Professional Documents
Culture Documents
Abstract
Obesity presents a growing public health crisis which has significant Obesity e stigma as a barrier to care
impact for individuals and healthcare provision worldwide. Mounting Obesity remains a highly stigmatized disease despite mounting
evidence from randomized controlled trials would suggest that bariat- evidence to support that it is the result of a highly complex
ric surgery, irrespective of the procedure performed, is the most effec- interaction between physiological pathways, genetic factors and
tive treatment currently available for obesity and related comorbidity. environmental influences. There is a widely held and pervasive
Given the increasing prevalence of obesity within all populations, clini- view amongst the public and, perhaps more worryingly, medical
cians in all specialties will treat patients with obesity and likely those professionals that it is primarily the end result of a deficiency of
who have had bariatric surgery. There are numerous barriers to personal will power. Society and the media perpetuate this unfair
improving obesity care, including stigma and a lack of understanding portrayal of patients with obesity, correlating the disease with a
amongst healthcare professionals and patients regarding the safety, range of highly negative attributes. The effect of this is not to be
efficacy and indications for bariatric surgery. It is essential that doctors underestimated and has significant effects on an individual’s
and surgeons caring for those with obesity have an understanding and personal perception and sense of self-worth. Studies have also
appreciation of the procedures performed, including the mechanism of shown weight stigma can result in patients with obesity receiving
action and outcomes for patients. Finally, an understanding of the poor medical care.2 This attitude that obesity is entirely self-
emergency postoperative complications will help further improve inflicted and not only the disease but the individuals affected
outcomes. are unworthy of treatment remains one of the most significant
obstacles. Treating obesity as a disease does not absolve patients
Keywords Bariatric surgery; obesity; Roux-en-Y gastric bypass;
of all personal responsibility, but it gives them the ability to play
sleeve gastrectomy; weight loss
an active role in the management of a chronic disease, supported
by effective medical or surgical treatment strategies.3
Introduction
Aims of treating obesity
Obesity is rapidly becoming one of the most challenging issues
Obesity is often viewed as primarily a disease characterized by
facing the global population from both a healthcare and socio-
excess adiposity and as such, management has traditionally been
economic point of view including personal implications for the
focused on weight loss or reduction in BMI which are also used
lives of those affected. On a population level, health awareness
as the main indicators of treatment success. This approach is
campaigns aimed at prevention as well as lifestyle interventions
being recognized as an overly simplistic method of assessing a
for those already affected appear to have had little impact on
complex disease process. The goals of treatment have since
reversing or even slowing down this trend. It is estimated at
shifted from weight loss to health gain and sustained improve-
present, 29% of adults within England are considered to have
ment in metabolic parameters as well as cardiovascular risk
obesity and perhaps more worryingly, the demographics appear
factors,5 obstructive sleep apnoea, subfertility, idiopathic intra-
to be shifting with 17% of 2e15 year old children now affected
cranial hypertension, type 2 diabetes mellitus and urinary in-
by obesity.1
continence. In addition, there are conditions whereby obesity
Obesity is a complex, multi-system disease directly associated
precludes an individual from undergoing surgical intervention
with the development of numerous comorbidity, including type 2
which could be life changing or saving such as organ transplant
diabetes mellitus (T2DM) and cardiovascular disease, which
and joint replacement. Again, in these conditions, bariatric sur-
have a significant impact on not only the patient’s quality of life,
gery may be considered as a bridge to definitive treatment as it
but also the duration. Despite research looking for sustainable
not only improves the safety of surgery but long-term outcomes
as well.
Clinicians must also be mindful of the importance of weight
Alexis Sudlow BSc MRCS is a Surgical Registrar and Royal College of loss maintenance when evaluating the usefulness of any inter-
Surgeons Research Fellow at Southmead Hospital, North Bristol vention for obesity. Weight loss is considered to be clinically
NHS Trust, Bristol, UK. Conflicts of interest: none declared. significant when a patient has lost 3e5% of their body weight as
Dimitri Pournaras PhD FRCS is a Consultant Bariatric Surgeon at this has been demonstrated to be the threshold at which patients
Southmead Hospital, North Bristol NHS Trust, UK. Conflicts of experience improvements in glycaemic control and cardiovas-
interest: none declared. cular risk factors.4 While numerous interventions, including
Alan Osborne MMED FRCS is a Consultant Bariatric Surgeon at lifestyle changes, have been shown to produce weight loss above
Southmead Hospital, North Bristol NHS Trust, Bristol, UK. Conflicts this threshold, only a small minority of patients will be able to
of interest: none declared. sustain this weight loss in the long term.
for people of Asian family origin with recent onset type 2 dia-
NICE (CG189) guidelines for bariatric surgery betes at a BMI <30. The current NICE guidelines for referral for
Bariatric surgery is a treatment option if ALL of the following criteria bariatric surgery within the NHS are shown in Box 1. Essential to
are fulfilled: the success of any procedure is active engagement of the patient
and commitment to long-term follow-up which includes careful
C BMI 40, or 35 BMI <40 with significant disease that could be monitoring of micronutrients and supplementation due to the
improved by weight loss risk of deficiency.
