You are on page 1of 7

OESOPHAGUS AND STOMACH

Bariatric surgery lifestyle interventions, to date none have proven to be effective in


reducing mortality. Conversely, bariatric surgery has been
consistently supported by a growing body of evidence as an
Alexis Sudlow intervention to produce not only effective and sustained weight
Dimitri J Pournaras loss, but also critical metabolic changes resulting in a resolution
or improvement in T2DM, reduction of cardiovascular risk fact-
Alan Osborne ors and, ultimately, improved long-term survival compared to
those with obesity treated without surgery.

Abstract
Obesity presents a growing public health crisis which has significant Obesity e stigma as a barrier to care
impact for individuals and healthcare provision worldwide. Mounting Obesity remains a highly stigmatized disease despite mounting
evidence from randomized controlled trials would suggest that bariat- evidence to support that it is the result of a highly complex
ric surgery, irrespective of the procedure performed, is the most effec- interaction between physiological pathways, genetic factors and
tive treatment currently available for obesity and related comorbidity. environmental influences. There is a widely held and pervasive
Given the increasing prevalence of obesity within all populations, clini- view amongst the public and, perhaps more worryingly, medical
cians in all specialties will treat patients with obesity and likely those professionals that it is primarily the end result of a deficiency of
who have had bariatric surgery. There are numerous barriers to personal will power. Society and the media perpetuate this unfair
improving obesity care, including stigma and a lack of understanding portrayal of patients with obesity, correlating the disease with a
amongst healthcare professionals and patients regarding the safety, range of highly negative attributes. The effect of this is not to be
efficacy and indications for bariatric surgery. It is essential that doctors underestimated and has significant effects on an individual’s
and surgeons caring for those with obesity have an understanding and personal perception and sense of self-worth. Studies have also
appreciation of the procedures performed, including the mechanism of shown weight stigma can result in patients with obesity receiving
action and outcomes for patients. Finally, an understanding of the poor medical care.2 This attitude that obesity is entirely self-
emergency postoperative complications will help further improve inflicted and not only the disease but the individuals affected
outcomes. are unworthy of treatment remains one of the most significant
obstacles. Treating obesity as a disease does not absolve patients
Keywords Bariatric surgery; obesity; Roux-en-Y gastric bypass;
of all personal responsibility, but it gives them the ability to play
sleeve gastrectomy; weight loss
an active role in the management of a chronic disease, supported
by effective medical or surgical treatment strategies.3
Introduction
Aims of treating obesity
Obesity is rapidly becoming one of the most challenging issues
Obesity is often viewed as primarily a disease characterized by
facing the global population from both a healthcare and socio-
excess adiposity and as such, management has traditionally been
economic point of view including personal implications for the
focused on weight loss or reduction in BMI which are also used
lives of those affected. On a population level, health awareness
as the main indicators of treatment success. This approach is
campaigns aimed at prevention as well as lifestyle interventions
being recognized as an overly simplistic method of assessing a
for those already affected appear to have had little impact on
complex disease process. The goals of treatment have since
reversing or even slowing down this trend. It is estimated at
shifted from weight loss to health gain and sustained improve-
present, 29% of adults within England are considered to have
ment in metabolic parameters as well as cardiovascular risk
obesity and perhaps more worryingly, the demographics appear
factors,5 obstructive sleep apnoea, subfertility, idiopathic intra-
to be shifting with 17% of 2e15 year old children now affected
cranial hypertension, type 2 diabetes mellitus and urinary in-
by obesity.1
continence. In addition, there are conditions whereby obesity
Obesity is a complex, multi-system disease directly associated
precludes an individual from undergoing surgical intervention
with the development of numerous comorbidity, including type 2
which could be life changing or saving such as organ transplant
diabetes mellitus (T2DM) and cardiovascular disease, which
and joint replacement. Again, in these conditions, bariatric sur-
have a significant impact on not only the patient’s quality of life,
gery may be considered as a bridge to definitive treatment as it
but also the duration. Despite research looking for sustainable
not only improves the safety of surgery but long-term outcomes
as well.
Clinicians must also be mindful of the importance of weight
Alexis Sudlow BSc MRCS is a Surgical Registrar and Royal College of loss maintenance when evaluating the usefulness of any inter-
Surgeons Research Fellow at Southmead Hospital, North Bristol vention for obesity. Weight loss is considered to be clinically
NHS Trust, Bristol, UK. Conflicts of interest: none declared. significant when a patient has lost 3e5% of their body weight as
Dimitri Pournaras PhD FRCS is a Consultant Bariatric Surgeon at this has been demonstrated to be the threshold at which patients
Southmead Hospital, North Bristol NHS Trust, UK. Conflicts of experience improvements in glycaemic control and cardiovas-
interest: none declared. cular risk factors.4 While numerous interventions, including
Alan Osborne MMED FRCS is a Consultant Bariatric Surgeon at lifestyle changes, have been shown to produce weight loss above
Southmead Hospital, North Bristol NHS Trust, Bristol, UK. Conflicts this threshold, only a small minority of patients will be able to
of interest: none declared. sustain this weight loss in the long term.

