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  • New Product of Sellek - MLN 2238 (Purity: 99%)

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    Selleck Chem
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    Technical Data: M.Wt: 361.03 Formula: C14H19BCl2N2O4 Solubility: Unknown Purity: >99% Storage: at -20℃ 2 years CAS No.: 1072833-77-2 Biological Activity of MLN 2238: MLN-2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM. Proteasome activity was significantly inhibited in both blood and tumor following a single dose of MLN2238 administered IV at 14 mg/kg or SC at 4 mg/kg. Proteasome activity was inhibited greater than 50% for up to 8 hrs following the IV dose in both blood and tumor, whereas proteasome activity recovered more quickly following the SC dose. It is active in preclinical models of lymphoma, and that MLN2238 has antitumor activity in a model of lymphoma that is refractory to bortezomib treatment. [1][2] References on MLN 2238: [1] http://ash.confex.com/ash/2009/webprogram/Paper20088.html [2] http://ash.confex.com/ash/2009/webprogram/Paper19135.html

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    New Product of Sellek-----MLN 2238(Purity: >99%)

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    Technical Data: M.Wt: 361.03 Formula: C14H19BCl2N2O4 Solubility: Unknown Purity: >99% Storage: at -20℃ 2 years CAS No.: 1072833-77-2 Biological Activity of MLN 2238: MLN-2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM. Proteasome activity was significantly inhibited in both blood and tumor following a single dose of MLN2238 administered IV at 14 mg/kg or SC at 4 mg/kg. Proteasome activity was inhibited greater than 50% for up to 8 hrs following the IV dose in both blood and tumor, whereas proteasome activity recovered more quickly following the SC dose. It is active in preclinical models of lymphoma, and that MLN2238 has antitumor activity in a model of lymphoma that is refractory to bortezomib treatment. [1][2] References on MLN 2238: [1] http://ash.confex.com/ash/2009/webprogram/Paper20088.html [2] http://ash.confex.com/ash/2009/webprogram/Paper19135.html

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    New Product of Sellek - MLN 2238 (Purity: 99%)

    Uploaded by

    Selleck Chem
    Technical Data: M.Wt: 361.03 Formula: C14H19BCl2N2O4 Solubility: Unknown Purity: >99% Storage: at -20℃ 2 years CAS No.: 1072833-77-2 Biological Activity of MLN 2238: MLN-2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM. Proteasome activity was significantly inhibited in both blood and tumor following a single dose of MLN2238 administered IV at 14 mg/kg or SC at 4 mg/kg. Proteasome activity was inhibited greater than 50% for up to 8 hrs following the IV dose in both blood and tumor, whereas proteasome activity recovered more quickly following the SC dose. It is active in preclinical models of lymphoma, and that MLN2238 has antitumor activity in a model of lymphoma that is refractory to bortezomib treatment. [1][2] References on MLN 2238: [1] http://ash.confex.com/ash/2009/webprogram/Paper20088.html [2] http://ash.confex.com/ash/2009/webprogram/Paper19135.html

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    Product Information

    S2180 MLN 2238


    Technical Data:
    M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 361.03 C14H19BCl2N2O4 Unknown 99% at -20 2 years 1072833-77-2
    Cl O N H Cl O H N OH B OH

    Novel Life Science Reagents


    for Cell Signaling Research

    Toll Free:
    (877)796-6397
    -- USA and Canada only --

    Proteasome

    Fax:
    +1-713-796-9816

    Orders
    +1-713-922-4115 enquiry@selleckchem.com

    Tech Support
    tech@selleckchem.com
    (chemistry support)

    techbio@selleckchem.com
    (bio support)

    Biological Activity
    MLN-2238 is a potent reversible and specific 5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM. Proteasome activity was significantly inhibited in both blood and tumor following a single dose of MLN2238 administered IV at 14 mg/kg or SC at 4 mg/kg. Proteasome activity was inhibited greater than 50% for up to 8 hrs following the IV dose in both blood and tumor, whereas proteasome activity recovered more quickly following the SC dose. It is active in preclinical models of lymphoma, and that MLN2238 has antitumor activity in a model of lymphoma that is refractory to bortezomib treatment. [1][2]

    Web
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    References
    [1] http://ash.confex.com/ash/2009/webprogram/Paper20088.html [2] http://ash.confex.com/ash/2009/webprogram/Paper19135.html

    Return Policy
    Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

    MSDS & CoA


    Please visit www.selleckchem.com to download MSDS and CoA.

    Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

    Notes
    PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
    Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

    be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

    For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

    Copyright 2010 Selleck

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