GeneMANIA report

Created on : 20 May 2022 14:18:49

Last database update : 13 August 2021 00:00:00
Application version : 3.6.0

Networks Functions
Co-expression N/A

Consolidated-Pathways-2013

MSigdb-c2-2020

Physical Interactions

NCI_Nature

WikiPathways

Pathway

Predicted

Co-localization

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Search parameters
Organism Homo sapiens (human)
Genes MTHFD2 , CEACAM1 , NOX4 , CAV1 , CRYAB , OAS2 , G0S2 , NDUFB5 ,
ECM1 , EGFR , PMF1 , IGFBP7 , CXCL11 , ADIPOQ , CFD , MTOR , FXYD1 ,
S6K , PI3K , AKT
Network Automatically selected weighting method
weighting
Networks A

Abbasi-Schild-Poulter-2019 , Abu-Odeh-Aqeilan-2014 , Achuthankutty-Mailand-

2019 , Agnelli-Neri-2007 , Agnelli-Neri-2009 , Agrawal-Sedivy-2010 , Ahn-Lee-2008 ,
Albers-Koegl-2005 , Alexander-Wang-2018 , Alexandru-Deshaies-2008 , Alizadeh-
Staudt-2000 , Alsulami-Cagney-2019 , Alter-Stephan-2011 , An-Sun-2017 , An-
Zhang-2015 , Andresen-Flores-Morales-2014 , Arbogast-Gros-2019 , Ariazi-Jordan-
2011 , Arijs-Rutgeerts-2009 , Arroyo-Aloy-2014 , Arroyo-Aloy-2015 , Asadi-
Dhanvantari-2018
B
Bahr-Bowler-2013 , Bailey-Hieter-2015 , Balgobind-den Boer-2011 , Bandyopadhyay-
Ideker-2010 , Banks-Washburn-2016 , Bantscheff-Drewes-2011 , Barnes-Colbert-
2009 , Barnes-Glass-2010 , Barr-Knapp-2009 , Barreiro-Alonso-Cerdán-2018 ,
Barretina-Singer-2010 , Barrios-Rodiles-Wrana-2005 , Baty-Brutsche-2006 , Beane-
Spira-2007 , Behrends-Harper-2010 , Behzadnia-Lührmann-2007 , Benleulmi-
Chaachoua-Jockers-2016 A , Benleulmi-Chaachoua-Jockers-2016 B , Bennett-
Harper-2010 , Benzinger-Hermeking-2005 , Berchtold-Cotman-2008 , Berggård-
James-2006 , Berkofsky-Fessler-Hilton-2009 , Bett-Hay-2013 , Beyer-Boldt-2018 ,
Bhatnagar-Attie-2014 , Bhojwani-Carroll-2006 , Bigler-Russell-2013 , Bild-Nevins-
2006 A , Bild-Nevins-2006 B , Bild-Nevins-2006 C , BIOGRID-SMALL-SCALE-
STUDIES , BIOGRID-SMALL-SCALE-STUDIES , Bishof-Seyfried-2018 ,
Bjornsdottir-O'Toole-2011 , Blader-Boothroyd-2001 , Blandin-Richard-2013 ,
Blomen-Brummelkamp-2015 , Blomen-Brummelkamp-2015 , Bogachek-Weigel-2014 ,
Boldrick-Relman-2002 , Boldt-Roepman-2016 , Bonome-Birrer-2008 , Bos-Massagué-
2009 , Botham-Schimmer-2019 , Botling-Micke-2013 , Bouwmeester-Superti-Furga-
2004 , Brady-Omary-2018 , Brajenovic-Drewes-2004 , Brehme-Superti-Furga-2009 ,
Brodmerkel-Krueger-2019 A , Brodmerkel-Krueger-2019 B , Broyl-Sonneveld-2010 ,
Brunner-Guttman-Yassky-2018 , Brunner-Guttman-Yassky-2019 , Burczynski-
Dorner-2006 , Burington-Shaughnessy-2008 , Butland-Hayden-2014 , Byron-
Humphries-2012
C
Cai-Conaway-2007 , Camargo-Brandon-2007 , Campos-Reinberg-2015 , Cao-
Chinnaiyan-2014 , Carmon-Liu-2014 , Caron-van Attikum-2019 , CELL_MAP ,

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C

Ceroi-Saas-2016 , Chang-Katzenellenbogen-2008 , Chapman-Golub-2011 , Chen-

Brown-2002 , Chen-Ge-2013 A , Chen-Ge-2013 B , Chen-Guan-2018 , Chen-Hessner-
2014 , Chen-Huang-2014 , Chen-Krogan-2018 , Chen-Yeatman-2010 , Chen-Yu-
2018 , Chen-Zhang-2013 , Chen-Zhao-2008 , Chen-Zhou-2019 , Cheng-DeCaprio-
2017 , Cheok-Evans-2003 , Chi-Reed-2018 , Chibon-Aurias-2010 , Chin-Gray-2006 ,
Chitale-Richly-2017 , Chng-Fonseca-2007 , Choi-Beutler-2019 , Choi-Busino-2018 ,
Choudhury-Michlewski-2017 , Chowdary-Mazumder-2006 , Choy-Arron-2016 ,
Christianson-Kopito-2011 , Chuang-Kipps-2012 , Clarke-Clynes-2013 , Cliff-Dockrell-
2013 , Cloutier-Coulombe-2013 , Cloutier-Coulombe-2017 , Coelho-Hearing-2015 ,
Colicelli-2010 , Colland-Gauthier-2004 , Compagno-Pasqualucci-2009 , Consolidated-
Pathways-2013 , Conte-Perez-Oliva-2018 , Cooper-Green-2015 , Corominas-
Iakoucheva-2014 , Corvol-Baranzini-2008 , Coustan-Smith-Campana-2011 , Couzens-
Gingras-2013 , Cox-Rizzino-2013 , Coyaud-Raught-2015 , Creighton-Chang-2012 ,
Crow-Cristea-2017 , Cuadras-Greenberg-2002
D
D'Alfonso-Shin-2013 , Daakour-Twizere-2016 , Dabbaghizadeh-Tanguay-2018 , Dart-
Wells-2015 , Das-Broemer-2019 , Davis-Glaunsinger-2015 , Day-Maxwell-2011 , de
Cremoux-Spyratos-2011 , de Hoog-Mann-2004 , De Jager-Oksenberg-2009 , de Sousa
E Melo-Medema-2011 , Del Rio-Martineau-2017 , Demmer-Papapanou-2008 , Den
Boer-Pieters-2009 A , Den Boer-Pieters-2009 B , den Boon-Ahlquist-2015 , Der-
Tsao-2014 , Desmedt-Sotiriou-2007 , Detweiler-Falkow-2001 , Devarajan-Ketha-
Kumar-2012 , Dhage-Schneider-2018 , Dhodapkar-Barlogie-2014 , Diner-Cristea-
2015 , Dittmer-Misteli-2014 , Dobbin-Giordano-2005 , Dombroski-Spielman-2010 ,
Douanne-Bidère-2019 , Driscoll-Munshi-2010 , Drissi-Boisvert-2015 , Drug-
interactions-2013 , Drug-interactions-2020 , Du-Krogan-2017
E
Einecke-Halloran-2010 , Elashoff-Topol-2011 A , Elashoff-Topol-2011 B , Elashoff-
Topol-2011 C , Elliott-Gyrd-Hansen-2016 , Ellis-Mardis-2012 , Emdal-Olsen-2015 ,
Enzo-Dupont-2015 , Ertych-Bastians-2016 , Ewing-Figeys-2007
F
Fang-Lin-2011 , Faust-Frankel-2018 , Feng-Cheng-2014 , Fenner-Prehn-2010 ,
Filipits-Gnant-2011 , Finak-Park-2006 , Finak-Park-2008 , Floyd-Pagliarini-2016 ,
Foerster-Ritter-2013 , Fogeron-Lange-2013 , Folkersen-Paulsson-Berne-2012 ,
Fonseca-Damgaard-2015 , Foster-Marshall-2013 , Fountzilas-Fountzilas-2013 ,
Fragoza-Yu-2019 , Freedman-Nevins-2011 , Freibaum-Taylor-2010 , Fry-Samson-
2008
G
Gabriel-Baumgrass-2016 , Gadd-Perlman-2012 , Gaedcke-Ghadimi-2010 , Gallardo-
Vara-Bernabeu-2019 , Galligan-Howley-2015 , Gao-Reinberg-2012 , Gao-Sellers-
2015 , Gao-Vaziri-2016 , Garber-Petersen-2001 , Garzia-Sonenberg-2017 , Gautier-

