Is.

N Paper Purpose Methodology Findings Future Author ‘s

O Name Recommendati name
on

1 The The effect  A test battery Caffeine alone H. M.

effect of of caffeine consisting of caused a Franks & G.
caffeine (300 standing Caffeine was significant A. Starmer
on mg/70 kg) steadiness, administered in increase in
human on decaffeinated body sway at
simple and
perform cognitive, coffee 40 min.
complex
ance, immediately
perceptual reaction
alone after finishing
and motor time,
and in
functions manual drinking the
combina
was dexterity, alcoholic
tion
with investigat numerical beverage. A
ethanol ed both reasoning, peak plasma
alone and perceptual ethanol
in speed and concentration of
combinati verbal 92 ± 4 mg/100
on with fluency was ml occurred at
ethanol used. 40 min which
(0.75 Placebos for was not
g/kg) in both drugs modified by
68 healthy were include caffeine.
student
volunteers
of both
sexes

2 The Caffeine Caffeine increases the The implications Another Eynav

effect of has been EE and decrease the EI of these findings possible Harpaz, Snait
caffeine found to by SNS activation [35]. for weight loss direction for Tamir, Ayelet
on influence The intracellular signal, or maintenance future research Weinstein und 
energy the energy which produces over longer is the effect of Yitzhak
balance balance by increased lipolysis, heat periods of time caffeine or Weinstein
increasing production in skeletal in coffee on EE
EE and muscle, and putative overweight/obes through
decreasing satiety signals in the e populations . mediation of
EI, liver, occurs by the gut bacteria.
therefore, inhibition of PDE and Several studies
it can also by increasing the have found
potentially UCPs that drinking
be useful coffee causes a
as a body change in the
weight composition of
regulator the intestinal
population

3 Effect of To Before-after trial of Caffeine had no Nighttime SA.kynale

caffeine determine caffeine abstinance and significant effect compensatory gales .
on if later consumption was on urinary renal
circadia renal conducted on two calcium or conservation
n conservati consecutive days in a magnesium was
excretio on occurs metabolic ward while excretion insufficient to
n of in calcium subjects ate a controlled between 4 p.m. offset morning
urinary (Ca) and diet containing 11.3 and 1 a.m. caffeine-
calcium magnesiu mmol Ca and 12.7 mmol Between 1 and 4 induced
and m (Mg) Mg. 17 healthy males a.m mineral losses,
magnesi excretion and females, ages 17-41 resulting in net
um . after yr volunteered. 24-hour
morning urinary
caffeine- increases of
induced 0.32 mmol Ca
 increases and 0.16 mmol
in urinary Mg
Ca and
Mg
excretion

4 Effect of The main A structured search was The systematic  Nevertheless, https://
Caffeine aim of this carried out following the review the effects of sciprofiles.co
Supplem systematic Preferred Reporting concluded that caffeine to m/profile/
entation review Items for Systematic four produce more 56279
on was to Review and Meta- investigations power, total
Sports analyze Analyses (PRISMA) (100% of the weight lifted Juan del cosco
Perform
and guidelines in the Web of number of and to improve
ance
compare Science investigations sprint
Based
on the effects on this topic) performance
Differen of caffeine had not found with respect to
ces intake differences a placebo was
Between between between sexes higher in men
Sexes: A men and in terms of than women
Systema women on caffeine athletes despite
tic sports supplementation the same dose
Review performan on aerobic of caffeine
ce to performance and being
provide a 3/3 (100%) on administered. 
source of the fatigue Thus, the
knowledg index. However, ergogenic
e to sports four out of effect of acute
practitione seven articles caffeine intake
rs and (57.1%) showed on anaerobic
coaches, that the performance
especially ergogenicity of might be
for those caffeine for higher in men
working anaerobic than in women
with performance
women was higher in
athletes, men than
on the use women.
of caffeine
as an
ergogenic
aid.

