An Insight in Pathophysiological Mechanism of Alzheimer’s Disease and its Management Using Plant Natural Products

Mini-Reviews in Medicinal Chemistry, 2021, 21, 35-57

Metabolic disorder in Alzheimer’s disease

Metabolic Brain Disease https://doi.org/10.1007/s11011-021-00673-z

Metabolic disorder in Alzheimer’s disease

Metabolic Brain Disease https://doi.org/10.1007/s11011-021-00673-z

Metabolic disorder in Alzheimer’s disease

Metabolic Brain Disease https://doi.org/10.1007/s11011-021-00673-z

Mechanisms Underlying Inflammation in Neurodegeneration

Cell 140, 918–934, March 19, 2010

Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer’s disease

Brain Research Bulletin 87 (2012) 144– 153

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

Frontiers in Cellular Neuroscience 2014|Volume8|Article112 | 2

Role of natural products for the treatment of Alzheimer’s disease

European Journal of Pharmacology 898 (2021) 173974

Role of natural products for the treatment of Alzheimer’s disease

European Journal of Pharmacology 898 (2021) 173974

Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer’s Disease: Mechanisms, Drug Candidates, and New Opportunities

ACS Chem. Neurosci. XXXX, XXX, XXX−XXX

 Insulin Resistance and Alzheimer’s Disease: Bioenergetic Linkages

FIGURE 1 | Hypothetical model of the bioenergetic shift in energy metabolism in Alzheimer’s disease (AD), as represented by relative contribution of glucose, ketone bodies and
other fuels to brain metabolism. Although classically associated with glucose hypometabolism, recent evidence points to an initial glucose hypermetabolic state with potential
shift towards use of alternate fuels. Insulin resistance may promote the development of AD through a variety of mechanisms, including a shift in energy metabolism. The
bioenergetic shift may also be an independent feature of AD pathology. Black: Glucose metabolism; Gray: Ketone body metabolism; Red: Other fuel metabolism.

Front. Aging Neurosci. 9:345.

Nutrition and Alzheimer Disease

Clin Geriatr Med - (2018) -–-

Brain Under Stress and Alzheimer’s Disease

Cell Mol Neurobiol DOI 10.1007/s10571-017-0521-1

Dietary intervention with edible medicinal plants and derived products for prevention of Alzheimer’s disease: A compendium of time-tested
strategy

Journal of Functional Foods 81 (2021) 104463

Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer’s Disease

Antioxidants 2021, 10, 23.

The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic
therapy

Ageing Research Reviews 67 (2021) 101271

Phytochemicals and cognitive health: Are flavonoids doing the trick?

Biomedicine & Pharmacotherapy 109 (2019) 1488–1497

Molecular mechanisms for Alzheimer’s disease: implications for neuroimaging and therapeutics

Journal of Neurochemistry, 2006, 97, 1700–1725

Phytochemicals as inhibitors of NF-B for treatment of Alzheimer’s disease

Pharmacological Research 129 (2018) 262–273

An updated review on Anti-Alzheimer’s herbal drugs

Journal of Drug Delivery & Therapeutics. 2018; 8(6):360-372

An updated review on Anti-Alzheimer’s herbal drugs

Journal of Drug Delivery & Therapeutics. 2018; 8(6):360-372

An updated review on Anti-Alzheimer’s herbal drugs

Journal of Drug Delivery & Therapeutics. 2018; 8(6):360-372

An updated review on Anti-Alzheimer’s herbal drugs

Journal of Drug Delivery & Therapeutics. 2018; 8(6):360-372

An updated review on Anti-Alzheimer’s herbal drugs

Journal of Drug Delivery & Therapeutics. 2018; 8(6):360-372

The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start?

Advanced Drug Delivery Reviews 61 (2009) 1316–1323

Nutrition and the Brain

Clin Geriatr Med 26 (2010) 89–98

A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease

Psychopharmacology (2010) 207:637–643

A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease

Psychopharmacology (2010) 207:637–643

A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease

Psychopharmacology (2010) 207:637–643

Can Nutraceuticals Prevent Alzheimer’s Disease? Potential Therapeutic Role of a Formulation Containing Shilajit and Complex B Vitamins

Archives of Medical Research 43 (2012) 699e704

Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine

Biochimica et Biophysica Acta 1822 (2012) 616–624

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

Free Radical Biology & Medicine 52 (2012) 35–45

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

Free Radical Biology & Medicine 52 (2012) 35–45

Nutrition: Review on the Possible Treatment for Alzheimer’s Disease

Journal of Alzheimer’s Disease 61 (2018) 867–883

Neuroinflammation in Alzheimer’s disease: different molecular targets and potential therapeutic agents including curcumin