C Failure to achieve or maintain adequate and clinically beneficial The referral pathway varies slightly across different health
weight loss despite all appropriate non-surgical measures for at systemd although all use a similar tiered approach, which is
least 6 months broadly the same for managing patients once referred. Central to
C The patient has been receiving or will receive intensive manage- the weight management pathway is the multidisciplinary team
ment in a specialist obesity service (MDT) including psychologists, dieticians, bariatric specialist
C The patient is generally fit for anaesthesia and surgery nurses, endocrinologists and surgeons. Once a patient has been
C The patient commits to long-term follow-up referred to the weight management services, they receive indi-
C Consider an expedited assessment for BMI of 30e34.9 who have vidualized care and input from all members of the MDT and may
recent onset type 2 diabetes proceed to weight loss surgery if it is indicated, wanted by the
C Consider an assessment for people of Asian family origin with patient and recommended by the MDT. The tiered structure
recent onset type 2 diabetes at a lower BMI than 30 approach to the MDT management of obesity services can be
seen in Figure 1.
Box 1
Bariatric procedures
Obesity is a chronic disease, and like other chronic diseases
There is ongoing debate regarding the ‘ideal’ bariatric procedure,
will require life-long treatment strategies that may need to be
but the reality is that at present, there is no level 1 evidence to
applied in a stepwise approach as the efficacy of some treatment
suggest the overall superiority of one over another. There are
modalities will invariably fatigue with time. Bariatric surgery is
differing effects regarding weight loss and the potential metabolic
often perceived as a last resort for advanced disease, which
implications, which vary between procedures, but this must also
effectively limits further treatment for those who have already
be weighed against the risk of short and long-term complications
undergone surgery. Clinicians should instead view bariatric
as well as individual patient factors. In practical terms, the ideal
surgery as one element in an overall treatment strategy, which
operation is one which suits the needs of the patient and the
may also include revisional surgery or weight loss medications to
expertise of the surgeon. The variety of surgical procedures
sustain or augment what can be achieved with surgery.5,6
available allows for the provision of treatment tailored to the
patient and their individual disease.
Bariatric surgery
Bariatric surgery as a treatment for obesity is now largely Sleeve gastrectomy
unrecognizable in comparison to when it first gained widespread Although initially conceived as part of a two-stage duodenal
acceptance nearly 30 years ago, as a result of fundamental switch, sleeve gastrectomy (SG) has widely become accepted as a
technical advances as well as a greater understanding of the procedure in its own right in recognition of the associated sig-
disease process. nificant weight loss and metabolic effects. In recent years, SG has
Rather than being thought to act by physically restricting food accounted for an increasing percentage of the bariatric proced-
intake or causing malabsorption, we now understand that bar- ures performed and is now one of the most common according to
iatric surgery has multisystemic effects, acting centrally within the International Federation for the Surgery of Obesity and
the hypothalamus to control appetite, hunger and satiety as well Metabolic Disorders (IFSO) World Surgery Report.8 SG is
as within the gut via hormones, bile acids and changes in the perceived by some to be faster, less technically demanding and
microbiome.7 therefore associated with fewer postoperative complications
Once seen as an extreme and risky weight loss procedure used which may be contributory factors in the recent rise in popu-
as a last resort, bariatric surgery is now recognized as a very safe larity. It is worth noting that while studies have largely indicated
procedure, and the adoption of the laparoscopic approach has no significant difference with regards to weight loss or resolution
resulted in many procedures being performed with a <24 hours of T2DM compared to Roux-en-Y gastric bypass, SG is generally
stay with a morbidity and mortality rate in line with that of contraindicated in patients who suffer from gastro-oesophageal
laparoscopic cholecystectomy.9 reflux disease (GORD). SG may result in new onset or a wors-
ening of pre-existing acid reflux which may also subsequently
Surgical pathways and indications for surgery increase the risk of developing Barrett’s metaplasia.9 Mechanistic
Referral pathways have long been dictated by outdated models studies would suggest that SG acts in a similar manner to bypass,
which are heavily reliant on BMI-related thresholds. In light of producing neurohormonal changes in GLP-1 (glucagon-like
the importance of non-BMI-related factors such as the presence peptide-1) and PYY (peptide YY) as well as reduced ghrelin
of comorbidity or ethnicity, recent reviews have introduced the production due to removal of the gastric fundus.10
need for an expedited assessment for patients with a BMI of 30 The procedure itself involves mobilizing the greater curve of
e34.9 who have recent onset type 2 diabetes or an assessment the stomach to allow stapled division of the stomach, usually