5 The Sorbitol-caffeine Present work We have Bhavya

Effect of present interaction analysis of describes that defined the srivastava
caffeine research blood samples of 16 caffeine can be relationship
on the has been patients with type 2 helpful in between blood
possible conducted diabetes from KPC reducing the glucose level,
ameliora
(1) to Medical College, sorbitol level in insulin level,
tion of
analyse Kolkata, India was made. diabetics, so the sorbitol and
diabetic
neuropat the levels The spectroscopic chances of caffeine in
hy of sorbitol analysis and their development human body
in diabetic interpretations were and progression and utilized
blood compared with 16 of diabetic them in the
samples healthy subjects. neuropathy can plausible
and be controlled remediation of
compare with the DN.
them with introduction of
non- caffeine
diabetic
ones and
(2) to
study the
reduction
 in sorbitol
levels
upon

6 The The aim caffeine could MakramSouiss

effects of the counteract the i a,⁎,
of present Thirteen healthy male A significant negative effect HamdiChtouro
caffeine study was physical education main effect for of sleep loss on ub,c, Salma
ingestio to students (age: 21.1 ± 1.1 Time-of-day (F both cognitive Abedelmalek
n on the investigat years; body mass: 77.1 ± = 27.82, p b and physical d, Imen Ben
reaction e the 7.2 kg; height: 1.77 ± 0.001) was perfor- Ghozlane a,
time and effects of 0.06 m) volunteered to observed mances. ZouhairSahno
short- caffeine participate in the present demonstrating However, un
term ingestion study that the oral experimental
maximal on temperature studies should
perform cognitive improved be conducted
ance and signifi- cantly to deter- mine
after 36 physical from morning to the effect of
h of perfor- afternoon (p b caffeine
sleep mances 0.001, Fig. 1). ingestion on
deprivati after 36 h However, there the diurnal
on of sleep were no variation of
deprivatio significant main short- term
n Sleep (F = 0.14, maximal
p N 0.05) and performance
Caffeine effects after sleep loss.
(F = 0.52, p N
0.05).

7 ACUTE The Experimental Approach The findings on Practitioners MICHAEL A.

EFFEC purpose of to the Problem caffeine use such as TREVINO,1
TS OF this study during maximal strength and JARED W.
CAFFEI was to This study used a anaerobic conditioning COBURN,2
NE ON investigat double-blind, exercise have coaches should LEE E.
STREN e the randomized cross-over been equivocal. consider that BROWN,2
GTH effects of design. Subjects made 4 For example, caffeine’s DANIEL A.
AND caffeine visits to the laboratory Bazzucchi et al. ergogenic JUDELSON,2
MUSCL on with at least between 48 (4) reported that effects may be AND MOH H.
E maximal hours of visits. a caffeine dose evident only MALEK3
ACTIV isometric of 6 mg$kg21 of with large
ATION strength, body mass muscle mass
OF THE RTD, improved exercises
ELBOW EMG and isometric and performed by
FLEXO MMG isokinetic highly resis-
RS amplitude performance of tance trained
and moder- ately individuals and
frequency, active men is less likely to
and EMD along the affect single-
and PMD torque-velocity joint, small
of the curve during muscle mass
elbow elbow flexion. exercises
flexors commonly
used by
athletes for
hypertrophy or
rehabilitation

8 THE The The study used a single- Caffeine Caffeine very LUCAS P.
EFFEC primary blind, randomized, ingestion had a adverse effects BLOMS,
TS OF purpose of crossover design to positive effect on vertical JOHN S.
CAFFEI this study investigate the effects of on both SJ high jumper so FITZGERAL
NE ON was to caffeine ingestion on height and CMJ avoid taking D, MARTIN
VERTI evaluate jump height and jump height (p = caffeine. W. SHORT,
 CAL the effects execution using 0.001; p = AND JAMES
JUMP of caffeine mechanography. 0.001). Squat R.
HEIGH on vertical jump height and WHITEHEAD
T AND jump CMJ height
EXECU height and were
TION jump significantly
IN execution
COLLE in NCAA improved 5.4 6
GIATE Division I 6.5% and 4.3 6
ATHLE athletes 4.6%,
TES competing respectively, in
in sports the caf- feine
involvinge trial compared
xecution with placebo.
detected
was likely
a product
of the
increased
time to
develop
force
during the
countermo
vement