Current Opinion in Pharmacology 2009, 9:434–444

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

Frontiers in Cellular Neuroscience 2014|Volume8|Article112 | 2

Phytochemicals for the prevention of AD

J. Neurochem. (2010) 112, 1415–1430

Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease

TRENDS in Pharmacological Sciences Vol.27 No.12

The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of
Alzheimer’s disease

Pharmacology, Biochemistry and Behavior 75 (2003) 675–686

Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomised, placebo controlled
trial

J Neurol Neurosurg Psychiatry 2003;74:863–866

Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomised, placebo controlled
trial

J Neurol Neurosurg Psychiatry 2003;74:863–866

Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial

Pharmacology, Biochemistry and Behavior 75 (2003) 651–659

Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomized and placebo-
controlled trial

Journal of Clinical Pharmacy and Therapeutics (2003) 28, 53–59

Systematic Review of Clinical Trials Assessing Pharmacological Properties of Salvia Species on Memory, Cognitive Impairment and Alzheimer’s
Disease

CNS Neuroscience & Therapeutics 20 (2014) 485–495

Systematic Review of Clinical Trials Assessing Pharmacological Properties of Salvia Species on Memory, Cognitive Impairment and Alzheimer’s
Disease

CNS Neuroscience & Therapeutics 20 (2014) 485–495

Systematic Review of Clinical Trials Assessing Pharmacological Properties of Salvia Species on Memory, Cognitive Impairment and Alzheimer’s
Disease

CNS Neuroscience & Therapeutics 20 (2014) 485–495

Systematic Review of Clinical Trials Assessing Pharmacological Properties of Salvia Species on Memory, Cognitive Impairment and Alzheimer’s
Disease

CNS Neuroscience & Therapeutics 20 (2014) 485–495

Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confirm the efficacy and
safety of a daily dose of 240 mg

Journal of Psychiatric Research 46 (2012) 716e723

L-Theanine and Caffeine in Combination Affect Human Cognition as Evidenced by Oscillatory alpha-Band Activity and Attention Task Performance

J. Nutr. 138: 1572S–1577S, 200.

L-Theanine and Caffeine in Combination Affect Human Cognition as Evidenced by Oscillatory alpha-Band Activity and Attention Task Performance

J. Nutr. 138: 1572S–1577S, 2008

L-Theanine and Caffeine in Combination Affect Human Cognition as Evidenced by Oscillatory alpha-Band Activity and Attention Task Performance

J. Nutr. 138: 1572S–1577S, 2008

Association of Crocus sativus with Cognitive Dysfunctions and Alzheimer’s Disease: A Systematic Review

https://biointerfaceresearch.com
Association of Crocus sativus with Cognitive Dysfunctions and Alzheimer’s Disease: A Systematic Review

https://biointerfaceresearch.com
Association of Crocus sativus with Cognitive Dysfunctions and Alzheimer’s Disease: A Systematic Review

https://biointerfaceresearch.com
Association of Crocus sativus with Cognitive Dysfunctions and Alzheimer’s Disease: A Systematic Review

https://biointerfaceresearch.com
Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Nutrients 2021, 13, 53.

Resveratrol—A boon for treating Alzheimer's disease?

Brain research reviews 52(2006) 316 – 326

Reductions in levels of the Alzheimer’s amyloid peptide after oral administration of ginsenosides

FASEB J. 20, E599–E604 (2006)

Panax Ginseng Enhances Cognitive Performance in Alzheimer Disease

Alzheimer Dis Assoc Disord 2008;22:222–226

Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

DOI https://doi.org/10.1055/a-0758-0188
Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

DOI https://doi.org/10.1055/a-0758-0188
Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

DOI https://doi.org/10.1055/a-0758-0188
Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

DOI https://doi.org/10.1055/a-0758-0188
Nutrition and Alzheimer Disease

Clin Geriatr Med - (2018) -–-

Nutrition and Alzheimer Disease

Clin Geriatr Med - (2018) -–-

Nutrition and Alzheimer Disease

Clin Geriatr Med - (2018) -–-

Nutrition and Alzheimer Disease

Clin Geriatr Med - (2018) -–-

Neuroprotective Herbs for the Management of Alzheimer’s Disease

Biomolecules 2021, 11, 543

Neuroprotective Herbs for the Management of Alzheimer’s Disease

Biomolecules 2021, 11, 543

Neuroprotective Herbs for the Management of Alzheimer’s Disease

Biomolecules 2021, 11, 543

Alzheimer - fitoterapia
• Memoria – acetilcolina.
• Memória – cafeína e teanina.
• Neuroproteção – antioxidantes, teanina.
• Neuroinflamação – polifenóis.
• Correção metabólica – resistência a insulina.
• Sinergia.
OBRIGADO