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CLINICAL SCHOLARSHIP

Translation of Oral Care Practice Guidelines Into Clinical Practice


by Intensive Care Unit Nurses
Freda DeKeyser Ganz, RN, PhD1 , Raanan Ofra, RN, MA2 , Rabia Khalaila, RN, PhD3 , Hadassa Levy, RN, MSc4 ,
Dana Arad, RN, MSN5 , Orly Kolpak, RN, MSN6 , Maureen Ben Nun, RN, BSN7 , Yardena Drori, RN, MSN8 ,
& Julie Benbenishty, RN, MSN9
1 Pi, Head, Master’s Program, Hadassah-Hebrew University School of Nursing, Faculty of Medicine, Jerusalem, Israel
2 Lecturer, Sheba School of Nursing, Tel Hashomer, Israel
3 Director, Faculty of Nursing, Zefat Academic College Zefat, Israel
4 Head Nurse, Cardiology, Rambam Health Care Campus, Haifa, Israel
5 Staff Nurse, Ichilov Medical Center, Tel Aviv, Israel
6 ICU Head Nurse, Western Galilee Hospital-Nahariya, Nahariya, Israel
7 Staff Nurse, Kaplan Medical Center, Rehovot, Israel
8 Head Nurse, Cardiac ICU, Haemek Hospital, Afula, Israel
9 Academic Consultant/Trauma Coordinator, Nursing Administration, Hadassah Hebrew University Hospital, Jerusalem, Israel

Key words Abstract


Oral care, intensive care, translation research
Purpose: The purpose of this study was to determine whether there was a
Correspondence change in the oral care practices of intensive care unit (ICU) nurses for ven-
Dr. Freda DeKeyser Ganz, Hadassah-Hebrew tilated patients after a national effort to increase evidence-based oral care
University, School of Nursing at the Faculty of practices.
Medicine, Kiryat Hadassah, Box 12000, Design: Descriptive comparison of ICU nurses in 2004–2005 and 2012.
Jerusalem, 91120 Israel.
Method: Two convenience national surveys of ICU nurses were collected in
E-mail: Freda@hadassah.org.il
2004–2005 (n = 218) and 2012 (n = 233). After the results of the initial survey
Accepted: April 6, 2013 were reported, a national effort to increase awareness of evidence-based oral
care practices was conducted that included in-service presentations; publica-
doi: 10.1111/jnu.12039 tion of an evidence-based protocol in a national nursing journal; publication
[Correction added after online publication
of the survey findings in an international nursing journal; and reports to the
12-July 2013. Author affiliations amended.]
local press. A repeat survey was conducted 7 to 8 years later. The same survey
instrument was used for both periods of data collection. This questionnaire in-
cluded questions about demographic and personal characteristics and a check-
list of oral care practices. Nurses rated their perceived priority level concern-
ing oral care on a scale from 0 to 100. An evidence-based practice (EBP)[O4]
score was computed representing the sum of 14 items related to equipment,
solutions, assessments, and techniques associated with the evidence. The EBP
score, priority score, and oral care practices were compared between the two
samples. A regression model was built based on those variables that were as-
sociated with the EBP score in 2012.
Findings: There was a statistically significant increase in the use of EBPs as
shown by the EBP score and in the perceived priority level of oral care. In-
creased EBPs were found in the areas of teeth brushing and oral assessment.
Decreases were found in the use of non–evidence-based practices, such as the
use of gauze pads, tongue depressors, lemon water, and sodium bicarbonate.
No differences were found in the use of chlorhexidine, toothpaste, or the nurs-
ing documentation of oral care practices. A multiple regression model was
found to be significant with the time of participation (2004–2005 vs. 2012) and
priority level of oral care significantly contributing to the regression model.

Journal of Nursing Scholarship, 2013; 45:4, 355–362. 355


C 2013 Sigma Theta Tau International
Translation of ICU Oral Care Guidelines Ganz et al.

Conclusions: The national effort was partially successful in improving


evidence-based oral care practices; however, increased awareness to EBP also
might have come from other sources. Other strategies related to knowledge
translation need to be attempted and researched in this clinical setting such
as the use of opinion leaders, audits and feedback, small group consensus,
provider reminder systems, incentives, clinical information systems, and com-
puter decision support systems.
Clinical Relevance: This national effort to improve EBP did reap some re-
wards; however, other knowledge translation strategies should be used to fur-
ther improve clinical practice.

