BGN UROCULTURA

SENSIBILITATE
CONCENTRATIE
Antibiotic (mm)
DISC (μg)
S≥ I R<
Ampicillin 10 14 - 14
Amoxicillin-clavulanic acid 20-10 16 - 16
Ceftazidime 10 22 19-21 19
Cefuroxime iv – 30 50 19-49 19
E.Coli, Klebsiella, Proteus mirabilis
Cefuroxime oral- (infectii necomplicate) 30 19 - 19
E.Coli, Klebsiella, Proteus mirabilis
Norfloxacin(infectii necomplicate) 10 22 - 22
Gentamicin 10 17 - 17
Fosfomicina** (E. coli) 200 24 - 24
(infectii necomplicate)
Trimethoprim-sulfamethoxazole 1.25-23.75 14 11-13 11
Nitrofurantoin (E. coli) 100 11 - 11
(infectii necomplicate)

Testare suplimentara

Amikacin 30 18 - 18

Ceftazidim-avibactam 10-4 13 - 13

Ertapenem 10 25 - 25
Meropenem 10 22 16-21 16
Meropenem CMI S ≤2 4-8 R >8
Imipenem 10 22 19-21 19
Imipenem(PMP) 10 50 19-49 19
Imipenem CMI S≤2 4 R>4
Colistin CMI S≤2 - R>2
Ciprofloxacin 5 25 22-24 22
Levofloxacin 5 23 19-22 19
.
 BGN DIVERSE

SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Ampicillin 10 14 - 14
Amoxicillin-clavulanic acid 20-10 19 - 19
Ampicilina-sulbactam* 10-10 14 - 14
Piperacilina-tazobactam 30-6 20 17-19
ATU 17
Ceftazidime 10 22 19-21 19
Ceftriaxone 30 25 22-24 22
Gentamicin 10 17 - 17
Meropenem 10 22 16-21 16
Meropenem CMI S ≤2 4-8 R >8
Trimethoprim-sulfamethoxazole 1.25-23.75 14 11-13 11

Amikacin 30 18 - 18
Tobramicina 10 16 - 16
Ertapenem 10 25 - 25
Imipenem 10 22 19-21 19
Imipenem (PMP) 10 50 19-49 19
Imipenem CMI S≤2 4 R>4
Ciprofloxacin 5 25 22-24 22
Levofloxacin 5 23 19-22 19

Ceftazidim-avibactam 10-4 13 - 13

Colistin CMI S≤2 - R>2

Tigeciclina (E.coli,Citrobacter koseri ) CMI S≤0.5 - R>0.5
Tigeciclina (E.coli) 15 18 - 18
 Enterococcus spp. UROCULTURA
SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Ampicillin 2 10 8-9 8
30 Negative test: Isolates with a
Gentamicin (test for zone diameter ≥8 mm*
high-level aminoglycoside
resistance)
Positive test: Isolates with a
zone diameter <8 mm**
Nitrofurantoin (E. faecalis) 100 15 - 15
(infectii de tract urinar
necomplicate)
Ciprofloxacin (infectii de 5 15 - 15
tract urinar necomplicate)
Levofloxacin (infectii de 5 13 - 15
tract urinar necomplicate)
Testare suplimentara
(AMP–R)
Vancomicina*** 5 12 - 12
Vancomicin CMI S≤4 - R>4
Tigeciclina E. faecalis 15 20 - 20
Tigeciclina E. faecium 15 22 - 22
Linezolid 10 20 - 20
* Test pozitiv pentru rezistenta de nivel inalt la aminoglicozide.
** Test negativ pentru rezistenta de nivel inalt la aminoglicozide.
*** La testarea pentru enterococi a vancomicinei:
 se raporteaza sensibil un diametru ≥ 12 mm si cu o margina clara
 se raporteaza rezistent daca marginile sunt stearse sau apar colonii in
interior, chiar daca diametrul este ≥ 12 mm.
 Izolatele nu trebuie raportate sensibile decat dupa 24 de ore de incubare.
 Enterococcus spp. - DIVERSE

SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Ampicillin 2 10 8-9 8
Gentamicin (test for 30 Negative test: Isolates with a
high-level zone diameter ≥8 mm*
aminoglycoside Positive test: Isolates with a
resistance) zone diameter <8 mm**
Tigeciclina E. faecalis 15 20 - 20
Tigeciclina E. faecium 15 22 - 22