SURGERY 38:11 738 Ó 2020 Published by Elsevier Ltd.


OESOPHAGUS AND STOMACH

for people of Asian family origin with recent onset type 2 dia-
NICE (CG189) guidelines for bariatric surgery betes at a BMI <30. The current NICE guidelines for referral for
Bariatric surgery is a treatment option if ALL of the following criteria bariatric surgery within the NHS are shown in Box 1. Essential to
are fulfilled: the success of any procedure is active engagement of the patient
and commitment to long-term follow-up which includes careful
C BMI 40, or 35  BMI <40 with significant disease that could be monitoring of micronutrients and supplementation due to the
improved by weight loss risk of deficiency.
C Failure to achieve or maintain adequate and clinically beneficial The referral pathway varies slightly across different health
weight loss despite all appropriate non-surgical measures for at systemd although all use a similar tiered approach, which is
least 6 months broadly the same for managing patients once referred. Central to
C The patient has been receiving or will receive intensive manage- the weight management pathway is the multidisciplinary team
ment in a specialist obesity service (MDT) including psychologists, dieticians, bariatric specialist
C The patient is generally fit for anaesthesia and surgery nurses, endocrinologists and surgeons. Once a patient has been
C The patient commits to long-term follow-up referred to the weight management services, they receive indi-
C Consider an expedited assessment for BMI of 30e34.9 who have vidualized care and input from all members of the MDT and may
recent onset type 2 diabetes proceed to weight loss surgery if it is indicated, wanted by the
C Consider an assessment for people of Asian family origin with patient and recommended by the MDT. The tiered structure
recent onset type 2 diabetes at a lower BMI than 30 approach to the MDT management of obesity services can be
seen in Figure 1.
Box 1
Bariatric procedures
Obesity is a chronic disease, and like other chronic diseases
There is ongoing debate regarding the ‘ideal’ bariatric procedure,
will require life-long treatment strategies that may need to be
but the reality is that at present, there is no level 1 evidence to
applied in a stepwise approach as the efficacy of some treatment
suggest the overall superiority of one over another. There are
modalities will invariably fatigue with time. Bariatric surgery is
differing effects regarding weight loss and the potential metabolic
often perceived as a last resort for advanced disease, which
implications, which vary between procedures, but this must also
effectively limits further treatment for those who have already
be weighed against the risk of short and long-term complications
undergone surgery. Clinicians should instead view bariatric
as well as individual patient factors. In practical terms, the ideal
surgery as one element in an overall treatment strategy, which
operation is one which suits the needs of the patient and the
may also include revisional surgery or weight loss medications to
expertise of the surgeon. The variety of surgical procedures
sustain or augment what can be achieved with surgery.5,6
available allows for the provision of treatment tailored to the
patient and their individual disease.
Bariatric surgery
Bariatric surgery as a treatment for obesity is now largely Sleeve gastrectomy
unrecognizable in comparison to when it first gained widespread Although initially conceived as part of a two-stage duodenal
acceptance nearly 30 years ago, as a result of fundamental switch, sleeve gastrectomy (SG) has widely become accepted as a
technical advances as well as a greater understanding of the procedure in its own right in recognition of the associated sig-
disease process. nificant weight loss and metabolic effects. In recent years, SG has
Rather than being thought to act by physically restricting food accounted for an increasing percentage of the bariatric proced-
intake or causing malabsorption, we now understand that bar- ures performed and is now one of the most common according to
iatric surgery has multisystemic effects, acting centrally within the International Federation for the Surgery of Obesity and
the hypothalamus to control appetite, hunger and satiety as well Metabolic Disorders (IFSO) World Surgery Report.8 SG is
as within the gut via hormones, bile acids and changes in the perceived by some to be faster, less technically demanding and
microbiome.7 therefore associated with fewer postoperative complications
Once seen as an extreme and risky weight loss procedure used which may be contributory factors in the recent rise in popu-
as a last resort, bariatric surgery is now recognized as a very safe larity. It is worth noting that while studies have largely indicated
procedure, and the adoption of the laparoscopic approach has no significant difference with regards to weight loss or resolution
resulted in many procedures being performed with a <24 hours of T2DM compared to Roux-en-Y gastric bypass, SG is generally
stay with a morbidity and mortality rate in line with that of contraindicated in patients who suffer from gastro-oesophageal
laparoscopic cholecystectomy.9 reflux disease (GORD). SG may result in new onset or a wors-
ening of pre-existing acid reflux which may also subsequently
Surgical pathways and indications for surgery increase the risk of developing Barrett’s metaplasia.9 Mechanistic
Referral pathways have long been dictated by outdated models studies would suggest that SG acts in a similar manner to bypass,
which are heavily reliant on BMI-related thresholds. In light of producing neurohormonal changes in GLP-1 (glucagon-like
the importance of non-BMI-related factors such as the presence peptide-1) and PYY (peptide YY) as well as reduced ghrelin
of comorbidity or ethnicity, recent reviews have introduced the production due to removal of the gastric fundus.10
need for an expedited assessment for patients with a BMI of 30 The procedure itself involves mobilizing the greater curve of
e34.9 who have recent onset type 2 diabetes or an assessment the stomach to allow stapled division of the stomach, usually