assessment Tier 2
Multicomponent weight
Lifestyle interventions,
management services
Diets, Pharmacotherapy
Figure 1
starting 4e7 cm from the pylorus, proceeding towards the left Roux-en-Y gastric bypass
crus, using a bougie (usually >32 Fr) to help guide the sizing of Although Roux-en-Y gastric bypass (RYGB) is widely seen as a
the remnant stomach (Figure 2). The dissected segment is safe procedure which provides reliable weight loss, diabetes
removed. Complications of SG include staple line leak and remission and weight loss maintenance, it is typically viewed as
bleeding in the early postoperative period. Longer-term compli- being more technically demanding as it requires the formation of
cations include stricture formation and de-novo or worsening of two anastomoses. It is also considered the procedure of choice in
pre-existing GORD. IFSO now recommends that following SG, patients with GORD rather than SG. Much like SG, RYGB is
patients undergo routine surveillance endoscopy one year post- thought to exert its primary actions due to bypass of the proximal
operatively and then every 2e3 years thereafter.21 duodenum. Duodenal exclusion results in neurohormonal
changes mediated by GLP-1 and PYY that act centrally in the
hypothalamus, increasing satiety, slowing gastric emptying and
producing important changes in glucose homeostasis.11 The pa-
tient feels less hungry and if they do eat, they feel full faster due
to these changes in gut hormones.
The procedure consists of the formation of a small gastric
pouch which is separated from the distal stomach. A loop of
jejunum is brought up and anastomosed to the gastric pouch
(gastrojejunostomy) to form the alimentary or Roux limb,
allowing the passage of ingested food to bypass the duodenum,
preventing it from mixing with biliary secretions. A second
anastomosis is created 100e120 cm down the alimentary limb,
joining the biliary limb (jejuno-jejunostomy) which allows the
mixing of food and bile within the common channel (Figure 3).
Two mesenteric defects are created during the procedure which
should be closed to reduce the risk of subsequent internal
herniation.
Early postoperative complications include staple line bleeding
and anastomotic leak. The potentially most serious late compli-
cation is internal herniation which occurs when small bowel
protrudes through the mesenteric defect that may compromise
bowel viability. In a small minority of patients, RYGB is associ-
ated with the development of chronic abdominal pain which may
be difficult to manage. It is also worth noting that future pro-
cedures such as ERCP may be challenging, although not
Figure 2
Figure 4
Gastric bypasseRYGB or OAGB: Patients presenting with severe
abdominal pain, nausea or vomiting in the early postoperative
anatomical changes produced by the formation of the gastro- period following RYGB/OAGB require urgent CT scan, although
jejunal anastomosis. Although a relatively new procedure for scans can be non-specific and even falsely reassuring. Early
which long-term data is lacking, there are concerns raised referral to a bariatric unit is advisable and diagnostic laparoscopy
regarding the implications of chronic bile acid reflux including is recommended to allow for the identification and treatment of
oesophageal and gastric malignancy. As such, IFSO now rec- critical emergencies such as anastomotic leak, mechanical
ommends that following OAGB, patients undergo routine sur- obstruction or acute bleeding. In the case of anastomotic leak,
veillance endoscopy one year postoperatively and then every two urgent management requires visualization of the defect with
to three years thereafter.19 laparoscopy, washout and drains to control sepsis. Long-term
management and control of the leak is ideally undertaken in a
Managing postoperative complications tertiary centre with a bariatric unit and may include endoluminal
vaccum therapy (Endovac). Longer term, after significant weight
While overall postoperative complications are rare, they can loss, the loss of internal fat results in hernial defects tending to
present a significant diagnostic and management challenge as the increase in size, resulting in an increased risk of internal hernia.
majority of general surgeons will only have limited experience CT scans may show a typical swirling pattern which is suggestive
with bariatric surgery. Although ideally all complications of of hernia however diagnostic laparoscopy is again indicated as
bariatric surgery would be dealt with in a centre with expertise, the CT appearances may be normal.
this is not feasible in many situations. Taking advice early on
from a bariatric unit is advisable when possible. However, this Sleeve gastrectomy: Staple line leak following sleeve gastrec-
should not delay investigation or indeed treatment in a patient tomy typically occurs near the angle of His. Patients tend to
who is unwell. Immediate management for control of sepsis or to present with signs of abdominal sepsis which may or may not be
relieve obstruction should be undertaken without delay as these accompanied by radiological evidence of a leak on CT scan with
may be lifesaving interventions. oral contrast. In patients with overt sepsis, prompt laparoscopy,
It is important to recognize that although symptoms such as washout and drainage are mandated. Further management to
abdominal pain and vomiting in a patient following bariatric promote leak healing is more complex and is best dealt with by