SAS 1

1. B
RATIONALE – The Primary goals of clinical pharmacokinetics include enhancing efficacy and
decreasing toxicity of a patient's drug therapy.
2. A
RATIONALE -When the combined effect of two different drugs exceeds the expected additive
effect of each of the drugs administered independently, one drug is said to potentiate the
other.
3. A
RATIONALE -  Medication is usually given orally, which is generally the most comfortable and
convenient route for the patient. 
4. D
RATIONALE - Nurses' responsibility for medication administration includes ensuring that the
right medication is properly drawn up in the correct dose, and administered at the right time
through the right route to the right patient.
5. A
RATIONALE- It is a medication that can be purchased without a medical prescription
6. A
RATIONALE - Efficacy is getting things done. It is the ability to produce a desired amount of the
desired effect, or success in achieving a given goal.
7. A
RATIONALE – A proportion that compares the blood concentration of a drug at which it has a
therapeutic effect to the amount that causes death (in animal studies) or toxicity (in human
studies)
8. B,D
RATIONALE -
9. C
RATIONALE- The percentage of drug NOT protein bound is the amount of drug that is free to
work as expected. In this case, 50% is unable to be effective, because it is protein-bound.
10. A

RATIONALE - The half-life of a drug is the time it takes for the amount of a drug's active substance
in your body to reduce by half. 

11. C
RATIONALE - The rate that a chemical is absorbed and distributed. The rate and pathways of
drug metabolism and excretion.
12. B
RATIONALE -
13. A

RATIONALE – If the baby is born prematurely it can take 8 weeks or more to reach the level of
enzymes necessary .

14. C
RATIONALE –
15. D
RATIONALE – Drigs may increase ,decrease or replace enzymes, hormoes of budy metabolic
functions .