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  • FCM Diphteria

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    D, a 9-year-old female, was never immunized and had close contact with a patient with similar symptoms. She developed Corynebacterium diphtheriae infection via inhalation of respiratory droplets, which caused bacterial colonization in her tonsils and pharynx. She was treated with antibiotics (erythromycin) and anti-diphtheria serum (antitoxin) to prevent further complications from the bacterial exotoxin, such as the formation of a pseudomembrane that makes swallowing and breathing difficult. Diagnostic testing confirmed C. diphtheriae culture from the pseudomembrane.

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    FCM DIPHTERIA

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    D, a 9-year-old female, was never immunized and had close contact with a patient with similar symptoms. She developed Corynebacterium diphtheriae infection via inhalation of respiratory droplets, which caused bacterial colonization in her tonsils and pharynx. She was treated with antibiotics (erythromycin) and anti-diphtheria serum (antitoxin) to prevent further complications from the bacterial exotoxin, such as the formation of a pseudomembrane that makes swallowing and breathing difficult. Diagnostic testing confirmed C. diphtheriae culture from the pseudomembrane.

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    © All Rights Reserved
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    3 views1 page

    FCM Diphteria

    Uploaded by

    Tutor20 FM-TM
    D, a 9-year-old female, was never immunized and had close contact with a patient with similar symptoms. She developed Corynebacterium diphtheriae infection via inhalation of respiratory droplets, which caused bacterial colonization in her tonsils and pharynx. She was treated with antibiotics (erythromycin) and anti-diphtheria serum (antitoxin) to prevent further complications from the bacterial exotoxin, such as the formation of a pseudomembrane that makes swallowing and breathing difficult. Diagnostic testing confirmed C. diphtheriae culture from the pseudomembrane.

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    of 1

    D, 9 y.o.

    , ♀ CASE 5  TM

    DIPHTERIA

    Source:
    E: Corynebacterium
    Rf: Was never diphteriae infection via Murphy JR. Corynebacterium Diphtheriae. In: Baron
    S, editor. Medical Microbiology. 4th edition.
    immunized inhalation of respiratory Galveston (TX): University of Texas Medical
    droplets  Branch at Galveston; 1996. Chapter 32. 
    M: Antibiotic Lamichhane A, Radhakrishnan S. Diphtheria.
    (Erythromycin) [Updated 2022 Aug 8]. In: StatPearls [Internet].
    Treasure Island (FL): StatPearls Publishing; 2022
    Jan-. 
    Rf: Close contact with Ted L. Hadfield, et al. The Pathology of
    Bacterial colonization
    patient of the same Diphtheria
    in tonsil and pharynx
    symptoms

    M: Anti-Diphteria
    Exotoxin production
    Serum (Antitoxin)

    Exotoxin undergo mild


    digestion with trypsin and Host immune
    reduction under denaturing response
    conditions

     Cleaved to two
    Inflammatory
    polypeptide
    response
    fragments (A and B)

    Fragment B

    Binding of the toxin to


    Leukocyte
    its cell surface Cytokine release
    recruitment
    receptor

    Toxin internalization Phagocytosis of


    by receptor-mediated PGE2 production bacteria, debris,
    endocytosis  antigens

     Acidification of the
    endocytic vesicle
    Increase
    Increased vascular
    hypothalamic set
    permeability
    point
    Fragment A

    Enzymatically active
    A fragment enters the Outpour of
    cytosol Bacterial colonization in

    Mild fever fibrinosuppurative pseudo membrane


    (Temperature= 37.9 C) (fibrin and pus filled)
    exudate

    ADP-ribosylation of
    elongation factor 2
    (EF-2) Exudate coagulation
    on the ulcerated
    necrotic surfaces

    Disables interaction
    with RNA during
    translation
    Formation of tough, dirty gray
    to gray-white
    superficial pseudomembrane
    Irreversible inhibition
    of protein synthesis in
    the cell

    Diagnostic tools:

    (+) C. diphteriae
    D: Faucial Diphteria
    Debris clumped in
    culture from
    Cell death and psuedomembrane pseudomembrane
    necrosis

    Debris of necrotic Airway lumen


    sloughed epithelial opening is smaller
    cells 

    Difficult to swallow Turbulent airflow Harder to breath

    Possible to have
    High pitch noise from Compensate by 
    difficulty in eating and
    breathing frequent breathing
    drinking

    Shortness of breath

    Stridor
    (RR = 36x/min)

    Lack of oxygen input

    General appearance:

    Severely Ill

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