ADRENERGIC ANTAGONIST

ALPHA
NON-SELECTIVE MOA USES SE NOTES
IRREVERSIBLE Blocks Pheochromocytoma Orthostatic Forms covalent
PHENOXYBEN- A1>A2 (presurgical) HypoTN bond w/ alpha
ZAMINE irreversibly receptors
Reflex
tachycardia Effects last for
several days
GI irritation

MI
REVERSIBLE Blocks Pheochromocytoma Orthostatic
PHENTOLAMINE A1>A2 (presurgical) HypoTN
TOLAZOLINE reversibly
ANTIDOTE to A1 Reflex
overdose tachycardia

Rebound HTN GI irritation

ALPHA 1 MOA USES SE NOTES
PRAZOSIN Blocks A1 BPH 1 st
dose TAMSULOSIN:
DOXAZOSIN adrenergic orthostatic Most selective
TERAZOSIN receptor HTN HypoTN for prostatic
TASULOSIN smooth muscle
SILODOSIN Reflex
ALFUZOSIN tachycardia D,T,S&A: not
indicated in
Dizziness & females for tx of
Drowsiness HTN

HA/nausea

Weakness &
Asthenia

Edema

BETA
NON- MOA USES SE NOTES
SELECTIVE
PROPANOLOL Blocks Angina Bronchospasm May mask
PINDOLOL B1&B2 prophylaxis symptoms of
TIMOLOL receptors. AV block Hypoglycemia
LABETALOL HTN in DM
CARVEDILOL Blocks HF
NADOLOL sympathetic Arrhythmias Carvedilol &
LEVOBUNOLOL effects on CNS sedation Labetalol –
METIPRANOLOL heart & BP PERFORMANCE Erectile combined A&B
CARTEOLOL Reduces renin AXIETY dysfunction blockade
release
Hyperthyroidism Propanolol –
IUGR, small
Glaucoma & Placenta &
migraine congenital
abnormalities
w/ use

Metipranolol –
used as
ophthalmic
drops
BETA 1 MOA USES SE NOTES
ATENOLOL Selectively Angina Bronchospasm May mask
BETAXOLOL Blocks B1 symptoms of
ESMOLOL receptors. HTN AV block Hypoglycemia
ACEBUTOLOL in DM
METOPROLOL Blocks HF HF
ALPRENOLOL sympathetic Esmolol –
NEBIVOLOL effects on SVT (esmolol) CNS sedation shortest half-
BISOPROLOL heart & BP & Erectile life
dysfunction Betaxolol –
used as
ophthalmic
sol’n.
Atenolol –
lowers
birthweights &
impair fetal
growth during
pregnancy
INTRINSIC SYMPATHOMIMETIC
ACTIVITY:
-partial agonist activity
-lowers BP with modest reduction in HR
-advantage in treating patients with asthma bec
these drugs are less likely to cause bronchospasm
-Acebutolol, Pindolol, Carteolol, Bopindolol,
Oxprenolol, Celiprolol, Penbutolo
BETA BLOCKERS IN DM:
-masking of premonitory symptoms of
hypoglycemia from insulin overdosage
(tachycardia, tremor, anxiety) -impaired hepatic
mobilization of glucose.