Professional Documents
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Radiation Detection
and Instrumentation
The passage of radiation such as x-rays and gamma rays in the detection event. The histogram of pulse heights is
through a given material leads to ionizations and excita- referred to as the pulse height spectrum or the energy spectrum
tions that can be used to quantify the amount of energy because it also plots a histogram of the energy deposited
deposited. This property allows measurement of the level within the detector.
of intensity of a radiation beam or small amounts of radio- Certain properties of radiation detectors characterize
nuclides, including from within the patient. The appropri- their operation. Some are applicable to all detectors,
ate choice of detection approach depends on the purpose. whereas others are used for detectors that operate in pulse
In some cases, the efficient detection of minute amounts mode. These characterizations are not only useful for
of the radionuclide is essential, whereas in other cases the describing the operation but can also give insight into the
accurate determination of the energy or location of the benefits and limitations of the particular detector.
radiation deposited is most important. A variety of The detection efficiency depends on several factors,
approaches to radiation detection are used, including those including the intrinsic and extrinsic efficiency of the detec-
that allow for in vivo imaging of radiopharmaceuticals. tor. The intrinsic efficiency is defined as the fraction of the
incident radiation particles that interact with the detector.
CHARATERISTICS OF A RADIATION It depends on the type and energy of the radiation and the
material and thickness of the detector. For photons, the
DETECTOR
intrinsic efficiency, DI, is given to first order by:
Consider the model of a basic radiation detector, as shown
in Figure 4-1. The detector acts as a transducer that con- DI = (1 − e − μx )
verts radiation energy to electronic charge. Applying a volt-
age across the detector yields a measureable electronic where μ is the linear attenuation coefficient for the material
current. Radiation detectors typically operate in either of of interest at the incident photon energy and x is the thick-
two modes, current mode or pulse mode. Detectors that oper- ness of the detector. Thus the intrinsic efficiency can be
ate in current mode measure the average current generated improved by using a thicker detector or choosing a photon
within the detector over some characteristic integration energy and detector material that optimizes the value of μ.
time. This average current is typically proportional to the The extrinsic efficiency is the fraction of radiation particles
exposure rate to which the detector is subjected or the emitted from the source that strike the detector. It depends
amount of radioactivity within the range of the detector. In on the size and shape of the detector and the distance of
pulse mode, each individual detection is processed with the source from the detector. If the detector is a consider-
respect to the peak current (or pulse height) for that event. able distance from the source (i.e., a distance that is
This pulse height is proportional to the energy deposited >5 times the size of the detector), the extrinsic efficiency,
DE, is given by:
37
38 Nuclear Medicine: The Requisites
Geiger-Müller
region
Proportional
counter region
Applied voltage
Figure 4-2. Spectrum for Tc-99m in air. The energy resolution is char- Figure 4-3. Amplitude of gas detector output signal as a function of
acterized by the width of the photopeak (the full width at half maximum applied voltage. This graph shows the relationship between the magni-
[FWHM]) normalized by the photon energy. For the particular detector tude of the output signal forma gas detector (related to the amount of
system illustrated, the FWHM is 18 keV. The energy resolution of the ionized charge collected) as a function of the voltage applied across the
detector system for Tc-99m is 13% (100 × 18/140). detector. There is no signal with no voltage applied. As the voltage is
increased, the detector signal starts to increase until the saturation voltage
is reached, the start of the plateau defining the ionization chamber region,
where all of the initially liberated charge is collected. Further increasing
that energy is referred to as the photopeak, as shown in the voltage leads to the proportional counter region, at which the liberated
Figure 4-2. The width of the photopeak, as characterized electrons attain sufficient energy to lead to further ionization within the
by the full width at half of its maximum value (FWHM) gas. Finally, the Geiger-Müller region is reached, at which each detection
yields a terminal event of similar magnitude (i.e., a “click”). (From
normalized by the photon energy represented as a per- Cherry, Sorenson JA, Phelps ME. Physics in Nuclear Medicine. 3rd ed.
centage, is used as a measure of the energy resolution of Philadelphia: WB Saunders, 2003.)
the detector.
