COLLEGE OF COMMUNITY HEALTH AND ALLIED MEDICAL SCIENCES

NURSING DEPARTMENT
MIGUEL Z. ZUBIRI
BSN 3D

TASK #4

DRUG STUDY

DRUG NAME Activase is indicated MODE OF ACTION SIDE EFFECTS CONTRAINDICATIO NURSING
for the treatment of AND ADVERSE NS MANAGEMENT/CONSIDERATI
acute ischemic REACTIONS ON
stroke. Exclude
intracranial
INDICATION

Generic name: - hemorrhage as the Alteplase is a serine -Bleeding - Do not administer -Alert: When used for acute
primary cause of protease responsible Activase to treat ischemic stroke, give drug
-Alteplase stroke signs and for fibrin-enhanced -Orolingual acute ischemic within 3 hours after symptoms
symptoms prior to conversion of -Cholesterol stroke, and Acute occur and only when
initiation of plasminogen to embolization Myocardial intracranial bleeding has been
Brand name: treatment plasmin. It produces Infarction or ruled out.
limited conversion of - Reembolization Pulmonary
-Activase - Activase is -Drug may be given to
plasminogen in the of Deep Venous Embolism, in the
indicated for use in absence of fibrin. Thrombi during following situations menstruating women.
acute myocardial Treatment for
When introduced in which the risk of -To recanalize occluded
Dose and Routes: infarction (AMI) for into the systemic Acute Massive bleeding is greater
the reduction of coronary arteries and to
circulation at Pulmonary than the potential improve heart function, begin
Activase injection: 2- mortality and pharmacologic Embolism benefit
mg single-patient reduction of the treatment as soon as possible
concentration, after symptoms start.
vial incidence of heart alteplase binds to
failure. -Anticoagulant and
Injection: 50-mg fibrin in a thrombus
(29million - Activase is and converts the antiplatelet therapy is
international units), indicated for the lysis entrapped commonly started during or
100-mg (58 million of acute massive plasminogen to after treatment, to decrease
international units) pulmonary plasmin. This risk of another thrombosis
vials embolism, initiates local
-Monitor vital signs and
fibrinolysis with
limited systemic neurologic status carefully.
Keep patient on strict bed
Classification: proteolysis.
rest.
- Thrombolytics -Coronary thrombolysis is
linked with arrhythmias
caused by reperfusion of
ischemic myocardium. Such
arrhythmias don't differ from
those commonly linked with
MI. Have antiarrhythmics
readily available, and carefully
monitor ECG.

- Avoid invasive procedures

during thrombolytic therapy.
Closely monitor patient for
signs of internal bleeding, and
frequently check all puncture
sites. Bleeding is the most
common adverse effect and
may occur internally and at
external puncture sites.

-If uncontrollable bleeding

occurs, stop infusion (and
heparin) and notify prescriber.

-Avoid IM injections.