgy.Bitas, Cabanatuan City, Philippines