When the detector is subjected to a radiation beam of low
intensity, the count rate is proportional to the beam inten- measureable current in the circuit. The current will last
sity. However, the amount of time it takes for the detector until all of the charge that was liberated in the event is
to process an event limits the maximum possible count rate. collected at the electrodes. The resulting current entity is
Two models describe the count rate limitations: nonparalyz- referred to as a pulse and is associated with a particular
able and paralyzable. In the nonparalyzable model, each detection event. As previously discussed, if only the aver-
event takes a certain amount of time to process, referred to age current is measured, this device operates in current
as the dead time, which defines the maximum count rate at mode. If the individual events are analyzed, the device is
which the detector will saturate. For example, if the dead operating in pulse mode.
time is 4 μs, the count rate will saturate at 250,000 counts Figure 4-3 shows the relationship between the charge
per second. With the paralyzable model, the detector count collected in the gas detector and the voltage applied across
rate not only saturates but can “paralyze”—that is, lose the gas volume. With no voltage, no electric field exists
counts at very high count rates. within the volume to cause the ions liberated in a detec-
tion event to drift, and thus no current is present and no
charge is collected. As the voltage is increased, the ions
TYPES OF RADIATION DETECTORS
start to drift and a current results. However, the electric
The three basic types of radiation detectors used in nuclear field may not be sufficient to keep the electrons and posi-
medicine are gas detectors, scintillators, and semiconductors. tive ions from recombining and thus not all of the original
These three operate on different principles and are typi- liberated ions are collected. This portion of Figure 4-3 is
cally used for different purposes. referred to as the recombination region. As voltage is
increased, the level is reached at which the strength of the
electric field is sufficient for the collection of all of the lib-
Gas Detectors
erated ions (no recombination). This level is referred to as
A gas radiation detector is filled with a volume of gas that the saturation voltage, and the resulting plateau in Figure
acts as the sensitive material of the detector. In some 4-3 is the ionization chamber region. When operating in this
cases, it is air and in others it is an inert gas such as argon region, the amount of charge collected is proportional to
or xenon, depending on the particular detector. Elec- the amount of ionization caused in the detector and
trodes are located at either end of the sensitive volume. thereby to the energy deposited within the detector. Ion-
The detector circuit also contains a variable voltage sup- ization detectors or chambers typically operate in current
ply and a current detector. As radiation passes through mode and are the detectors of choice for determining the
the sensitive volume, it causes ionization in the gas. If a radiation beam intensity level at a particular location. They
voltage is applied across the volume, the resulting ions can directly measure this intensity level in either exposure
(electrons and positive ions) will start to drift, causing a in roentgens (R) or air kerma in rad. Dose calibrators and
Radiation Detection and Instrumentation 39
the ionization meters used to monitor the output of an which depends on the number of emitted photons. Finally,
x-ray device or the exposure level from a patient who has the response time affects the temporal resolution of the
received a radiopharmaceutical are examples of ionization scintillator. The most common scintillation crystalline
chambers (or ion chambers) used in nuclear medicine. material used in nuclear medicine is thallium-drifted
If the voltage is increased further, the drifting electrons sodium iodide (NaI).
within the device can attain sufficient energy to cause fur- Once the light is emitted in a scintillation detector, it
ther ionizations, leading to a cascade event. This can cause must be collected and converted to an electrical signal.
substantially more ionization than with an ionization The most commonly used device for this purpose is the
chamber. The total ionization is proportional to the amount photomultiplier tube (PMT). Light photons from the scintil-
of ionization initially liberated; therefore these devices are lator enter through the photomultiplier entrance window
referred to as proportional counters or chambers. Proportional and strike the photocathode, a certain fraction of which
counters, which usually operate in pulse mode, are not (approximately 20%) will lead to the emission of photo-
typically used in nuclear medicine. If the voltage is electrons moving toward the first dynode. For each elec-
increased further, the drifting electrons attain the ability to tron reaching the first dynode, approximately a million
cause a level of excitations and ionizations within the gas. electrons will eventually reach the anode of the photomul-
The excitations can lead to the emission of ultraviolet tiplier tube. Thus the photomultiplier tube provides high
radiation, which also can generate ionizations and further gain and low noise amplification at a reasonable cost. Other
excitations. This leads to a terminal event in which the solid-state light detection approaches are now being intro-
level of ionization starts to shield the initial event and the duced into nuclear medicine devices. In avalanche photodi-
level of ionization finally stops. This is referred to as the odes (APDs), the impinging light photons lead to the
Geiger-Müller process. In the Geiger-Müller device, every liberation of electrons that are then drifted in the photodi-
event leads to the same magnitude of response, irrespec- ode, yielding an electron avalanche. The gain of the APD
tive of the energy or the type of the incident radiation. is not as high as with the PMT (several hundred compared