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G

Hall-2009 , Giannone-Liu-2010 , Gibault-Aurias-2012 , Gilmore-Washburn-2016 ,

Giurato-Tarallo-2018 , Glatter-Gstaiger-2009 , Gloeckner-Ueffing-2007 , Gobble-
Singer-2011 , Goehler-Wanker-2004 , Gordon-Krogan-2020 , Goudreault-Gingras-
2009 , Govoni-Singh-2020 , Greco-Cristea-2011 , Griffin-Glass-2009 , Grigoryev-
Salomon-2010 , Grossmann-Stelzl-2015 , Guarani-Harper-2014 , Guard-Old-2019 ,
Guardia-Laguarta-Przedborski-2019 , Guderian-Grimmler-2011 , Gupta-Pelletier-
2015 , Gysin-McMahon-2012 , Gómez-Abad-Piris-2011
H
Haferlach-Falini-2009 , Han-Bassik-2017 A , Han-Bassik-2017 B , Hanamura-
Shaughnessy-2006 , Hannenhalli-Cappola-2006 , Hanson-Clayton-2014 , Harms-
Bichakjian-2013 , Hatzis-Symmans-2011 A , Hatzis-Symmans-2011 B , Hatzis-
Symmans-2011 C , Haugen-Van Houten-2010 , Hauri-Beisel-2016 , Hauri-Gstaiger-
2013 , Havrylov-Redowicz-2009 , Havugimana-Emili-2012 , Hayes-Urbé-2012 ,
Hegde-Luini-2015 , Hegele-Stelzl-2012 A , Hegele-Stelzl-2012 B , Heidelberger-Beli-
2018 , Hein-Mann-2015 , Hendrix-Cho-2006 , Hermjakob-Apweiler-2004 , Herold-
Gökbuget-2017 A , Herold-Gökbuget-2017 B , Herr-Helleday-2015 , Hessel-Tilley-
2014 , Heuck-Barlogie-2012 , Hinze-Grom-2010 , Hirabayashi-Kiyokawa-2017 ,
Hochstenbach-van Delft-2012 , Hoffmeister-Längst-2017 , Holland-Grimbacher-
2007 , Holleman-Evans-2004 , Homminga-Meijerink-2011 , Honda-Kaneko-2010 ,
Horak-Liu-2013 , Horiuchi-Sawa-2016 , Horlbeck-Gilbert-2018 A , Horlbeck-Gilbert-
2018 B , Hosp-Selbach-2015 , Hou-Chen-2018 , Hou-Huang-2017 , Hou-Philipsen-
2010 , Hu-Woods-2019 , Hu-Yin-2019 , Huang-Perlman-2009 , Hubel-Pichlmair-
2019 , Huber-Hoelz-2017 , HUMANCYC , Hummel-Siebert-2006 , Humphries-
Humphries-2009 , Hussain-Aldaz-2018 , Hutchins-Peters-2010 , Huttlin-Gygi-2015 ,
Huttlin-Harper-2017 , Hägg-Björkegren-2009 , Hüttenhain-Krogan-2019
I
I2D-BIND-Fly2Human , I2D-BIND-Mouse2Human , I2D-BIND-Rat2Human , I2D-
BIND-Worm2Human , I2D-BIND-Yeast2Human , I2D-BioGRID-Fly2Human , I2D-
BioGRID-Mouse2Human , I2D-BioGRID-Rat2Human , I2D-BioGRID-
Worm2Human , I2D-BioGRID-Yeast2Human , I2D-Chen-Pawson-2009-PiwiScreen-
Mouse2Human , I2D-Formstecher-Daviet-2005-Embryo-Fly2Human , I2D-
Formstecher-Daviet-2005-Head-Fly2Human , I2D-Giot-Rothbert-2003-High-
Fly2Human , I2D-Giot-Rothbert-2003-Low-Fly2Human , I2D-INNATEDB-
Mouse2Human , I2D-IntAct-Fly2Human , I2D-IntAct-Mouse2Human , I2D-IntAct-
Rat2Human , I2D-IntAct-Worm2Human , I2D-IntAct-Yeast2Human , I2D-Krogan-
Greenblatt-2006-Core-Yeast2Human , I2D-Krogan-Greenblatt-2006-NonCore-
Yeast2Human , I2D-Li-Vidal-2004-CE-DATA-Worm2Human , I2D-Li-Vidal-2004-
CORE-1-Worm2Human , I2D-Li-Vidal-2004-CORE-2-Worm2Human , I2D-Li-Vidal-
2004-interolog-Worm2Human , I2D-Li-Vidal-2004-literature-Worm2Human , I2D-Li-
Vidal-2004-non-core-Worm2Human , I2D-Manual-Mouse2Human , I2D-Manual-
Rat2Human , I2D-MGI-Mouse2Human , I2D-MINT-Fly2Human , I2D-MINT-
Mouse2Human , I2D-MINT-Rat2Human , I2D-MINT-Worm2Human , I2D-MINT-
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I

