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Mid-transverse colon up
Hindgut Hypogastric Region
to rectum
II. ACUTE ABDOMINAL PAIN Pyelonephritis, Renal stone, Ovarian
▪ Usually self-limiting, however, initial assessment torsion/cyst, PID
should focus on severity and whether there is a
potential surgical cause of abdominal pain. Cystitis, Bladder anomalies, Sigmoid
Hypogastrium
▪ In children presenting in the ER with acute abdominal volvulus, PID
pain, the incidence of appendicitis or other cause
Left Lower UPJ obstruction, Pyelonephritis, Renal
needing surgical intervention ranges from 10-30%.
Quadrant stone, Ovarian torsion/cyst, PID
• However, in general, the incidence of surgical acute
abdominal pain is 2%. CAUSES OF ACUTE ABDOMINAL PAIN:
• Emergent cause
A.DIFFERENTIAL DIAGNOSIS OF ACUTE ABDOMINAL
Surgical in nature
PAIN BY PREDOMINANT AGE Located intra-abdominally or extra-abdominally
▪ Understanding the pathophysiology of abdominal pain Can be acute or chronic
helps in the differential diagnosis. • Non-emergent cause
▪ Good history and PE helps narrow it down.
• In taking the history of the patient, always know the
III. CHARACTERISTICS OF ABDOMINAL
age.
PAIN
Differential diagnosis of acute abdominal pain by
predominant age Organic causes based on regional location
Age Differential Diagnosis Pain Characteristic
Appendicitis (common cause of acute • Perforation
abdominal pain), Bowel obstruction, Child • Torsion-twisted bowel
Sudden
All Ages abuse, Constipation, Gastroenteritis, HUS, • Intussusception (apparently well child
Onset
Mesenteric adenitis, Pancreatitis, Sickle suddenly crying)
cell crisis, Trauma, URTI, UTI • Ectopic pregnancy
Hirschsprung disease, Infantile colic, • Appendicitis: dull, periumbilical to RLQ
0-4 yo Inguinal hernia, Intussusception, Lactose • Pancreatitis: steady pain slowly increasing in
intolerance, Malrotation, Volvulus Slow
character localizing in epigastric area, then
Onset
Abdominal migraine, Functional pain, HSP, radiating to the back
5-11 yo
Intussusception, Lead poisoning • Cholecystitis
Colicky
Ectopic pregnancy, Functional pain, IBD, Pain
12-18 yo • From: Intestines, biliary tree, pancreatic
IBS, Dysmenorrhea, Mittelschmerz, PID (Organs
with duct, uterus, fallopian tube
lumen, • Usually intermittent
B. ORGANIC CAUSES BASED ON REGIONAL tubular
LOCATION structures)
Organic causes based on regional location • Sickle cell anemia
Regional • IBD (Inflammatory Bowel Disease)
Organic Causes Severe
Location
Chronic • Cystic Fibrosis
Right Upper PUD, Cholecystitis, Cholangitis, Pain • Does not move, lie still, and usually
Quadrant Cholelithiasis, Pneumonia persistent
Vital Signs
• BP 100/60 Doc’s Case on Nov 28, 2019
• CR 117
• RR 21 L.J.L., 16/F, ILOILO CITY
• Temp 39.2°C
Laboratory Studies
General Survey
• Arrives at ER ambulatory but limping, in pain, CBC
not in CP distress • Hemoglobin 122 g/L
• Hematocrit 0.36 L/L
HEENT • WBC 13.02 10^9 /L
• Slightly pale conjunctivae, PERRLA o Segmenters 0.70
• Dry lips and buccal mucosa, anicteric sclerae o Lymphocyte 0.25
o Eosinophil 0.00
Chest o Monocyte 0.05
• Symmetric chest expansion, CBS • Platelet count 232 10^9 /L
Heart Urinalysis
• Regular rhythm but tachycardic • Specific gravity 1.025
• No murmur • Pus cells 3-5
• RBC 0-5
Abdomen • Squamous epithelial cells many
• Slightly distended, hypoactive bowel sounds
• (+) direct tenderness on all quadrants IMAGING STUDIES
• (+) rebound tenderness right and left lower ▪ Radiographs
quadrants 2 abdominal views – if you want to rule out
possible surgical etiology
Pelvic Exam
• IE: admits 2 fingers with ease, cervix firm o Cross table lateral – if child cannot stand up
close with wriggling tenderness, no vaginal o Upright supine view – if child can stand up
discharge Chest X-ray if indicated
• Uterus small, adnexa not fully assessed due ▪ Sonograms, if indicated
to guarding ▪ CT scans, if indicated
Rectal Exam
