Antibiotics Workbook- Medicosis

• Welcome to Medicosis Workbook on Cardiac Pharmacology.

• Questions and Answers.
• I have another workbook for antibiotics, and it is part of my Antibiotics Course;
available on my website.
• Find out more at www.medicosisperfectionalis.com
• Email me at medicosisperfectionalis@gmail.com
Cardiac Pharmacology agents
Who am I: (Questions)
1. I block the rate-limiting step of the de-novo cholesterol synthesis in the liver. I do this by inhibiting the
HMG-CoA reductase. This leads to upregulation of LDL receptors and lowering of plasma LDL. I cause
elevation of liver transaminases, myalgia, myositis, and rhabdomyolysis.
2. I am a lipoprotein lipase (LPL) activator leading to catabolism of VLDL. I reduce the level of
triglycerides. I can cause cholesterol gallstones, drug-induced hepatitis as well as muscle problems.
3. I trap the bile acids in the GI tract and make them end up in the stool. I inhibit the enterohepatic
circulation of bile acids, and therefore deplete the intrahepatic cholesterol pool. I cause malabsorption
of fat, and fat-soluble vitamins.
4. I inhibit hormone sensitive lipase (HSL) as well as VLDL synthesis in the liver. I raise HDL. I can cause
flushing, hyperuricemia, and hyperglycemia.
5. I inhibit the absorption of dietary cholesterol from the gut. I am usually added to statin. I can cause
diarrhea.
6. I am an anti-sense oligonucleotide against Apo-B100 mRNA. I am useful in homozygous familial
hypercholesterolemia. I can cause pain and inflammation at injection sites.
7. I inhibit LDL receptor degradation. I am administered subcutaneously, and useful in heterozygous
familial hypercholesterolemia. I lower LDL.
8. I inhibit gastric lipase and pancreatic lipase, and thus lower fat absorption. I am used to help with
weight loss. I can cause anorexia.
9. I am a bipyridine that inhibits PDE-3 à increased cAMP. I increase cardiac contractility and
vasodilation. I am used in CHF.
10. I am a beta-1 adrenergic agonist. I increase cardiac contractility and renal perfusion. I am used in CHF. I
can cause hypertension.
11. I stimulate beta-1 and beta-2 receptors. I increase cardiac contractility. I am used in CHF. I am also used
with echocardiography in cardiac stress testing. I don’t raise the blood pressure.
12. I am a Brain Natriuretic Peptide analog…I am used in CHF.
13. I am an epithelial sodium channel (ENaC) blocker in the collecting tubules. I am a diuretic that can
cause hyperkalemia.
14. I am an aldosterone receptor antagonist. I am a diuretic. I am not anti-androgen.
15. I block the Na+/Cl- symporter in the DCT. I have more efficacy than HCTZ. I can give you a better
management of your HTN than HCTZ.
16. I block Na+ channels…I am the best in treating arrythmia post-MI.
17. I block Na+ channels in the muscles of the ventricle. I am the most pro-arrhythmic antiarrhythmic.
18. I am an antiarrhythmic prodrug that blocks Na+ channels. I can raise the anti-histone antibodies in your
serum.

2
 AfraTafreeh.com for more

19. We are a class of meds that is antihypertensive, antianginal, antiarrhythmic, and anti-CHF. We can
cause erectile dysfunction, asthma and bronchospasm, PVD, and we mask symptoms of hypoglycemia
in diabetics.
20. I am a class I, II, III and IV antiarrhythmic. I have a very high volume of distribution. I cause corneal
deposits. I cause abnormal LFTs, TFTs, and PFTs.
21. We don’t lower mortality. We are used to treat SVTs, HTN, and stable angina. We can cause edema,
flushing, headache and constipation.
22. I have a very short half-life (30 sec.). I block the AVN and decrease the heart rate. I am the D.O.C for
paroxysmal SVT. I can cause flushing and bronchospasm.
23. I am a potassium-channel opener. I treat HTN, and insulinoma. I am not good for diabetics.
24. I inhibit beta-oxidation of fatty acids. I block the late-inward Na channels à decreased intracellular Ca
overload in the cardiac myocytes. I don’t affect the HR or BP. I am the Drug of Choice (D.O.C.) for
chronic angina. I can prolong the QT interval.
25. I block the funny current (funny channels; If) in the nodal tissue à bradycardia. I am used in angina and
CHF (when patient cannot tolerate beta blockers). I don’t lower mortality. I can cause a luminous
phenomenon as a side effect.

3
Answers:

1. Statins (atorvastatin)
2. Fibrates (fenofibrates)
3. Bile acid sequestrants (Cholestyramine)
4. Niacin.
5. Ezetimibe.
6. Mipomersen
7. PCSK9 inhibitors.
8. Orlistat.
9. Amrinone.
10. Dopamine.
11. Dobutamine.
12. Nesiritide.
13. Triamterene, amiloride.
14. Eplerenone.
15. Chlorthalidone.
16. Class IB (e.g. Lidocaine)
17. Class IC (e.g. Flecainide)
18. Procainamide (Class IA)
19. Beta-blockers.
20. Amiodarone.
21. Calcium Channel Blockers.
22. Adenosine.
23. Diazoxide.
24. Ranolazine.
25. Ivabradine.

4
 AfraTafreeh.com for more