Yeast2Human , I2D-MIPS-Yeast2Human , I2D-Ptacek-Snyder-2005-Yeast2Human ,

I2D-Stanyon-Finley-2004-CellCycle-Fly2Human , I2D-Tarassov-PCA-
Yeast2Human , I2D-Tewari-Vidal-2004-TGFb-Worm2Human , I2D-vonMering-
Bork-2002-High-Yeast2Human , I2D-vonMering-Bork-2002-Low-Yeast2Human ,
I2D-vonMering-Bork-2002-Medium-Yeast2Human , I2D-Wang-Orkin-2006-EScmplx-
Mouse2Human , I2D-Wang-Orkin-2006-EScmplxIP-Mouse2Human , I2D-Wang-
Orkin-2006-EScmplxlow-Mouse2Human , I2D-Yu-Vidal-2008-GoldStd-
Yeast2Human , IMID , Ingham-Pawson-2005 , Innocenti-Brown-2011 ,
INTERPRO , InterPro , Ioannidis-Flaño-2012 , IOB , Iqbal-Chan-2010 , Iradi-
Borchelt-2018 , IREF-bhf-ucl , IREF-bind , IREF-bind-translation , IREF-biogrid ,
IREF-corum , IREF-dip , IREF-hpidb , IREF-hprd , IREF-huri , IREF-innatedb ,
IREF-intact , IREF-intcomplex , IREF-matrixdb , IREF-mbinfo , IREF-mint ,
IREF-mppi , IREF-quickgo , IREF-reactome , IREF-SMALL-SCALE-STUDIES ,
IREF-SMALL-SCALE-STUDIES , IREF-spike , IREF-uniprotpp , IREF-virushost ,
Ivanochko-Arrowsmith-2019 , Iwamoto-Kato-2005 , Iwamoto-Pusztai-2011 , Iyer-
Brown-1999
J
Jabbari-Christiano-2016 , Jain-Parker-2016 , Jang-Trono-2018 , Jeronimo-
Coulombe-2007 , Jiang-de Kok-2017 , Jin-Pawson-2004 , Jirawatnotai-Sicinski-2011 ,
Johnson-Kerner-Wichterle-2015 , Johnson-Shoemaker-2003 , Jones-Libermann-2005 ,
Jones-MacBeath-2006 , Jorissen-Sieber-2008 , Jorissen-Sieber-2009 , Joshi-Cristea-
2013 , Jozwik-Carroll-2016 , Jäger-Krogan-2011 , Jézéquel-Campone-2015 , Jézéquel-
Campone-2019
K
Kabbarah-Chin-2010 , Kahle-Zoghbi-2011 , Kaiser-Aronow-2007 , Kalikstad-
Isaksson-2017 , Kaltenbach-Hughes-2007 , Kang-Shin-2015 , Kang-Willman-2010 A ,
Kang-Willman-2010 B , Kannan-Zweidler-McKay-2011 , Kao-Huang-2011 ,
Karlovich-Caulfield-2009 , Karn-Rody-2010 , Karras-Soengas-2019 , Kato-Sternberg-
2014 , Katsogiannou-Rocchi-2014 , Kawahara-Paes Leme-2017 , Kazmin-Pulendran-
2017 , Keller-Lee-2014 , Kennedy-Kolch-2020 A , Kennedy-Kolch-2020 B , Khanna-
Parnaik-2018 , Kikuchi-Sugihara-2013 , Kim-Green-2011 A , Kim-Green-2011 B ,
Kim-Major-2015 , Kim-Paik-2011 , Klein-Dugas-2009 , Kneissl-Grummt-2003 ,
Kobayashi-DeLeo-2010 , Koch-Hermeking-2007 , Kogo-Mori-2011 , Kohlmann-
Haferlach-2008 A , Kohlmann-Haferlach-2008 B , Kotlyar-Jurisica-2015 , Kristensen-
Foster-2012 , Kuehner-Speit-2013 , Kumar-Maddika-2017 , Kumar-Vertegaal-2017 ,
Kupka-Walczak-2016 , Kärblane-Sarmiento-2015 , Kırlı-Görlich-2015
L
LaBreche-Huang-2011 , Lai-Park-2014 , Lambert-Gingras-2015 , Lampert-Peter-
2018 , Landi-Jen-2008 , Lau-Ronai-2012 , Lauwerys-Houssiau-2013 , Le-Niculescu-
Niculescu-2020 , Lee-Choi-2016 , Lee-Choi-2017 , Lee-Fine-2006 , Lee-Jeong-2017 ,
Lee-Jou-2019 , Lee-Kim-2008 , Lee-MacDonald-2013 , Lee-Mayr-2019 , Lee-

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L

Songyang-2011 , Lehner-Sanderson-2004 A , Lehner-Sanderson-2004 B , Lenz-

Staudt-2008 , Lesluyes-Chibon-2016 , Leung-Jones-2014 , Leung-Miller-2017 , Levy-
Hessner-2012 A , Levy-Hessner-2012 B , Lewis-Ortel-2011 , Li-Ahuja-2014 , Li-
Bhatia-2011 , Li-Bleecker-2015 , Li-Chen-2015 , Li-Dorf-2011 A , Li-Dorf-2011 B ,
Li-Dorf-2014 , Li-Fu-2017 , Li-Han-2009 , Li-Haura-2013 , Li-Hung-2019 , Li-
Johnson-2014 , Li-Lu-2018 , Li-Wang-2010 A , Li-Wang-2010 B , Li-Wang-2016 , Li-
Zhou-2017 , Liang-Stephan-2007 , Liebelt-Vertegaal-2020 , Lim-Zoghbi-2006 , Lin-
Smith-2010 , Lipp-Guthrie-2015 , Lisowska-Kupryjańczyk-2014 , Liu-Bratslavsky-
2013 , Liu-Chen-2019 , Liu-Godbout-2011 , Liu-Hsieh-2012 , Liu-Sun-2019 , Liu-
Takahashi-2017 , Liu-Tan-2018 , Liu-Varjosalo-2018 , Liu-Wang-2012 , Liu-Xu-
2018 , Liu-Yang-2019 , Llères-Lamond-2010 , Loch-Strickler-2012 , Low-Cheah-
2017 , Low-Heck-2014 , Lu-Bohr-2017 , Lu-Chuang-2010 , Lu-Richardson-2008 , Lu-
Zhang-2013 , Lucas-Chute-2014 , Luck-Calderwood-2020 , Lugthart-Evans-2005 ,
Lum-Cristea-2018 , Luo-Elledge-2009 , Lv-Zhang-2017
M
Ma-Ellis-2017 , Maertzdorf-Kaufmann-2011 , Mak-Moffat-2010 , Malinová-
Verheggen-2017 , Mallon-McKay-2013 , Malovannaya-Qin-2010 , Malty-Babu-2017 ,
Marisa-Boige-2013 , Markson-Sanderson-2009 , Martin-Elledge-2017 , Maréchal-Zou-
2014 , Maser-DePinho-2007 , Mateescu-Mechta-Grigoriou-2011 , Matlawska-
Wasowska-Winter-2016 , Matsumoto-Nakayama-2005 , Matsuoka-Elledge-2007 ,
Matsuyama-Sugihara-2010 , McCracken-Blencowe-2005 , McFarland-Nussbaum-
2008 , McNamara-D'Orso-2016 , Meek-Piwnica-Worms-2004 , Meier-Seiler-2009 ,
Melis-Farci-2014 , Menon-Litovchick-2019 , Metzger-Filho-Sotiriou-2013 , Meyer-
Debatin-2011 , Micke-Botling-2011 , Milev-Mouland-2012 , Miller-Dixon-2007 ,
Miller-Dixon-2012 , Mills-Haferlach-2009 , Minn-Massagué-2005 , miRNA-target-
predictions-2013 , miRNA-target-predictions-2020 , Miyake-Noguchi-2012 ,
Miyamoto-Sato-Yanagawa-2010 , Moffatt-Cookson-2007 , Mohammed-Carroll-2013 ,
Moon-Kim-2014 , Moutaoufik-Babu-2019 , Mraz-Kipps-2014 , MSigdb-c2-2020 ,
Mugabo-Lim-2018 , Muller-Demeret-2012 , Mullighan-Downing-2009 , Murakawa-
Landthaler-2015
N
Naesens-Sarwal-2011 , Nagel-Meijers-Heijboer-2012 , Nair-Abecasis-2009 ,
Nakamura-Groth-2019 , Nakamura-Takeuchi-2016 , Nakayama-Hasegawa-2007 ,
Nakayama-Ohara-2002 , Napolitano-Meroni-2011 , Narayan-Bennett-2012 , Nassa-
Weisz-2019 , Nathan-Goldberg-2013 , Navarro-Beà-2017 , NCI_NATURE ,
NCI_Nature , Neganova-Lako-2011 , NetPath , Newman-Keating-2003 , Newman-
Radeke-2012 , Niculescu-White-2019 , Niu-Wang-2010 , Noble-Diehl-2008 , Noble-
Diehl-2010 , Noguchi-Kawahara-2018 , Nookaew-Carlsson-2013 , Nowak-Sommer-
2019
O
Okayama-Yokota-2012 , Oliviero-Cagney-2015 , Oliviero-Cagney-2016 , Olma-

