Continuing Education Activity

Mucoceles and ranulas result when there is a disruption of the flow of secretions of the salivary
glands mostly due to trauma and present as asymptomatic swellings in the oral cavity. Usually,
they tend to resolve spontaneously but sometimes may interfere with swallowing, speech, or
respiration. Therefore, in such cases, these lesions must be promptly diagnosed and treated. This
activity illustrates the evaluation and management of mucoceles and ranulas and explains the
role of the interprofessional team in managing patients with this condition.
Objectives:
 Identify the etiology of mucocele and ranula.
 Describe the appropriate evaluation of mucocele and ranula.
 List the management options available for mucocele and ranula.
 Discuss interprofessional team strategies for improving care coordination and
communication to advance mucocele and ranula and improve outcomes.
Access free multiple choice questions on this topic.

Introduction
Mucoceles and ranulas are among the most common disorders of the salivary glands. Mucocele,
which is of minor salivary gland origin, arises when there is a disruption of the flow of its
secretions. Mucoceles are of two types: extravasation mucoceles and retention mucoceles. The
former results mostly from trauma to the salivary duct, leading to the collection of secretions in
the connective tissue.[1] Whereas the latter, which is a less common type, arises due to
obstruction of the salivary duct leading to the accumulation of saliva within the ductal system.[2]
[3][4]
Ranulas are mucoceles that are of major salivary gland origin and occur on the floor of the
mouth. Like mucoceles, these lesions also have two types: oral ranulas and cervical/plunging
ranulas. While the oral ranulas form because of leakage and accumulation of secretions of major
salivary gland above the mylohyoid muscles, cervical/plunging ranulas result from the collection
of mucus along the fascial planes of the neck.

Etiology
Mucoceles occur when there is an injury to the minor salivary glands, which are scattered
throughout the oral cavity. The most frequent involved minor salivary glands are those of the
lower lip, which can be injured in a variety of ways. Among them, mechanical trauma is the most
common in biting one's own lip during chewing.[5] Other means by which these glands can be
injured include chronic inflammation/irritation (e.g., from heat and smoking), excretory duct
fibrosis, trauma from intubation, and rarely from sialolithiasis of the minor salivary glands.[6]
The origin of ranulas is similar to that of mucoceles with trauma to the excretory duct of the
major salivary glands as the leading cause and obstruction of the duct (sialolith or mucus plug) as
the less common one. Other causes leading to ranulas formation include chronic inflammation
(sarcoidosis and  Sjogren syndrome) or infection (HIV) with periductal scarring, ductal
hypoplasia, ductal stenosis, ductal agenesis, and neoplasia.[7] Anatomic variation in the ductal
system of the sublingual gland may increase the risk of development of a ranula. The risk
appears to be increased when the Bartholin duct is connected to and empties into the Wharton
duct.[8]

Epidemiology
The prevalence rate of mucoceles is 2.4 cases per 1000 persons, with the highest percentage
(70%) occurring in those ranging from 3-20 years old.
Ranulas, on the other hand, have a frequency of 0.2 cases per 1000 persons. Like mucoceles,
these lesions also have a predilection for teenagers and young adults.[4]
The inner aspect of the lower lip, often subjected to trauma such as lip biting, is a common site
for the development of mucoceles. However, they can develop anywhere in the oral cavity. Other
common sites for mucoceles development involve the soft palate, retromolar region, and the
dorsum of the tongue. For ranulas, the floor of the mouth is the most common site to develop.
Although sublingual glands give rise to most of the ranulas (90%), they may arise from the
submandibular gland in rare cases.
No racial or sexual predilection has been reported for these lesions.

Pathophysiology
The primary pathology that lies behind the formation of mucoceles and ranulas is the disruption
to the flow of secretions of salivary glands. Trauma is the most common cause, following which
mucus extravasates and accumulates in the surrounding tissue. Another way that leads to the
development of these lesions is the obstruction of the excretory duct of the salivary glands
secondary to sialolith, periductal scarring or fibrosis, tumor.