About 10 years ago, several members of the Israeli Car- brushing or the use of chlorhexidine decreased VAP in
diology and Critical Care Nursing Society formed a group their units (Adams & Wilson, 2012; Duey et al., 2008;
called the Evidence-Based Nursing Working Group (EBN Fields, 2008; Sona et al., 2009). However, not all inves-
group). This group has dedicated itself to promoting nurs- tigators have found such an association. Gu, Gong, Pan,
ing research and evidence-based practice (EBP) in critical Ni, and Liu (2012) completed a meta-analysis of random-
care on a national level. One of the first major projects ized clinical trials and found that tooth brushing did not
of this group was to describe oral care practices of Israeli reduce VAP, mortality, ICU length of stay, or ventila-
ICU nurses for ventilated patients and to compare them tor days in ventilated patients in the ICU. It should be
with the current best evidence. One of the results of this noted that this meta-analysis included only randomized
project was a survey, previously published in the Jour- clinical trials, and several of the studies mentioned above
nal of Nursing Scholarship (Ganz et al., 2009). A major used other research designs. Johnson, Domb, and John-
finding of this study was that a large percentage of nurses son (2012) implemented an oral care protocol similar to
were not practicing according to the best available evi- our protocol. They found that this protocol was associ-
dence and there was a lack of consistency between and ated with a decrease in VAP in a general ICU but did not
among the sampled intensive care units (ICUs). It has also apply to trauma patients. The authors of the study, John-
been shown that oral care has a significant impact on ICU son, Domb, and Johnson, concluded that one protocol is
patient outcomes (Cuccio et al., 2012; Hutchins, Karras, not right for every ICU patient.
Erwin, & Sullivan, 2009; Sona et al., 2009). In light of Another goal of the original survey was to determine
these results, the EBN group decided to promote the use the oral care practices of ICU nurses as compared to the
of the best evidence related to oral care of the ventilated best evidence found in the literature. We found that a
patient. This study describes those efforts and compares very large percentage of nurses were not practicing ac-
these practices on a national level before and after this cording to the latest evidence (Ganz et al., 2009). Since
project. then, several investigators from around the world, using
different survey instruments, have found very similar re-
sults. For example, Lin, Chang, Chang, and Lou (2011)
Background found that knowledge levels of evidence related to oral
In the early 2000s, when the EBN group started its care was low to moderate among Taiwanese nurses. Chan
work, the evidence related to the importance of oral care and Ng (2012) from Singapore described low knowledge
and its association to ventilator-associated pneumonia levels and practice that was not evidence based. Turk,
(VAP) was just beginning to develop. Based on what was Guler, Eser, and Khorshid (2012) conducted a study very
available at that time, the group developed an oral care similar to ours in Turkey and reported similar results.
protocol for the ventilated patient that was appropriate They found that 60% of the ICU nurses rated oral care
for the local climate that included assessment, cleaning of with the highest level of priority, yet 79% used sodium
the mouth, tooth brushing using a soft toothbrush, and bicarbonate and 82% used a foam swab. Similar to our
the use of a chlorhexidine rinse (Ganz et al., 2009). It findings, they also found a very wide variety of prac-
was recommended that these be completed at least once tices between units. American nurses also strongly pre-
per shift. ferred the foam swab (97%) and often did not perform
Studies have been published since that time that have oral care according to written policies (Feider, Mitchell, &
supported these choices. Several sets of investigators have Bridges, 2010). Similar results were reported by Soh et al.
recently found that an oral care protocol including tooth (2011) in Malaysia, who found that nurses use cotton and

356 Journal of Nursing Scholarship, 2013; 45:4, 355–362.


C 2013 Sigma Theta Tau International
Ganz et al. Translation of ICU Oral Care Guidelines