SURGERY 38:11 739 Ó 2020 Published by Elsevier Ltd.


OESOPHAGUS AND STOMACH

Tiered structure of obesity management in the NHS

Clinical care components Commissioned services

Preoperative assessment Bariatric medical and


Tier 4 multidisciplinary team
Surgery
Specialist assessment Tier 3
Specialist Multidisciplinary team
Services

assessment Tier 2
Multicomponent weight
Lifestyle interventions,
management services
Diets, Pharmacotherapy

reinforcement of healthy Tier 1 Environmental and


eating and physical activity Universal interventions population wide services
messages and initiatives

Figure 1

starting 4e7 cm from the pylorus, proceeding towards the left Roux-en-Y gastric bypass
crus, using a bougie (usually >32 Fr) to help guide the sizing of Although Roux-en-Y gastric bypass (RYGB) is widely seen as a
the remnant stomach (Figure 2). The dissected segment is safe procedure which provides reliable weight loss, diabetes
removed. Complications of SG include staple line leak and remission and weight loss maintenance, it is typically viewed as
bleeding in the early postoperative period. Longer-term compli- being more technically demanding as it requires the formation of
cations include stricture formation and de-novo or worsening of two anastomoses. It is also considered the procedure of choice in
pre-existing GORD. IFSO now recommends that following SG, patients with GORD rather than SG. Much like SG, RYGB is
patients undergo routine surveillance endoscopy one year post- thought to exert its primary actions due to bypass of the proximal
operatively and then every 2e3 years thereafter.21 duodenum. Duodenal exclusion results in neurohormonal
changes mediated by GLP-1 and PYY that act centrally in the
hypothalamus, increasing satiety, slowing gastric emptying and
producing important changes in glucose homeostasis.11 The pa-
tient feels less hungry and if they do eat, they feel full faster due
to these changes in gut hormones.
The procedure consists of the formation of a small gastric
pouch which is separated from the distal stomach. A loop of
jejunum is brought up and anastomosed to the gastric pouch
(gastrojejunostomy) to form the alimentary or Roux limb,
allowing the passage of ingested food to bypass the duodenum,
preventing it from mixing with biliary secretions. A second
anastomosis is created 100e120 cm down the alimentary limb,
joining the biliary limb (jejuno-jejunostomy) which allows the
mixing of food and bile within the common channel (Figure 3).
Two mesenteric defects are created during the procedure which
should be closed to reduce the risk of subsequent internal
herniation.
Early postoperative complications include staple line bleeding
and anastomotic leak. The potentially most serious late compli-
cation is internal herniation which occurs when small bowel
protrudes through the mesenteric defect that may compromise
bowel viability. In a small minority of patients, RYGB is associ-
ated with the development of chronic abdominal pain which may
be difficult to manage. It is also worth noting that future pro-
cedures such as ERCP may be challenging, although not
Figure 2

SURGERY 38:11 740 Ó 2020 Published by Elsevier Ltd.


OESOPHAGUS AND STOMACH

accessible underneath the skin to allow for band adjustment


(filling/emptying) at subsequent follow-up visits.
Complications following AGB insertion include port site
infection, GORD, pouch dilatation, band slippage and, infre-
quently, band erosion. Studies indicate up to 50% of AGBs ulti-
mately may require reoperation however the indications are
highly variable.15,16

Biliopancreatic diversion and duodenal switch (BPD/


DS)
These procedures consist of largely similar steps to SG and RYGB
and produce comparable results with regards to weight loss,
resolution of comorbidity and risks. The biliopancreatic diver-
sion (BPD) is performed by creating a small gastric pouch which
does not include the pylorus. Duodenal switch (DS) is a two-
stage procedure beginning with the formation of a sleeve gas-
trectomy and therefore preservation of the pylorus. In the second
stage of the DS procedure, following formation of the sleeve
