Lab-on-Chip Digital Assignment: (Due Date- 29.04.

2022)
Search for a journal papers on any latest works in MEMS/NEMS/Microfluidics/ F lexible
sensors and make a 2-3 page write-up (single column – 11 pt 1.15 spacing) in your own
words (without copy-pasting anything):

Note the following things while writing the paper:

1. It should contain the following Sections:

Title (Provide an Appropriate Title)

Abstract (Max 200 words)

1. Introduction,
2. Experiment / Materials and methods
3. Results and discussion
4. Conclusion
References (8-10 nos. minimum)
2. Use IEEE S tandard for t he ref erences and while citing them in the manuscript as
indicated in the template below: (Highlighted ones are for Journals, Conferences and online
materials)

REFERENCES
[1] G. O. Young, “Synthetic structure of industrial plastics (Book style with paper title and
editor),” in Plastics, 2nd ed. vol. 3, J. Peters, Ed. New York: McGraw-Hill, 1964, pp. 15–64.
[2] W.-K. Chen, Linear Networks and Systems (Book style). Belmont, CA: Wadsworth, 1993, pp.
123–135.
[3] H. Poor, An Introduction to Signal Detection and Estimation. New York: Springer-Verlag,
1985, ch. 4.
[4] J. U. Duncombe, “Infrared navigation—Part I: An assessment of feasibility (Periodical style),”
IEEE Trans. Electron Devices, vol. 11, pp. 34–39, 1959.
[5] S. Chen, B. Mulgrew, and P. M. Grant, “A clustering technique for digital communications
channel equalization using radial basis function networks,” IEEE Trans. Neural Networks, vol.
4, pp. 570–578, July 1993.
[6] S. P. Bingulac, “On the compatibility of adaptive controllers (Published Conference
Proceedings style),” in Proc. 4th Annu. Allerton Conf. Circuits and Systems Theory, New York,
1994, pp. 8–16.
[7] G. R. Faulhaber, “Design of service systems with priority reservation,” in Conf. Rec. 1995
IEEE Int. Conf. Communications, pp. 3–8.
[8] W. D. Doyle, “Magnetization reversal in films with biaxial anisotropy,” in 1987 Proc.
INTERMAG Conf., pp. 2.2-1–2.2-6.
[9] J. G. Kreifeldt, “An analysis of surface-detected EMG as an amplitude-modulated noise,”
presented at the 1989 Int. Conf. Medicine and Biological Engineering, Chicago, IL.
[10] J. P. Wilkinson, “Nonlinear resonant circuit devices (Patent style),” U.S. Patent 3 624 12, July
16, 1990.
[11] IEEE Criteria for Class IE Electric Systems (Standards style), IEEE Standard 308, 1969.
[12] (Basic Book/Monograph Online Sources) J. K. Author. (year, month, day). Title (edition) [Type
of medium]. Volume(issue). Available: http://www.(URL)
[13] J. Jones. (1991, May 10). Networks (2nd ed.) [Online]. Available: http://www.atm.com
[14] (Journal Online Sources style) K. Author. (year, month). Title. Journal [Type of medium].
Volume(issue), paging if given. Available: http://www.(URL)
3. Remember to always cite t he Reference p apers at appropriate places in the manuscript
while using them. Don’t f orget t o ref er t he Main pap er also. (See sample writing style for
including references at appropriate places)

4. You can also use the images from the Main paper you are following. Use Max of 2-3
figures.

5. Label every figure used and quote them appropriately in the manuscript in your own
words. Don’t copy-paste it from the figure legends in the Main paper.

6. Limit your writing to Max of 2 p ages with one additional page max for the
figures/references.

7. You can go through the following links for latest state-of –the art MEMS based work
going on around globally:

MEMS important links:

1. Microneedle: https://youtu.be/cNwVvcXLiWc

2. Pdms microfluidic ch.: https://youtu.be/RxoZhAevZVo,

https://youtu.be/lH-FCSxRvrU

3. Paper microfluidics: https://youtu.be/J5LwNGm0tbw

4. Surface mod: https://youtu.be/fMUemBZ0k5Q

5. Drop actuation: https://youtu.be/t9vGEFjMJ7o

6. Lung on a chip: https://youtu.be/52IL9gemyDw

7. Flex electronic: https://youtu.be/4oqf--GMNrA,

8. https://youtu.be/4oeFBGFzcrg

After watching the above links you can choose any current topics related to the area of
MEMS, Microfluidics, Flexible electronics, surface modifications techniques for any
biomedical applications.