forceps for oral care but do not use toothbrushes. There- were also asked regarding their perceived priority level of
fore, even though there have been reports in the litera- oral care on a scale from 1 to 100. This question used a
ture supporting changing traditional oral care practices, visual analog format with a range of 0 (lowest priority)
nurses around the world often are not doing so. to 100 (highest priority). For further details about the de-
The similarity among these international findings leads velopment of the instrument, see Ganz et al. (2009).
to the conclusion that while publishing the evidence is an
important first step in changing clinical practice, it is not
Intervention
enough. For example, Titler (2004) commented that pas-
sive dissemination (such as publishing the results) has a In the time period between the initial (T1: 2004–2005)
minimal effect on changing clinical practice. Therefore, and the second data collection (T2: 2012), a national ef-
it was important for our EBN group to conduct a na- fort was conducted by the EBN group to increase the
tional campaign to change oral care practices in Israel. awareness of evidence-based oral care practices among
After completing this campaign, we resurveyed the oral critical care nurses. An oral care clinical practice guideline
care practices of the ICU nurses. Thus, the purpose of this was created based on the group’s review of the literature
study was to determine whether ICU nurses had changed (Raanan et al., 2008). This guideline was then sent to ev-
their oral care practices when treating the ventilated ery adult ICU in the country and to the Nursing Division
patient. of the Ministry of Health. The guideline and the process
by which it was created were published in the journal
of the national nurses’ association (Raanan et al., 2008).
Methods Results of the initial survey and the protocol were also
Sample reported to the local press. In-service presentations of the
importance of EBP using oral care as an example were
The study consisted of two convenience samples, one also given on the units where the initial survey was con-
collected in 2004–2005 and the second in 2012. Both ducted. In addition, members of the EBN group acted as
samples were collected using the same method. Mem- local champions and encouraged the use of EBPs on their
bers of the EBN group volunteered to recruit nurses from own units. Also during this time period the concept of
their own units, and some members also recruited nurses EBP became more familiar in the country due to factors
from other units in their home institution. Due to the other than the efforts of the EBN group.
turnover of members of the EBN group who agreed to
recruit subjects, different units were sampled in the two
time periods. For the most part, different nurses collected Data Collection
data for the two data collection time periods. Therefore, Data were collected similarly for both time periods.
different units were studied. In 2004–2005, nurses from Each member of the EBN group obtained both ethical and
12 units were studied (general or respiratory ICU [n = institutional approval to collect the data. The study was
5]; cardiovascular-surgical ICU [n = 3]; and neurological explained to nurses during a staff meeting, informed con-
[n = 2] and cardiac care [n = 2]) and in 2012, 12 units sent was obtained, and questionnaires were distributed,
were sampled (cardiac care [n = 6); general or respiratory then enclosed in an envelope that was placed in a conve-
ICU [n = 4]; medical ICU [n = 1]; and neurological ICU nient location on each unit.
[n = 1]), of which three units (two general ICUs and one
cardiac ICU) were sampled at both time periods.
Data Analysis
Descriptive statistics, including measures of central ten-
Instrument
dency and dispersion, and frequency data were used to
The same instrument was used for both data collection describe the sample as well as responses to the oral care
periods. It contained two major sections: a demographic practices survey. Not all participants completed all of the
and professional characteristics section and a checklist items, and these were not included in the missing data
which included a list of oral care practices that included analyses. Differences in responses between data collec-
the type of equipment used, solutions used, technique, tion periods were determined using either independent t
and the type and timing of oral assessment. Of the 27 tests (for interval level data, the EBP score, and the pri-
items on the checklist, 14 were based on evidence from ority score) or chi-square analysis (for categorical data for
the literature. An EBP score was therefore determined as all of the oral care practices). A multiple regression analy-
the number of items that were checked off among these sis was conducted to determine what factors were related
14 items. A higher score shows higher use of EBPs. Nurses to the EBP score. Only those variables that were found to

Journal of Nursing Scholarship, 2013; 45:4, 355–362. 357


C 2013 Sigma Theta Tau International
Translation of ICU Oral Care Guidelines Ganz et al.

Table 1. Sample Professional Characteristics (T1 [2004–2005]: n = 218; in the use of chlorhexidine, toothpaste, or the nursing
T2 [2012]: n = 233) documentation of oral care practices (Table 2).
T1 T2 The EBP score was not related to most of the demo-
Variable n (Valid%) n (Valid%) graphic variables (including years of nursing experience,
type of ICU, gender, level of nursing education, and per-
Level of nursing education∗
cent employment). However, three variables were found
LPN 8 (3.8) 0
RN 78 (36.6) 55 (24.8) to be significantly associated with the EBP score: having
RN + BA 107 (50.2) 139 (66.6) completed a post–basic certification ICU course (a signifi-
RN + MA/PhD 20 (9.4) 28 (12.6) cant difference between those that completed the course
Missing data 5 11 vs. those that did not: t(424) = 2.3, p = .024); age [Pear-
Post-basic critical care certification son product moment correlation between age and EBP
Yes 152 (72.4) 175 (78.8)
score: (r(387) = .11, p = .027) and the level of priority
No 58 (27.6) 47 (21.2)
given to the ventilated patient’s oral care (Pearson prod-
Missing 8 11
Work full or part time uct moment correlation between the EBP score and the
Full time 121 (56.5) 139 (64.1) level of priority: r(392) = .15, p = .004).
Part time 93 (43.4) 78 (35.9) These variables were then placed into a multiple re-
Missing 4 16 gression model along with whether the participant was
sampled at T1, T2, or both times, with the EBP score as
Note. LPN = licensed practical nurse; RN = registered nurse; BA = bach-
elor of arts; MA = master of arts. ∗ χ2 (4) = 18.7, p = .001.
the criterion variable. This model was significant (R = .21,
F(4,349) = 3.98, p = .004) with only the time of partici-
pation (T1 vs. T2, β = .105, p = .048) and level of priority
be statistically associated with the EBP score on bivariate of oral care (β = .134, p = .014) significantly contributing
analysis were entered into the regression. to the regression model.

