There is a need to optimize natural product leads because it is

important to make sure that the identified or isolated

metabolite would be deemed safe and efficient to illicit the
pharmacological effect. Furthermore, along with the process
such as semisynthesis we can be certain that we can enhance
the pharmaceutical performance of the natural product,
reproduce the natural metabolites through total synthesis and
applying biosynthetic modifications which can improve the
solubility and chemical stability to be produce later as a dosage
form.

The importance of ethnopharmacology is that we can discover

new drug molecules in drug development which we can use to
find new indications for the drug to be treated to other
conditions while ensuring the efficacy and safety of herbal
medicines that are used by everyone.