9 Effects Caffeine A search through eight Ten studies on Caffeine JozoGrgic,

of is databases was performed the strength appears to Eric T.
caffeine commonly to find studies on the outcome and ten provide Trexler, Bruno
intake used as an effects of caffeine on: (i) studies on the significant Lazinica&Zelj
on ergogenic maximal muscle strength power outcome ergogenic koPedisic
muscle aid. measured using 1 met the effects on
strength Literature repetition maximum inclusion criteria muscle
and about the tests; and (ii) muscle for the meta- strength and
power: a effects of power assessed by tests analyses. power
systemat caffeine of vertical jump. Meta- Caffeine
ic ingestion analyses of standardized ingestion
review on muscle mean differences (SMD) improved both
and strength between placebo and strength (SMD
meta- and power caffeine trials from = 0.20; 95%
analysis is individual studies were confidence
equivocal. conducted using the interval [CI]:
The aim random effects model 0.03, 0.36; p =
of this 0.023) and
systematic power (SMD =
review 0.17; 95% CI:
and meta- 0.00, 0.34; p =
analysis 0.047). A
was to subgroup
summariz analysis
e results indicated that
from caffeine
individual significantly
studies on improves upper
the effects (SMD = 0.21;
of caffeine 95% CI: 0.02,
intake on 0.39; p = 0.026)
muscle but not lower
strength body strength
and power (SMD = 0.15;
95% CI: -0.05,
0.34; p = 0.147
10 Caffeine The There are many Avoid caffeine Vikas Kumar,
: a boon purpose of physiological Jaspreet Kaur,
or bane the review effects of Anil Panghal,
paper was caffeine on Sawinder
to explore respiratory, Kaur,
the cardiovascular, VanshikaHand
sources of gastrointestinal, a,
caffeine, reproductive and
its central nervous
utilization system. It has
in positive effect in
different reducing the risk
food of diabetes,
products, Alzheimer’s
along with disease,
its impact Parkinson’s
on human disease, liver
health in injury and at the
terms of same time
benefits improves mood,
and psychomotor
adverse performance as
effect well as immune
response

11 Possitive  Purpose to get as much energy By this we We all are

Effects ON of this out of caffeine as can learn that focusing on
Body reasearc possible, don't drink caffeine also many
his that too much, drink lots of have positive negative
to water, drink caffeine effects on effects of
diliver over a longer period of body. caffeine so
informa time (and wait a bit if we
tion to before your second change or
people cup), stay away from thinking
that sugary energy drinks, state
caffine don't drink caffeine on caffeine
also an empty stomach (or would help
have first thing in the us a lot in
some morning), and eat very future.
positive well if you ...
effects

 You
could
live
longer. .
..

 Your
body
may
process
glucose
(or
sugar)
better. ..
.

 You're
less
likely to
develop
heart
failure. .
..

 You are
less
likely to
develop
Parkins
on's
disease.
...

 Your
liver
will
thank
you. ...

 Your
DNA
will be
stronger
.
12 Daily use Purpose of this Coffee. Coffee is a We cant use Where its
research To get brewed beverage any drug too have
knowledge about prepared from coffee high in dose positive
is it OK to drink beans, which are a and also we effects it
caffeine every natural source of cant use less also have
day? so caffeine ( 1 , 2, 3 ). ... than some
requirement. negative
Up to 400 Cocoa beans and So it is effects with
milligrams (mg) chocolate. ... necessary to daily use so
of caffeine a day learn how we stay in
appears to be safe Kola nut. ...
can use limit.
for most healthy caffeine.
Green tea. ...
adults. That's
roughly the Guarana. ...
amount of
caffeine in four Yerba mate drink. ...
cups of brewed
Chewing gum. ...
coffee, 10 cans of
cola or two Energy drinks.
"energy shot"
drinks.