Discussion
Results
The results of this study lend further support to the
A total of 218 nurses participated in the study in 2004– challenges associated with the translation of evidence
2005 (T1) and 233 in 2012 (T2). The majority of both into clinical practice. Overall, nurses were more aware
samples were female (2004–2005: n = 172, 82%; 2012: of EBPs associated with oral care and increased its level
n = 154, 71%), with an average age of 37.4 + 8.6 years of priority. Some of the practices that received support in
at T1 and 37.4 + 8.6 years at T2. Nurses were mostly the literature were implemented more frequently, while
registered nurses with a baccalaureate degree who had other practices that are not supported were used less of-
completed a post–basic certification course (Table 1). The ten. However, while a concerted effort was made to alert
Israel Ministry of Health requires that staff nurses who critical care nurses to changes in oral care practices, those
work in an ICU complete an ICU post–basic certification nurses who were sampled in 2012 continued to similarly
course. Compliance with this requirement is not always perform oral care, with some changes in their practice.
100% because many units have new nurses who have Some of the equipment and solutions that have not
not yet completed the course and/or older nurses with been supported in the literature (such as gauze pads,
tenure who are unwilling to complete it. This course con- tongue depressors, sodium bicarbonate, and lemon wa-
tains both theoretical and clinical content, is given over ter) decreased in use. On the other hand, there was a
the course of 1 year, and usually consists of two study significant increase in teeth brushing, conducting assess-
days per week. ments, and using a known tool to conduct this assess-
There was a statistically significant increase in the use ment. These practices have also been supported in the
of EBPs as shown by the EBP score (T1: M = 7.6, SD = literature (Berry & Davidson, 2006; Berry, Davidson,
2.5; T2: M = 8.3, SD = 2.4; t(436) = 3.05, p = .002) Masters, Rolls, & Ollerton, 2011; Berry, Davidson,
and in the perceived level of priority of oral care (T1: Nicholson, Pasqualotto, & Rolls, 2011). However, despite
M = 67.7, SD = 26.7; T2: M = 73.4, SD = 25.5; t(397) = evidence supporting the practices of cleaning the up-
2.20, p = .028). Increased EBPs were found in the areas per and lower mouth as well as the tongue (Berry &
of teeth brushing and oral assessment. Decreases were Davidson, 2006; Berry, Davison, Nicholson, et al., 2011;
found in the use of non–evidence-based practices such Berry, Davidson, Masters, et. al., 2011), these practices
as the use of gauze pads, tongue depressors, lemon wa- were used less frequently. It is unclear why certain spe-
ter, and sodium bicarbonate. No differences were found cific evidence-based practices and equipment or solutions

358 Journal of Nursing Scholarship, 2013; 45:4, 355–362.


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Ganz et al. Translation of ICU Oral Care Guidelines

Table 2. Frequencies of Equipment and Solutions Used and Assessment Practices Related to Oral Care (T1 [2004–2005]: n = 218; T2 [2012]: n = 233)