Testare suplimentara

Linezolid 10 20 - 20
Teicoplanin 30 16 - 16
Teicoplanin CMI S ≤2 - R >2
Vancomycin*** 5 12 - 12
Vancomicin CMI S ≤4 - R >4
* Tulpina testata este negativa pentru rezistenta de nivel inalt la aminoglicozide.
**Tulpina testata este pozitiva pentru rezistenta de nivel inalt la aminoglicozide.
*** La testarea pentru enterococi a vancomicinei:
 se raporteaza sensibil un diametru ≥ 12 mm si cu o margina clara
 se raporteaza rezistent daca marginile sunt stearse sau apar colonii in
interior, chiar daca diametrul este ≥ 12 mm.
 Izolatele nu trebuie raportate sensibile decat dupa 24 de ore de incubare.
 Pseudomonas spp.
SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Piperacillin-tazobactam 30-6 50 18-49 18
Ceftazidime 10 50 17-49 17

Ceftazidime-Avibactam 10-4 17 - 17
Imipenem 10 50 20-49 20
Meropenem 10 24 18-23 18
Levofloxacin 5 50 22-49 22
Amikacin 30 15 - 15
Tobramicina 10 18 - 18
Colistin CMI S≤2 - R>2

Acinetobacter baumannii

SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Imipenem 10 24 21-24 21
Meropenem 10 21 15-20 15
Levofloxacin 5 23 20-22 20
Amikacin 30 19 - 19
Gentamicin 10 17 - 17
Tobramycin 10 17 - 17
Trimethoprim-
1.25-23.75 14 11-13 11
sulfamethoxazole
Colistin CMI S≤2 - R>2
Stenotrophomonas maltophilia

SENSIBILITATE
CONCENTRATIE
Antibiotic (mm)
DISC (μg)
S≥ I R<
Trimethoprim-
sulfamethoxazole 1.25-23.75 50 16-49 16
 Staphylococcus spp.
SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Cefoxitin (screen)*, S. aureus and CG-negative 30 22 - 22
staphylococci other than S.epidermidis
Cefoxitin (screen)*, S. epidermidis 30 25 - 25
Moxifloxacin, S. aureus 5 25 - 25
Moxifloxacin, S.Co.Neg 5 28 - 28
Gentamicin, S. aureus 10 18 - 18
Gentamicin, S.Co.Neg 10 22 - 22
Erythromycin 15 21 18-20 18
Clindamycin** 2 22 19-21 19
tetraciclina 30 23 - 23
Rifampicin 5 26 23-25 23
Trimethoprim-sulfamethoxazole 1.25-23.75 17 14-16 14

Testare suplimentara (tulpini MRSA)

Linezolid*** 10 21 - 21
Vancomicina S. aureus CMI S≤2 - R>2
Vancomicina S.Co.Neg CMI S≤4 - R>4
Teicoplanin S. aureus CMI S≤2 - R>2
Teicoplanin S.Co.Neg CMI S≤4 - R>4
Ceftarolin ,S. aureus 5 20 - 20
Ceftarolin ,S.Co.Neg 5 20 17-19 17
Nitrofurantoin (ITU necomplicate) 100 13 - 13
Acid fusidic (! Exsudat nazal) 10 24 - 24
* Daca nu se identifica la nivel de specie stafilococii coagulaza-negativi,,tulpinile cu
diametrul la FOX > de 22 se vor raporta rezistente.
** Daca se detecteaza rezistenta inductibila la CD se raporteaza tulpina ca rezistenta
la CD si se adauga comentariul: “Tulpina testata prezinta rezistenta inductibila la CD.
Acest antibiotic poate fi folosit pentru terapia de scurta durata a infectiilor cutanate
sau a tesuturilor moi, deoarece este putin probabil ca in timpul unei astfel de terapii sa
se dezvolte rezistenta completa (integrala).”
*** Se examineaza zona de inhibitie in lumina (placa se tine ridicata catre o sursa de
lumina).
 Streptococ de grup A, B, C sau G

SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Penicillin 1 unit 18 - 18
Penicillin CMI S≤0.25 - R>0.25
#Levofloxacin 5 50 - 17
#Moxifloxacin 5 19 - 19
Erythromycin 15 21 18-20 18
Clindamycin 2 17 - 17
Minocycline 30 23 - 23
Nitrofurantoin, S. agalactiae 100 15 - 15
(infectii de tract urinar necomplicate)
Rifampicin (endocardite pe
5 21 15-20 15
proteza valvulara)
Trimethoprim-
1.25-23.75 18 15-17 15
sulfamethoxazole
TIGECICLINA
Testare suplimentara
(infectii invazive)
Teicoplanin 30 15 - 15
Teicoplanin CMI S≤2 - R>2
Vancomycin 5 13 - 13
Vancomicina CMI S≤2 - R>2
 Pentru uroculturi nu se raporteaza E.
 Trusa de baza pentru uroculturi: F, (E, CD), SXT
 Trusa de baza pentru diverse:, E, CD,SXT, MH +/- RD si VA.
 Streptococcus pneumoniae

SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Oxacillin (screen) 1 20 - *
Moxifloxacin 5 22 - 22
Rifampicin 5 22 17-21 17
Trimethoprim- 1.25-23.75 18 15-17 15
sulfamethoxazole
Erythromycin 15 22 19-21 19
Clindamycin 2 19 - 19
TETRACICLINA 30 24 - 24
Testare
suplimentara
Penicilina - CMI S≤0.06 - R>0.06
meningite
Penicilina - CMI S≤0.06 ** R>2
nonmeningite
Ceftriaxon CMI S≤0.5 R>2
Vancomicina 5 16 - 16
Linezolid 10 22 - 22
Meropenem - CMI S≤0.25 R>0.25
meningite
Meropenem - CMI S≤2 - R>2
nonmeningite
Haemophilus influenzae/parainfluenzae
SENSIBILITATE
CONCENTRATI
Antibiotic E DISC (μg)
(mm)
S≥ I R<
Benzylpenicillin 1 unit 12 - *
Ampicillin 2 18 - 18
Amoxicillin-clavulanic 2-1 50 - 15
acid !! oral
Amoxicillin-clavulanic 2-1 15 - 15
acid !! IV

Cefotaxime 5 27 - 27
Ceftriaxone 30 32 - 32
Ertapenem 10 23 - 23
Moxifloxacin 5 28 - 28
Minocycline 30 24 21-23 24
Rifampicin (for 5 18 - 18
prophylaxis only)
Trimethoprim- 1.25-23.75 23 20-22 20
sulfamethoxazole1

Testare suplimentara

Meropenem CMI ≤0.25 >1

(meningite)
Meropenem (infections CMI ≤2 - >2
other than meningitis)
Ceftriaxon CMI ≤0.125 - >0.125
 *Tuplinile cu P ≥12 se raporteaza sensibile la toate antibioticele cu structura beta-lactam din
trusa.
 Pentru tulpinile cu P <12 se efectueaza testul de detectie pentru beta-lactamaze.
 Cand testul este negativ este prezent un alt mecanism de rezistenta decat cel de producere de
beta-lactamaza. Se testeaza si se raporteaza individual sensibilitatea la antibioticele cu
structura beta-lactam.
 Cand testul este pozitiv AMP si AMX se raporteaza rezistente. Pentru celelalte antibiotice
beta-lactam se testeaza individual sensibilitatea.
 Moraxella catarrhalis
SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Amoxicillin-clavulanic 2-1 19 - 19
acid
Cefotaxime 5 20 17-19 17
Ceftriaxone 30 24 21-23 21
Meropenem 10 33 - 33
Moxifloxacin 5 26 - 26
Erythromycin 15 23 20-22 20
tetracycline 30 25 - 25
Trimethoprim- 1.25-23.75 18 15-17 15
sulfamethoxazole

Listeria monocytogenes
SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Benzylpenicillin 1 unit 13 - 13
Ampicillin 2 16 - 16
Meropenem 10 26 - 26
Erythromycin 15 25 - 25
Trimethoprim- 1.25-23.75 29 - 29
sulfamethoxazole
 Corynebacterium spp. except Corynebacterium
diphtheriae
SENSIBILITATE
CONCENTRATIE
Antibiotic DISC (μg)
(mm)
S≥ I R<
Penicillin 1 unit 29 - 29
Moxifloxacin 5 25 - 25
Vancomycin 5 17 - 17
Clindamycin 2 20 - 20
Tetracycline 30 24 - 24
Linezolid 10 25 - 25
Rifampicin 5 30 25-29 25

Viridans group streptococci

CONCENTRATIE
SENSIBILITATE
Penicillins DISC (μg)
(mm)
S≥ I R<
Benzylpenicillin 1 unit 18 12-17 12
Benzylpenicillin (screen) 1 unit 18 - NoteA
Benzylpenicillin CMI < 0,25 >2
Ampicillin 2 21 15-20 15

CONCENTRATIE
SENSIBILITATE
Cephalosporins DISC (μg)
(mm)
S≥ I R<
Cefotaxime 5 23 - 23
Ceftriaxone 30 27 - 27

CONCENTRATIE
SENSIBILITATE
Glycopeptides DISC (μg)
(mm)
S≥ I R<
Teicoplanin 30 16 - 16
Vancomycin 5 15 - 15

Macrolides, lincosamides CONCENTRATIE

SENSIBILITATE
(mm)
and streptogramins DISC (μg)
S≥ I R<
Clindamycin 2 19 - 19

*<18mm – raporteaza sensib la Ampicilina