Doxycycline hyclate

Catalog Number D9891

Storage Temperature 2–8 C

Synonym: Doxycycline hydrochloride hemiethanolate Preparation Instructions

hemihydrate This product is soluble in water (50 mg/ml), yielding a
clear, yellow-green solution. Mild warming may be
Product Description required to fully dissolve the material.
Molecular Formula:
C22H24N2O8  HCl  0.5H2O  0.5C2H6O This product is also reported to be soluble in methanol,
Molecular Weight: 512.94 sparingly soluble in ethanol, and insoluble in chloroform
pKa: 3.5, 7.7, 9.5 (20 C)
1
or ether.
Melting Point: 201 C
max: 351 nm, 267 nm Storage/Stability
mM
Extinction Coefficient: E = 13.2 (351 nm), 17.4 Solutions in sodium chloride or glucose should be used
(267 nm) (10 mM HCl in methanol) within 48 hours of preparation and protected from direct
sunlight. Solutions should be stored at 2–8 C.
2 3
Specific Rotation: –110 (10 mg/ml, 10 mM HCl in
methanol)
References
Doxycycline is a relative of tetracycline often used in 1. Clarke 's Isolation and Identification of Drugs, 2nd
culture at a concentration of 0.1–12 g/ml. Ed., p. 575.
2. The Merck Index, 10th ed., Entry# 3436
Precautions and Disclaimer 3. Martindale The Extra Pharmacopoeia, 30th ed, 160
For R&D use only. Not for drug, household, or other (1993).
uses. Please consult the Safety Data Sheet for
information regarding hazards and safe handling SS,MWM,RLG,NSB,MAM 05/19-1
practices.

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