T1 T2 Significant difference
Practice n (Valid%) n (Valid%) χ2 (df), p

Equipment
Gauze pad 182 (84) 24 (10) −86.6 (1), < .0001
Tongue depressor 118 (55) 64 (27) −34.8 (1), < .0001
Toothbrush 75 (35) 175 (75) 77.4 (1), <.0001
Gloved finger 46 (21) 38 (16) NS
Solution
Chlorhexidine 161 (75) 176 (76) NS
Sodium bicarbonate 90 (42) 34 (15) −41.1 (1), < .0001
Petroleum jelly 87 (40) 83 (37) NS
Toothpaste 72 (33) 66 (28) NS
Lemon water 55 (26) 24 (10) −18.0 (1), < .0001
Glycerin 40 (19) 37 (16) NS
Saline 30 (14) 43 (19) NS
Sterile water 24 (11) 20 (9) NS
Oral care practice
Clean the tongue 196 (91) 211 (91) NS
Clean the upper mouth 190 (88) 179 (77) −11.2 (1), < .001
Clean the lower mouth 187 (87) 172 (74) −12.2 (1), < .0001
Brush teeth 95 (44) 160 (69) 27.3 (1), < .0001
Assessment
Does oral assessment 205 (95) 175 (75) 34.7 (1), < .0001
Does assessment on admission 53 (25) 82 (35) 6.0 (1), = .014
Does assessment each shift 70 (33) 84 (36) NS
Uses assessment tool 5 (2) 64 (27) 55.5 (1), < .0001
Documents assessment and care 120 (57) 140 (60) NS

were chosen more often as compared with others. One practice. But on a practical basis, at least some of the
possible explanation is that practices that required an nurses either are unwilling or are unable to practice what
active process such as cleaning and documenting were they believe. A possible reason could be time constraints
decreased but passive practices such as not using cer- associated with performing oral care. However, our re-
tain products like gauze pads or tongue depressors were sults show that those who view oral care as a priority are
increased. Other barriers to performance of the proto- more likely to practice according to the evidence.
col might include lack of resources, high cost, and lim- In recent years there has been a dramatic increase
ited time. One major health fund now stocks a ready- in the number of articles in the literature about how
made kit that includes a disposable toothbrush connected clinicians use evidence and bridge the gap between re-
to suction. This could also explain some of the results. search and clinical decision making. This type of research
Chlorhexidine was shown to be commonly used (even in has been given many names, most commonly trans-
the first study), so there might not have been room for lation research or knowledge transfer-translation. Sev-
improvement, thereby creating a type of ceiling effect. eral authors (Bhattacharyya, Estey, & Zwarenstein, 2011;
No difference was found between those units that par- Curran, Grimshaw, Hayden, & Campbell, 2011) have
ticipated in the study one time (either in 2004–2005 or commented that this area of research is extremely com-
2012) or both times. It is possible that different nurses plicated because factors associated with the healthcare
were on staff when the first survey was conducted. This system, the home institution or organization, the local
also suggests that the intervention might not have been as unit or peer group, and the individual all influence how
effective as we would have preferred, given the fact that research plays a part in clinical decision making.
those units that participated twice received the entire in- Some have looked at the barriers in knowledge trans-
tervention, including staff presentations and the presence fer such as the lack of usable, specific clinical information
of local evidence-based champions. reported in systematic reviews or meta-analyses (Tricco,
In general, nurses rated oral care as a very high level Tetzlaff, & Moher, 2011). Bosch, Tavender, Bragge,
of priority. Therefore, they realize the importance of this Gruen, and Green (2012) recommend a stepped process

Journal of Nursing Scholarship, 2013; 45:4, 355–362. 359


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Translation of ICU Oral Care Guidelines Ganz et al.