gastrectomy, the duodenum is divided and a loop of ileum
brought up to be anastomosed just distal to the pylorus and
proximal to the sphincter of Oddi. The alimentary limb allows the
passage of ingested food from the stomach to the distal ileum,
bypassing a long segment of the small bowel. The biliopancreatic
limb carrying the biliary secretions is then anastomosed to the
distal ileum, proximal to the ileocecal valve, creating a common
channel usually 80e100cm long. BPD is similar; but it is per-
Figure 3 formed as a single procedure and the loop of ileum is anasto-
mosed directly to the gastric pouch.
Both BPD and DS are infrequently performed, accounting for
impossible due to difficulty in accessing the duodenum via the less than 1% of bariatric surgeries worldwide.12 Although it is
remnant stomach. In populations where there is a high risk of well recognized that BPD/DS produces the most profound weight
gastric cancer, access to the remnant stomach may be of partic- loss and greatest improvement in glucose homeostasis and dia-
ular concern. betes remission, one of the primary limitations of the procedure
is the significant risk of micronutrient and fat-soluble vitamin
Adjustable gastric banding deficiencies requiring strict lifelong supplementation. Even in
Adjustable gastric banding (AGB) now accounts for <5% of the those adhering to nutritional guidelines, a proportion will remain
bariatric procedures worldwide having been the most common in refractory to treatment and up to 10% require re-operation due to
2003e2008.12 A significant contributory factor in this decline is these deficiencies.17 Although rare, the implications can be sig-
the perception that AGB does not produce equivalent weight loss nificant with reports of patients developing night-blindness and
to other procedures such as RYGB and SG in addition to the re- irreversible brain damage due to Wernicke’s encephalopathy.
intervention rate. In spite of this, there are still indications for
performing AGB as it is arguably a lower-risk procedure. Level 1 One anastomosis gastric bypass (OAGB)
evidence to support the ongoing use of AGB can be found from a The one anastomosis gastric bypass (OAGB) is increasing in
randomized controlled trial (RCT) demonstrating near equivalent popularity. Similar to RYGB, the procedure involves the forma-
weight loss to other bariatric procedures; however, this requires tion of a gastric pouch to effectively exclude the proximal duo-
patient review every 4e6 weeks.13 Long-term data would suggest denum. A loop of small bowel is brought up and anastomosed to
that nearly 50% weight loss can be maintained over 15 years.14 the gastric pouch to create a gastro-jejunostomy, bypassing up to
The widely held view that this level of weight loss is not 200 cm of the proximal duodenum and jejunum. It has been
possible with AGB is in part due to the variability in post- demonstrated to have similar metabolic effects to RYGB as a
operative follow-up which is critical to its success. The mecha- result of bypassing the proximal bowel with the formation of one
nisms by which gastric banding works are not completely anastomosis. Studies have suggested that weight loss is compa-
understood, but are thought to go beyond the simple effect of rable to RYGB and proponents would argue that it carries a lower
mechanical restriction. AGB appears to promote satiety, thereby perioperative risk of leak and shorter operating time. This has to
reducing food intake which is mediated by the effect of the band be weighed up against the evidence suggesting a significantly
on the vagus nerve. higher percentage of patients suffering from long-term nutritional
The pars flaccida approach allows the insertion of an adjust- deficiencies following OAGB versus RYGB as well as post-
able band, positioned around the top of the stomach (Figure 4). operative diarrhoea or steatorrhea.18 Studies have also demon-
The band is then secured with gastrogastric stitches to reduce the strated that a number of patients have endoscopic findings
risk of migration or slippage. A port connected to the band is suggestive of bile acid reflux following OAGB due to the

