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    4 views17 pages

    CN103340827B

    Uploaded by

    nisa nurhidayati

    Copyright:

    © All Rights Reserved
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    CN 103340827 B (19) PH A RSA BAAR ey a (12) KAAS Al +*| “I (10) HEALS CN 103940827 B (45) BURA A 2014.12.10 (21) IBS 201310298: (22) INF) 2013.07. 16 (13) BALA, RAK Be LAAT RAS Hib 611531 OY) AAG I IBIR TE AR AGE 88 SKA Le C2) RBA BAH HELE RA TEL ei RH (51) Int. cl ABIK 9/08 (2006. 01) AGIK 31/7016(2008. 01) ABIP 7/06 (2006.01) FER Fe WALBERG BLLATE (54) RRA MEER a Se A OG STE EA 2 PHBE. PCH Hh, A AE te Ha EAE WR HEY EH AE SA HAE AFB AK, PEST RAY pH (HH 10.0 ~ 11. 5, 38 FE 9 1100 ~ 1400m0smol/L, 4 Lm) #4 15 ~ 25mg YEA 240 ~ 400mg BEBE. EVER LEE pl Hh HE 4.4 ~ 5.3 HT PY, SE SY ah FE (Mw) Ze 34000 ~ 60000Da st FH PS, 5) 5)-F tat (Mn) BAF 24000Da, 5) F HE SP AG (UL N/M Ht) A 1 Te ACRE EME ERE SHOES LAT FL PAT RE Sod RECA: eT i A FA A BE 9 OE LR AN AE SER Ma RAV TAF BIA 7 AL BRAS EEA AB AE AAA. cX 103340827 B QR wHe R + 12H Le ATER ESAS WBE SHEE 2 (TE a FE HE WGA 0 EB I A FE A 7K TENTH pH (FI 10. O11. 5, BATE EAE Lm Pa HEWN Fe thy 15° 25mg 1% TESOL IN EL FA GREG Ty til te FB) (a) HEAT He FEE EE EF ey RY 4555 TE AL AP HMA 0. 05°O. 2% (w/v) TEER, FRCEARSE FAA IM ab RELI RETIN pH (FE 5. 56. 5, BEAL ZI AE 60-70 CHEF PRIA I 20°30 4}FP FEAL IM SAC BES CAE REG pH {ALE 10. 710. 9, ARAL ARZI LTE GO-TO'C HAE FFARR A LO™1S 3 Fh LUE BER 5 Cc) SMITE SRT FE 7 28 Ach Ty 4 PEELED pH (AL, UBER FED RC VHA TEL pL {HE 10. 7~10. 9 EFAS EAI AAR UA 0. 4 us m All O, 22 m GALERIE WE GP APH Be SPORE BEL, 115 CAME ET 30min, RUA. 2. HABA BEK 1 YEMEN, SEVSIEIE WY 1100°1400 mOsmol /L. 3. HUBRIS 1 AY AERE RE HL, JERE Ll pA AUTEM ERLA Fe Ht29 182mg. 4. HUAI 1 AUREL, SEE Um PAL RL Fe H+ 19°21mg. 5. AURIS 1 AY AERA BL, SURE Ul PAL RL Fe it 24 20mg. 6. 7. 8. 9. HUE BAIR 1 ARR EBL JE HET 240~400me, RUE BOAR 1 ARR EB, Je HUE BAER 1 ARR EB, JE . HUE BAER 1 AREER, Ie 10. HU BCA EAR 1 EAN BEG. HE UL, HRA ACAD 1 ERIE INT OL PTA EAD OR ATLL A a ie 12, ARAB AAU 1 (TERE EIN TOL, SLES 1 Hi ED Ab Jeg» AT BB POR F Bh 13, HESCAUBEAR 1 AUTRE REIN, SCLE RS ACE EE Ab a» DAT HT Re A BT PRD F 5h 14, RAR SCAUSESR. 1 (ADI BREIL HBL, SE CELE AM A Jk DT A TL WALRAD F ho 15. FERRER 1 ARTES BE SPC PEMUAUA pH HP 4E 4. 