SAS 4

1. C

RATIONALE – Development of rash, especially if accompanied by blisters and irritation signify worsening
of condition and development of hypersensitivity reaction.

2. A

RATIONALE – Ketoconazole, fluconazole, and itraconazole block the activity of a sterol in a fungal wall.
Therefore, they may also block the activity of human steroids such as testosterone and cortisol.

3. B

RATIONALE – This include tight diapers, which can facilitate systemic absorption and occurrence of drug
adverse effects. Rashes can be a sign of allergy to the drug.

4. D

RATIONALE- Amphotericin B remains the drug of choice for the treatment of systemic fungal infections
in pregnancy. There are serious risks of fetal malformations associated with the use of griseofulvin,
ketoconazole, voriconazole, flucytosine and potassium iodide.

5. A

RATIONALE – Amphotericin B remains the drug of choice for the treatment of systemic fungal infections
in pregnancy. There are serious risks of fetal malformations associated with the use of griseofulvin,
ketoconazole, voriconazole, flucytosine and potassium iodide.

6. B

RATIONALE – This is because diagnosis of fungal infection caused by virus or bacteria is necessary before
beginning therapy with anti-fungal agents.

7. C

RATIONALE – Miconazole reduces vaginal burning, itching, and discharge that may occur with this
condition

8. A

RATIONALE – Factors which might increase the possibility of the occurrence of ADRs include; extremes
of age, gender, multiple drugs, disease state, past history of ADR or allergy, genetic factors, large doses
and many other factors.

9. C AND D

RATIONALE –

10. D
RATIONALE – Primaquine disrupts the mitochondria and causes death to the gametocyte and
exoerythrocytic forms. Mefloquine increases the acidity of plasmodial food vacuoles, causing cell
rupture and death. Pyrimethamine blocks the use of folic acid in protein synthesis by the plasmodium.
Chloroquine changes the metabolic pathways necessary for reproduction of the plasmodium.