DD Solver Sirup Simplex

DDSolver 1.
0 Dissolution Data Modeling of Zero-order Model
Time Unit min Analyst user

Model Zero-order Date 2021-9-8
Equation F=k0*t Time 16:39:02
Time No.1
(min) F(%) Mean SD RSD(%)
0 082 082
5 057 057
10 068 068
15 082 082
30 086 086
45 078 078
60 212 212
Time No.1
(min) F(%)_Pre Mean SD RSD(%)
0 000 000
5 015 015
10 031 031
15 046 046
30 092 092
45 137 137
60 183 183
Best-fit Values
Parameter No.1 Mean SD RSD(%)
k0 0,003 0,003
Secondary Parameter
T25 0,008 0,008
T50 0,016 0,016
T75 0,025 0,025
T80 0,026 0,026
T90 0,029 0,029
Goodness of Fit
Parameter No.1
N_observed 7
DF 6
R_obs-pre 00,001
Rsqr 00,000
Rsqr_adj 00,000
MSE 02,573
MSE_root 00,051
Weighting 1
SS 15,436
WSS 15,436
AIC 00,070
MSC 00,000
No.1
250
Observed
No.1
250
Observed
200
Predicted
Fraction dissolved (%)
150
100
50
0
0 10 20 30 40 50 60 70
Time (min)
Mean
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (min)
Predicted Data
Time No.1
0 000 000
1.2 004 004
2.4 007 007
3.6 011 011
4.8 015 015
6 018 018
7.2 022 022
8.4 026 026
9.6 029 029
10.8 033 033
12 037 037
13.2 040 040
14.4 044 044
15.6 048 048
16.8 051 051
18 055 055
19.2 059 059
20.4 062 062
21.6 066 066
22.8 070 070
24 073 073
25.2 077 077
26.4 081 081
27.6 084 084
28.8 088 088
30 092 092
31.2 095 095
32.4 099 099
33.6 103 103
34.8 106 106
36 110 110
37.2 114 114
38.4 117 117
39.6 121 121
40.8 125 125
42 128 128
43.2 132 132
44.4 136 136
45.6 139 139
46.8 143 143
48 147 147
49.2 150 150
50.4 154 154
51.6 158 158
52.8 161 161
54 165 165
55.2 169 169
56.4 172 172
57.6 176 176
58.8 180 180
60 183 183
DDSolver 1.0 Dissolution Data Modeling of First-order Model

Model First-order Date 2021-9-8
Equation F=100*[1-Exp(-k1*t)] Time 16:40:10
Time No.1
0 082 082
5 057 057
10 068 068
15 082 082
30 086 086
45 078 078
60 212 212
Time No.1
0 000 000
5 032 032
10 054 054
15 069 069
30 090 090
45 097 097
60 099 099
Best-fit Values
k1 0,000 0,000
Secondary Parameter
T25 0,004 0,004
T50 0,009 0,009
T75 0,018 0,018
T80 0,021 0,021
T90 0,030 0,030
Goodness of Fit
Parameter No.1
N_observed 7
DF 6
R_obs-pre 00,000
Rsqr 00,000
Rsqr_adj 00,000
MSE 03,455
MSE_root 00,059
Weighting 1
SS 20,733
WSS 20,733
AIC 00,072
MSC -00,001
No.1
250
Observed
No.1
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (min)
Mean
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (min)
Predicted Data
Time No.1
0 000 000
1.2 009 009
2.4 017 017
3.6 024 024
4.8 031 031
6 037 037
7.2 043 043
8.4 048 048
9.6 052 052
10.8 057 057
12 060 060
13.2 064 064
14.4 067 067
15.6 070 070
16.8 073 073
18 075 075
19.2 077 077
20.4 079 079
21.6 081 081
22.8 083 083
24 084 084
25.2 086 086
26.4 087 087
27.6 088 088
28.8 089 089
30 090 090
31.2 091 091
32.4 092 092
33.6 093 093
34.8 093 093
36 094 094
37.2 094 094
38.4 095 095
39.6 095 095
40.8 096 096
42 096 096
43.2 096 096
44.4 097 097
45.6 097 097
46.8 097 097
48 098 098
49.2 098 098
50.4 098 098
51.6 098 098
52.8 098 098
54 098 098
55.2 099 099
56.4 099 099
57.6 099 099
58.8 099 099
60 099 099
DDSolver 1.0 Dissolution Data Modeling of Higuchi Model