4°5. 3 WEIL 16. HEB AANEE AR 1 RAN RES 4) FEE 34000 - 60000Da {EIB 17. ARBAB 1 (TERE HEY} F-BHE 34000 - 54000Da HEA PY» 18, HERBAL 1 AREER, HCI F RAY F 24000Da, 19, HERBAL 1 REAR BEE RAATEA Mw /Mn tt FL. To 20. AREA AU EER 1 (URE BEBE BL, FE AG AR (a) PORE ERE ERE ETAL 77 LY 50% AVN Ah 21. eeiaie LARS AL, SE AER (Cb) HP FAL LM GR RSAC BAY DH fF 2. eR LFDTS eR EG LER FTA, BE PH PL TRE PRA Fe HICARZE 10°500mg wEIH PY. cX 103340827 B QR wHe R + 2/28 23. ARYA ABER 1 (TREE Tg Ae FAL Hl a, BE — A PO REL Pe HICH 10mg, 20mg.50mg, 100mg, 150mg. 200mg. 250mg. 300mg.400mg ek 500mg. 2A. tid RAUBER 1-23 (ETT A BSE BLY Aa TAS, PAE EL a oe BURA Pe ity 15° 25mg, ALG FER (a) HOT tt AREER PAAR TA i EY 4555 HEAR (b) FLAPRR Ca) TEI AGRE TMA 0. 0570. 2% (w/v) THEIR FECES FAL IM RR ARGH WHELAN pH (ELE 5. 56. 5, Be AAL AT HLLE 60-70°C HELE PF PRAIA 20°30 S}-Ph EAL 1M 20 PUG EUSA BE pH {ELAS 10. 7~10. 9, ARSE HEY ELE 60-70°C ALE F FRLIR BH LO™15. SES FEL Ak A Dy a EARL AY p AEE BENE FC WY PALLY Hd SPRAY (RE 2H MAAR UCL O. 4m m AU O. 22 um GFL MERE UB KF 2 AP He SPORT, BEST, 115°C AMER BY 30min, RIA. 25. HRA ACA BEAR 24 GAT aE, Her 2b ORE Cb) FAD UM ab GSA HBCU AE AY Hd EL 5.876. 20 CN 103840827 B wom Fs Via RAE SRR He AT Coon) A AR AT Bey 25 NSE CoD HY HL RB — BD RS AL Oo LAG ML LPS AEE TEN. AOE A He IL. AR VNAL A PRS SALSA TL FP ae He A GUL. FSA AS 2 LL PT: EAN Hy A GSE AL a IFA AS GE AH A BH AS SE A Be AMR TUBA HE (FH BRA Coooe] AFA IE AIL PIAL A AUS i 1 GA ARETE RE HA PER A ASA A SE PL TE ‘HOE AB 2S ES AIEEE SPAHR TEE 8 DL RUBLE TT BA HERE, SEI ak PCNA Sb BAIA HE AL PE EP eS LR FA. Bt PERE 5 AF AAAS AS WIEN» BAC RR ASE SORT NECA BCE, 5 BCA AL DI WGA» APMP AGE AL TEL MD BAPE 3a Ue SHE ER WP PRU UY 0 38 1 AM WSC TELA SRD RAC TE EAL TRE BR AS EL REPT EAS ORR GBS TT EL ARE SACP 7 AER NR RIG A HPAL BIB AL TORR ER Cri FAA EE A RE SZ SE AL PAE PARAS. CESY FHP BL NEB AM SS IAEA, TERI EIS TAN RE RO AA I FG BEET SPH ADD ASE OP BEAD FTA ID 0 LEDERER, TERI 2a SLL BIB A (SLE £6, HERE SSL PRI BFE AST. NS EY CR EES WORE} FRR, MATTE RR — TAL A3Kda AKA SAD CEFR RE BEE At (Mw) 3 #4) 34000 4% 60000 1H RGRAY ), RS OS Aw EARL PR AEAENRY BEI» ADD FAS HE TE PAE» FY RIE fc EEA ASF BAT TT IE I SE NE HE ARIE THE EAE PE A ERICA PL, DHE» Jed EAL Rg