Thus the Geiger-Müller meter does not directly measure to about a million), but the detection efficiency is substan-
exposure, although it can be calibrated in a selected energy tially higher (approximately 80%). A second solid-state
range in milliroentgens per hour. However, the estimate of approach is the silicon photomultiplier tube (SiPMT). This
exposure rate in other energy ranges may not be accurate. device consists of hundreds of very small APD channels
However, the Geiger Müller survey meter is excellent at that operate like small Geiger-Müller detectors—that is,
detecting small levels of radioactive contamination and each detection is a terminal event. The signal from the
thus is often used to survey radiopharmaceutical packages SiPMT is the number of channels that respond to a par-
that are delivered and work areas within the nuclear medi- ticular detection event in the scintillator. SiPMTs have
cine clinic at the end of the day. moderate detection efficiency (approximately 50%) and
Gas detectors are used every day in nuclear medicine for operate at low voltages. One further advantage of APDs
assaying the amount of radiopharmaceutical to be adminis- and SiPMTs compared to PMTs is that they can operate
tered and to survey packages and work areas for contamina- within a magnetic field. Thus the development of positron
tion. However, because of the low density of gas detectors, emission tomography/magnetic resonance (PET/MR) and
even when the gas is under pressure, the sensitivity of gas single-photon emission computed tomography/magnetic
detectors in not high enough to be used for clinical count- resonance (SPECT/MR) scanners will most likely involve
ing and imaging applications. the use of either APDs or SiPMTs.
Solid-state technology is used to detect the light from a
scintillation detector and also can be used to directly detect
Scintillation and Semiconductor Detectors
gamma x-rays. The detection of radiation within a semicon-
Some crystalline materials emit a large number of light ductor detector leads to a large number of electrons liberated,
photons upon the absorption of ionizing radiation. This resulting in high energy resolution. The energy resolution
process is referred to as scintillation, and these materials of the lithium-drifted germanium (GeLi) semiconductor
are referred to as scintillators. As radiation interacts within detector has approximately 1% energy resolution compared
the scintillator, a large number of excitations and ioniza- to the 10% energy resolution associated with a sodium
tions occur. On deexcitation, the number of light photons iodide scintillation detector. However, thermal energy can
emitted is directly proportional to the amount of energy lead to a measureable current in some semiconductor
deposited within the scintillator. In some cases, a small detectors such as GeLi, even in the absence of radiation,
impurity may be added to the crystal to enhance emission and thus these semiconductor detectors must be operated
of light and minimize absorption of light within the crys- at cryogenic temperatures. On the other hand, semicon-
tal. Several essential properties of scintillating materials ductor detectors such as cadmium telluride (CdTe) or cad-
can be characterized, including density, effective Z num- mium zinc telluride (CZT) can operate at room temperature.
ber (number of atomic protons per atom), amount of light CdTe and CZT do not have the excellent energy resolution
emitted per unit energy, and response time. The density of GeLi, but at approximately 5%, it is still significantly
and effective Z number are determining factors in the better than that of sodium iodide.
detection efficiency because they affect the linear attenu- The pulse height spectrum corresponding to the detec-
ation coefficient of the scintillation material. The amount tion of the 140-keV gamma rays from technetium-99m is
of emitted light affects both energy and, in the gamma illustrated in Figure 4-4. The photopeak corresponds to
camera, spatial resolution. Resolution is determined by events where the entire energy of the incident photon is
the statistical variation of the collected light photons, absorbed within the detector. These are the events of
40 Nuclear Medicine: The Requisites
For accuracy, calibrated sources (typically cobalt-57 evaluations. For example, after the administration of
and 137Cs) are assayed; the resultant reading cannot vary Tc-99m diethylenetriamepentaacetic acid (DTPA), blood
by more than 10% from the calibrated activity decay cor- samples can be counted at several time points (e.g., at 1, 2,
rected to the day of the test. The accuracy test should be and 3 hours) to estimate the patient’s glomerular filtration
performed during acceptance testing, annually thereaf- rate (GFR). The amount of radioactivity in a 0.2-mL blood
ter, and after a major repair or move. sample will be very small, and thus the well counter is the
The linearity protocol tests that the dose calibrator oper- appropriate instrument for these measurements. By mak-
ates appropriately over the wide activity range to which it ing these measurements as well as the measurements of
is applied. The device is tested from 10 μCi (370 kBq) to a standards of known activity concentration (kilobecquerel
level higher than that routinely used in the clinic and per- per milliliter), the patient’s GFR can be estimated. The
haps as high as 1 Ci (37 GBq). The activity readings are thyroid probe consists of an NaI crystal on a stand with the
varied by starting with a sample of radioactivity of Tc-99m associated counting electronics. The patient is adminis-
at the highest value to be tested (e.g., tens of gigabequer- tered a small amount of radioactive iodine. The probe is
els). The activity readings are then varied by either allow- placed at a certain distance from the thyroid, and a count is
ing the source to radioactively decay over several days or obtained. In addition, a count is acquired of a known stan-
using a set of lead shields of varying thicknesses until a dard at the same distance. The thyroid uptake of iodine
reading close to 370 kBq is obtained. Each reading should can be estimated from these measurements.