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O

Pintard-2009 , Olmos-de Bono-2012 , Oláh-Ovádi-2011 , Ong-Howell-2009 , Ooi-

Tan-2009 , Ouyang-Gill-2009
P
Pajtler-Pfister-2015 , Panigrahi-Pati-2012 , Pankow-Yates-2015 , Panther , Pao-
Virdee-2018 , Papapanou-Demmer-2009 , Papp-Lamia-2015 , Payton-Ley-2009 ,
Pech-Settleman-2019 , Pellagatti-Boultwood-2010 , Peng-Katze-2009 , Perez-
Hernandez-Yáñez-Mó-2013 , Perez-Perri-Espinosa-2016 , Peri-Russo-2012 , Perou-
Botstein-1999 , Perou-Botstein-2000 , Persaud-Rotin-2009 A , Persaud-Rotin-2009
B , Petruzziello-Pellegrini-Marsden-2012 , Petschnigg-Stagljar-2014 , PFAM ,
Pfister-Pommier-2009 , Phatak-Kopelovich-2019 , Phillips-Corn-2013 , Pichlmair-
Superti-Furga-2011 , Pichlmair-Superti-Furga-2012 , Pilling-Cooper-2017 ,
Pladevall-Morera-Lopez-Contreras-2019 , Polak-Buitenhuis-2019 , Popovici-Pusztai-
2010 A , Popovici-Pusztai-2010 B , Postel-Vinay-Delattre-2012 , Potti-Nevins-2006 ,
Ptushkina-Ray-2017
R
Radtke-Downing-2009 , Raisner-Gascoigne-2018 , Ramachandran-LaBaer-2004 ,
Raman-Crystal-2009 , Raman-Harper-2015 , Ramaswamy-Golub-2001 , Raponi-
Beer-2006 , Raue-Trappe-2012 , Ravasi-Hayashizaki-2010 , REACTOME ,
Reactome , Reeve-Halloran-2013 , Reinke-Keating-2010 , Reinke-Keating-2013 ,
Rengasamy-Walsh-2017 , Reyniers-Taymans-2014 , Richter-Chrzanowska-
Lightowlers-2010 , Rieger-Chu-2004 , Rivera-Paes Leme-2018 , Rodriguez-von
Kriegsheim-2016 , Roewenstrunk-de la Luna-2019 , Rolland-Vidal-2014 , Rosenbluh-
Hahn-2016 , Rosenwald-Staudt-2001 , Ross-Brown-2000 , Ross-Perou-2001 , Roth-
Zlotnik-2006 , Rotunno-Landi-2011 , Rousseaux-Khochbin-2013 , Rowbotham-
Mermoud-2011 , Roy-Pardo-2014 , Roy-Parent-2013 , Rual-Vidal-2005 , Rudat-
Scholl-2018 , Rusch-Gill-2019
S
Sabatier-Bertucci-2011 A , Sabatier-Bertucci-2011 B , Saez-Vilchez-2018 , Sahni-
Vidal-2015 , Saito-Kobarg-2017 , Sala-Ampe-2017 , Salas-Chibon-2015 , Salaverria-
Siebert-2011 , Salvetti-Greco-2016 , Sang-Jackson-2011 , Sato-Conaway-2004 ,
Savidis-Brass-2016 , Savola-Vakkila-2011 , Scatolini-Chiorino-2010 , Schadt-
Shoemaker-2004 , Scherzer-Gullans-2007 , Schiza-Diamandis-2018 , Schmidt-
Gehrmann-2008 , Scholtysik-Küppers-2015 , Scholz-Taylor-2016 , Scifo-Lalowski-
2015 , Scott-Guy-2017 , Scott-Rimsza-2014 , Scott-Schulman-2016 , Sears-
Subramaniam-2009 , Seok-Tompkins-2013 , Shahmanesh-Tomlinson-2015 ,
Shalhoub-Martin-2010 , Shami Shah-Baskin-2019 , Shaykhiev-Crystal-2011 , Shea-
Musser-2010 , Shedden-Beer-2008 , Sheffer-Domany-2009 A , Sheffer-Domany-2009
B , Shen-Chen-2019 , Shen-Mali-2017 , Sherman-Teitell-2010 , Shimada-Tanaka-
2019 , Simabuco-Zanchin-2019 , Singh-Celli-2011 , Singh-Moore-2012 , Sinnaeve-
Granger-2009 , Skov-Hasselbalch-2011 , Skrzypczak-Ostrowsk-2010 , Smeets-
Christiaens-2011 , Smirnov-Cheung-2009 , Smirnov-Cheung-2012 , Smith-

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S

Beauchamp-2010 , So-Colwill-2015 , Sokolina-Stagljar-2017 , Soler-López-Aloy-2011 ,

Solimena-Marchetti-2018 A , Solimena-Marchetti-2018 B , Solimena-Marchetti-2018
C , Sorich-Evans-2008 , Sotiriou-Delorenzi-2006 , Sowa-Harper-2009 , Spira-Brody-
2007 , Srivas-Ideker-2016 , St-Denis-Gingras-2015 , St-Denis-Gingras-2016 , Stehling-
Lill-2012 , Stehling-Lill-2013 , Steidl-Gascoyne-2010 , Stelzl-Wanker-2005 , Stinson-
Dornan-2011 , Stirewalt-Radich-2008 , Stratford-Yeh-2010 , Stretch-Baracos-2013 ,
Strulovici-Barel-Crystal-2010 , Stuart-Kim-2003 , Sun-Fine-2006 , Sun-Troester-
2013 , Sundell-Ivarsson-2018 , Suter-Wanker-2013 , Suárez-Fariñas-Krueger-2012 ,
Swan-Spiller-2013 , Swayampakula-Dedhar-2017 , Symmans-Pusztai-2010 , Sørlie-
Børresen-Dale-2001
T
Tabchy-Pusztai-2010 , Tacchetti-Cavo-2014 , Taipale-Lindquist-2012 , Taipale-
Lindquist-2014 , Takahashi-Conaway-2011 , Takahashi-Sugihara-2015 , Tan-Thiery-
2014 , Tanaka-Sasaki-2015 , Tang-Wang-2019 , Tarallo-Weisz-2011 , Tarca-Zechner-
2013 , Tasaki-Takeuchi-2018 A , Tasaki-Takeuchi-2018 B , Tasaki-Takeuchi-2018
C , Taskesen-Döhner-2011 , Tateno-Hirabayashi-2013 , Taylor-Belle-2007 , Taylor-
Kwo-2008 , Teixeira-Gomes-2010 , Teixeira-Laman-2016 A , Teixeira-Laman-2016
B , Thalappilly-Dusetti-2008 , Thomas-Potter-2015 , Thompson-Luchansky-2014 ,
Thurnherr-Lee-2016 , Tian-Shaughnessy-2003 A , Tian-Shaughnessy-2003 B ,
Tiemann-Kani-2019 , Tilley-Crystal-2011 , Tilley-Crystal-2016 , Toedter-Baribaud-
2011 , Tomalin-Krueger-2020 , Tomasson-Ley-2008 , Tomida-Takahashi-2009 ,
Tomkins-Manzoni-2018 , Tong-Moran-2014 , Tothill-Bowtell-2008 A , Tothill-
Bowtell-2008 B , Toyoshima-Grandori-2012 , Transcriptional-factor-targets-2013 ,
Transcriptional-factor-targets-2020 , Trepte-Wanker-2018 A , Trepte-Wanker-2018
B , Tripathi-Beauchamp-2014 , Tsai-Cristea-2012 , Tsukamoto-Sugihara-2011
U
Ugidos-Vandenbroeck-2019
V
Vallat-Bahram-2013 , Van Acker-Dewilde-2019 , Van Alstyne-Pellizzoni-2018 , Van
Loon-Naesens-2019 , Van Quickelberghe-Gevaert-2018 , van Wijk-Timmers-2009 ,
Vandamme-Angrand-2011 , Varier-Vermeulen-2016 , Varjosalo-Gstaiger-2013 A ,
Varjosalo-Gstaiger-2013 B , Varjosalo-Superti-Furga-2013 , Vastrik-Stein-2007 ,
Venet-Textoris-2017 , Venkatesan-Vidal-2009 , Verhaak-Valk-2009 , Viita-
Vartiainen-2019 , Vinayagam-Wanker-2011 , Virok-Fülöp-2011 , Vizeacoumar-
Moffat-2013 , von Hundelshausen-Weber-2017 , Voraphani-Wenzel-2014
W
Wagner-Ashkenazi-2007 , Wallach-Kramer-2013 , Wan-Emili-2015 , Wang-Balch-
2006 , Wang-Cheung-2015 , Wang-Crystal-2010 A , Wang-Crystal-2010 B , Wang-
Crystal-2011 , Wang-Foekens-2005 , Wang-He-2008 , Wang-Huang-2017 , Wang-
Hui-2007 , Wang-Liu-2019 , Wang-Maris-2006 , Wang-McClelland-2010 A , Wang-