AT SE A AS BLL BT AE REE BRA Ee PL HE OR SLY Coos] FL4 Ar REN 5} aE GEL LAL AY a kw AE RE ERAS PAP SEE AGE AS EL SEA BE OAD AR eo DPD RHE SAS FA SRE AS PEE A ‘Aa Lk a Fe 2 SS SG FB A EES NB Be HE VR EL EPIRA, HEEB FP IRE BAT BAT 25 Ch eB RE AB EST TE RE EE BREN NS HFA LS, USPSA LS TERED FY 9} PAE HE BER RE BRB. Coos] REBAR (a WP NR BR SAS A 1 AAP TB AS FAT Wenofer) (ey RERE BRIS WE (Zi THHIES 120080403, SL 29 Sl: 100mg RAT REP IP he SURMISE SBE IL be ae MY, {EL k AE DEAS ASE LS, (QO ALBEDO. Fa A LEI IR ‘HL EEE SUR ao yt RS SAR A TAS SB IY Ab 9 a RI SR IE ME °C ~ 25° CHRME FICE FRAME RET. BERLIN, AE. RTE Se SBOE AI AY 4 CN 103840827 B wom Fs 2/14 (SERED. MELE PDA HCHEDAY Veno fer FET RR 2G MEAN 131 A wba TLE PB OE BARE {Ee 20° C~ 25° C FIRE, FLITE 15° ~ 30° CZ IAIN. RANDUR". TS AS BALE BIRLA Ah TRL, PI 247 BOK LE HE Locos] FAN, AS Sita (1S a BE PT A ABT TSK Hl TRE EDL SU SAY SOLUTE TE Ef SS Ae EA / SIE RET BAAS (ooos] A ALBA EA WA PHA Aa TA Hh DERE NL MPR EE FRE AG BE RE TE EA MAPA BE 5 ASDA ADI He Az PL AY SLT. NG 0 RS as CEE A / BAe AG eT >A ARB. AAWIE TH ARTI ASEM (ooo7] Ayes, AAC BH Sr TNE PT RR AL SL AE BO Pe PEREIRA (ZEAL PORE] By pel USA) » AES AL AK Coons] HE AS AWS Ar ESI i 7a EB RTE TA JE pH ALL Ay 10.0 ~ 11. 5, Ba dT 10.5 ~ 11 1, HI 10.5 ~ 11. 0, PAI 10.7 ~ 10. 96 (ooos] ARH AS Ag WH SS — Fy TH AE — Se HE AY TE BE SG, J YB GE 1100 ~ 1400m0smo1/L, fl 4 AW 1150 ~ 1350m0smo1/L, fal 4 9 1200 ~ 1300m0smo1/L, fa) 4 29% 1250n0smo1 /Ls (ooro] RIE AS AeA SS Ay LEDER ET HE EAE Im PAT 15 ~ 25mg PR, BME Am] PAL 18 ~ 22mg Bk, ANAL LL AAT 19 ~ img Be, PAGUAE LmL AT #1 20mg Be Coon] ERR AS AWS x ESI i Fa TB RTE SEA Lm AL 240 ~ 400mg TORE, PALMA Ll AAT 260 ~ 380mg TEBE, HAGE Im] HAT 270 ~ 330mg TEE fal an Iml 447 300 ~ 330mg HAE, (ANE Lm) PAT 29 320mg IRAE. Coor2] ARIE AS Az HE Sy TES Ha SR MS EI GR, CE Li PAT ERA A 15 ~ 25mg ( (Hl M1 18 ~ 22mg, Bisel 19 ~ 21mg, fi AL) 20mg) » Coors] RYE AS Ac WAS — a TL AEG Ar HS A NE BE ESS RE, AE LL AT AE BE EWE ty 240 ~ 400mg ( {fi 11 260 ~ 380mg, (2 1 270 ~ 330mg, fi 441 300 ~ 330mg, $i) 4124 320mg) « Coorg] RYE AS Ac HES — a TD CEI A Ar HS A UN BE ESS RE SAE Ld AT RE BE Pit A 15 ~ 25mg ( fA) 18 ~ 22mg, fA) A 19 ~ 21mg, fF] AZ 20mg), LAE BE tt Ay 240 ~ 400mg ( {i dat 260 ~ 380mg, {At 270 ~ 330mg, fF 300 ~ 