not vary by more than 10% from the line drawn through The quality control program for both the well counter
the calculated activity values. The linearity test should be and the thyroid probe include the energy calibration, the
performed during acceptance testing, quarterly thereafter, energy resolution, the sensitivity, and the chi square test.
and after a major repair or move. For the energy calibration, the energy window is set for the
The constancy protocol tests the reproducibility of the calibration source of a particular radionuclide—for exam-
readings as compared to a decay-corrected estimate for a ple, the 662-keV peak of Cs-127. The amplifier gain is var-
reference reading obtained from the dose calibrator on a ied until the maximum count is found that corresponds
particular day. Today’s constancy reading cannot vary from with the alignment of the window with the 662-keV energy
the decay-corrected reference reading by more than 10%. peak. In addition, the counts in a series of narrow energy
The constancy test varies from accuracy in that it evaluates windows across the peak can be measured to estimate the
the precision of the readings from day to day rather than energy resolution. A standard window can be set, and the
accuracy. The constancy test should be performed on counts of a known calibration source can be counted and
every day that the device is used to assay a dose to be normalized by the number of nuclear transformations to
administered to a patient. estimate the sensitivity in counts per transformation (or
counts per second per becquerel). Finally, the chi square
Well Counter and Thyroid Probe test evaluates the operation of the counter by comparing
the uncertainty of the count to that expected from the
Two nonimaging devices are based on the scintillator, the Poisson distribution.
well counter, and the thyroid probe that are routinely used
in the nuclear medicine clinic. The well counter is used for
both radiation protection and clinical protocols. The thy- NUCLEAR MEDICINE IMAGING
roid probe can provide clinical studies with a fraction of The Patient as a Radioactive Source
the equipment costs and space requirements of the use of
nuclear imaging equipment. However, these devices also In nuclear medicine, the patient is administered a radio-
require comprehensive quality-control programs. pharmaceutical that distributes according to a specific
The well counter consists of a NaI crystal with a hole physiological or functional pathway. The patient is then
drilled into it allowing for test tubes, and other samples imaged using external radiation detectors to determine the
can be placed within the device for counting. The sample in vivo distribution and dynamics of the radiopharmaceuti-
placed in the counter is practically surrounded by the cal through which the patient’s physiology can be inferred,
detector, with a geometric efficiency in excess of 90%. providing this essential information to the patient’s doctor
Thus the well counter can measure very small amounts of to aid in diagnosis, prognosis, staging, and treatment. The
radioactivity, on the order of a kilobecquerel. The well equipment used to acquire these data will be described in
counter should not be confused with the dose calibrator, the sections ahead. Single photon emission computed
which is a gas-filled ionization chamber that can measure tomography (SPECT) and positron emission tomography
activities up to 37 GBq. The well counter is used to test for (PET) will be described in the next chapter. However,
small amounts of removable radioactivity. It is used to test before examining how the instrumentation operates, it is
packages of radiopharmaceuticals to ensure that no radio- instructive to understand the nature of the signal itself—
activity has been spilled on the outside of the package or that is, the radiation being emitted from within the patient.
leaked from the inside. The device also can be used to The radiopharmaceutical is administered to the patient
measure removable activity from working surfaces where most commonly by intravenous injection, but also in
radioactivity has been handled or from sealed sources such some cases through other injection routes, such as intraar-
as calibration sources to ensure that the radioactivity is not terial, intraperitoneal, or subdermal. In other cases, the
leaking out. radiopharmaceutical may be introduced through the gas-
The well counter can also be used for the assay of bio- trointestinal tract or through the breathing of a radioac-
logical samples for radioactivity for a variety of clinical tive gas or aerosol. After administration, the path and rate
42 Nuclear Medicine: The Requisites
Collimator
Crystal
Positioning
pulses
Position computer
X-ray or Gamma
gamma ray (X)
camera
photon oscilloscope
(Y) and
computer
memory
focused collimator to an NaI crystal and a mechanism for a prespecified energy window (e.g., within 10% of the
acquiring the counts from the patient at multiple locations photopeak energy), the event is accepted and the location
in a raster fashion and plotting the spatial distribution of of the event recorded. In this manner, the gamma camera
the counts. This device, the rectilinear scanner, provided image is constructed on an event-by-event basis, and a
nuclear medicine images of physiological function. As a single nuclear medicine image may consist of hundreds of
result the term scan, as in a thyroid or bone scan, has thousands of such events. Each component of the gamma
remained in the nuclear medicine lexicon. However, these camera will be described.
