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Yuritci Martinez

Dr. Sharity Nelson

ENGL 1302-101

28 October 2022

Covid-19 Vaccines effectiveness and safety toward the community

There have been more than 100 million cases of the Coronavirus illness (Covid-19 or

known as SARS CoV-2) and that have resulted in fatal situations millions of fatalities. To defend

against Covid-19, the government has approved five to eight immunizations. Determining the

best vaccination for various demographic groups is essential since several vaccines shown good

safety profiles and considerable effectiveness against Covid-19 in clinical studies. “The four

vaccines, Covid-19 messenger RNA (mRNA) vaccine BNT162B2 (Pfizer), mRNA-1273 vaccine

(Moderna), ChAdOx1nCoV-19 vaccine/AZD1222 (AstraZeneca), and Sinovac, which have low

safety risk and higher efficacies of 95%, 94%,70.4%, and 78%, respectively, were used in many

countries because there is no specific drug to treat Covid-19 virus worldwide” (Qamar et al.

3555). The SARSCoV-2 was prevented with the Covid-19 vaccine and booster shots, which

have also been reducing hospitalizations. The researchers have shown that the more booster shots

a someone receives, the lower their chance of being admitted. The Covid-19 vaccinations have

shown that doing so will assist the globe limit the spread of SARS-CoV-2 and prevent further

deaths from occurring globally. “Vaccination is an effective way to fight against Covid-19,

which can help reduce the rate of serve illness and morality, to curb further spread of the disease,

and potentially to achieve herd immunity” (Tian et al. 4645). The Covid-19 vaccines must be

mandatory because is an efficient method of preventing the disease, which can assist to lower the
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risk of serious sickness and fatality, to stop the disease from spreading, and perhaps to create

herd immunity.

The Covid-19 vaccines have helped a lot of people from not getting hospitalized or even

causing death. Many people of all ages have been hospitalized in the ER because of the Covid-19

virus and has caused them health problems. (Add support). Additionally, Pfizer, AstraZeneca,

Johnson & Johnson) and boosters are among the five anti-Covid-19 immunizations that have

received official government approval. Each vaccination has a unique set of responses or side

effects in human. Erazo et al. Recognize the fact that the Covid-19 vaccination is secure and has

a history of lowering hospitalizations, yet they all work well in lowering hospitalization rates,

demonstrating their effectiveness. The results "affirm the protection offered by the

immunizations against the risks of hospitalization in all age categories," (Erazo et al. 4). The

second SARSCoV-2 was prevented with the Covid-19 vaccine and booster shots, which have

also been reducing hospitalizations. The Covid-19 vaccination has been shown to protect against

hospitalization, and studies have shown that the more booster shots a person receives, the lower

their chance of being admitted.

Veerle et al. agrees that the Covid-19 are safe and effectiveness for the people, but as the

other authors stated that some vaccines can have more side effects than others. “For these

vaccines, clinical trials have shown high vaccine efficacy against symptomatic infection and

under real-world circumstances, great vaccine efficacy has been established” (Veerle et al. 1).

Although these vaccinations can be both safe and efficacious, they cannot simultaneously be

effective. This finding was "supported by empirical data on the efficacy of viral vector-based

vaccinations as compared to mRNA-based immunizations against the delta variation, and it was

also proven in other assessments of emerging diseases," according to the study (Veerle et al. 9).
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They concluded that this finding increased the body of knowledge on variances in the amount of

protection offered by different vaccine brands and may justify updated or new government

immunization regulations.

The Covid-19 immunizations have had a significant impact since they have prevented

people from needing hospitalization, re-infecting themselves with the virus, and maybe even

dying. Since many patients have reported that the Covid-19 immunizations have kept them

healthy, Chirico et al. believe that the vaccines are safe and effective. There are currently eight

vaccines against Covid-19 that have received emergency use authorization by the who that can

offer some protection to the world’s population during the Covid-19 pandemic (Chirico et al.

91). The researchers stated that all these vaccines are efficacy, but some of the vaccines can have

mild effects after getting vaccinated. These vaccinations have showed significant efficiency

against the virus and extremely high levels of protection against illness, hospitalization, and

morality/deaths (Chirico et al. 92). These vaccinations demonstrated both a very high level of

protection against sickness, hospitalization, and mortality as well as great effectiveness against

the infection.

Therefore, it has been established that these immunizations are both efficient and safe for

everyone, but not everyone is the same. Liu et al. evaluate the "Covid-19 vaccine's effectiveness

and safety" in the real world (3). Vaccinations against Covid-19 are safe and effective, according

to Liu et al., and they will help avoid hospitalization, infections, admission to the ICU or

Emergency department, and mortalities. Worldwide, coronavirus vaccines are extremely safe and

have the potential to drastically reduce the number of virus-related illnesses, infections, and

fatalities” (1). The researchers found that while two doses of a vaccination might have moderate

side effects, they are more effective than other immunizations.

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Chen et al., believes that the Covid-19 vaccinations are safe and could progressively

lower the number of infections, deaths, and the other Covid-19 related illnesses around the

world. Two doses of the Covid-19 vaccine had an effectiveness of 85% or higher (Chen et al. 9).

Although immunizations against strains of the SARS-CoV-2 virus were less effective than the

initial strain, they were still more than 50% effective in those who had received all available

vaccinations (Chen et al. 9). The results of the study showed that while various immunization

types are usually safe and effective, certain vaccinations may nonetheless have more adverse

effects than others. These immunizations helped the virus spread less widely and significantly

reduced the number of mortalities among persons of all ages.