330mg, $i)4124 320mg) . Coons) ARSE AS Az HH Sy TEES HE Ar SE RSS ae HA SG AUC IN AUCH OER BN EA — AN IR — A RG A — RR ET WEIR BHAA AS 6 AE ASST TS SP FIT SASL RTS PLE BRL A RE HO IM ER ARIAR RECA 1M ARCANE © CEA STATS SE FIT AS RT HIE AC PEFIBL, Bil A 1M AUPE BEE RK. Coors) ARIE AS Ae BAS Aa TN AE SME Aa A NE HO GEV AU BG RE 2010 SEN EA ERIE A LE 25 CREAR AREA fT 010 HBR OL ih 5 CN_ 103340827 B wom Fs 3/14 Bh) PAR IX HRY WL SRR ETS ey ds CAT RIES ) GAG EAR RB PT AT HA” BORAT RG ) WET ROE, TT MLB AE ASF 8, BEE AF 5, EGIL 30 (oor7] EAR ARENT, Ei “Voda Bt” FL, 1 ET SN) WL PUTER AE “> 100 i, ZE 25-£ 1° C ABE F CEE 3 KR, Be EB AE 1° HSK, TEM VAN st BEAT LE 30 KAS LEO 6 Coors] dE AACA, Lid8 TY IAL Sei” LAA SGT WL Se em] Le — A AT Coors] AE AS AREA, Jas a] IL setiy bia ths 3” Sete PAT HOSS ES A HB HESS HR SE > 100 BL, CELE DG TVS VO BTA AARP BI EE AT BOD SLE NT Le » AES DIL OPI SBCA AS ROHL 4 (oozo] — CLeR Hi ARSE ACBL, 28 A Be BI Da sd tl 28-9 SU I U AAR AE ATTN SEE I SEA BEART ILS BEL Cooat] ARMAS ACH Fy TN ESTHET SE ER, EAC ERB 2 RE iil AB + (ooz2] (a) AAR Ay i} HORE INR FAL TE AARP [0023] (b) Faz (a) TAZ HEF IMA. 0.05 ~ 0. 28 (w/v) HES, TA CERGEE FAL 1M 2b PEFSBCUT WYER RAY pH (LE 5. 5 ~ 6. 5, BEA TE 2G ELE 60-70 °C ARLE F CRIMI D 20 ~ 30 4} FU FEL 1M PU ACRES CTT AYRE HL (ELZE 10. 7 ~ 10. 9, AR BEAE ZU WELE 60-70°CHARE BPA PA 10 ~ 15 SP, hae Bb a + (ooz4] Cc) PAINE SR FH zk 28 Why eat, Hoy PERE EL MEL, Ds BR FE TAY I BY pH CELE 10. 7 ~ 10. 9 EFBIPS AES UHH 0. 4 vm A110, 22 m PAL UERRL WE HEA AY DEBI BORORT, BEL, 115° CANARY 30min, ROA. (oo2s] ARMAS ACH ——a TH HES 7 SO ER, SOR (a) ad aN ARTY DALE TG Ae EL 30 ~ 60% ATES A, BiH] Je Sey BY 45 ~ 55% HEAT pi AY LA Sh Ay A AREAL 50% BESET FLAK 0 (ooze) UAC ACH GR art ‘SETAE TS RAAT BH BRE SSB, SCPE BE Cb) FEF LM ARBRE [0027] idk Pa MDA T i EBERT RE ARGU AS Be BH SD TE STETS FETT AE EIA) NTI, HEAL ALR, BER (ooze) (a) AAR Ay it HOLA INR RPA a Tad AARP [0029] (b) Faz Ca) PTE HEF IMA. 0.05 ~ 0. 26 (w/v) THESE, TA CEREEE FAL 1M 2b EFT VS PAF HBEE pH APLAR 5. 5 ~ 6. 5, HEATH BECE 60-70 CHHLME F GRRL DH 20 ~ 30 SHE FUPEL 1M ASU APEC AEH oH (ELAR 10. 7 ~ 10, 9, SRE 25 HELE 60-70 CHIE FPR PA 10 ~ 15 4b haba + [0030] Gc) PAINE SR FH zk 28 by eat, Hoe PERE BEATS EL MEL, Ds BE mF eA IS BY pH CELE 10. 