Scribd Logo
Upload

Welcome to Scribd!

  • Patofisiologi Dislipidemia

    Uploaded by

    GFORCE .ID.
    54 views1 page
    Obesity leads to increased production of pro-inflammatory proteins like TNFα and IL-6 from adipose tissue and decreased levels of the anti-inflammatory protein adiponectin, resulting in insulin resistance. This insulin resistance causes fat breakdown in adipose tissue and release of free fatty acids into the liver through the portal vein, contributing to non-alcoholic fatty liver disease, increased blood sugar and fat levels, and damage to pancreatic beta cells.

    Original Description:

    Original Title

    Patofisiologi dislipidemia

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Obesity leads to increased production of pro-inflammatory proteins like TNFα and IL-6 from adipose tissue and decreased levels of the anti-inflammatory protein adiponectin, resulting in insulin resistance. This insulin resistance causes fat breakdown in adipose tissue and release of free fatty acids into the liver through the portal vein, contributing to non-alcoholic fatty liver disease, increased blood sugar and fat levels, and damage to pancreatic beta cells.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    54 views1 page

    Patofisiologi Dislipidemia

    Uploaded by

    GFORCE .ID.
    Obesity leads to increased production of pro-inflammatory proteins like TNFα and IL-6 from adipose tissue and decreased levels of the anti-inflammatory protein adiponectin, resulting in insulin resistance. This insulin resistance causes fat breakdown in adipose tissue and release of free fatty acids into the liver through the portal vein, contributing to non-alcoholic fatty liver disease, increased blood sugar and fat levels, and damage to pancreatic beta cells.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    Obesity

    Pro-inflammatory adipokibes (TNα, iL-6) Adiponectin

    Insulin Reisitance

    Lipolysis in adipose tissue

    Free fatty acids (portal circulation)

    β-cell damage Free acid ingress into liver

    Steatohepatitis (NAFLD; NASH)

    Liver gluconeogenesis hyperglycemia Dyslipidemia

    You might also like