Sample writing style for including references at appropriate places:

INTRODUCTION
Micro-fabrication technology has led to the realization of various BioMEMS devices [1-2] for low
cost point-of-care clinical healthcare monitoring sensors like sheer stress sensors [3-5], flow sensors
[6-7], pressure sensors [8], implantable micro-chips [9] and actuators like micromotors, microvalves
and microfluidic devices for drug delivery systems [10-12], etc. Coronary Artery Disease (CAD) is a
leading cause of premature morbidity and mortality due to plaque formation in blood vessel and is
triggered by chemical as well as mechanical interaction of the blood particles with the vessel wall.
Catheter-based MEMS flow sensor provides high spatial and temporal resolution for real-time
monitoring in the vasculature for various vascular stenotic lesions [3-5]. A polymer-based
cardiovascular shear stress sensor built on catheter for atherosclerosis diagnosis has been developed
by T. K. Hsiai et al. [3]. Present study aims at the development of MEMS based flow sensors on
flexible polymer to monitor real-time blood flow thereby determining plague formation and satisfying
sensitivity, biocompatibility, and reliability requirements. The flow sensor is based on the principle of
thermal anemometry that measures fluid velocity by accounting the amount of heat dissipated in the
fluid from an electrically heated sensing element exposed in the fluid medium. The sensing element in
the present study is a nichrome (80% Ni and 20% Cr) thin film resistor fabricated on biocompatible
and flexible elastomers like PDMS mounted around the catheter tip. PDMS is used as a substrate for
various BioMEMS devices because of its optical transparency, chemical & thermal stability, low
thermal conductivity, biocompatibility, high flexibility and ease of fabrication [1, 10, 12-13].
Initial modeling of the sensor and its response characteristics in the blood vessel is simulated using
COMSOL Multiphysics® 4.2. Nichrome thin film heater structures have been successfully fabricated
and its thermal coefficient of resistance (TCR) has been measured. Initial measurements have been
performed over fabricated sensors for flow measurement without any bending of the sensor.
…..

REFERENCES:

[1] R. Bashir, "BioMEMS: state-of-the-art in detection, opportunities and prospects," Advanced Drug
Delivery Reviews, vol. 56, pp. 1565-1586, 2004.
[2] T. James, M. Mannoor, and D. Ivanov, "BioMEMS –Advancing the Frontiers of Medicine," Sensors, vol.
8, pp. 6077-6107, 2008.
[3] T. K. Hsiai, S. K. Choi, P. K. Wong, M. H. Ing, A. Salazar, S. Hama, M. Navab, L. L. Demer, and C.-M.
Ho, "Micro Sensors: Linking Real-Time Oscillatory Shear Stress with Vascular Inflamatory Responses,"
Annals of Biomedical Engineering, vol. 32, pp. 189-201, 2004.
[4] Y. Hongyu, A. Lisong, M. Rouhanizadeh, D. Patel, E. S. Kim, and T. K. Hsiai, "Flexible Polymer Sensors
for In Vivo Intravascular Shear Stress Analysis," Journal of Microelectromechanical Systems, vol. 17, p.
1178, 2008.
[5] H. Yu, L. Ai, M. Rouhanizadeh, R. Hamilton, J. Hwang, E. Meng, E. S. Kim, and T. K. Hsiai, "Polymer-
Based Cardiovascular Shear Stress Sensors," ASME Conference Proceedings, vol. 2007, pp. 29-30, 2007.
[6] T. H. Kim and S. J. Kim, "Development of a micro-thermal flow sensor with thin-film thermocouples,"
Journal of Micromechanics and Microengineering, vol. 16, p. 2502, 2006.
[7] T. H. Kim, D.-K. Kim, and S. J. Kim, "Study of the sensitivity of a thermal flow sensor," International
Journal of Heat and Mass Transfer, vol. 52, pp. 2140-2144, 2009.
[8] L. A. Liew and V. M. Bright, "Disposable CMOS catheter-tip pressure sensor for intracranial pressure
measurement," CORD Conference Proceedings, pp. 130-135, 2000.
[9] A. Y. Chow, V. Y. Chow, K. H. Packo, J. S. Pollack, G. A. Peyman, and R. Schuchard, "The artificial
silicon retina microchip for the treatment of visionloss from retinitis pigmentosa," Archives of
Ophthalmology, vol. 122, pp. 460-469, 2004.
[10] J. C. McDonald and G. M. Whitesides, "Poly(dimethylsiloxane) as a Material for Fabricating Microfluidic
Devices," ChemInform, vol. 33, pp. 265-265, 2002.
[11] M. Focke, D. Kosse, C. Muller, H. Reinecke, R. Zengerle, and F. von Stetten, "Lab-on-a-Foil:
microfluidics on thin and flexible films," Lab on a Chip, vol. 10, pp. 1365-1386, 2010.
[12] S. K. Sia and G. M. Whitesides, "Microfluidic devices fabricated in Poly(dimethylsiloxane) for biological
studies," Electrophoresis, vol. 24, pp. 3563-3576, 2003.
[13] Y. Xia and G. M. Whitesides, "SOFT LITHOGRAPHY," Annual Review of Materials Science, vol. 28,
pp. 153-184, 1998.
List of few MEMS0LFURIOXLGLFV Journals

o Nature
o Science
o Nature – Scientific Reports
o Nature - Microsystems & Nanoengineering
o Biosensors and Bioelectronics
o Biomedical Microdevices
o Sensors and Actuators A: Physical
o Sensors and Actuators B: Chemical
o Nature Nanotechnology
o Small
o Lab on a Chip (Miniaturisation for chemistry, physics, biology, materials
science and bioengineering)
o Journal of Micromechanics and Microengineering (JMM)
o IEEE Journal of Microelectromechanical Systems (JMEMS)
o Microelectronics Journal
o Nanotechnology
o Nano Letters