Parameter Probiotics for Promoting Feed
Tolerance in Very Low Birth Improves Feeding Intolerance in
Weight Neonates — A
Randomized Controlled Trial
Desain Double blinded randomized control trial
Periode August 2012 to November 2013
Lokasi A tertiary neonatal intensive care unit (NICU) the Neonatology Unit, Department of
in Southern India
Tujuan to determine the efficacy of probiotics on
feed tolerance in very low birthweight
(VLBW) neonates
Kriteria Inklusi All neonates with a birth weight between 750 neonates with a gestational age of
g to 1499 g admitted to the NICU in whom
enteral feeds
Partisipan 104 newborns with a birth weight of 750 -
1499 g on enteral feeds
Intevensi Probiotic group received a multicomponent
probiotic formulation of Lactobacillus
acidophilus, Lactobacillus rhamnosus,
Bifidobacterium longum and Saccharomyces
boulardii once a day at a dose of 1.25×109
CFU from the time of initiation of enteral
feeds till discharge and the control group
received only breast milk
Lactobacillus reuteri DSM 17938
Preterm Infants
double-blind randomized controlled
trial
January to October 2017
Pediatric Health of the Dr. Cipto
Mangunkusumo Hospital
to evaluate the effect of L. reuteri
DSM 17938 on feeding intolerance in
preterm infants
28–34 weeks and a birth weight of
1,000–1,800 g in a stable condition
allowing the administration of oral and
enteral nutrition and was conducted at
the Neonatology Unit
94 neonates with a gestational age of
28–34 weeks and birth weight of
1,000–1,800 g
The probiotic intervention in this study
was L. reuteri DSM 17938 (Interlac)
suspension
Luaran (Outcome) Primary outcome : Time to reach full
enteral feeds (150 mL/kg/day)
Secondary outcome : episodes of feed
intolerance, incidence of NEC stage 2 or
more, duration of hospital stay, days on total
parenteral nutrition (TPN), weight gain and
mortality during hospital stay
Bias Cross-contamination in the control arm is
expected to underestimate the true effects of
probiotics
Primary outcome : Feeding intolerance
Secondary outcome : differences
between probiotics and placebo in
duration of total parenteral nutrition
(TPN), number of days needed to
reach full enteral feeding, length of
stay, sepsis, diarrhea, and NEC
incidence and severity
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