8 of 22
W

McClelland-2010 B , Wang-Xiong-2019 , Wang-Xu-2015 , Wang-Yang-2011 ,

Wardell-McDonnell-2012 , Warren-Tompkins-2009 , Watanabe-Fujita-2018 ,
Watanabe-Muto-2011 , Watanabe-Nagawa-2007 , Wei-Tan-2017 , Weimann-Stelzl-
2013 A , Weimann-Stelzl-2013 B , Weinmann-Meister-2009 , Weishäupl-Schmidt-
2019 , Weith-Meyer-2018 , Whisenant-Salomon-2015 , Whitfield-Botstein-2002 ,
WikiPathways , Wilkinson-Coba-2019 , Williams-DeVane-Edwards-2013 , Williams-
Gascoyne-2010 , Willingham-Muchowski-2003 , Winczura-Jensen-2018 , Winter-
Larson-2007 , Wong-Aronow-2007 , Wong-O'Bryan-2012 , Wong-Shanley-2009 A ,
Wong-Shanley-2009 B , Woodruff-Fahy-2007 , Woods-Ginsburg-2013 , Woods-
Monteiro-2012 A , Woods-Monteiro-2012 B , Woodsmith-Sanderson-2012 , Wouters-
Delwel-2009 , Wu-Garvey-2007 , Wu-Li-2007 , Wu-Ma-2012 , Wu-Stein-2010 , Wu-
Stein-2010 , Wynn-Wong-2011
X
Xiang-Weilbaecher-2015 , Xiao-Brown-2018 , Xiao-Lefkowitz-2007 , Xiao-Tompkins-
2011 , Xie-Cong-2013 , Xie-Green-2012 , Xie-Zhang-2017 , Xu-Shannon-2013 , Xu-
Ye-2012 , Xu-Zetter-2016
Y
Yachie-Roth-2016 , Yadav-Varjosalo-2017 , Yamauchi-Maeda-2018 , Yang-Brasier-
2015 , Yang-Chen-2010 , Yang-Maurer-2018 , Yang-Steele-2012 , Yang-Vidal-2016 ,
Yang-Wang-2018 , Yao-Jallal-2008 , Yao-Stagljar-2017 A , Yao-Stagljar-2017 B ,
Yatim-Benkirane-2012 , Yeung-Dougan-2019 , Yoshihara-Tanaka-2010 , Yu-Chow-
2013 , Yu-Engel-2018 , Yu-Lee-2012 , Yu-Tan-2008 , Yu-Vidal-2011 , Yue-Liu-2018
Z
Zaas-Ginsburg-2009 , Zangrando-Basso-2009 , Zanon-Pichler-2013 , Zeller-Wei-
2006 , Zhang-Cheng-2020 , Zhang-Crystal-2020 , Zhang-Foekens-2009 , Zhang-
Mullighan-2012 , Zhang-Shang-2006 , Zhang-Vermeulen-2017 , Zhang-Wang-2018 ,
Zhang-Wheeler-2014 , Zhang-Xu-2018 , Zhang-Zou-2011 , Zhao-Krug-2005 , Zhao-
Yang-2011 , Zhong-Vidal-2016 , Zhou-Conrads-2004 , Zhou-Hanemann-2016 , Zhou-
O'Keefe-2010 , Zhu-Liu-2018

9 of 22
Genes
Gene Description Rank
CEACAM1 CEA cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:1814] N/A
IGFBP7 insulin like growth factor binding protein 7 [Source:HGNC Symbol;Acc: N/A
HGNC:5476]
OAS2 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] N/A
CXCL11 C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC: N/A
10638]
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, N/A
methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:
HGNC:7434]
G0S2 G0/G1 switch 2 [Source:HGNC Symbol;Acc:HGNC:30229] N/A
ECM1 extracellular matrix protein 1 [Source:HGNC Symbol;Acc:HGNC:3153] N/A
CFD complement factor D [Source:HGNC Symbol;Acc:HGNC:2771] N/A
NOX4 NADPH oxidase 4 [Source:HGNC Symbol;Acc:HGNC:7891] N/A
PMF1 polyamine modulated factor 1 [Source:HGNC Symbol;Acc:HGNC:9112] N/A
FXYD1 FXYD domain containing ion transport regulator 1 [Source:HGNC N/A
Symbol;Acc:HGNC:4025]
ADIPOQ adiponectin, C1Q and collagen domain containing [Source:HGNC Symbol; N/A
Acc:HGNC:13633]
CRYAB crystallin alpha B [Source:HGNC Symbol;Acc:HGNC:2389] N/A
NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 [Source:HGNC Symbol; N/A
Acc:HGNC:7700]
MTOR mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc: N/A
HGNC:3942]
RPS6KB1 ribosomal protein S6 kinase B1 [Source:HGNC Symbol;Acc:HGNC:10436] N/A
CAV1 caveolin 1 [Source:HGNC Symbol;Acc:HGNC:1527] N/A
EGFR epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] N/A
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha N/A
[Source:HGNC Symbol;Acc:HGNC:8975]
AKT1 AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] N/A
PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [Source:HGNC Symbol; 1
Acc:HGNC:8979]
PTEN phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588] 2
PDPK1 3-phosphoinositide dependent protein kinase 1 [Source:HGNC Symbol; 3

10 of 22
Gene Description Rank
Acc:HGNC:8816]
PDK2 pyruvate dehydrogenase kinase 2 [Source:HGNC Symbol;Acc:HGNC: 4
8810]
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 [Source: 5
HGNC Symbol;Acc:HGNC:3288]
EIF4E eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc: 6
HGNC:3287]
RPS6 ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:10429] 7
EIF4A1 eukaryotic translation initiation factor 4A1 [Source:HGNC Symbol;Acc: 8
HGNC:3282]
PPP2CA protein phosphatase 2 catalytic subunit alpha [Source:HGNC Symbol; 9
Acc:HGNC:9299]
EIF4A2 eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc: 10
HGNC:3284]
EIF4G2 eukaryotic translation initiation factor 4 gamma 2 [Source:HGNC 11
Symbol;Acc:HGNC:3297]
EIF4G3 eukaryotic translation initiation factor 4 gamma 3 [Source:HGNC 12
Symbol;Acc:HGNC:3298]
IGF1 insulin like growth factor 1 [Source:HGNC Symbol;Acc:HGNC:5464] 13
LEP leptin [Source:HGNC Symbol;Acc:HGNC:6553] 14
IRS1 insulin receptor substrate 1 [Source:HGNC Symbol;Acc:HGNC:6125] 15
EIF4G1 eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC 16
Symbol;Acc:HGNC:3296]
TSC2 TSC complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:12363] 17
MKNK1 MAPK interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc: 18
HGNC:7110]
EIF2S1 eukaryotic translation initiation factor 2 subunit alpha [Source:HGNC 19
Symbol;Acc:HGNC:3265]
EIF2S2 eukaryotic translation initiation factor 2 subunit beta [Source:HGNC 20
Symbol;Acc:HGNC:3266]