13 caffeine as a Purpose of this According to the Basically its As drug its

drug research To get Dietary Guidelines for drug and helping
knowledge about Americans, it's safe for chemical people and
Caffeine working most women to drink compound so by more
as drug three to five cups of it can also researches
(pronounced: ka- coffee a day with a work as drug and
FEEN) is a drug maximum intake of or medicine. findings we
because it 400 milligrams of can make
stimulates the caffeine. (Caffeine more
central nervous content can vary medication
system, causing depending on the type s.
increased of coffee, but an
alertness. average 8-ounce cup
Caffeine gives has 95 milligrams.)
most people a
temporary energy
boost and
improves mood.
Caffeine is in tea,
coffee, chocolate,
many soft drinks,
and pain relievers
and other over-
the-counter
medicines and
supplements.For
mula:
C8H10N4O2

Molar mass:
194.19 g/mol

Metabolism:
Primary:
CYP1A2; Minor:
CYP2E1,
CYP3A4,
CYP2C8,
CYP2C9

Protein binding:
 25–36%

Other names:
Guaranine;
Methyltheobromi
ne; 1,3,7-
Trimethylxanthin
e; 7-
methyltheophyllin
e Theine

Metabolites:
Paraxanthine
(84%);
Theobromine
(12%);
Theophylline
(4%)

Addiction
liability: Low /
none

14 caffeine as Purpose of this Because caffeine acts As Its also

depressant research To get as a central nervous antidepression working As
knowledge about system (CNS) drug its help a anti
caffeine as stimulant, people lot of so many depression
depressant usually take it to feel people so we wre should
more alert and can use use this in
Is caffeine a energetic. Caffeine can accordingly. medication
depressant? improve mood and for youth.
help people feel more
After drinking a
productive. It is
cup of coffee,
believed to work by
caffeine is
blocking the
absorbed into the
neurotransmitter
blood stream and
adenosine's receptors,
transported
increasing excitability
around the body
in the brain.08-Jul-
to the brain. In the
2021
brain, adenosine
acts as a central
nervous system
depressant and
promotes feelings
of tiredness.

15 Financisl Purpose of this Due to the COVID-19 After health By

benefits of research To get pandemic, the global and other increasing
caffeine knowledge about Caffeine market size is benefits export we
how Pakistan estimated to be worth Pakistan is can earn
exporting and USD 454 million in taking royalty more if we
earning from 2021 and is forecast to by exporting increase
caffeine a readjusted size of caffeine. So caffeine
USD 454 million by we should production
. Exports In 2020, 2028 with a CAGR of have to know we will
Pakistan exported 7.7% during the review that caffeine is earn more.
$16.2k in Coffee, period. Fully helping to
making it the considering the make money.
154th largest economic change by
exporter of this health crisis, by
Coffee in the Type accounting for
world. At the (%) of the Caffeine
same year, Coffee global market in 2021,
 was the 924th is projected to value
most exported USD million by 2028,
product in growing at a revised
Pakistan. The (%) CAGR in the post-
main destination COVID-19 period.
of Coffee exports While by Type
from Pakistan are: segment is altered to an
United States (%) CAGR throughout
($16.1k) and this forecast period.
Poland ($48).

Global Caffeine key

players include CSPC,
BASF, Shandong
Xinhua, Kudos Chemie
Limited, etc. Global
top four manufacturers
hold a share about
55%.

North America is the

largest market, with a
share over 35%,
followed by China, and
Europe, both have a
share over 40 percent.

16 Effects of A systematic We searched for Caffeine Therefore, Ruishan

caffeine review and meta- studies on caffeine's intake had a future sun, junya
ingestion on analysis of effects on relatively research sun,
physiologica experimental neuromuscular fatigue large effect on needs to jingqiang
l indexes of findings on the and the influence of VA, explore Li,shuwen
human effects of caffeine physiological indexes potentiated other li
neuromuscul on physiological changes. Meta-analysis twitch (PTw), physiologic
ar fatigue indexes before was performed for M-wave. This al
and after standardized mean conclusion indicators
neuromuscular differences (SMD) tends to and their
fatigue has been between caffeine and indicate the indicative
published in placebo trials in effect of effects in
Clinical individual studies. The caffeine on order to
Pharmacology Preferred Reporting neuromuscula determine
and Experimental Items for Systematic r fatigue effective
Therapeutics, a Reviews and Meta- during and
journal of the analyses are followed. endurance accurate
American exercise. characterist
Chemical Society Future ic
(ACTV) and the research needs indicators
American to explore of caffeine
Diabetes other on
Association physiological neuromusc
(ADA). indicators and ular fatigue
their
indicative
effects.
17 Risk or The aim of this Systematic searches Caffeine high doses Vázquez, J.
benefit? Side study was to through the PubMed, supplementati of caffeine C., Martin
effects of systematically VHL, Scopus, and Web on in the should be de la Torre,
caffeine review evidence of Science databases doses carried out O., López
supplementa on the prevalence were conducted habitually in the Palomé, J.,
tion in sport: and magnitude of according to the used to afternoon & Redolar-
 a systematic side effects PRISMA guidelines. enhance to clearly Ripoll, D.
review associated with Peer-reviewed articles physical understand
caffeine that reported the performance if there is a
supplementation prevalence/percentage produces dose–
in athletes or magnitude/effect several side response
size of side effects effects, both effect of
after caffeine after exercise caffeine on
supplementation in and at least 24 insomnia.
athletes in a sports h after the
context were included. ingestion