to knowledge transfer, where practice recommendations leaders, continuing education, self-learning, audits and
are developed that are locally applicable and are evidence feedback, small group consensus, provider reminder sys-
based. Gagnon (2011) added that the findings should be tems, incentives, continuous quality improvement initia-
targeted to specific audiences. This process was followed tives, clinical information systems, and computer deci-
by our EBN group. Bosch and colleagues (2012) suggest sion support systems. While some of these strategies were
that the first step is to identify high-quality guidelines, used by the EBN group, many were not implemented.
then to select the strongest recommendations, update the This could be another reason for our partial success.
evidence, create an overview, discuss the evidence and There were several limitations associated with this
make an evidence statement, discuss the evidence with study. This study was a “grass roots” effort by nurses
stakeholders, and develop local best practice guidelines. who were members of an EBN workgroup. They volun-
This could explain our partial success. teered their time and effort to attend meetings and collect
Another important resource in the translation process data. There was some turnover among the members of
is the use of clinical leaders or experts to advance the this group between the two data collection periods, and
process. Tuite and George (2010) and Richardson and most of the units that were surveyed at T1 were not sur-
Tjoelker (2012) used clinical nurse specialists to facili- veyed at T2. Therefore, the study cannot be considered as
tate clinical change. Others have stressed that it is im- a repeated measures study, thereby weakening its design.
portant to create a community of practice or a network of There might have been some nurses who completed the
practitioners who can act as knowledge brokers (Gagnon, survey at both data collection points. Therefore, the sam-
2011; Shea, 2011) and who can develop active collab- ple might consist of nurses who were surveyed once or
orations between researchers and clinicians. Our EBN twice. The goal of the initial study was to describe nurs-
group is composed of staff nurses as well as nurse lead- ing practice and so no identifying data were collected that
ers and researchers from many different ICUs through- could be used to determine whether a specific nurse par-
out the country. This group has turned into a network of ticipated previously or not. Therefore, there is no way
like-minded nurses who have acted as EBP champions at to test whether nurses who participated once as opposed
their own institutions. to twice differed. However, no difference was found be-
Administration support is another critical element re- tween those units that collected data once as opposed to
lated to knowledge transfer (Gallagher-Ford, Fineout- twice. The overall nature of the units could have changed
Overholt, Melnyk, & Stillwell, 2011; Gawlinski, 2008). because at T2 there were more critical care units than at
Aitken et al. (2011) suggested that nursing administra- T1. However, there were no significant differences in EBP
tions provide mentors as well as the time and resources, scores based on type of unit. We cannot conclude that
and create a culture that expects EBP and uses prac- changes in practices were directly due to our efforts be-
tical strategies such as working groups, a journal club, cause many other programs were conducted during this
and nursing rounds. They recommend that staff be ed- time period throughout the country. However, this inter-
ucated by being involved in the process. These actions nal validity threat of “history” might not be present be-
help to create internal expertise in knowledge transfer, cause all of the units might have been exposed equally to
the creation of a clinical practice committee, and a nurs- these efforts and there is no way of determining which
ing practice research council. Unfortunately, changes in units were exposed and the degree of exposure. In addi-
administrative support were beyond the capabilities of tion, no process measure or measure of uptake was col-
the EBN group. However, we found a significant dif- lected. Therefore, there is no quantitative assessment of
ference between T2 and T1 (including units not tested how much new information nurses received.
at T1), suggesting increased compliance with the com-
ponents of the recommended oral care protocol. These
results show that our efforts and continuing efforts on
Recommendations
the part of some nursing administrations throughout the
country (EBP seminars and conferences at local and na- We recommend that further attempts be made to in-
tional levels were conducted throughout this time period) corporate evidence into other aspects of critical care prac-
might have influenced clinical practice in this area. The tice, including the use of other strategies to improve oral
study therefore might express changes over time on a na- care practices. Such attempts at knowledge translation
tional level, not only related to our efforts alone. should be investigated to determine what strategies work
Several sources (Agency for Health Quality Research, best. Future studies could include measures of research
2004; Duffy, 2005) have suggested different ways to ef- uptake as well as investigate which combination of trans-
fectively transfer evidence to clinical practice. They rec- lation strategies are most appropriate for a specific proto-
ommend a combination of strategies, including opinion col or work environment.

360 Journal of Nursing Scholarship, 2013; 45:4, 355–362.


C 2013 Sigma Theta Tau International
Ganz et al. Translation of ICU Oral Care Guidelines

Conclusions ventilated patients: A randomised control trial. International


Journal of Nursing Studies, 48, 681–688.
Changing practice moves slowly. However, a coordi- doi:10.1016/j.ijnurstu.2010.11.004
nated national effort can lead to increased EBP and hope- Berry, A. M., Davidson, P. M., Nicholson, L., Pasqualotto, C.,
fully to improved quality of care. & Rolls, K. (2011). Consensus based clinical guideline for
oral hygiene in the critically ill. Intensive and Critical Care
Acknowledgments Nursing, 27, 180–185. doi:10.1016/j.iccn.2011.04.005
Bhattacharyya, O. K., Estey, E. A., & Zwarenstein, M. (2011).
We thank the Israeli Cardiology and Intensive Care Methodologies to evaluate the effectiveness of knowledge
Nursing Society and its members for supporting this translation interventions: A primer for researchers and
study. health care managers. Journal of Clinical Epidemiology, 64,
32–40. doi:10.1061/j.jclinepi.2010.02.022
Bosch, M., Tavender, E., Bragge, P., Gruen, R., & Green, S.
(2012). How to define best practice for use in knowledge
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