PMID- 29018121

OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR - 20191227
IS - 2150-7511 (Electronic)
VI - 8
IP - 5
DP - 2017 Oct 10
TI - Dysbiosis and Its Discontents.
LID - 10.1128/mBio.01492-17 [doi]
LID - e01492-17
AB - Dysbiosis is a key term in human microbiome research, especially when
microbiome
patterns are associated with disease states. Although some questions have
been
raised about how this term is applied, its use continues undiminished in the
literature. We investigate the ways in which microbiome researchers discuss
dysbiosis and then assess the impact of different concepts of dysbiosis on
microbiome research. After an overview of the term's historical roots, we
conduct
quantitative and qualitative analyses of a large selection of contemporary
dysbiosis statements. We categorize both short definitions and longer
conceptual
statements about dysbiosis. Further analysis allows us to identify the
problematic implications of how dysbiosis is used, particularly with regard
to
causal hypotheses and normal-abnormal distinctions. We suggest that
researchers
should reflect carefully on the ways in which they discuss dysbiosis, in
order
for the field to continue to develop greater predictive scope and explanatory
depth.
CI - Copyright © 2017 Hooks and O’Malley.
FAU - Hooks, Katarzyna B
AU - Hooks KB
AUID- ORCID: 0000-0003-0687-4393
AD - Centre de Bioinformatique de Bordeaux, Centre de Génomique Fonctionnelle de
Bordeaux, University of Bordeaux, Bordeaux, France katarzyna.hooks@u-
bordeaux.fr
maureen.omalley@u-bordeaux.fr.
AD - Immunoconcept, CNRS UMR 5164, University of Bordeaux, Bordeaux, France.
FAU - O'Malley, Maureen A
AU - O'Malley MA
AD - Centre de Bioinformatique de Bordeaux, Centre de Génomique Fonctionnelle de
Bordeaux, University of Bordeaux, Bordeaux, France katarzyna.hooks@u-
bordeaux.fr
maureen.omalley@u-bordeaux.fr.
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
DEP - 20171010
TA - mBio
JT - mBio
JID - 101519231
SB - IM
MH - Biodiversity
MH - *Dysbiosis
MH - Homeostasis
MH - Humans
MH - *Microbiota
PMC - PMC5635691
OTO - NOTNLM
OT - dysbiosis
OT - homeostasis
OT - microbial diversity
OT - microbiome
OT - microbiota
EDAT- 2017/10/12 06:00
MHDA- 2018/06/05 06:00
CRDT- 2017/10/12 06:00
PHST- 2017/10/12 06:00 [entrez]
PHST- 2017/10/12 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
AID - mBio.01492-17 [pii]
AID - mBio01492-17 [pii]
AID - 10.1128/mBio.01492-17 [doi]
PST - epublish
SO - mBio. 2017 Oct 10;8(5):e01492-17. doi: 10.1128/mBio.01492-17.