7 ~ 10, 9 AERIS 100 HHL, E254 1° C AYE PGE 3K, BEG) 1° C ASHE FRE 3 Ky FEMUR UH HE SET UATE 30 KALE SER TUE . AEA Be, Eid LS” AAR AE OT LAA TA. PEAR 5 TT ILS OO A A” HA PRAT DHS I AM BTL EAE IN EAE D> 100 HHL, TER, FUTUR AG BITS HA BA PRAT OTS: BRE OL I THY Le BO SAT FORA AA RGA EP 7 CN 103840827 B wom Fs 5/4 Loos] fc ACARI LSA il dhe Ards eR, BAR SHH (Ee Se EA a HB LB CY Fy ARS Hd 4 PTA C2 RATT HL AT, AS UREA, SRNR AE AS BR 4 SCAT ZS FE 3G Fe A OA tH LE TS TS Coosa] A AHMET IESE MT FR, AY AG IE Sh RTA REE TAS SMA HE. Woh HEA ROE Dy EE — Se Oe EE BORE] BE PSOE SE BETTE AAR TE, BEE ATA A IEG TEL EAS BR SL A Loos] ARAL SLA AT SCAR, EMU EB PHD SLA IE AAS SC LB Re Se PROTA LG ARIA BOY, AAG WME Sh AE A ARE A SEG TE FUAE AS TUR ARAB 25 I) — eS LB 5 AS Be I a SLT SEIS 0 EI UE A A AR TBH BOA 2S SAS BI, A BT AE, RS MAME Coos] AE ASA. FS 9 ARG SCAT AFH DHA, HY DL LAE AS LARA 2 5 SL Me C0047] PERI AAR BHA ZR TRI, ACRE ALA Ok ZS Sa, RF fa 24) 0, 45 um VFL UE BE EAT HUE LAE, TENE A OHEE AH Z EF 29 , 22um FEL AE AT UAE BITTE LS Ko (ooas] ALAC HIE GET — AT] CAR AR AMER TET GR RTE BE TE REI RE . AAC BT PRES ROY pH GES ZE 10.0 ~ 11. 5, BAI 10.5 ~ 11. 1, fA 10.5 ~ 11. 0, fl 10.7 ~ 10.96 (oo4s] A Be BI AEA PST TOT kek ( (A a] SHE EA 24 USP35-NF30 IESE REE TE YEiiR (lurbidity) SPATE CATT TE ) WL pl HE 4.4 ~ 5. 3 SORA. (ooso] Ax Ae HY IME A TE ST HOLY AY 4} Ft (Mw) 2 34000 - 60000Da si [BAL fal a Ze 34000 - 54000Da 38 [HAI Coost] AR AH RE DEIN PAI} Fat (iin) AvP 24000Da. (o0s2] AR ACH IBRRUE NTA Tah AG CLL Mw/Min tt) AF 1.70 Coosa] Ei AS Ag HA IN REE SAL LA RP PRE AT RIN ITF TLE 8 aS AEE» FRE ATA BU ELAS BR TR ET MERE CLEAR 2 BAY SC PU A i A EL ETPERET AER) PRB HERES BTS AAG FR LR TE ADP TH AS TAL a HON REA RA BB Coosa] A Ae HN Arvest 2 fe 38) GA AE A EN HT BLE IT PJ I SL HOSES BEY pH CEL TERE AR BY} FE EY 9} PR) PRD A eB 1 AT / STE 25 MAIR: Coos] CER Hi ARSE Ac BI RPE A BA) 7 HAH 4 8 SE BS ES A Fei Si PRA Le Bt 9 AREAS CHIL SHEN RTE IN EES PP Se FE SEAR Ee BUR ASERE AS BALE. IAT ATER A BS. Coosa) ARIE AS Az HF) RE BE TE SHOR a PER TE HE RE XE ST SE 5 BEST As PLE FA CSCI RR TEIN) PLP REL (Pe) FP SERENT EAE 10 ~ 500mg ENA, BAAR P29 10mg. 24) 20mg, 24 50mg.24 100mg. 25 150mg.24 200mg! 250me.24 300mg.24 400mg. 524 500me. 8 CN 103840827 B wom Fs 6/1 CooS7] BZ Ha AIA GR A GGA AS