11 of 22
Networks
Co-expression 40.30%

Chin-Gray-2006 1.76%
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Chin et al (2006). Cancer Cell
Co-expression with 485,897 interactions from GEO

Gadd-Perlman-2012 1.66%
Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's
Oncology Group Study. Gadd et al (2012). Neoplasia
Co-expression with 487,479 interactions from GEO

Miller-Dixon-2012 1.45%
Sequential changes in gene expression profiles in breast cancers during treatment with the aromatase inhibitor, letrozole. Miller et
al (2012). Pharmacogenomics J
Co-expression with 514,360 interactions from GEO

Sotiriou-Delorenzi-2006 1.45%
Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. Sotiriou et
al (2006). J Natl Cancer Inst
Co-expression with 485,464 interactions from GEO

Hatzis-Symmans-2011 C 1.31%
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. Hatzis et al
(2011). JAMA
Co-expression with 539,754 interactions from GEO

Perou-Botstein-2000 1.20%
Molecular portraits of human breast tumours. Perou et al (2000). Nature
Co-expression with 189,373 interactions from supplementary material

Kim-Paik-2011 1.16%
Estrogen receptor (ESR1) mRNA expression and benefit from tamoxifen in the treatment and prevention of estrogen receptor-
positive breast cancer. Kim et al (2011). J Clin Oncol
Co-expression with 537,001 interactions from GEO

Tabchy-Pusztai-2010 1.13%
Evaluation of a 30-gene paclitaxel, fluorouracil, doxorubicin, and cyclophosphamide chemotherapy response predictor in a
multicenter randomized trial in breast cancer. Tabchy et al (2010). Clin Cancer Res
Co-expression with 454,200 interactions from GEO

Hatzis-Symmans-2011 A 1.03%
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. Hatzis et al
(2011). JAMA
Co-expression with 521,605 interactions from GEO

Wang-McClelland-2010 B 1.00%
In silico estimates of tissue components in surgical samples based on expression profiling data. Wang et al (2010). Cancer Res
Co-expression with 489,309 interactions from GEO

Bonome-Birrer-2008 0.89%

12 of 22
Co-expression 40.30%
Bonome-Birrer-2008
A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer. Bonome et al (2008). Cancer Res
Co-expression with 506,810 interactions from GEO

Spira-Brody-2007 0.88%
Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Spira et al (2007). Nat Med
Co-expression with 509,169 interactions from GEO

Harms-Bichakjian-2013 0.84%
Distinct gene expression profiles of viral- and nonviral-associated merkel cell carcinoma revealed by transcriptome analysis. Harms
et al (2013). J Invest Dermatol
Co-expression with 667,553 interactions from GEO

Metzger-Filho-Sotiriou-2013 0.84%
Genomic grade adds prognostic value in invasive lobular carcinoma. Metzger-Filho et al (2013). Ann Oncol
Co-expression with 694,173 interactions from GEO

Compagno-Pasqualucci-2009 0.76%
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Compagno et al (2009). Nature
Co-expression with 562,647 interactions from GEO

Lauwerys-Houssiau-2013 0.75%
Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid.
Lauwerys et al (2013). Arthritis Rheum
Co-expression with 738,405 interactions from GEO

Brunner-Guttman-Yassky-2019 0.75%
Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab. Brunner et al (2019). J
Allergy Clin Immunol
Co-expression with 572,796 interactions from GEO

Honda-Kaneko-2010 0.74%
Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C. Honda et al (2010). J
Hepatol
Co-expression with 640,013 interactions from GEO

de Cremoux-Spyratos-2011 0.72%
Importance of pre-analytical steps for transcriptome and RT-qPCR analyses in the context of the phase II randomised multicentre
trial REMAGUS02 of neoadjuvant chemotherapy in breast cancer patients. de Cremoux et al (2011). BMC Cancer
Co-expression with 689,506 interactions from GEO

Lucas-Chute-2014 0.71%
A translatable predictor of human radiation exposure. Lucas et al (2014). PLoS One
Co-expression with 502,485 interactions from GEO

Bigler-Russell-2013 0.70%
Cross-study homogeneity of psoriasis gene expression in skin across a large expression range. Bigler et al (2013). PLoS One
Co-expression with 669,863 interactions from GEO

Chuang-Kipps-2012 0.68%
Subnetwork-based analysis of chronic lymphocytic leukemia identifies pathways that associate with disease progression. Chuang et
al (2012). Blood

13 of 22
Co-expression 40.30%
Chuang-Kipps-2012
Co-expression with 662,207 interactions from GEO

Coelho-Hearing-2015 0.68%
Photobiological implications of melanin photoprotection after UVB-induced tanning of human skin but not UVA-induced tanning.
Coelho et al (2015). Pigment Cell Melanoma Res
Co-expression with 594,833 interactions from GEO

Wang-Cheung-2015 0.67%
Genetic variation in insulin-induced kinase signaling. Wang et al (2015). Mol Syst Biol
Co-expression with 422,896 interactions from GEO

Liu-Godbout-2011 0.67%
Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy. Liu et
al (2011). Am J Pathol
Co-expression with 613,156 interactions from GEO

Petruzziello-Pellegrini-Marsden-2012 0.59%
The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in
humans and mice. Petruzziello-Pellegrini et al (2012). J Clin Invest
Co-expression with 373,835 interactions from GEO

Finak-Park-2006 0.58%
Gene expression signatures of morphologically normal breast tissue identify basal-like tumors. Finak et al (2006). Breast Cancer
Res
Co-expression with 607,238 interactions from GEO

Day-Maxwell-2011 0.52%
Identifier mapping performance for integrating transcriptomics and proteomics experimental results. Day et al (2011). BMC
Bioinformatics
Co-expression with 628,456 interactions from GEO

Thomas-Potter-2015 0.51%
Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin
intervention trial. Thomas et al (2015). BMC Med Genet
Co-expression with 674,033 interactions from GEO

Suárez-Fariñas-Krueger-2012 0.48%
Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis. Suárez-
Fariñas et al (2012). J Invest Dermatol
Co-expression with 713,703 interactions from GEO

Ariazi-Jordan-2011 0.48%
Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene
expression across time. Ariazi et al (2011). Proc Natl Acad Sci U S A
Co-expression with 538,637 interactions from GEO

Zhang-Foekens-2009 0.47%
The 76-gene signature defines high-risk patients that benefit from adjuvant tamoxifen therapy. Zhang et al (2009). Breast Cancer
Res Treat
Co-expression with 471,772 interactions from GEO

Iwamoto-Pusztai-2011 0.47%

14 of 22
Co-expression 40.30%
Iwamoto-Pusztai-2011
Gene pathways associated with prognosis and chemotherapy sensitivity in molecular subtypes of breast cancer. Iwamoto et al
(2011). J Natl Cancer Inst
Co-expression with 488,436 interactions from GEO

Hatzis-Symmans-2011 B 0.46%
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. Hatzis et al
(2011). JAMA
Co-expression with 494,618 interactions from GEO

Tothill-Bowtell-2008 B 0.46%
Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Tothill et al (2008). Clin Cancer
Res
Co-expression with 736,577 interactions from GEO

