Scribd Logo
Upload

Welcome to Scribd!

  • Non-Selective: Adrenergics/Sympathomimetics Direct MOA Uses SE Notes Epinephrine

    Uploaded by

    Kimberly Munsayac
    12 views5 pages
    1. Adrenergics can be direct-acting or indirect-acting. Direct-acting adrenergics include epinephrine, norepinephrine, dopamine, and isoproterenol which act on alpha and beta receptors. 2. Epinephrine, norepinephrine, and dopamine are non-selective direct adrenergics used for conditions like cardiac arrest, shock, asthma, and hemorrhage. They can cause hypertension, tachycardia, arrhythmias, and ischemia. 3. Indirect adrenergics like phenylpropanolamine work mainly by causing norepinephrine release but also have some direct agonist activity. They are used as nasal

    Original Description:

    Original Title

    ADRENERGICS:SYMPATHOMIMETICS

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    1. Adrenergics can be direct-acting or indirect-acting. Direct-acting adrenergics include epinephrine, norepinephrine, dopamine, and isoproterenol which act on alpha and beta receptors. 2. Epinephrine, norepinephrine, and dopamine are non-selective direct adrenergics used for conditions like cardiac arrest, shock, asthma, and hemorrhage. They can cause hypertension, tachycardia, arrhythmias, and ischemia. 3. Indirect adrenergics like phenylpropanolamine work mainly by causing norepinephrine release but also have some direct agonist activity. They are used as nasal

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    12 views5 pages

    Non-Selective: Adrenergics/Sympathomimetics Direct MOA Uses SE Notes Epinephrine

    Uploaded by

    Kimberly Munsayac
    1. Adrenergics can be direct-acting or indirect-acting. Direct-acting adrenergics include epinephrine, norepinephrine, dopamine, and isoproterenol which act on alpha and beta receptors. 2. Epinephrine, norepinephrine, and dopamine are non-selective direct adrenergics used for conditions like cardiac arrest, shock, asthma, and hemorrhage. They can cause hypertension, tachycardia, arrhythmias, and ischemia. 3. Indirect adrenergics like phenylpropanolamine work mainly by causing norepinephrine release but also have some direct agonist activity. They are used as nasal

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 5

    ADRENERGICS/SYMPATHOMIMETICS

    DIRECT
    NON-SELECTIVE MOA USES SE NOTES
    EPINEPHRINE A1: Cardiac HTN Inactive PO
    Vasoconstriction, Arrest
    BP Tachycardia Do not enter
    Anaphylaxi CNS
    B1:  HR, s (DOC) Ischemia
    Conduction, & Short DOA
    Contractility Asthma & Hyperglycemi
    COPD a Can cross
    B2: Placenta
    Bronchoconstrictio Hemostasis (causing
    n FETAL
    ANOXIA)
    NOREPINEPHRINE A1: Neurogenic Extreme Compensatory
    Vasoconstriction, shock vasospasm vagal reflexes
    BP tend to
    Cardiogenic Tissue overcome the
    B1:  HR, shock (last necrosis direct positive
    Conduction, & resort) chronotropic
    Contractility Excessive BP effects

    B2: A>B
    Bronchodilation Arrythmias &
    (not so much B2 infarction Inactive PO
    act)
    Reflex Do not cross
    Bradycardia CNS

    Short DOA
    DOPAMINE A1: Cardiogenic CVS Inactive PO
    Vasoconstriction, shock disturbance &
    BP Arrythmias Do not enter
    HF CNS
    B1:  HR,
    Conduction, & Short DOA
    Contractility
    Very effective
    D1: vasodilation in in renal failure
    splanchnic & renal associated w/
    BV shock
    ISOPROTERENOL Non-selective beta Asthma CVS Synthetic
    adrenergic disturbance & catecholamine
    receptors activator Arrythmias
    Not readily
    B1:  HR, taken up into
    Conduction, & nerve endings
    Contractility

    B2:
    bronchodilation
    ALPHA 1 MOA USES SE NOTES
    PHENYLEPHRINE A1: Nasal Rebound nasal Avoid
    PSEUDOEPHEDRINE Vasoconstriction, congestion Congestion - PSESUDO-
    OXYMETAZOLINE BP Rhinitis EPHEDRINE
    TETRAHYDROZOLIN Mydriatic medicamentos in 1st term
    E a
    MIDODRINE Drug- May cause
    NAPHAZOLINE induced Supine HTN, gastroschisis
    XYLOMETAZOLINE HTN stroke, MI

    Hypotensio Piloerection
    n
    Urinary
    Orthostatic retention
    HypoTN

    Spinal
    Shock
    ALPHA 2 MOA USES SE NOTES
    CLONIDINE A2:  Central HTN Sedation Taper use
    sympathetic prior to d/c to
    outflow Cancer pain Rebound HTN avoid rebound
    HTN
    Opioid Dry mouth
    Withdrawal PHENTOLA-
    MINE: tx for
    rebound HTN

    METHYLDOPA A2:  Central Pre- Sedation


    GUANFACINE sympathetic eclampsia
    GUANABENZ outflow Hemolytic
    DEXMEDETOMIDIN GHPN anemia (+)
    E sedative Coomb’s test
    TIZANIDINE (dexmetomi
    -dine)

    Muscle
    relaxant
    (tizanidine)
    APRACLONIDINE  secretion of Glaucoma Blurring of
    BRIMONIDINE aqueous humor vision
    Dry mouth

    Hyperemia

    Pruritus

    Eye
    discomfort
    BETA MOA USES SE NOTES
    BETA 1  HR & Acute HF Tachycardia
    DOBUTAMINE Contractility Arrhythmias
    Cardiogenic Tachyphylaxis
    shock HTN
    Eosinophilic
    myocarditis
    PVB
    Angina
    Dysnea
    Fever
    HA
    Nausea
    BETA 2 Bronchodilation S: DOC for Tachycardia May
    SALBUTAMOL Acute precipitate
    TERBUTALINE Asthma Tremors arrhythmias in
    ISOXUPRINE COPD and HD
    RITODRINE T,R,I: Restlessness
    Tocolysis ISOXUPRINE
    for pattern Arrythmias - used as
    labor when used vasodilator in
    excessively Reynaud’s
    Phenomenon
    Loss of & may cause
    responsiveness maternal
    (tolerance) pulmonary
    edema

    INDIRECT
    REUPATKE MOA USES SE NOTES
    INHIBITOR
    RELEASERS MOA USES SE NOTES
    PHENYLPROPANO- Act mainly by Nasal Precipitate
    LAMINE causing release of constrictor hemorrhagic
    NE but also has stroke esp. in
    direct agonist Appetite women
    activity at some suppressant
    adrenergic
    receptors

    Activates A & B
    adrenergic
    receptors in respi
    mucosa

    You might also like