HISTAMINE

H2 blockers work to inhibit histamine released

from the gastrointestinal system

GERD Ulcers Gastritis

Sores in stomach Treated with
Gastroesophag
or intestinal antacids which
eal reflux mucosa that can be will raise PH to
disease also caused by stress, 3-4, medications
known as bacteria, acidic can be systemic or
heartburn food, and chronic non systemic (the
use of some drugs only systemic is
like NSAIDs and sodium
steroids bicarbonate)

Agents Used to Treat These Diseases

Ranitidine- Zantac
Famotidine- Pepcid
Cimetidine- Tagamet (Prototype)

These drugs cause some

inhibition of the p450
enzymes, meaning metabolism
of other drugs will decrease,
and if we are decreasing
metabolism of other drugs, we
increase risk of them being
at toxic levels
Calcium will attract some other
agents like tetracycline iron,
digoxin, and indomethacin in
which they will bind to and form
a kelate. This means that both
agents will be excreted
unchanged.

RDHonors Study Courses

RDHopes.com