Dhage-Schneider-2018 0.42%
A genomic ruler to assess oncogenic transition between breast tumor and stroma. Dhage et al (2018). PLoS One
Co-expression with 710,403 interactions from GEO

Fry-Samson-2008 0.42%
Genomic predictors of interindividual differences in response to DNA damaging agents. Fry et al (2008). Genes Dev
Co-expression with 609,761 interactions from GEO

Karn-Rody-2010 0.41%
Data-driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancer. Karn et
al (2010). Breast Cancer Res Treat
Co-expression with 474,896 interactions from GEO

Nagel-Meijers-Heijboer-2012 0.41%
Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes. Nagel et al (2012). Breast
Cancer Res Treat
Co-expression with 647,260 interactions from GEO

Maser-DePinho-2007 0.39%
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Maser et al (2007). Nature
Co-expression with 288,308 interactions from GEO

Solimena-Marchetti-2018 B 0.39%
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic
signature of islets from individuals with type 2 diabetes. Solimena et al (2018). Diabetologia
Co-expression with 481,826 interactions from GEO

Wynn-Wong-2011 0.38%
The influence of developmental age on the early transcriptomic response of children with septic shock. Wynn et al (2011). Mol
Med
Co-expression with 727,546 interactions from GEO

Brodmerkel-Krueger-2019 A 0.34%
Modulation of inflammatory gene transcripts in psoriasis vulgaris: Differences between ustekinumab and etanercept. Brodmerkel
et al (2019). J Allergy Clin Immunol
Co-expression with 718,992 interactions from GEO

Perou-Botstein-1999 0.31%
15 of 22
Co-expression 40.30%
Perou-Botstein-1999
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Perou et al (1999). Proc Natl Acad
Sci U S A
Co-expression with 68,200 interactions from supplementary material

Detweiler-Falkow-2001 0.30%
Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death. Detweiler et
al (2001). Proc Natl Acad Sci U S A
Co-expression with 259,729 interactions from supplementary material

Kazmin-Pulendran-2017 0.30%
Systems analysis of protective immune responses to RTS,S malaria vaccination in humans. Kazmin et al (2017). Proc Natl Acad
Sci U S A
Co-expression with 701,690 interactions from GEO

Ellis-Mardis-2012 0.30%
Whole-genome analysis informs breast cancer response to aromatase inhibition. Ellis et al (2012). Nature
Co-expression with 642,920 interactions from GEO

Gómez-Abad-Piris-2011 0.29%
PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma. Gómez-Abad et al (2011). Blood
Co-expression with 631,630 interactions from GEO

Brunner-Guttman-Yassky-2018 0.29%
Early-onset pediatric atopic dermatitis is characterized by T_H2/T_H17/T_H22-
centered inflammation and lipid alterations. Brunner et al (2018). J Allergy Clin Immunol
Co-expression with 617,019 interactions from GEO

Li-Bhatia-2011 0.28%
Altered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and
identifies patients at risk. Li et al (2011). Cancer Cell
Co-expression with 686,475 interactions from GEO

Popovici-Pusztai-2010 A 0.26%
Effect of training-sample size and classification difficulty on the accuracy of genomic predictors. Popovici et al (2010). Breast
Cancer Res
Co-expression with 533,446 interactions from GEO

Bild-Nevins-2006 C 0.25%
Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Bild et al (2006). Nature
Co-expression with 441,617 interactions from GEO

Niculescu-White-2019 0.24%
Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs. Niculescu et al (2019). Mol Psychiatry
Co-expression with 791,707 interactions from GEO

Hochstenbach-van Delft-2012 0.23%

Global gene expression analysis in cord blood reveals gender-specific differences in response to carcinogenic exposure in utero.
Hochstenbach et al (2012). Cancer Epidemiol Biomarkers Prev
Co-expression with 332,641 interactions from GEO

Zaas-Ginsburg-2009 0.23%

16 of 22
Co-expression 40.30%
Zaas-Ginsburg-2009
Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans. Zaas et al (2009).
Cell Host Microbe
Co-expression with 490,662 interactions from GEO

Sinnaeve-Granger-2009 0.22%
Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease. Sinnaeve et al (2009). PLoS
One
Co-expression with 475,088 interactions from GEO

Clarke-Clynes-2013 0.22%
Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis. Clarke et al (2013).
Carcinogenesis
Co-expression with 675,754 interactions from GEO

Levy-Hessner-2012 A 0.22%
Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes. Levy et al (2012).
Genes Immun
Co-expression with 716,605 interactions from GEO

Yu-Tan-2008 0.21%
A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers. Yu et al
(2008). PLoS Genet
Co-expression with 486,600 interactions from GEO

Dobbin-Giordano-2005 0.20%
Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays. Dobbin et al (2005).
Clin Cancer Res
Co-expression with 452,322 interactions from GEO

Hannenhalli-Cappola-2006 0.20%
Transcriptional genomics associates FOX transcription factors with human heart failure. Hannenhalli et al (2006). Circulation
Co-expression with 488,771 interactions from GEO

Swan-Spiller-2013 0.20%
Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and
TNFα. Swan et al (2013). Gut
Co-expression with 651,164 interactions from GEO

Karlovich-Caulfield-2009 0.20%
A longitudinal study of gene expression in healthy individuals. Karlovich et al (2009). BMC Med Genomics
Co-expression with 608,990 interactions from GEO

Desmedt-Sotiriou-2007 0.19%
Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG
multicenter independent validation series. Desmedt et al (2007). Clin Cancer Res
Co-expression with 481,413 interactions from GEO

Haugen-Van Houten-2010 0.16%

Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology.
Haugen et al (2010). PLoS Genet
Co-expression with 492,620 interactions from GEO

17 of 22
Co-expression 40.30%

Tan-Thiery-2014 0.16%
Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer
patients. Tan et al (2014). EMBO Mol Med
Co-expression with 722,067 interactions from GEO

Mraz-Kipps-2014 0.15%
miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1. Mraz
et al (2014). Blood
Co-expression with 685,214 interactions from GEO

Chen-Zhao-2008 0.14%
Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. Chen et al (2008). Cancer Epidemiol
Biomarkers Prev
Co-expression with 686,182 interactions from GEO

Seok-Tompkins-2013 0.14%
Genomic responses in mouse models poorly mimic human inflammatory diseases. Seok et al (2013). Proc Natl Acad Sci U S A
Co-expression with 722,515 interactions from GEO

Peng-Katze-2009 0.13%
Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. Peng et al
(2009). BMC Genomics
Co-expression with 463,217 interactions from GEO

Iwamoto-Kato-2005 0.13%
Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as
revealed by large-scale DNA microarray analysis. Iwamoto et al (2005). Hum Mol Genet
Co-expression with 448,825 interactions from GEO

Whitfield-Botstein-2002 0.13%
Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Whitfield et al (2002). Mol
Biol Cell
Co-expression with 254,587 interactions from supplementary material

Rieger-Chu-2004 0.12%
Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Rieger et al (2004). Proc
Natl Acad Sci U S A
Co-expression with 266,879 interactions from GEO

Payton-Ley-2009 0.11%
High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. Payton et al
(2009). J Clin Invest
Co-expression with 686,114 interactions from GEO

Rotunno-Landi-2011 0.10%
A gene expression signature from peripheral whole blood for stage I lung adenocarcinoma. Rotunno et al (2011). Cancer Prev Res
(Phila)
Co-expression with 513,799 interactions from GEO

Sabatier-Bertucci-2011 A 0.10%
A gene expression signature identifies two prognostic subgroups of basal breast cancer. Sabatier et al (2011). Breast Cancer Res
Treat
Co-expression with 759,371 interactions from GEO