SURGERY 38:11 741 Ó 2020 Published by Elsevier Ltd.


OESOPHAGUS AND STOMACH

surgery are not necessarily surgery related, this must be ruled


out. The most common cause of mortality in patients following
bariatric surgery is not directly procedure related but due to
venous thromboembolism (VTE).20 A high index of suspicion
should be maintained for patients presenting with symptoms
suggestive of VTE in the postoperative period for 2 months.

Procedure specific emergencies and management


Adjustable gastric band: The most common band related
complication, which presents as an emergency is a slipped
gastric band (Figure 5), occurring when the distal stomach her-
niates upward through the band causing proximal pouch dilata-
tion. Left untreated, this can result in ischaemia and necrosis.
Patients typically present with upper abdominal or chest pain,
dysphagia and regurgitation of all fluid. An erect chest X-ray may
be helpful in quickly establishing a diagnosis by allowing for
assessment of the band position. The ‘phi angle’ can determined
drawing a vertical line down the spine and measuring the angle it
forms with the horizontal axis of the band which may be indic-
ative of a slipped band. Normally the phi angle should measure
between 4 and 58 degrees. An angle greater than this or a band
that lies in a horizontal position is suggestive of slippage. Addi-
tionally, the band should appear as a single rectangular line
rather than a visible ‘O’-shaped ring. Although these signs may
allow for quick diagnosis, CT scan or oral contrast studies may
be more helpful. A high index of suspicion for band slippage
should be maintained until ruled out and immediate manage-
ment includes complete deflation of the band. This can be done
readily on the ward with a long, ideally non-coring Huber needle
to remove all of the fluid in the band. Deflation is not always
successful in relieving symptoms in which case the band needs to
be removed urgently in theatre.