scans took a long time to acquire and did not allow for the The detection material of the gamma camera is typically
acquisition of time-sequence or dynamic studies. Still, the a single, thin large-area NaI scintillation crystal. Some
rectilinear scanner continued to be used in nuclear medi- smaller cameras rely on a 2D matrix of smaller crystals, but
cine clinics through the late 1970s. most rely on a single large crystal. In the most common
In the mid-1950s, Hal Anger developed his first proto- gamma camera designs, the NaI crystal is about 30 cm × 50
type of the gamma camera, which allowed a section of the cm in area and 9.5 mm thick. Some cameras designed for
body to be imaged without a raster scan, opening the door imaging only photons with energies below 150 keV may
for the possibility of both dynamic and physiologically have thinner crystals. Others used more commonly for
gated studies. Further developments of the technology higher-energy photons may be thicker, but the 9.5-mm
took place over the next 10 years, and the first commercial thickness provides a reasonable compromise because it
gamma camera was introduced in the mid-1960s. With fur- detects more than 85% of the photons with energies of 140
ther advances that have improved and stabilized the oper- keV or lower and stops about 28% of the 364-keV gamma
ation of the instrument, as well as the addition of rays emitted by I-131. NaI is hygroscopic and thus dam-
tomographic capability, the gamma camera remains the aged by water, It is hermetically sealed and has a transpar-
most commonly used imaging device in the nuclear medi- ent light guide on the side adjacent to the PMT array and
cine clinic. aluminum on the side closer to the collimator. The NaI
A block diagram of the gamma camera is shown in Fig- crystal is the most fragile component of the gamma cam-
ure 4-6. Gamma rays emitted from within the patient pass era, being susceptible to both physical and thermal shock.
through the holes of an absorptive collimator to reach the When the collimator is not in place, the bare NaI crystal
NaI crystal. On interaction of the gamma ray with the NaI must be treated with extreme care. In addition, the envi-
scintillating crystal, thousands of light photons are emit- ronment in the room must be controlled so that the air
ted, a portion of which are collected by an array of PMTs. temperature is maintained at a reasonable level (18-24° C)
By taking weighted sums of the PMT signals within the and is not subject to wide variations over a short period.
associated computer, the two-dimensional (2D) x and y The PMT array consists of about 60 to 100 photomulti-
location and the total energy of the detection event plier tubes that are each about 5 cm in diameter. The
deposited is estimated. If the energy deposited is within PMTs are usually hexagonal and arranged in a hexagonal
44 Nuclear Medicine: The Requisites
close-packed array to collect as many light photons as pos- inherently very insensitive, because practically all of the
sible. Although PMTs are used in practically all gamma emitted photons will be absorbed and only a very few will
cameras, some recent small camera designs are using ava- be accepted. In general, only 0.01% (i.e., 1 in 10,000) pho-
lanche photodiodes to collect the scintillation light. The tons emitted from the radioactive source will be accepted
signal from each PMT is input into the gamma camera by the collimator and incorporated into the image.
host computer. First, the sum of all of the PMT signals is The simplest form is the pinhole collimator (Fig. 4-7). It
used to estimate the energy deposited in the detection consists of a single, small hole or aperture located a set dis-
event. In addition, each PMT has a weight associated with tance (typically on the order of 20 cm) from the surface of
its position in both the x and y direction. For example, the the NaI crystal. Photons from one end of the source that
PMTs on the left side of the camera may have a low weight pass through the aperture will be detected on the opposite
and those on the right side of the camera would have a side of the detector. In addition, objects that are closer to
higher weight. For a particular detection event, if the the aperture will be magnified compared to those farther
weighted sum of the signal is low, the event would be on away. If b is the distance from the aperture to the object
the left side, and if it were high, it would be on the right and f is the distance from the aperture to the detector, the
side of the camera. However, the weighted sum as amount of magnification, M, is given by:
described is dependent not only on the position of the
event but also on the total amount of light collected, which M = f/b
is directly proportional to the energy deposited. Therefore
the sum must be normalized by the energy estimate. This
approach to determining the position of the detection
event is often referred as Anger logic, in honor of the devel-
oper of the gamma camera, Hal Anger. This leads to an
estimate of the detection event location to within 3 to 4
mm, which is referred to as the intrinsic spatial resolution
of the camera.