18 CYP1A2 gen To systematically This review was CYP1A2 geno Future Grgic, J.,

otype and review studies performed in type studies Pickering,
acute that examined the accordance with the variations with larger C., Del
ergogenic influence of PRISMA guidelines. may modulate sample Coso, J.,
effects of the CYP1A2 −163 The search for studies caffeine’s sizes are Schoenfeld,
caffeine C>A was performed through ergogenic needed to B. J., &
intake on polymorphism on nine databases effects, but fully Mikulic, P.
exercise the ergogenic the elucidate (2021).
performance effects of caffeine differences this
: a and to discuss between research
systematic some of the genotypes area.
review reasons for the were small,
discrepancies in inconsistent,
findings between or limited to
the studies specific
exercise
scenarios

19 To investigate Systematic review with We found no physiologic Ferreira, R.

Effects of and update the meta-analysis significant al E. S.,
Caffeine effects (benefits improvement mechanism Pacheco, R.
and harms) of in soccer- of caffeine, L., de
Supplementa caffeine to related which acts Oliveira
improve performance as an Cruz
tion on
performance on with caffeine adenosine Latorraca,
Physical soccer players compared receptor C., Riera,
with placebo antagonist, R., Eid, R.
Performance or no delaying G., &
of Soccer intervention. fatigue, and Martimbian
However, providing co, A. L. C.
Players: caffeine support for (2021).
appears to be intense
Systematic safe training.
Review and

Meta-

Analysis
20 The effects The aims of this PubMed/MEDLINE, S This Besides the This meta-
of caffeine paper are copus, and meta-analysis effects of analysis
ingestion on threefold: (1) to SPORTDiscus were demonstrates caffeine on demonstrat
isokinetic summarize the searched using relevant that acute pain es that
muscular research terms. caffeine perception, acute
strength: A examining the The PEDro checklist ingestion the effects caffeine
meta- effects of caffeine was used for the caffeine may of caffeine ingestion
analysis on isokinetic assessment of study significantly on strength caffeine
strength, (2) pool quality. A random- increase at different may
the effects using a effects meta-analysis isokinetic velocities, significantl
meta-analysis, of standardized mean strength. and the y increase
and (3) to explore differences (SMDs) Additionally, effects of isokinetic
if there is a was done. this meta- caffeine on strength.
muscle group or a analysis upper vs. Additionall
 velocity specific reports that lower-body y, this
response to the effects of strength meta-
caffeine ingestion caffeine on analysis
. isokinetic reports that
muscular the effects
strength are of caffeine
predominantly on
manifested in isokinetic
knee extensor muscular
muscles and at strength are
greater predomina
angular ntly
velocities manifested
in
knee extens
or
muscles an
d at greater
angular
velocities.

21 Effect of The hormonal A recent study found This review The results Xu, H.,
Caffeine changes brought that the chance of also shows could lead Liu, T., Hu,
Consumptio on by getting Parkinson's that the risk to the L., Li, J.,
n on the menstruation and disease (PD) is 2.5 for developing creation of Gan, C.,
Risk for menopause make times higher in men dementia is fresh plans Xu, J., ... &
Neurologica women more who have the mutant reduced to a for creating Sheng, J.
l and prone to CYP2D6 * 4A greater extent caffeine (2019).
Psychiatric sleeplessness than genotype (allelic in women treatments Effect of
Disorders: men [60]. This is variants of CYP2D6) than in men that are caffeine on
Sex due to the fact than in those who have sex- ovariectom
Differences that oestrogen, a the wild type. specific. y-induced
in Human key female Additionally, high-risk osteoporosi
hormone, declines alleles in both CYP17 s in rats.
and that hormonal and CYP19 increased Biomedicin
imbalances in the the risk of AD in e &
body are what menopausal women by Pharmacot
lead to symptoms about a four-fold. herapy,
like hot flashes 112,
and perspiration. 108650.