Model Higuchi Date 2021-9-8
Equation F=kH*t^0.5 Time 16:40:31
Time No.1
0 082 082
5 057 057
10 068 068
15 082 082
30 086 086
45 078 078
60 212 212
Time No.1
0 000 000
5 045 045
10 063 063
15 077 077
30 109 109
45 134 134
60 155 155
Best-fit Values
kH 0,020 0,020
Secondary Parameter
T25 0,002 0,002
T50 0,006 0,006
T75 0,014 0,014
T80 0,016 0,016
T90 0,020 0,020
Goodness of Fit
Parameter No.1
N_observed 7
DF 6
R_obs-pre 00,001
Rsqr 00,000
Rsqr_adj 00,000
MSE 02,298
MSE_root 00,048
Weighting 1
SS 13,789
WSS 13,789
AIC 00,069
MSC 00,000
No.1
250
Observed
No.1
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (min)
Mean
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (min)
Predicted Data
Time No.1
0 000 000
1.2 022 022
2.4 031 031
3.6 038 038
4.8 044 044
6 049 049
7.2 054 054
8.4 058 058
9.6 062 062
10.8 066 066
12 069 069
13.2 073 073
14.4 076 076
15.6 079 079
16.8 082 082
18 085 085
19.2 087 087
20.4 090 090
21.6 093 093
22.8 095 095
24 098 098
25.2 100 100
26.4 103 103
27.6 105 105
28.8 107 107
30 109 109
31.2 111 111
32.4 114 114
33.6 116 116
34.8 118 118
36 120 120
37.2 122 122
38.4 124 124
39.6 126 126
40.8 127 127
42 129 129
43.2 131 131
44.4 133 133
45.6 135 135
46.8 137 137
48 138 138
49.2 140 140
50.4 142 142
51.6 143 143
52.8 145 145
54 147 147
55.2 148 148
56.4 150 150
57.6 151 151
58.8 153 153
60 155 155
DDSolver 1.0 Dissolution Data Modeling of Korsmeyer-Peppas Model

Model Korsmeyer-Peppas Date 2021-9-8
Equation F=kKP*t^n Time 16:41:01
Time No.1
0 082 082
5 057 057
10 068 068
15 082 082
30 086 086
45 078 078
60 212 212
Time No.1
0 000 000
5 069 069
10 082 082
15 091 091
30 107 107
45 118 118
60 127 127
Best-fit Values
kKP 0,047 0,047
n 0,000 0,000
Secondary Parameter
T25 0,000 0,000
T50 0,001 0,001
T75 0,007 0,007
T80 0,009 0,009
T90 0,015 0,015
Goodness of Fit
Parameter No.1
N_observed 7
DF 5
R_obs-pre 00,000
Rsqr 00,000
Rsqr_adj 00,000
MSE 03,273
MSE_root 00,057
Weighting 1
SS 16,366
WSS 16,366
AIC 00,072
MSC -00,001
No.1
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (min)
Mean
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (min)
Predicted Data
Time No.1
0 000 000
1.2 049 049
2.4 058 058
3.6 064 064
4.8 068 068
6 072 072
7.2 076 076
8.4 079 079
9.6 081 081
10.8 084 084
12 086 086
13.2 088 088
14.4 090 090
15.6 091 091
16.8 093 093
18 095 095
19.2 096 096
20.4 098 098
21.6 099 099
22.8 100 100
24 102 102
25.2 103 103
26.4 104 104
27.6 105 105
28.8 106 106
30 107 107
31.2 108 108
32.4 109 109
33.6 110 110
34.8 111 111
36 112 112
37.2 113 113
38.4 114 114
39.6 115 115
40.8 116 116
42 116 116
43.2 117 117
44.4 118 118
45.6 119 119
46.8 120 120
48 120 120
49.2 121 121
50.4 122 122
51.6 122 122
52.8 123 123
54 124 124
55.2 125 125
56.4 125 125
57.6 126 126
58.8 126 126
60 127 127
DDSolver 1.0 Dissolution Data Modeling of Hixson-Crowell Model
Time Unit h Analyst user

Model Hixson-Crowell Date 2021-9-8
Equation F=100*[1-(1-kHC*t)^3] Time 16:42:06
Time No.1
(h) F(%) Mean SD RSD(%)
0 082 082
5 057 057
10 068 068
15 082 082
30 086 086
45 078 078
60 212 212
Time No.1
(h) F(%)_Pre Mean SD RSD(%)
0 000 000
5 027 027
10 048 048
15 065 065
30 093 093
45 100 100
60 101 101
Best-fit Values
kHC 0,000 0,000
Secondary Parameter
T25 0,005 0,005
T50 0,010 0,010
T75 0,019 0,019
T80 0,021 0,021
T90 0,027 0,027
Goodness of Fit
Parameter No.1
N_observed 7
DF 6
R_obs-pre 00,000
Rsqr 00,000
Rsqr_adj 00,000
MSE 03,515
MSE_root 00,059
Weighting 1
SS 21,087
WSS 21,087
AIC 00,072
MSC -00,001
No.1
250
Observed
No.1
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (h)
Mean
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (h)
Predicted Data
Time No.1
0 000 000
1.2 007 007
2.4 014 014
3.6 020 020
4.8 026 026
6 032 032
7.2 037 037
8.4 042 042
9.6 047 047
10.8 051 051
12 056 056
13.2 060 060
14.4 063 063
15.6 067 067
16.8 070 070
18 073 073
19.2 076 076
20.4 079 079
21.6 081 081
22.8 083 083
24 086 086
25.2 087 087
26.4 089 089
27.6 091 091
28.8 092 092
30 093 093
31.2 094 094
32.4 095 095
33.6 096 096
34.8 097 097
36 098 098
37.2 098 098
38.4 099 099
39.6 099 099
40.8 099 099
42 100 100
43.2 100 100
44.4 100 100
45.6 100 100
46.8 100 100
48 100 100
49.2 100 100
50.4 100 100
51.6 100 100
52.8 100 100
54 100 100
55.2 100 100
56.4 100 100
57.6 100 100
58.8 100 100
60 101 101
DDSolver 1.0 Dissolution Data Modeling of Hopfenberg Model
Time Unit h Analyst user