However, distortions can occur in images with respect to
both the energy and position estimates. Detection events
directly over PMTs lead to the collection of slightly more
light than the events between PMTs and therefore to a
slightly higher pulse height. Energy calibration notes the
shift in the pulse height spectrum as a function of position.
Subsequently, an opposite shift is applied on an event-by-
event basis, leading to improved energy resolution and
greater energy stability. In addition, there is an inherent
nonlinearity, with events being bunched over PMTs and
spread out between PMTs. Analogous to energy calibra-
tion, linearity calibration determines the spatial shift from
linearity as a function of position across the entire field of
view. Again, these shifts in both energy and position are
applied on an event-by-event basis, providing an image
that is free of linear distortion. A very-high-count unifor-
mity calibration map is acquired that characterizes the
remaining nonuniformities inherent in the gamma camera
acquisition process. These uniformity calibration maps are
used to generate uniformity corrections that are applied
during each acquisition.
Collimators
Although the NaI crystal, PMTs, and electronics can esti-
mate the location of a detection event to within 3 to 4 mm,
the directionality of the event is not known. Gamma rays
from a point source could be detected anywhere across the
field of view and the counts detected at a particular loca-
tion in the NaI crystal could have also originated from
practically anywhere within the patient. Thus collimation Figure 4-7. Pinhole collimator. The image is inverted. The image is
is required to determine the directionality of the detected magnified if the distance from the aperture to the object is smaller than
event. Because gamma rays cannot be easily focused, the distance from the aperture to the gamma camera crystal. Spatial reso-
absorptive collimation must be used—that is, all photons lution improves and sensitivity decreases as the aperture diameter
decreases. The sensitivity also decreases with the source-to-aperture dis-
not heading in the desired direction will be absorbed by tance, according to the inverse square law. In general, the pinhole colli-
the collimator and those heading in the correct direction mator provides the best spatial resolution and the lowest sensitivity of
will be allowed to pass. Therefore absorptive collimation is any collimator used in nuclear medicine.
Radiation Detection and Instrumentation 45
Magnification can be of significant value when imaging one hole to its neighboring hole. The holes are typically
small objects using a camera with a large field of view. hexagonal and arranged in a hexagonal, close-packed array
Magnification will minimize the effect of the intrinsic spa- (Fig. 4-8). A typical low-energy, parallel-hole collimator
tial resolution of the camera and thus enhance overall sys- may have hole diameters and lengths of about 1 and 20
tem resolution. The collimator spatial resolution of the mm, respectively, and septal thicknesses between holes of
pinhole, RPH, is determined by the diameter or the aper- about 0.1 mm. No magnification occurs with a parallel-hole
ture, d (typically 4-6 mm) and the distances from both the collimator. The collimator spatial resolution depends on
object and the NaI crystal to the aperture. the diameter (d) and the length (a) of the collimator holes
and the distance from the source to collimator (b).
RPH = d × (f + b)/f
RP = (d/a)(a + b)
It must be kept in mind that spatial resolution is typi-
cally characterized by the size of an imaged point source A parallel-hole collimator with either small or long holes
and thus a large value corresponds to poor resolution and a will provide the best spatial resolution (Fig. 4-8, top). Sim-
very small value indicates excellent spatial resolution. ilarly to the pinhole collimator, the spatial resolution of
A system with 1-mm spatial resolution will lead to an the parallel-hole collimator is best at the surface of the
image with greater acuity than one with 5-mm spatial reso- collimator and degrades with distance from the collimator.
lution. For this reason, the term high resolution can be The geometric sensitivity of the parallel-hole collimator
ambiguous because it may be unclear whether the system also depends on the thickness of the septa between the
referred to has very high resolution or a high R value (poor holes (t) in addition to the hole diameter and length.
