.

LPL - LPL-ROHINI (NATIONAL REFERENCE LAB)

SECTOR - 18, BLOCK -E ROHINI DELHI 110085

Name DUMMY N037 Collected 28/7/2020 12:33:00PM

Received 28/7/2020 2:36:47PM

Lab No. 153672155 Age: 25 Years Gender: Male Reported 29/7/2020 3:33:39PM

A/c Status P Ref By: UNKNOWN Report Status Final

(Real Time PCR)

RESULTS

BCR-ABL gene rearrangement

Negative

Note
1. Sensitivity of the assay is 0.01% when copies of ABL detected is 100,000
2. Limit of detection is 10 copies of BCR-ABL fusion gene transcripts per PCR
3. This is an in-house developed assay designed as per EAC (Europe Against Cancer) protocol
4. This test detects Major (M) gene rearrangements namely- e13a2 & e14a2 and Minor (m) gene
arrangement e1a2. This test does not detect micro gene rearrangement e19a2
5. Test conducted on Whole blood / Bone Marrow

Comments
Chronic Myeloid Leukemia (CML) is the commonest myeloproliferative neoplasm and possibly the
commonest adult leukemia in India. This clonal stem cell disorder is characterized by a proliferation of
myeloid cells at all stages of differentiation and the t(9:22) (q34:q11) leading to formation of BCR-ABL
fusion gene. Cytogenetic and molecular studies are vital for the diagnosis of CML by using detection
procedures for Philadelphia chromosome. The abnormality is present in over 95% patients of CML while
remainder 5% have complex or variant translocations involving additional chromosomes. Major gene
rearrangements are detected in CML while minor gene rearrangement may be detected in ALL.

Uses
· To detect & monitor therapy in CML patients.
· As a prognostic marker in ALL patients. Presence of BCR-ABL gene rearrangement is associated with
poor prognosis.

Dr Anand Chandrasekaran Annan Dr Atul Thatai

MD (American Board of Pathology) PhD, Biotechnology
PhD (Molecular & Cellular Pathology) HOD Molecular Diagnostics
HOD - Oncopathology NRL - Dr Lal PathLabs Ltd

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PatientReportSCSuperPanel.FLOWCYTO_DYNAMIC_SC (Version: 6)

*153672155*
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LPL - LPL-ROHINI (NATIONAL REFERENCE LAB)

SECTOR - 18, BLOCK -E ROHINI DELHI 110085

Name DUMMY N037 Collected 28/7/2020 12:33:00PM

Received 28/7/2020 2:36:47PM

Lab No. 153672155 Age: 25 Years Gender: Male Reported 29/7/2020 3:33:39PM

A/c Status P Ref By: UNKNOWN Report Status Final

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circumstances. Inconvenience is regretted.*Certain tests may require further testing at additional cost for derivation of exact value. Kindly submit
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jurisdiction in all disputes/claims concerning the test(s) & or results of test(s).*Test results are not valid for medico legal purposes. * Contact
customer care Tel No. +91-11-39885050 for all queries related to test results.
(#) Sample drawn from outside source.

PatientReportSCSuperPanel.FLOWCYTO_DYNAMIC_SC (Version: 6)

*153672155*
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