CA 5 LA A ERIE RE hd DP SAC WE Se AIDC LS UL PS HS HEAD AS US 52 HE A A S SLM Lawrence, “Ai KERH ATF” Hui OF HI AILCAR "PDA Journal of Pharmaceutical Scie nee&Technology52 (5) : 190-197 (1998) » is A i Mie WHINE kU 2 Ik A DEF SE LAC HT 7A FN A RACK. Coosa] CER AIFHN HS Bite SRIF ARVN AAT BE (AS at UAL Pk HT BE ER AS ERE TSE 7 ESE AD FS SM ME RR SUA I REI TL A Pe AE Coos) i RE AH Hi WRG (AS TL AR EC A 28 GB PAR BR I TALUS To PRBS PG HE A HE VE TA TG 8 PTS HN HIE RAAT A RTE EE (oso) PRIDE AUAUA (REAR RE AUR TERRE = MR. BOR LA DEAE AREEY RE A LSD» TRIE RRA TSP LY [ (FeOOH) , (Fe) OPOHLIn 1% BASU PRONG ERE. PREC EYE A Sb BE REA LA 24 RE AE, AAR HR PIB BOP IS Ft ALY 440000 AREER RSET Fo BARRE A SSC E29 13 SK, TRAY 7 AK. Coe) AG 1 EA G5 ABE BR BR BE a LES A ATELIER dE A GTR — OE WS AUC RTE EE NEE. PRA FB IE 4500 PIRATE MED AY FAY SY Fit 9 700000 % 800000. FRALEY FH 30% DENSE BERT LEK. Cooe2] 24 MY ANF EY PRET AB OS EP IL TD J RR HL HE A RL PRE, Hy SMB — EE ARSE TEP RY» LSE LTE RS AN SEE FRYER TES Fo MRSS BAA IM IE FE IE AE I = PL EAE OE, SEE PAR PSB RETA A PB [006s] PRAGA AK HEPEIY. FEAL MTA IS EAE A Lite. DRE TE LAC THES / SERS, Ay 40 FE 160ng/mL. HRA » CELL IRE PR Be I — OP AT SEE SER PAR BED LAH AR AI A BE = PR, RS LE EA BEIGE BEE A TG IE RS « ERE AAS) Ft 4 76000, ENE FA BARES TA LR (ooes] iM FAL TP PeINh, IMR ES Cy ( SIC Er 1) FA I HT RTL IP RIE) TE Aa SDH PAR Be HR 2 EO MIA TRS ER, WA, UPA A AL SHE BE AE ALI RE REE 5 A ILIA BR Ss AUT A (VRLAEALAM Coes] BRAM ARAL A Met Ca BOI Ee RUE AAC A Co neat 2 MN BGT EE PRAEGER (IEZ) » EPG A RU A PAL pH Wy 2 TATA. HET pH RAN URURIS T- AE 3 FE nO TA SC CTE 0 5 BAI A AP TE Foo EATERIES TEA 5 RAK Po GEL iL SP IE eS RR he a Oo IAC Fi GR A. Coos] BREA S WEAR AL ZIYI SE AIP} TD AD 5 SOUR Ae TT TE FELT AEH A AR OF 9 EE Ge Sh IS FD 0 9 CN_ 103340827 B wom Fs VAR Cooe7] fi, ERNE AY FARE (Mw) A944 24000 48 60000 HAH, SARS sChW K [0068] [Na,Fe,0, (OH) + 3(H,0)],, * m(C.Hh,0,,) (ooss] SEH n ALARA ATE, m Je RE A BEEK [Na,Fe,0, (OH) + 3(H,0) ],, SFr TERE SY F Cultn0,) Be (oo70] ZERIT, ES BRA ERK (Pn) SIU IRR A (L) ZAR Oe [0071] [Pn}+(m){L] <= [Pn}-m[L] . Coor2] Ay F WARS 1 Fak ae A AA EEE ER oD a EC, OP Be {0073} [Pn ]+(x) [L] + [Pn] + m[L]+(x-m) [L]. Coo74] Ar RR a2 EATER ALD Cs ae 79 2 eld Lawrence “#46204 f4) PCT Nia WO97/1ITI1 (1997) "PHEAT TH) Coors) FEL Fuki PASAY TRE RE TH SNR Aa PAH CG PAP IA 8 FT TO ASE og BE PARSER T HFA AC, O01 = IRI ASSIS AEA A, 5 URSA BASIE A FF 3 Sm +100mg SAL 1. 