22 The effects This narrative In addition to lowering In order to Future César G.

of review aims to the incidence of stroke, assess the research Fraga
polyphenols investigate how myocardial infarction, effects of should take
and other polyphenols, and diabetes, it has polyphenols the Kevin D.
bioactives either alone or in been found that flavan- measured in likelihood Croft
on human combination with 3-ols from cocoa are whole foods, of
health other plant associated with pure extracts, interactions
compounds, improvements in or whole food with other
influence human lipids, endothelial- extracts, it is bioactives
health. dependent blood flow important to (such as
and blood pressure, consider how fibre,
insulin resistance, and polyphenols terpenoids,
systemic inflammation. interact with and
other alkaloids)
phytochemical that are
s. found in
foods or
that can be
taken as
supplement
s into
account.
23 In addition to The FBDG mention I For 56 of As a Celine
being significant higher limits for these nations, nation's Marie
dietary sources of caffeine intake to we discovered nutritional Reyes
Caffeine in
caffeine, coffee, prevent hazards, (ii) references to priorities
the Diet:
tea, caffeinated CCB as alternatives to caffeine or evolve and
Country-
soda, and energy plain water, (iii) CCB caffeine- nutrition
Level
drinks also each as sources of added containing research
Consumptio
have particular sugar, and (iv) the drinks (CCB) advances,
n and
nutritional health advantages of in 81 FBDG the FBDG
Guidelines
benefits. We CCB usage. and CCB are
discuss how our consumption reviewed
understanding and data (volume and
worry about the sales). updated.
effects of dietary Therefore,
caffeine on we expect
human health adjustment
have increased. s to the
rules
governing
caffeine in
subsequent
FBDG
releases.

24 Review The most popular Phase I (cytochrome Caffeine For Pavithra,

Article on psychoactive P450) enzymes, stimulates the sustained V. (2021).
Caffeine chemical taken particularly CYP1A2, central maximal Review
Activity worldwide is which appears to be nervous endurance Article on
caffeine (1,3,7- polymorphically system in exercise, Caffeine
trimethylxanthine distributed in human addition to caffeine is Activity.
), which works by populations, having health ergogenic, Journal of
antagonistically extensively metabolise benefits that, and it has Nanotechn
binding to caffeine in the liver frequently been ology
adenosine and virtually entirely when demonstrat Research,
receptors, absorb it. combined ed to 3(1), 1-5.
primarily A1 and with other significantl
A2A. chemicals, can y improve
avoid a time-trial
number of performanc
chronic e. Team
disorders. sports like
Caffeine's soccer and
possible rugby,
drawbacks which both
have also been involve
well intermittent
researched in action over
both animal a lengthy
and human period of
species. time, are
examples
of high-
intensity
exercise
that
benefits
from
caffeine
administrat
ion.

25 The The Cochrane Library, In contrast, all Those who Magdalen

Ambiguous PubMed, MEDLINE, treatment experience a
Role of Caffeine has long Google Scholar, and studies found migraines Nowaczew
Caffeine in been associated other clinical databases caffeine to be should be ska
Migraine with migraines, were searched to find safe and mindful of
Headache: both as a cause of the list. A literature helpful in their
From them and as a search was conducted treating acute caffeine
Trigger to treatment for to locate any papers migraines, intake and
Treatment them. Migraine is that discussed the typically limit it to
a chronic illness. potential link between when no more
Since the majority caffeine and migraines. combined than 200
of people, with other mg per day.
including analgesics. To prevent
migraineurs, Only a small withdrawal
consume a lot of fraction of headaches,
caffeine every subjects (2– people
day, the question 30%) were should
of whether it shown to be maintain
affects their affected by their daily
headaches caffeine/caffei intake of
emerges. ne withdrawal caffeinated
as a migraine beverages
trigger.. as
consistentl
y as they
can.