Figure 4
Gastric bypasseRYGB or OAGB: Patients presenting with severe
abdominal pain, nausea or vomiting in the early postoperative
anatomical changes produced by the formation of the gastro- period following RYGB/OAGB require urgent CT scan, although
jejunal anastomosis. Although a relatively new procedure for scans can be non-specific and even falsely reassuring. Early
which long-term data is lacking, there are concerns raised referral to a bariatric unit is advisable and diagnostic laparoscopy
regarding the implications of chronic bile acid reflux including is recommended to allow for the identification and treatment of
oesophageal and gastric malignancy. As such, IFSO now rec- critical emergencies such as anastomotic leak, mechanical
ommends that following OAGB, patients undergo routine sur- obstruction or acute bleeding. In the case of anastomotic leak,
veillance endoscopy one year postoperatively and then every two urgent management requires visualization of the defect with
to three years thereafter.19 laparoscopy, washout and drains to control sepsis. Long-term
management and control of the leak is ideally undertaken in a
Managing postoperative complications tertiary centre with a bariatric unit and may include endoluminal
vaccum therapy (Endovac). Longer term, after significant weight
While overall postoperative complications are rare, they can loss, the loss of internal fat results in hernial defects tending to
present a significant diagnostic and management challenge as the increase in size, resulting in an increased risk of internal hernia.
majority of general surgeons will only have limited experience CT scans may show a typical swirling pattern which is suggestive
with bariatric surgery. Although ideally all complications of of hernia however diagnostic laparoscopy is again indicated as
bariatric surgery would be dealt with in a centre with expertise, the CT appearances may be normal.
this is not feasible in many situations. Taking advice early on
from a bariatric unit is advisable when possible. However, this Sleeve gastrectomy: Staple line leak following sleeve gastrec-
should not delay investigation or indeed treatment in a patient tomy typically occurs near the angle of His. Patients tend to
who is unwell. Immediate management for control of sepsis or to present with signs of abdominal sepsis which may or may not be
relieve obstruction should be undertaken without delay as these accompanied by radiological evidence of a leak on CT scan with
may be lifesaving interventions. oral contrast. In patients with overt sepsis, prompt laparoscopy,
It is important to recognize that although symptoms such as washout and drainage are mandated. Further management to
abdominal pain and vomiting in a patient following bariatric promote leak healing is more complex and is best dealt with by

SURGERY 38:11 742 Ó 2020 Published by Elsevier Ltd.


OESOPHAGUS AND STOMACH

likely to have long-term implications for reducing the develop-


ment of complications related to T2DM.