Model Hopfenberg Date 2021-9-8
Equation F=100*[1-(1-kHB*t)^n] Time 16:42:47
Time No.1
(h) F(%) Mean SD RSD(%)
0 082 082
5 057 057
10 068 068
15 082 082
30 086 086
45 078 078
60 212 212
Time No.1
0 000 000
5 027 027
10 048 048
15 065 065
30 093 093
45 100 100
60 100 100
Best-fit Values
kHB 0,000 0,000
n 0,003 0,003
Secondary Parameter
T25 0,005 0,005
T50 0,010 0,010
T75 0,019 0,019
T80 0,021 0,021
T90 0,027 0,027
Goodness of Fit
Parameter No.1
N_observed 7
DF 5
R_obs-pre 00,000
Rsqr 00,000
Rsqr_adj -00,001
MSE 04,247
MSE_root 00,065
Weighting 1
SS 21,233
WSS 21,233
AIC 00,074
MSC -00,001
No.1
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (h)
Mean
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (h)
Predicted Data
Time No.1
0 000 000
1.2 007 007
2.4 014 014
3.6 020 020
4.8 026 026
6 032 032
7.2 037 037
8.4 042 042
9.6 047 047
10.8 051 051
12 056 056
13.2 060 060
14.4 063 063
15.6 067 067
16.8 070 070
18 073 073
19.2 076 076
20.4 079 079
21.6 081 081
22.8 083 083
24 086 086
25.2 087 087
26.4 089 089
27.6 091 091
28.8 092 092
30 093 093
31.2 094 094
32.4 095 095
33.6 096 096
34.8 097 097
36 098 098
37.2 098 098
38.4 099 099
39.6 099 099
40.8 099 099
42 100 100
43.2 100 100
44.4 100 100
45.6 100 100
46.8 100 100
48 100 100
49.2 100 100
50.4 100 100
51.6 100 100
52.8 100 100
54 100 100
55.2 100 100
56.4 100 100
57.6 100 100
58.8 100 100
60 100 100
DDSolver 1.0 Dissolution Data Modeling of Baker-Lonsdale Model

Model Baker-Lonsdale Date 2021-9-8
Equation 3/2*[1-(1-F/100)^(2/3)]-F/100=kBL*t Time 16:43:15
Time No.1
0 082 082
5 057 057
10 068 068
15 082 082
30 086 086
45 078 078
60 212 212
Time No.1
0 000 000
5 031 031
10 042 042
15 050 050
30 066 066
45 077 077
60 084 084
Best-fit Values
kBL 0,000 0,000
Secondary Parameter
T25 0,003 0,003
T50 0,015 0,015
T75 0,042 0,042
T80 0,051 0,051
T90 0,075 0,075
Goodness of Fit
Parameter No.1
N_observed 7
DF 6
R_obs-pre 00,001
Rsqr -00,001
Rsqr_adj -00,001
MSE 04,269
MSE_root 00,065
Weighting 1
SS 25,614
WSS 25,614
AIC 00,073
MSC -00,001
No.1
250
Observed
No.1
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (min)
Mean
250
Observed
200
Predicted
150
100
50
0
0 10 20 30 40 50 60 70
Time (min)
Predicted Data
Time No.1
0 000 000
1.2 016 016
2.4 022 022
3.6 026 026
4.8 030 030
6 033 033
7.2 036 036
8.4 039 039
9.6 041 041
10.8 043 043
12 046 046
13.2 047 047
14.4 049 049
15.6 051 051
16.8 053 053
18 054 054
19.2 056 056
20.4 057 057
21.6 058 058
22.8 060 060
24 061 061
25.2 062 062
26.4 063 063
27.6 064 064
28.8 065 065
30 066 066
31.2 067 067
32.4 068 068
33.6 069 069
34.8 070 070
36 071 071
37.2 072 072
38.4 073 073
39.6 073 073
40.8 074 074
42 075 075
43.2 076 076
44.4 077 077
45.6 077 077
46.8 078 078
48 079 079
49.2 079 079
50.4 080 080
51.6 080 080
52.8 081 081
54 082 082
55.2 082 082
56.4 083 083
57.6 083 083
58.8 084 084
60 084 084
sirup simplex
waktu %pelepasan
0 81.742
5 56.679
10 67.627
15 81.732
30 86.248
45 78.006
60 211.758

DD Solver Sirup Simplex

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DD Solver Sirup Simplex

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DDSolver 1.

0 Dissolution Data Modeling of Zero-order Model

Time Unit min Analyst user

Time Unit min Analyst user

Time Unit min Analyst user

Time Unit min Analyst user

Time Unit h Analyst user

Time Unit h Analyst user

Time Unit min Analyst user

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