.

LPL - LPL-ROHINI (NATIONAL REFERENCE LAB)

SECTOR - 18, BLOCK -E ROHINIDELHI 110085

Name DUMMY H209 Collected 28/7/2020 1:04:00PM

Received 28/7/2020 2:31:58PM

Lab No. 153672128 Age: 45 Years Gender: Male Reported 29/7/2020 3:45:34PM

A/c Status P Ref By: UNKNOWN Report Status Final

TEST CONDUCTED FACTOR V LEIDEN MUTATION ANALYSIS

(Real Time PCR)

RESULTS

Factor V Leiden Mutation Prothrombin gene Mutation MTHFR gene Mutation

Not Detected Not detected Not detected

Interpretation
--------------------------------------------------------------------
| RESULT | COMMENTS |
|-----------------------|--------------------------------------------|
| Homozygous mutation | Both copies of the gene carry mutation |
| detected | |
|-----------------------|--------------------------------------------|
| Heterozygous mutation | One copy of the gene carries mutation |
| detected | |
|-----------------------|--------------------------------------------|
| Not Detected | Mutation not detected |
--------------------------------------------------------------------

Note
1. This assay detects mutation in 3 genes namely Factor V Leiden (R506Q), Factor II Prothrombin gene
mutation (G20210A) & MTHFR (C677T)
2. This is an in-house developed assay
3. Test conducted on Whole blood
4. Genetic counseling available

Comments
A mutational defect in factor V causes APC (Activated Protein C) resistance which can be homozygous or
heterozygous. Factor V Leiden increases the relative risk of thrombosis by 2-3 fold in the heterozygous
condition and by 8-10 fold in the homozygous individual. Factor V Leiden mutation is a risk factor for venous as
well as arterial thrombosis.
Homozygous mutation for MTHFR (Methylenetetrahydrofolate reductase) is associated with
hyperhomocysteinemia which is an independent risk factor for vascular disease. Indian studies suggest that
heterozygosity for MTHFR C677T is also associated with elevated homocysteine levels. Multiple mutations
have synergistic effects.

Uses
Used as a thrombosis risk factor in patients prior to major surgery, pregnancy, post partum, oral contraceptive
use, estrogen replacement therapy, transient ischemic attacks, premature stroke, peripheral vascular disease,
pulmonary embolism & family history of thrombosis or known Factor V mutation.

PatientReportSCSuperPanel.FLOWCYTO_DYNAMIC_SC (Version: 6)

*153672128*
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.

LPL - LPL-ROHINI (NATIONAL REFERENCE LAB)

SECTOR - 18, BLOCK -E ROHINIDELHI 110085

Name DUMMY H209 Collected 28/7/2020 1:04:00PM

Received 28/7/2020 2:31:58PM

Lab No. 153672128 Age: 45 Years Gender: Male Reported 29/7/2020 3:45:34PM

A/c Status P Ref By: UNKNOWN Report Status Final

Dr Anand Chandrasekaran Annan Dr Atul Thatai

MD (American Board of Pathology) PhD, Biotechnology
PhD (Molecular & Cellular Pathology) HOD Molecular Diagnostics
HOD - Oncopathology NRL - Dr Lal PathLabs Ltd

-------------------------------End of report --------------------------------

IMPORTANT INSTRUCTIONS

*Test results released pertain to the specimen submitted .*All test results are dependent on the quality of the sample received by the Laboratory .
*Laboratory investigations are only a tool to facilitate in arriving at a diagnosis and should be clinically correlated by the Referring Physician .*Sample
repeats are accepted on request of Referring Physician within 7 days post reporting.*Report delivery may be delayed due to unforeseen
circumstances. Inconvenience is regretted.*Certain tests may require further testing at additional cost for derivation of exact value. Kindly submit
request within 72 hours post reporting.*Test results may show interlaboratory variations .*The Courts/Forum at Delhi shall have exclusive
jurisdiction in all disputes/claims concerning the test(s) & or results of test(s).*Test results are not valid for medico legal purposes. * Contact
customer care Tel No. +91-11-39885050 for all queries related to test results.
(#) Sample drawn from outside source.