Follow-up and long-term monitoring


A commitment to long-term follow-up is an essential element in
the success of bariatric surgery and all patients should be fol-
lowed up by the multidisciplinary bariatric team for a minimum
of 2 years and by their GP thereafter. During follow-up visits,
patients should be reviewed regarding nutritional intake,
adherence to nutritional supplementation, medications and dis-
cussion of comorbidities, physical activity and any psychological
issues. In addition, patients should have access to peer or pro-
fessionally led support groups.
Following bariatric surgery, patients will need long-term
monitoring with regards to vitamins and minerals, however the
requirements are specific to the procedure with some such as
BPD/DS mandating much more strict monitoring. All patients are
advised to take a complete multivitamin and then supplemen-
tation with additional vitamins or minerals as dictated by blood
tests.24
Mounting evidence from RCTs consistently demonstrates the
safety and efficacy of bariatric surgery as the most effective
long-term treatment available for obesity and related comor-
bidity. However, they also indicate that the efficacy may reduce
over time. Additional technical advances with the adoption of
Figure 5 Slipped gastric band. robotic surgery as well as novel procedures such as single
anastomosis sleeve ileal (SASI) bypass or single anastomosis
an experienced bariatric unit. Management decisions may be duodeno-ileal bypass with sleeve gastrectomy (SADI-S) may
guided by factors such as timing (early vs late), extent/severity of further increase the range of treatments available to allow for
leak and location. The use of Endovac has increased in popu- individualized care. Recent advances in our understanding of
larity in recent years as an effective method of managing obesity have contributed to developments of highly effective
gastrointestinal leaks, including those arising as a result of SG.21 and well-tolerated pharmacological agents for weight loss
which marks a potential turning point in how obesity will be
Future directions managed in the future. Although weight loss pharmacotherapy
Bariatric surgery as a speciality has developed rapidly in the past has previously been widely seen as either ineffective or unsafe,
20 years with the refinement of existing techniques, the adoption novel classes of drugs which mimic the effects of bariatric
of novel procedures and significant advances in our under- surgery (GLP-1 agonists) or are complimentary to its actions
standing of the pathophysiology contributing to the development (sodium-glucose transport protein 2 (SGLT-2) inhibitors) have
of obesity and T2DM. Bariatric surgery is considered by both the recently become available, changing the way we are able to
American Diabetes Association and International Diabetes treat obesity. For the first time, clinicians are adopting a multi-
Federation to be part of the standard treatment algorithm in modal approach to care whereby the outdated model of using
patients with obesity and T2DM with evidence from RCTs either medications or surgery is being replaced with combina-
consistently demonstrating bariatric surgery to be more effective tional treatment to enhance or sustain what can be achieved
than medical therapy.22,23 In spite of this, there is no level 1 with bariatric surgery.6,25
evidence at present to suggest the superiority of any one pro- Bariatric surgery remains an underutilized resource with less
cedure over another with regards to normalizing or controlling than 1% of patients in the UK who would benefit being offered
the metabolic effects of obesity. Most studies demonstrate that in surgical intervention.26 Promisingly, we are at a potential turning
the short term, a significant proportion of patients will go in to point in the treatment of obesity as there is a growing impetus to
remission with regards to T2DM. However, the rates may vary ensure patients are adequately treated either by improving access
depending on the definition of remission used as well as the to surgery, offering novel weight loss pharmacotherapy or, in
length of follow-up. A proportion of patients who initially go in to some cases, combinational therapy.
remission will experience a relapse of symptoms which may be All clinicians, irrespective of their speciality will treat patients
related to weight re-gain or non-weight-related factors such as with obesity and likely those who have had bariatric surgery as
the duration of diabetes and previous insulin use which may well. An understanding of the principles and potential compli-
reflect underlying residual b cell function. It is important for cations of individual surgical approaches as well as a mindful-
clinicians and patients to recognize that even in patients who ness of the importance of avoiding stigmatizing those with
experience a relapse, glycaemic control remains good which is obesity is a critical aspect of improving care. A

SURGERY 38:11 743 Ó 2020 Published by Elsevier Ltd.