resolution). Based on the earlier formula, better spatial
resolution is attained using a smaller aperture (small d GP ≈ 1/16 (d/a)2 d/(d + t)2
value) with the source as close to the pinhole aperture as
possible. In fact, all gamma camera collimators provide the The geometric sensitivity will be the highest for a collima-
best spatial resolution very close to the collimator and spa- tor with the thinnest interhole septa. On the other hand,
tial resolution will degrade as the object is moved farther the septa must be thick enough to minimize septal penetra-
from the collimator. The geometric sensitivity of the pin- tion when a photon enters one hole, traverses the septa,
hole collimator, GPH, depends on the area of the pinhole and enters the neighboring hole. The septa are typically
(πd2) compared to the squared distance of the source from designed to be as thin as possible while limiting the
the pinhole (b2). amount of septal penetration to less than 5% of photons
striking the septa. As a result, collimators designed for low-
GPH ≈ 1/16 (d/b)2 energy photons (under 200 keV) will require thinner septa
than those designed for higher energies. Converse to col-
Thus the geometric collimator sensitivity is highest with a limator spatial resolution, the best geometric sensitivity is
large aperture diameter and drops off as the inverse square attained with a collimator with either large or short holes.
of the distance from the source to the aperture—that is, it Thus, again, a trade-off occurs between spatial resolution
follows the inverse square law. A larger aperture diameter and geometric sensitivity. Because the geometric sensitiv-
leads to better geometric sensitivity but poorer spatial res- ity is proportional to (d/a)2 and the spatial resolution is pro-
olution, whereas the converse is true for a smaller aperture portional to (d/a), the geometric sensitivity of the collimator
diameter. As is true in some other instances in nuclear
medicine imaging, a trade-off occurs between sensitivity
and spatial resolution and improvement in one area may
cause degradation of another. The choice of whether to
lean toward high sensitivity or better resolution may
depend on the clinical imaging task at hand, but often a
compromise will lead to a reasonable value for both param-
eters. The pinhole collimator typically provides the best
spatial resolution and the lowest sensitivity of all of the
collimators commonly used in nuclear medicine. It is often
used when imaging small organs (e.g., the thyroid gland)
with a gamma camera with a large field of view or in special
cases when a very-high-resolution spot view image is
required, such as when trying to discern which bone in the
foot may be demonstrating increased radiopharmaceutical
uptake on a bone scan.
The multihole collimator provides substantially better
geometric sensitivity compared to the pinhole collimator,
because the object is viewed through many small holes
rather than through a single hole. The most commonly Figure 4-8. Multihole, parallel-hole collimator. The collimator shown
at the top has longer holes designed to provide higher resolution. How-
used multihole collimators consist of a very large number ever, it would also have lower sensitivity than the collimator shown at the
of parallel holes with absorptive septa between the holes bottom. Septal thickness and thus energy rating are the same for both col-
to restrict the emitted gamma rays from traversing from limators.
46 Nuclear Medicine: The Requisites
12 25
2 5
1 6 11 1 6 11
Distance from collimator (cm) Distance from collimator (cm)
Figure 4-10. System sensitivity (left) and spatial resolution (right) as a function of the source-to-collimator distance. The system spatial resolution of
all collimators degrades (increases in value) with distance. The pinhole collimator (blue) provides the best spatial resolution (lowest value) but the lowest
sensitivity that varies according to the inverse square law. The converging collimator (blue) provides very good spatial resolution with a sensitivity that
increases with distance as the source approaches the focal distance of the collimator. The high-resolution parallel-hole collimator (red) has good resolu-
tion and reasonable sensitivity. The general-purpose, parallel-hole collimator (orange) has poorer spatial resolution than the high-resolution collimator
but with a 50% increase in sensitivity. It is noted that the sensitivity of the two parallel-hole collimators do not vary with distance.
Parameter Comment
DAILY
Uniformity Flood field; intrinsic (without collimator)
or extrinsic (with collimator)
Window setting Confirm energy window setting relative to
photopeak for each radionuclide used
with each patient
WEEKLY OR MONTHLY
Spatial resolution Requires a “resolution” phantom such as
the four-quadrant bar A
Linearity check Qualitative assessment of bar pattern
linearity
ANNUALLY
System uniformity High count flood with each collimator
Multi-window For cameras with capability of imaging
registration multiple energy windows simultaneously
Count rate Vary counts using decay or absorber
performance method
Energy resolution Easiest in cameras with built in multi-
channel analyzers
System sensitivity Count rate performance per unit of
activity for each collimator
Figure 4-14. List mode data acquisition. In list mode, the (x,y) position of each detection event is determined at the highest available resolution and
stored in sequence. In addition, time markers and physiological signals (such as the timing of the R wave from the electrocardiogram trigger) are peri-
odically stored. Once the acquisition is completed, the desired matrix size, time-sequence, and physiological gate framing can be selected and a format-
ting program is run to provide the acquired data for viewing and analysis.