History and Physical

Patients with mucoceles present with asymptomatic, painless swelling in their mouths.[9] These
lesions develop suddenly and enlarge rapidly and become fluctuant. Many tend to involute
spontaneously as the mucocele ruptures, and its content gets reabsorbed by the oral mucosa.[10]
[11] There may be a trauma to the face or mouth either in the form of oral surgery or tongue
biting, but mostly no traumatic cause is identified. The course of these lesions ranges from 3 to 6
weeks, with some taking a few days to years to resolve in rare cases.
Patients with oral ranula mostly present with painless swelling in the floor of the mouth. This
swelling can interfere with speech, swallowing, mastication, and even respiration as it displaces
the tongue in an upward and medial direction. Sometimes, the tongue may put pressure on the
lesion, interfering with the saliva outflow, thus leading to obstructive salivary gland signs and
symptoms (pain when eating or chewing).
Cervical ranula, however, presents as an asymptomatic mass in the neck. There is usually a
trauma to the floor of the mouth or dental surgical procedure leading to the lesion.
On physical examination, mucoceles appear as dome-shaped, non-tender, fluctuant, non-
blanchable on applying pressure, and mobile swellings ranging from 0.1-4 cm in size. While
superficial mucoceles have bluish to translucent hue, deep lesions have pinkish mucosal color.
[12] Although mucoceles can form anywhere in the oral cavity, about 80% tend to form in lower
labial mucosa with the floor of the mouth, ventral tongue, buccal mucosa, and palate as less
common sites.
Oral ranulas, on the other hand, appear as large, cystic, translucent to blue swelling in the floor
of the mouth resembling the belly of a frog.[13] Like mucoceles, they have a soft consistency
and do not blanch on compression. Cervical ranulas or plunging ranulas present as an
asymptomatic, mobile, fluctuant, and enlarging mass in the neck, having soft consistency. Like
oral ranulas, they mostly occur unilaterally but may cross the midline.

Evaluation
The diagnosis of mucocele and oral ranula is mainly based on the clinical picture. Although
imaging studies are not generally indicated for the evaluation of mucoceles and oral ranulas, they
can undoubtedly help in excluding other differential diagnoses, determining the cause (e.g.,
calculi) as well as the extent of the swellings, thus aiding in surgery.[5]
 Ultrasonography: In expert hands, high-resolution ultrasonography can detect calculi,
abscesses, and cysts, and can even correctly assess up to 90% of benign versus malignant
tumors. Vascular lesions, however, require color doppler imaging for their evaluation.
 CT and MRI: They are seldomly required, except if there is a large plunging or cervical
ranula that has breached through a defect in the mylohyoid muscle. Also, they aid in
determining the extent of the swelling, which is crucial to know before proceeding to the
surgery.[1]
 Biopsy: It is required to differentiate between the benign and the malignant disease.

Treatment / Management
Mucoceles and ranulas tend to resolve spontaneously. But if they are symptomatic, persistent,
and are not self-resolving, multiple treatment approaches can be considered, which are discussed
below.
 Mucoceles                1. Surgical Excision: Surgical excision of the mucocele along with
the associated minor salivary gland, is preferred when the lesion is persistent, recurrent,
or symptomatic. After adequate removal, the chances of recurrence are reasonably low.2.
Aspiration: It is not considered as an appropriate therapy for mucoceles as the recurrence
rate is quite higher. Instead, it is preferred to eliminate other entities before surgical
excision.3. Marsupialization: It is performed when the lesion is more extensive as it
prevents the significant loss of the tissue and also decreases the risk of complications
occurring as a result of surgical excision. However, if it fails, then surgical removal of the
lesion is performed. Micromarsupialization of lesions smaller than 1 cm in diameter has
been reported in pediatric patients with variable success in which a suture is taken
through the dome of the lesion, allowing re-epithelialization of the injured duct and
improving the secretory flow of the minor salivary gland.[14]4. Laser Ablation,
 Cryosurgery, and Electrocautery: They are mostly performed for the superficial
mucoceles.[1][15]
 Ranulas1. Surgical Excision: Both oral and cervical ranulas can be treated effectively
with this approach involving the removal of the lesion along with the associated major
salivary gland with insignificant recurrence rates.2. Marsupialization: Some providers
prefer it before embarking on surgical removal. The whole pseudocyst is packed with
gauze for 7-10 days. This allows re-epithelialization of the cavity and also seals off the
leakage site. Besides, it also provokes a foreign body reaction causing fibrosis and
atrophy of the offending acini. If marsupialization fails to eliminate the disease, then
surgical excision is the next treatment of choice. 3. Laser Ablation, Cryosurgery, and
Electrocautery: These have also been employed for the treatment of smaller ranulas
either alone or before the marsupialization.4. Intralesional Injection of a Sclerosant
Agent: Although considered experimental, intracystic injection of the streptococcal
preparation, OK-432, has been reported to treat the disease with variable success rates.
[16][17]

