ichroma™ II

Technical Training

양식-GE02-15 (Rev.03)
 Contents

1. Components

2. Specification

3. Installation

4. S/W Update

5. Back up (To save raw data)

6. Maintenance

7. Principle

양식-GE02-15 (Rev.03)
 Basic Components

Optional Components

양식-GE02-15 (Rev.03)
 Specification

Item Specification

Product name ichroma™ Ⅱ

Principle Fluorescent Immunoassay

Dimensions 276mm (W) X 220mm (L) X 91mm (H)

Weight 1.3kg

DC 12V/5A

AC/DC Adaptor

Power Input: 100-240V ~ 50/60Hz, 1.8A

Output: DC 12V/5A

Battery : DC 1.5V X 4ea

Display 7 inch touch color LCD

Motor Stepper Linear Actuators(5V, 0.34A)

Communication ports USB 4 ports, LAN Port, USB OTG port

Temperature 15-35℃
Operation temperature / humidity
Humidity 10~70% (Non-condensing)

Temperature -20 ~ 50℃

Storage temperature / humidity
Humidity < 90% (Non-condensing)

Output LCD, Built-in Printer(optional)

Patient test : 1,000 results

Saving test results System check test results : 500 results

Control materials test results : 1,000 results

Saving ID chip information 500 ID chips (maximum 5 LOTs per item)

양식-GE02-15 (Rev.03)
Installation of ichroma II

1. Connect a power cord and

AC adaptor to the power port.

2. Turn on the power switch.

ichroma™ Ⅱ displays the product logo and loading screen serially. When loading, it takes few seconds. Please wait.

If loading screen lasts more than 5 minutes, please turn off and on ichroma™ Ⅱ once again.
If the problem continues, please contact Boditech Med Inc.’s technical service or authorized regional distributor.

양식-GE02-15 (Rev.03)
Installation of ichroma II

When loading is completed, ichroma™ Ⅱ

will proceed the self-checking and display
either OK! or Not available!

**If “Not available!” is displayed, it means that there are some

problems in the relevant parts.

When self-checking is completed, Log in

menu will be displayed.
User ID: admin / Password: 0000

**The initial User ID and P/W are factory set-up. The P/W can be
changed from Setup→ User ID→ admin→ Change Password

양식-GE02-15 (Rev.03)
 Use of Batteries

The use of batteries is highly recommended just in case of a blackout for instant
operation. It is not meant for normal use with batteries for a long time.
It is possible to run 30 multi tests or 2 single tests with batteries.
We suggest to use AC adaptor and power cable for stable and safe operation.
It is possible to use AC adaptor and batteries simultaneously.
However, we suggest to remove batteries when AC adaptor is used.

Please do not use a printer when ichroma™ Ⅱ is operating with batteries.

The use of a printer could cause power shortage due to excessive power consumption.

Open the battery cover from the

bottom of ichroma™ Ⅱ.

Please check the direction of batteries

and insert them with correct direction.

양식-GE02-15 (Rev.03)
Application Update

Copy and paste “Application file”

to “boditech” folder

**Application file will be provided via e-mail

양식-GE02-15 (Rev.03)
Application Update

1. Go to “Update” and 2. Press “Yes” 3. Tap “OK”

Tap “Application”

When updating is completed,

ichroma™ Ⅱ will restart
automatically.

4. Tap “Install” 5. Tap “Done”

양식-GE02-15 (Rev.03)
Firmware Update

Copy and paste “Firmware file”

to “boditech” folder

**Firmware file will be provided via e-mail

**SD Card is inserted inside battery cover
양식-GE02-15 (Rev.03)
Firmware Update

1. Go to “Setup” 2. Go to “System” 3. Go to “Update”

When updating is completed,

please, turn off and on
ichroma™ Ⅱ and confirm the
firmware S/W version.

4. Tap “Firmware” 5. Tap “OK”

양식-GE02-15 (Rev.03)
Spot Calibration

1. Log in with 2. If the reader is already 3. Tap “Yes”

User ID: boditechmed logged in with “Admin,”
Password: ichroma log out first

4. User ID: boditechmed 5. Go to “Setup” 6. Tap “Calibration”

Password: ichroma
**Normally calibration function is
disabled and hidden.
양식-GE02-15 (Rev.03)
Spot Calibration

7. Choose the item to change 8. Change calibration 9. Tap “Save”

its calibration factor factor(%)

양식-GE02-15 (Rev.03)
Calibration /Adjusting the
test values

• User provides % factor needed for adjustment .