6 BEE (0076) iA vi ea» EAN RE AT HORA REG 0 Oitwe/w AE SHE BR AC Tee Se A FL SL PAS EH WaT RAEI. GEA ANF ee EAN MA. RA AT, BEIM 25H AT FN «AG TT RE GE NT: EIN OY HR SG FLBDE IS BU HG BE AP MK, APG ASI Ae IL PLES BR GAs BR OA A AF © CE BTI AR — UATE TAL ER HE PEL A ER — 4 RUE TA AC 1-2. 5m] (20-50mg) Be, E> 14 TLE ml (20mg 8), <4 ZF LR FE CL. Smg/ke) » BLA LSE IR A. UR PEER 2G 15 SP EMAC BLAS BBR, BE SIGE TRE SA I PLUS Aa 2 Hy AES (OT aH A A SE SL FEIES ) © Lm ASHE Hae & REA AE 20m10, w/v 4B ke ks AGA CIR Jk NM GF Char 5m Acti Se & HAE A) 100M10. 9 EMER AY Ti 25m1 ALS HEEB] 50010. Ow/v AEBRARARY ) © QGP RIE NG Ay 100m) RAR ADAATE 15 SPH .200m] AED iRFE 30 FPF s 300m1 25 “YP TE 1.5 ANNE :400m1 38 “HELE 2. 5 Anihh 300m) EDR: 3. 5 AML. MOURA RE BE, AIH 0, 9% ABER AC SU RASPEABE PUT ly Pe DAB RH A BE PRT WET De RAR AE} BPE FPR ACTA CUNT 10m] Shs = 200mg PRALAR “> 30 SP PHATE 525m] ALK =50Omg EMV ALD 3. 5 AERTS)» AEA LEE A SOPH CC SE LIFE Coors] ARPS siRR MEO IN SBC FT ANE RBI, HEME AE Oy Tee) BP mL Ach CAD TERE 5 Oh BP ml ASH) REVISE RIE 10m] ASH (200mg SE). HARES PAR IANO HEB (oo7e] (EARP ARALHE I «AS AAPL ELBE MN BIA PASS Moi PATIL TAD TT “RTE” Coosa] wh A Ailes: ATS fis FAL Fe amt Ap ARR A 2 AO DD 2 AB, 5-10m1 (100-200mg ) © foot] JLFE 9 HALA a Be OF 2 BUR, CEA 0. 15ml ABA (38mg KE / AT ARE) « 10 CN 103840827 B wom Fs 8/1 (loose) A AeA A HRN RTE AL, SE SE CLL) A Re TT AES SEEN AD FTL, MATTIE OPE FE A3KDa SLA, RK RT DURE IN ENIAC ER. ASS AH AE EERE FRAME. BEB WO PRE SE HS AE RAS PRR AAR. RUD A os SL A IR, PATE RTE. ACHAEA. (7) LHR KEE YA sth Ja) LD50>200 SESE BE / AIT (SHE, DL HST ARLES Ay 30 (200/7) Cooes] WERE RRS EZ AC Ha Fe AE HR RES DS 2h HAAR ARE LOOme BEA ACA, 10 Sy PIE NYA 13 Bl Saeies FY 538 b mol/Le HI Ab AG PEERS MUR ABUSE (KY BL) ASL AY Ee A | PEMLI A 6 ANN. BAAS A BAY A BL, WERE BpAG LD «He TAC AT ER Bk BR Aeke PEA, FY WAG BUA BAG RE LE PEE BE RLY GEM 3lmg Be /24 tht. TENA SNOT 4 ANH BRIE BRET ASB) 4: AAR EY 58 24 ANIL AE MIL PRA FE SUTE IN TRAP 29) 75% ARE AE ARTHAK (ooss] LAF Sei APRA AH TASER AC eH. 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