Differential Diagnosis
Mucoceles and ranulas occurring beneath the tongue may mimic a lot of other entities and must
be differentiated. The broad list of differential diagnosis of these lesions is as follows.
 Hemangioma
 Lymphangioma
 Dermoid cyst
 Benign or malignant salivary gland neoplasm
 Lipoma
 Abscess
 Venous lake
 Fibroma
 Benign mesenchymal neoplasm

Prognosis
Overall the prognosis for mucoceles and ranulas is quite good. Mostly, these lesions present as
painless and asymptomatic swellings in the oral cavity with no associated morbidity or mortality.
However, some large lesions may interfere with the speech, mastication, deglutition, or even
with the respiration depending on the location. With complete excision of the lesion along with
the offending gland, the recurrence rate is significantly low. In contrast, other procedures,
including marsupialization and aspiration of the cyst, are associated with a higher recurrence
rate. In recent pediatric studies, the recurrence rates range from 6%-8% following surgery.[18]
[19]
Complications
Complications of mucoceles and ranulas include:
1. Infection
2. Rupture and reformation
3. Dysphagia in case of large ranula
Possible surgical complications include the following:
Intraoperative
1. Hemorrhage
2. Wharton duct damage leading to stenosis, and obstructive sialadenitis
3. Injury to the lingual nerve causing temporary or permanent paresthesia
4. Facial nerve marginal mandibular branch damage-causing paresthesia
Postoperative
1. Hematoma
2. Infection
3. Dehiscence of the wound
About half of the plunging or cervical ranulas arise as a result of the failure to excise oral ranulas
completely. These plunging ranulas may enlarge and result in a respiratory compromise or acute
mediastinitis, a life-threatening complication

Postoperative and Rehabilitation Care

Diet: A liquid or soft or bland diet is preferred postoperatively for a period ranging from a few
days (in case of a minor procedure) to longer durations (in case of major salivary gland
excision).
Activity: Strenuous exercises are generally prohibited for a few days to a few weeks depending
on the procedure.

Consultations
Before the surgical excision of mucoceles or ranulas, it is mandatory to consult with a radiologist
to help in defining the boundaries and extension of the lesion. This would prove to be of
paramount significance for the surgeon in terms of a better outcome of the surgery by avoiding
severe complications.
Consultation with the anesthesiologist becomes necessary when the ranula is large enough to
cause respiratory compromise.

Deterrence and Patient Education

Patients need to be made aware that mucoceles and ranulas tend to resolve spontaneously in most
of the case. However, if the swelling becomes symptomatic interfering with speech, deglutition,
or becomes infected, the patient must seek medical care. Oral habits such as lip biting may lead
to the formation of such lesions, and if that is the case, the patients should be advised against it.
The provider must inform the patient regarding all the treatment options in terms of success rate
and complications and opt for what is in the best interest of the patient. The patient ought to be
informed regarding the recurrence of the disease. Finally, the patient should be educated about
the signs and symptoms of wound infection after the surgical intervention and advised to seek
medical care if necessary.

Enhancing Healthcare Team Outcomes

Mucoceles and ranulas are common salivary gland disorders that are often first seen by the
primary care provider or even may present in the emergency room provided ranulas are massive
and causing respiratory compromise. These providers should contact with radiologists as to help
them in determining the extent of the lesions, thus aiding in surgical excision, and
anesthesiologists if airway compromise is the possibility. This type of coordination is necessary
for the better outcome of the disease.
The effective management of the disease is highly dependent on the interprofessional approach,
particularly between the surgeons and the radiologists. The role of surgeons is evident as the
most effective treatment of choice for persistent symptomatic mucoceles or ranulas with the
minimum recurrence rate is considered to be the surgical removal of the lesion along with the
salivary gland associated. Similarly, radiologists play a significant and imperative role in the
management of the disease. They not only help in correctly diagnosing the disease by
eliminating other differential diagnoses via imaging but also aid in its treatment by defining the
boundaries of the swelling before the surgery.
Finally, the nursing staff is also an essential segment of the interprofessional group as they
educate the patient about the disease. Only through this approach of interprofessional
collaboration, optimal patient outcomes can be achieved.