OESOPHAGUS AND STOMACH

REFERENCES 15 Aarts EO, Dogan K, Koehestanie P, Aufenacker TJ, Janssen IM,


1 Statistics on Obesity, Physical Activity and Diet, England, 2019, Berends FJ. Long-term results after laparoscopic adjustable
NHS, Editor. 2019. gastric banding: a mean fourteen year follow-up study. Surg Obes
2 Phelan SM, Burgess DJ, Yeazel MW, Hellerstedt WL, Griffin JM, Relat Dis 2014; 10: 633e40.
van Ryn M. Impact of weight bias and stigma on quality of care 16 Lanthaler M, Aigner F, Kinzl J, Sieb M, Cakar-Beck F, Nehoda H.
and outcomes for patients with obesity. Obes Rev 2015; 16: Long-term results and complications following adjustable gastric
319e26. banding. Obes Surg 2010; 20: 1078e85.
3 Rubino F, Puhl RM, Cummings DE, et al. Joint international 17 Bolckmans R, Himpens J. Long-term (>10 yrs) Outcome of the
consensus statement for ending stigma of obesity. Nat Med 2020; laparoscopic biliopancreatic diversion with duodenal switch. Ann
26: 485e97. Surg 2016; 264: 1029e37.
4 Wing RR, Lang W, Wadden TA, et al. Benefits of modest weight 18 Robert M, Espalieu P, Pelascini E, et al. Efficacy and safety of one
loss in improving cardiovascular risk factors in overweight and anastomosis gastric bypass versus Roux-en-Y gastric bypass for
obese individuals with type 2 diabetes. Diabetes Care 2011; 34: obesity (YOMEGA): a multicentre, randomised, open-label, non-
1481e6. inferiority trial. Lancet 2019; 393: 1299e309.
5 Pournaras DJ, le Roux CW. Type 2 diabetes: multimodal treatment 19 Brown WA, Johari Halim Shah Y, Balalis G, et al. IFSO position
of a complex disease. Lancet 2015; 386: 936e7. statement on the role of esophago-gastro-duodenal endoscopy
6 C Sudlow A, W le Roux C, J Pournaras D. Review of advances in prior to and after bariatric and metabolic surgery procedures.
anti-obesity pharmacotherapy: implications for a multimodal Obes Surg 2020; 30: 3135e53.
treatment approach with metabolic surgery. Obes Surg 2019; 29: 20 Dang JT, Switzer N, Delisle M, et al. Predicting venous throm-
4095e104. boembolism following laparoscopic bariatric surgery: develop-
7 Pournaras DJ, le Roux CW. Obesity, gut hormones, and bariatric ment of the BariClot tool using the MBSAQIP database. Surg
surgery. World J Surg 2009; 33: 1983e8. Endosc 2019; 33: 821e31.
8 Welbourn R, Pournaras DJ, Dixon J, et al. Bariatric surgery 21 Pournaras DJ, Hardwick RH, Safranek PM, et al. Endoluminal
worldwide: baseline demographic description and one-year out- vacuum therapy (E-Vac): a treatment option in oesophagogastric
comes from the second IFSO global registry report 2013-2015. surgery. World J Surg 2018; 42: 2507e11.
Obes Surg 2018; 28: 313e22. 22 Rubino F, Nathan DM, Eckel RH, et al. Metabolic surgery in the
9 Felsenreich DM, Kefurt R, Schermann M, et al. Reflux, sleeve treatment algorithm for type 2 diabetes: a joint statement by in-
dilation, and barrett’s esophagus after laparoscopic sleeve gas- ternational diabetes organizations. Diabetes Care 2016; 39:
trectomy: long-term follow-up. Obes Surg 2017; 27: 3092e101. 861e77.
10 Pournaras DJ, le Roux CW. Ghrelin and metabolic surgery. Int J 23 Dixon JB, Zimmet P, Alberti KG, Rubino F, International Diabetes
Pept 2010; 2010. Federation Taskforce on Epidemiology and Prevention. Bariatric
11 Pournaras DJ, Aasheim ET, Bueter M, et al. Effect of bypassing surgery: an IDF statement for obese Type 2 diabetes. Diabet Med
the proximal gut on gut hormones involved with glycemic control 2011; 28: 628e42.
and weight loss. Surg Obes Relat Dis 2012; 8: 371e4. 24 O’Kane M, Pinkney J, Aasheim ET, Barth J, Batterham R,
12 Welbourn R, Hollyman M, Kinsman R, et al. Bariatric surgery Welbourn R. BOMSS Guidelines on peri-operative and post-
worldwide: baseline demographic description and one-year out- operative biochemical monitoring and micronutrient replacement
comes from the fourth IFSO global registry report 2018. Obes for patients undergoing bariatric surgery, 2014.
Surg 2019; 29: 782e95. 25 Sudlow A, le Roux CW, Pournaras DJ. Review of multimodal
13 Dixon JB, O’Brien PE, Playfair J, et al. Adjustable gastric banding treatment for type 2 diabetes: combining metabolic surgery and
and conventional therapy for type 2 diabetes: a randomized pharmacotherapy. Ther Adv Endocrinol Metab 2019; 10.
controlled trial. J Am Med Assoc 2008; 299: 316e23. 2042018819875407.
14 O’Brien PE, MacDonald L, Anderson M, Brennan L, Brown WA. 26 Welbourn R, le Roux CW, Owen-Smith A, Wordsworth S,
Long-term outcomes after bariatric surgery: fifteen-year follow-up Blazeby JM. Why the NHS should do more bariatric surgery; how
of adjustable gastric banding and a systematic review of the much should we do? BMJ 2016; 353: i1472.
bariatric surgical literature. Ann Surg 2013; 257: 87e94.

SURGERY 38:11 744 Ó 2020 Published by Elsevier Ltd.

You might also like