temporal or physiological framing rate a posteriori. Based study, a TAC can be used to evaluate both renal perfusion
on these criteria, a postacquisition program is run to format and clearance of the agent.
the data as defined. The user could then decide to refor-
mat the data to a different set of parameters. In this way, SUMMARY
list mode acquisition is very flexible because it does not
require the user to define the acquisition matrix and fram- Radiation detection and counting is the corner stone of
ing a priori. On the other hand, it typically requires more nuclear medicine. Detectors of all types—gas detectors,
computer storage and running the formatting program to scintillators, and semiconductors—are used every day in
view the data. For these reasons, matrix mode is most com- the nuclear medicine clinic. Some are used for ancillary
monly used. purposes that support the clinic, such as those used in the
Each pixel in the planar nuclear medicine image can context of radiation protection. Others are used to specifi-
be considered its own detector, and thus the total counts cally acquire biological data for a particular clinical purpose.
in a pixel is governed by Poisson statistics similar to a Most notably, the gamma camera is used to obtain images
well counter or a thyroid probe. Therefore the standard of the in vivo distribution of the administered radiopharma-
deviation of the pixel counts is simply estimated by the ceutical from which the patient’s physiology or function
square root of the pixel counts. In addition, the sum of can be inferred to further define the patient’s medical pic-
Poisson distributed values is also a Poisson distributed ture. A rigorous quality control program must be main-
value. Therefore, if a region of interest is defined on a tained for all equipment used in the nuclear medicine clinic
planar nuclear medicine image and the pixel values to ensure the integrity of the data obtained from the patient.
within that region are added, the result is also Poisson The quality control program for the gamma camera includes
distributed. Nuclear medicine studies are often quanti- acceptance testing and tests that need to be performed on a
fied by defining regions of interest (ROIs) over features routine basis. The nuclear medicine image acquired with
of interest and subsequently comparing the counts. In the gamma camera provides a snapshot of the patient’s
some cases, the counts from different views of the patient in vivo radiopharmaceutical distribution from a certain view
can be combined to provide more accurate quantitation. and at a particular point in time. These images also can be
For example, taking the geometric mean (square root of acquired as a dynamic (time-sequence) study or in conjunc-
the product of the counts) of similar regions from oppo- tion with a physiological gate such as the ECG. Regions of
site, conjugate views such as the anterior and posterior interest can be drawn about specific features to provide
views, can provide an estimate that, to first order, does regional quantitation or TACs of dynamic processes.
not depend on the depth of the activity within the body. Nuclear medicine instrumentation continues to evolve,
Theoretically, this approach works for point sources, but including the development of devices designed for a spe-
also has been shown to work reasonably well for extended cific clinical task such as breast imaging. It is expected that
sources. The counts are determined from the ROIs this development will continue in the years ahead.
drawn about each lung, right and left, on images acquired Suggested Reading
from both the anterior and posterior views of the patient.
The geometric mean of the counts in each lung is calcu- Chandra R. Nuclear Medicine Physics: The Basics. 7th ed. Philadelphia: Williams &
Wilkins; 2011.
lated, and the differential function of each lung is esti- Cherry SR, Sorenson JA, Phelps ME. Physics in Nuclear Medicine. 4th ed.
mated by dividing the counts for that lung by the sum of Philadelphia: WB Saunders; 2012.
counts for both lungs. International Atomic Energy Agency. IAEA Quality Control Atlas for Scintillation
Camera Systems. Publication 1141. Vienna, Austria: International Atomic Energy
In a dynamic study, the region of interest counts in each Agency; 2003.
frame can be plotted as a function of time. The resulting International Atomic Energy Agency. Nuclear Medicine Resources Manual.
Publication 1198. Vienna, Austria: International Atomic Energy Agency; 2006.
plot is referred to as the time activity curve (TAC). In the National Electrical Manufacturers Association. Performance Measurements of Gamma
case of relatively short-lived radionuclides, each value Cameras: NEMA NU 1-2007. Rosslyn, VA: National Electrical Manufacturers
along the plot should be decay corrected to the beginning Association; 2007.
Powsner RA, Powsner ER. Essentials of Nuclear Medicine Physics. 2nd ed. Malden,
of the acquisition or the time of radiopharmaceutical MA: Blackwell Science; 2006.
administration. In the example of a Tc-99m MAG3 renal Saha GP. Physics and Radiobiology of Nuclear Medicine. 3rd ed. New York: Springer; 2006.