PatientReportSCSuperPanel.FLOWCYTO_DYNAMIC_SC (Version: 6)

*153672128*
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LPL - LPL-ROHINI (NATIONAL REFERENCE

LAB)
SECTOR - 18, BLOCK -E ROHINI
DELHI 110085

Name : H252 Collected : 12/8/2020 3:16:00PM

Received : 12/8/2020 3:17:07PM
Lab No. : 153672777 Age: 25 Years Gender: Male Reported : 12/8/2020 3:58:10PM
A/c Status : P Ref By : UNKNOWN Report Status : Final

Test Name Results Units Bio. Ref. Interval

PROTEIN S, (FREE) ANTIGEN 26.00 % 60.00 - 140.00
(Immuno-turbidimetry)

Note
1. Determination of both Free & Bound Protein S are recommended to identify hereditary or acquired
protein S deficiency.
2. Very high factor VIII (>400%) activity, Activated protein C resistance, Coumadin therapy & acute or
chronic inflammation may cause spuriously low results.
3. Mutation in factor V at its protein Ca cleavage site may lead to diminished recovery of protein S.
4. Test conducted on citrated plasma.

Classification of Protein S deficiency

-----------------------------------------------------------------
| TYPE OF DEFICIENCY | REMARKS |
|--------------------|---------------------------------------------|
| Type I | Decreased antigen levels of both total and |
| | free protein S. |
|--------------------|---------------------------------------------|
| | Decreased protein S activity with normal |
| Type II | antigen levels of both total and free |
| | protein S. |
|--------------------|---------------------------------------------|
| | Decreased antigen level & activity of free |
| Type III | Protein S with normal antigen level of total|
| | protein S. |
------------------------------------------------------------------

Comment
Protein S is a vitamin K dependent plasma glycoprotein, exists in plasma as 40% free and 60% bound to C4b
Binding protein. Free protein S possesses both ACP - dependent & independent anticoagulant properties. Its
deficiency is associated with increased risk of thrombosis. The prevalence of protein S deficiency in
thrombophilic population is 7 - 12%. The estimated thrombotic risk is 10-15 folds in patient with this
deficiency. There is characteristic decrease of free protein S during pregnancy. At birth protein S activity is
close to that of adult with total & free protein S being low.

Decreased Levels (Same)

- Hereditary
- Acquired - Vitamin K deficiency, liver diseases, Oral anticoagulant therapy, acute illness, pregnancy,

PatientReportSCSuperPanel.SP_GENERAL_TEMPLATE01_SC (Version: 7)

*153672777*
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.

LPL - LPL-ROHINI (NATIONAL REFERENCE

LAB)
SECTOR - 18, BLOCK -E ROHINI
DELHI 110085

Name : KAMAL Collected : 12/8/2020 3:16:00PM

Received : 12/8/2020 3:17:07PM
Lab No. : 153672777 Age: 25 Years Gender: Male Reported : 12/8/2020 3:58:10PM
A/c Status : P Ref By : UNKNOWN Report Status : Final

Test Name Results Units Bio. Ref. Interval

use of oral contraceptives, estrogen therapy and Nephrotic syndrome .

Dr Anil Arora Dr Parul Chopra Dr Sunanda

MD, Pathology MD, Laboratory Medicine MD, Pathology
HOD Hematology & Consultant Consultant
Immunohematology NRL - Dr Lal PathLabs Ltd NRL - Dr Lal PathLabs Ltd
NRL - Dr Lal PathLabs Ltd

-------------------------------End of report --------------------------------

IMPORTANT INSTRUCTIONS

*Test results released pertain to the specimen submitted .*All test results are dependent on the quality of the sample received by the Laboratory .
*Laboratory investigations are only a tool to facilitate in arriving at a diagnosis and should be clinically correlated by the Referring Physician .*Sample
repeats are accepted on request of Referring Physician within 7 days post reporting.*Report delivery may be delayed due to unforeseen
circumstances. Inconvenience is regretted.*Certain tests may require further testing at additional cost for derivation of exact value. Kindly submit
request within 72 hours post reporting.*Test results may show interlaboratory variations .*The Courts/Forum at Delhi shall have exclusive
jurisdiction in all disputes/claims concerning the test(s) & or results of test(s).*Test results are not valid for medico legal purposes. * Contact
customer care Tel No. +91-11-39885050 for all queries related to test results.
(#) Sample drawn from outside source.

PatientReportSCSuperPanel.SP_GENERAL_TEMPLATE01_SC (Version: 7)

*153672777*
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