18 of 22
Co-expression 40.30%

Papapanou-Demmer-2009 0.09%
Subgingival bacterial colonization profiles correlate with gingival tissue gene expression. Papapanou et al (2009). BMC Microbiol
Co-expression with 774,556 interactions from GEO

Wang-Foekens-2005 0.08%
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Wang et al (2005). Lancet
Co-expression with 480,897 interactions from GEO

Watanabe-Nagawa-2007 0.08%
Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarray. Watanabe et al
(2007). Clin Cancer Res
Co-expression with 601,484 interactions from GEO

Garber-Petersen-2001 0.07%
Diversity of gene expression in adenocarcinoma of the lung. Garber et al (2001). Proc Natl Acad Sci U S A
Co-expression with 262,003 interactions from supplementary material

Agnelli-Neri-2009 0.07%
A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: an integrated genomics approach
reveals a wide gene dosage effect. Agnelli et al (2009). Genes Chromosomes Cancer
Co-expression with 498,644 interactions from GEO

Ramaswamy-Golub-2001 0.07%
Multiclass cancer diagnosis using tumor gene expression signatures. Ramaswamy et al (2001). Proc Natl Acad Sci U S A
Co-expression with 284,829 interactions from supplementary material

Li-Ahuja-2014 0.07%
Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Li et
al (2014). Oncotarget
Co-expression with 348,654 interactions from GEO

Tacchetti-Cavo-2014 0.06%
Bortezomib- and thalidomide-induced peripheral neuropathy in multiple myeloma: clinical and molecular analyses of a phase 3
study. Tacchetti et al (2014). Am J Hematol
Co-expression with 688,066 interactions from GEO

Reeve-Halloran-2013 0.06%
Molecular diagnosis of T cell-mediated rejection in human kidney transplant biopsies. Reeve et al (2013). Am J Transplant
Co-expression with 775,869 interactions from GEO

Iyer-Brown-1999 0.06%
The transcriptional program in the response of human fibroblasts to serum. Iyer et al (1999). Science
Co-expression with 137,135 interactions from supplementary material

Creighton-Chang-2012 0.06%
A gene transcription signature of obesity in breast cancer. Creighton et al (2012). Breast Cancer Res Treat
Co-expression with 467,000 interactions from GEO

Huang-Perlman-2009 0.06%
Predicting relapse in favorable histology Wilms tumor using gene expression analysis: a report from the Renal Tumor Committee
of the Children's Oncology Group. Huang et al (2009). Clin Cancer Res
Co-expression with 447,376 interactions from GEO

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Co-expression 40.30%

Barretina-Singer-2010 0.04%
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Barretina et al (2010). Nat Genet
Co-expression with 473,711 interactions from GEO

Grigoryev-Salomon-2010 0.04%
Deconvoluting post-transplant immunity: cell subset-specific mapping reveals pathways for activation and expansion of memory
T, monocytes and B cells. Grigoryev et al (2010). PLoS One
Co-expression with 745,798 interactions from GEO

D'Alfonso-Shin-2013 0.03%
BreastPRS is a gene expression assay that stratifies intermediate-risk Oncotype DX patients into high- or low-risk for disease
recurrence. D'Alfonso et al (2013). Breast Cancer Res Treat
Co-expression with 674,167 interactions from GEO

Cuadras-Greenberg-2002 0.02%
Gene expression pattern in Caco-2 cells following rotavirus infection. Cuadras et al (2002). J Virol
Co-expression with 193,609 interactions from supplementary material

Chibon-Aurias-2010 0.02%
Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature
related to genome complexity. Chibon et al (2010). Nat Med
Co-expression with 614,423 interactions from GEO

Shahmanesh-Tomlinson-2015 0.02%
Differential adipose tissue gene expression profiles in abacavir treated patients that may contribute to the understanding of
cardiovascular risk: a microarray study. Shahmanesh et al (2015). PLoS One
Co-expression with 551,517 interactions from GEO

Wong-Shanley-2009 A 0.02%
Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum.
Wong et al (2009). Crit Care Med
Co-expression with 769,440 interactions from GEO

Lisowska-Kupryjańczyk-2014 0.00%
Gene expression analysis in ovarian cancer - faults and hints from DNA microarray study. Lisowska et al (2014). Front Oncol
Co-expression with 650,324 interactions from GEO

Tateno-Hirabayashi-2013 0.00%
Podocalyxin is a glycoprotein ligand of the human pluripotent stem cell-specific probe rBC2LCN. Tateno et al (2013). Stem Cells
Transl Med
Co-expression with 536,790 interactions from GEO

Noble-Diehl-2010 0.00%
Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis. Noble et al (2010).
Inflamm Bowel Dis
Co-expression with 662,680 interactions from GEO

Consolidated-Pathways-2013 16.34%

BIOCARTA_IGF1MTOR_PATHWAY 4.86%

Signaling events mediated by ... 4.26%

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Consolidated-Pathways-2013 16.34%

BIOCARTA_EIF4_PATHWAY 3.70%

BIOCARTA_MTOR_PATHWAY 3.53%

MSigdb-c2-2020 16.34%

BIOCARTA_IGF1MTOR_PATHWAY 4.86%

PID_PTP1B_PATHWAY 4.26%

BIOCARTA_EIF4_PATHWAY 3.70%

BIOCARTA_MTOR_PATHWAY 3.53%

Physical Interactions 11.08%

Li-Fu-2017 7.16%
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies. Li et
al (2017). Nat Commun
Physical Interactions with 749 interactions from BioGRID

Petschnigg-Stagljar-2014 1.62%
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Petschnigg et
al (2014). Nat Methods
Physical Interactions with 116 interactions from iRefIndex

Kotlyar-Jurisica-2015 0.88%
In silico prediction of physical protein interactions and characterization of interactome orphans. Kotlyar et al (2015). Nat Methods
Physical Interactions with 121 interactions from BioGRID

Foerster-Ritter-2013 0.72%
Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.
Foerster et al (2013). Proteomics
Physical Interactions with 179 interactions from BioGRID

IREF-innatedb 0.43%
Physical Interactions with 2,355 interactions from iRefIndex

Vastrik-Stein-2007 0.12%
Reactome: a knowledge base of biologic pathways and processes. Vastrik et al (2007). Genome Biol
Physical Interactions with 111,926 interactions from iRefIndex

IREF-reactome 0.12%
Physical Interactions with 111,926 interactions from iRefIndex

IREF-hprd 0.02%
Physical Interactions with 33,375 interactions from iRefIndex

NCI_Nature 4.26%

SIGNALING EVENTS MEDIATED BY PTP1B 4.26%

WikiPathways 4.07%

AMP-ACTIVATED PROTEIN KINASE (AMPK) SIGNALING 4.07%

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Pathway 2.92%

REACTOME 2.81%
Pathway with 24,890 interactions from Pathway Commons

NCI_NATURE 0.10%
Pathway with 10,118 interactions from Pathway Commons

Predicted 2.92%

I2D-BioGRID-Fly2Human 2.72%
BioGRID: a general repository for interaction datasets. Stark et al (2006). Nucleic Acids Res
Predicted with 8,676 interactions from I2D

I2D-BioGRID-Mouse2Human 0.19%
BioGRID: a general repository for interaction datasets. Stark et al (2006). Nucleic Acids Res
Predicted with 10,524 interactions from I2D

Co-localization 1.77%

Chen-Huang-2014 1.47%
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Chen et al (2014). J Proteome Res
Co-localization with 559 interactions from BioGRID

Schadt-Shoemaker-2004 0.30%
A comprehensive transcript index of the human genome generated using microarrays and computational approaches. Schadt et al
(2004). Genome Biol
Co-localization with 59,920 interactions from GEO

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