12% set, then end results are increased by 12%

(Target − Measured) 15 − 12
100 = 25 (%)
CAL = 100 12
Measured

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Back up (To save raw data)

1. Log in with 2. If the reader is already 3. Tap “Yes”

User ID: boditechmed logged in with “Admin,”
Password: ichroma log out first

4. User ID: boditechmed 5. Go to “Setup” 6. Tap “Backup”

Password: ichroma
**Normally back-up function is
disabled and hidden.
양식-GE02-15 (Rev.03)
Back up (To save raw data)

7. Tap “Export All” 8. Take out the SD Card 9. Insert the SD

from ichroma II Card to PC

11. Compress the folder and send it to

Technical Support Team via e-mail

10. Raw data is saved in the

ICHROMA2_DATA folder

양식-GE02-15 (Rev.03)
Maintenance_Stepper moter replacement

Motor block

Stepper motor

Optic

Moving base

Cartridge holder Barcode B/D

Barcode PCB bracket

양식-GE02-15 (Rev.03)
Maintenance_Stepper moter replacement

1. Unscrew the bolts from 2. Remove the upper case 3. Turn on the reader
the bottom case and front case

4. Tap “Holder In/Out” 5. Remove the connection 6. Unscrew 6 bolts

cables

양식-GE02-15 (Rev.03)
Maintenance_Stepper moter replacement

7. Unscrew 2 bolts of 8. Take out the barcode 9. Turn the axis of motor
barcode sensor sensor counterclockwise

10. Take out the holder
양식-GE02-15 (Rev.03)
11. Unscrew 2 bolts from 12. Unscrew 2 bolts from
the moving base the motor bracket and
replace the stepper motor
with the new one
Overview of i-Chroma diagnostic system

• Protein-based
• Antigen-antibody reaction (immuno..)
• Lateral Flow Immuno Assay

• Multi-parameter
• POC diagnostic system

• Fluorescence signal
• Remote operation supported
• Printer supported

양식-GE02-15 (Rev.03)
 Detecting (Invisible) Antibodies

양식-GE02-15 (Rev.03)
Visualizing the Invisible

Protein molecules in natural states are invisible/clear.

How do you make them visible?

Use something visible that

sticks to the invisible

양식-GE02-15 (Rev.03)
Detecting the Invisible

Fluorescence ImmunoAssay Attaching fluorescent molecules

Target

양식-GE02-15 (Rev.03)
 Understanding Fluorescence

양식-GE02-15 (Rev.03)
Fluorescence

Electromagnetic Wave Spectrum

Higher energy Lower energy

Electric Field

양식-GE02-15 (Rev.03)
 Fluorescence
• Luminescence from certain materials under external illumination
• Emitted light is less energetic than the incoming

Higher energy Lower energy

Excitation Emission

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Paper Chromatography

http://www.youtube.com/watch?v=Oy_yTOwyRLM
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Lateral Flow
Immuno-chromatography
ELISA on paper chromatography base

http://www.youtube.com/watch?v=FvIIozN58gw

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ichroma Technology

Lateral flow reaction ichroma reader

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ichroma Technology

Control Ab/fluo

Test Ab/fluo

Antigen
Detection buffer

Test Control
30
 4500

4000

3500

3000
F-units

2500

2000

1500

1000

500

0
0 20 40 60 80 100 120 140 160
1st Test zone 2nd Test zone

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Optics System

Detector 1

Detector 2

Laser

Barcode
Sensor

LED

Photo sensor
B.
B - 1.시료
B - 2.LE D 광원
B - 3.A p erture
B - 4.P ho to d etecto r
B -4

LED
B -3
B -2

B -1

Sample Well

Test device on the moving

stage
Optics of ichroma II
Diverse Diagnostic Reagent Portfolio

Cardiac Hormone Cancer Diabetes Infection

▪ Tn-I ▪ TSH ▪ PSA ▪ HbA1c ▪ PCT

▪ hsCRP ▪ TSH WB ▪ AFP ▪ MAU ▪ CRP
▪ CK-MB ▪ T4 ▪ CEA ▪ ASO
▪ D-Dimer ▪ T3 ▪ iFOB
▪ Myoglobin ▪ hCG
▪ b-HCG
▪ FSH
▪ LH
▪ Testosterone
▪ PRL
▪ Cortisol
▪ RF IgM
▪ Ferritin ▪ Prostate Cancer ▪ Diabetes
▪ Cardiovascular ▪ Thyroid Diseases ▪ Sepsis
diseases ▪ Liver Cancer ▪ Bacterial
▪ Pregnancy-
▪ Stroke/High ▪ Colorectal Infection
related Diseases
blood pressure Cancer
▪ Sex Hormone
▪ Anemia Disorder

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Technology Development

1st Generation 2nd Generation 3rd Generation

• Quantitative test results based
on Fluorescent LFIA
• Compact sized machine
• Highly sensitive diagnostic
• Semi-automated analyzer
technology
• Fully automatic analyzer
• Cross-over diagnostic
• Improved diagnostic quality
platform

WHAT NEXT?

Development direction

Price
Automation User-friendliness High sensitivity
competitiveness

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