Most of the vaccines showed a good safety profile and significant efficacy against Covid-

19. The researchers wanted to examine how efficacy each Covid-19 vaccine is and for every

vaccine they did trials to make sure they are safe. They examined first Moderna, AstraZeneca,

CoronaVac, Baharat, Sinopharm, Clover, Casino, CureVac, and ZyCov-D vaccines only. These

vaccines tested to be more effective in preventing Covid-19 infection. Sinopharm and Sputnik

vaccines exhibited the highest safety profile and most effectives. Toubasi et.al stated that “In the

elderly population it is important to balance between the safety and efficacy for each individual”

(259). The researchers revealed that Pfizer was the most effective toward the elderly population.

The researchers wanted to examine four vaccines, which are Pfizer, Moderna,

AstraZeneca, and Sinovac. These four vaccines have low safety risk and have higher efficacy of

95%,44%,70% and 78%. Also, these vaccines are effective and save, but they can show some

adverse effects. Most of the adverse effect were caused by the second dose. The AstraZeneca

Covid-19 vaccine was not safe nor effective for the people. The government banned the use of

these vaccine because it was causing blood clots. The Sinopharm vaccine has been approved as a
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2-dose vaccine for prevention of Coronavirus and this vaccine has help people from not getting

infected. The Pfizer vaccines is the most popular and has a 95% efficacy against the Covid-19

virus. The Sputnik V vaccine has efficacy of 91.6% and has help a lot of people with lowering

the side effects.

The Covid-19 vaccine is an efficient method of preventing the disease, which can assist

to lower the risk of serious sickness and fatality, to stop the disease from spreading, and perhaps

to create herd immunity. These vaccines have been widely used on the adult’s population and try

it with some younger generation. The Covid-19 vaccines has helped the children’s and

adolescents to have less chance of getting infected or get another type of virus because the

vaccines are helping them to not get sick again. “According to a prior study, people who received

mRNA vaccinations in full or in part were protected against Covid-19 in 91% of cases and in

81% of cases, respectively” (Tian et al. 4652). The vaccines have been shown that are efficacy

and are safe for everyone. The researchers stated that these vaccines have help the world to

reduce the disease, and has made a change to world because A lot of people

Worldwide, the Covid-19 sickness claimed many lives and infected many more. Many

people have demonstrated the safety and efficacy of the Covid-19 vaccines. Covid-19 vaccines

are safe and effective for everyone. The Covid-19 vaccines were evaluated by different people to

make sure they are safe and effective for the community. The clinical trials used to assess and

approve Covid-19 vaccinations shown that the vaccine considerably lowers the risk of getting the

virus.

Even if you contract the virus, the Covid-19 vaccination may help prevent you from becoming

extremely unwell, according to what has been demonstrated concerning vaccines for other

illnesses. Getting vaccinated may help protect individuals close to you, especially those who are
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more susceptible to Covid-19's severe disease. Regardless of whether people have favorable or

unfavorable experiences and perspectives, they should get vaccinated for the safe of everyone.

This study suggests that patients should receive Covid-19 vaccines to help prevent mortality or

other diseases, allowing them to lead normal lives without worrying about catching the disease

again.

Works Cited

Chen, Yamin, et al. “Covid-19 Vaccine Research Focusses on Safety, Efficacy,

Immunoinformatics, and Vaccine Production and Delivery: A Bibliometric

Analysis Based on VOSviewer.” BioScience Trends, vol. 15, no. 2, 2021, pp.

64–73., https://doi.org/10.5582/bst.2021.01061. 

Chirico, Francesco, et al. “Safety & Effectiveness of COVID-19 Vaccines: A

Narrative Review.” Indian Journal of Medical Research, vol. 155, no. 1, Jan.

2022, pp. 91–104., https://doi.org/10.4103/ijmr.ijmr_474_21. 

Liu, Qiao, et al. “Effectiveness and Safety of SARS-COV-2 Vaccine in Real-

World Studies: A Systematic Review and Meta-Analysis.” Infectious

Diseases of Poverty, vol. 10, no. 1, 14 Nov. 2021, pp. 1–15.,

https://doi.org/10.1186/s40249-021-00915-3. 
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Erazo, Diana, et al. “Investigating Covid-19 Vaccine Impact on the Risk of

Hospitalisation through the Analysis of National Surveillance Data Collected

in Belgium.” Viruses, vol. 14, no. 6, 16 June 2022, pp. 2–8.,

https://doi.org/10.3390/v14061315. 

Tian, Fangyuan, et al. “Safety and Efficacy of Covid‐19 Vaccines in Children and

Adolescents: A Systematic Review of Randomized Controlled

Trials.” Journal of Medical Virology, vol. 94, no. 10, 2022, pp. 4644–4653.,

https://doi.org/10.1002/jmv.27940. 

Qamar, Naila, et al. “Vaccines for Covid‐19: An Insight on Their Effectiveness and

Adverse Effects.” Journal of Medical Virology, vol. 94, no. 8, 2022, pp.

3554–3560., https://doi.org/10.1002/jmv.27810. 

Toubasi, Ahmad A., et al. “Efficacy and Safety of Covid‐19 Vaccines: A Network

Meta‐Analysis.” Journal of Evidence-Based Medicine, vol. 15, no. 3, 2022,

pp. 245–262., https://doi.org/10.1111/jebm.12492. 

Yang, Bingyi, et al. “Immunogenicity, Efficacy, and Safety of SARS-COV-2

Vaccine Dose Fractionation: A Systematic Review and Meta-Analysis.” BMC

Medicine, vol. 20, no. 1, 2022, https://doi.org/10.1186/s12916-022-02600-0. 

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