• Soft stools palpated on rectal vault KEY RECOMMENDATIONS FOR PRACTICE
• (+) para-rectal tenderness Key recommendations for practice
Evidence
Clinical Recommendation
Extremities Rating
• Grossly normal extremities Urinalysis, CBC, pregnancy test, and erythrocyte
sedimentation rate or C-reactive protein should be the C
• Full pulses
initial laboratory tests in the evaluation of acute
• CRT <2 sec abdominal pain in children
Patients
Pediatric Appendicitis Score
Score
Anorexia 1 1
Nausea/Emesis 1 1
Fever 1 1
Migration of pain 1 1
Tenderness in the RLQ 2 2
Cough/Percussion/Hop
2 2
Tenderness
Leukocytosis 1 1
Neutrophilia 1 0
Total 10 9
Clinical Manifestations
ACID PEPTIC DISEASE Clinical manifestations of Acid Peptic
▪ Umbrella Term that refers to the following disorders: Disease
Reflux esophagitis (GERD)
Y2 B11 M1 L3 | Acute & Chronic Abdominal Pain in Pediatric Patients 6 | 13
Infants/Young Children School Age/Adolescents ▪ Urea breath test
▪ Feeding difficulty ▪ Epigastric Pain/Nausea The 13C-UBT is a reliable non-invasive test to
▪ Crying ▪ Nocturnal pain determine whether H. pylori has been eradicated.
▪ Vomiting ▪ Dyspepsia/Fullness Not standardized in young patient
To determine responsiveness to treatment
Hematemesis/Melena
Not for diagnosis
o Patient drinks a solution of urea labeled with
Diagnosis the nonradioactive isotope 13C and then blows
in the tube.
o If H. pylori urease is present, the urea is
hydrolyzed, and the labeled carbon dioxide is
detected in breath samples (Harrison’s IM,
20th Ed.)
▪ Stool antigen test
A 2-step monoclocal stool H. pylori antigen test
can be used to determine whether H. pylori has
Upper GI Series (left) and Upper GI Endoscopy (right)
been eradicated.
Polyclonal stool antigen – cannot be used as a
screening test due to low sensitivity; only used to
▪ Upper GI series will require the child to be sedated
establish the diagnosis.
▪ Endoscopy readily visualizes ulcers
▪ Endoscopic test
The diagnosis of H. pylori infection should be
CAUSES OF ACID PEPTIC DISEASE based on either:
▪ Primary: Helicobacter pylori infection o Positive culture
▪ Secondary: o H. pylori gastritis on histopathology
NSAID and other drug use o With at least 1 other positive biopsy-based test
Stress ulcerations o Giemsa stain can be used
EPIDEMIOLOGY
▪ Philippine study
15.4% abdominal pain related FGID
o 8.4% dyspepsia
o 5.6% IBS
Acid Peptic Disease algorithm. o 1.3% childhood functional abdominal pain
▪ Therapeutic trial is not done in very young patients
DIFFERENTIAL DIAGNOSIS BIOPSYCHOSOCIAL CONCEPTUAL MODEL
▪ Inflammatory Bowel Disease (Crohn’s Disease and
Ulcerative Colitis) – chronic inflammation of the bowel
IBD PRESENTATION
Crohn’s disease vs Ulcerative colitis
Signs/Symptoms Crohn’s Disease Ulcerative Colitis
Rectal Bleeding ++ ++++
Abdominal pain ++++ +++
Diarrhea ++ ++++
Weight loss ++++ ++
Growth failure +++ +
Perianal disease ++
Mouth ulcers ++ + A biopsychosocial approach to understanding the
Erythema nodosum + + development of chronic abdominal pain.
Fevers ++ +
Anemia +++ +++ ▪ The child really has abdominal pain but the way the
Arthritis + + child perceives the abdominal pain is affected by a lot
of factors
DIAGNOSTIC APPROACH TO IBD If there is an imbalance of good and bad bacteria
▪ Suspect the diagnosis where the bad bacteria predominate, there will be
History, exam, CBC, ESR, CRP, albumin abdominal pain.
▪ Exclude other etiology ▪ If the child is stressed or the pain threshold is very low,
Stool culture, C. difficile, TB skin test simple stretching of the intestine will cause him a lot
▪ Classify disease of pain compared to a child who can eat a lot that
Upper endoscopy, colonoscopy would lead to the stretching of the intestine but will not
▪ Identify extra-intestinal manifestations cause him pain.
Liver function tests, joint, skin, eye exams Please see Appendix B for Biopsychosocial Conceptual
Model.
SUMMARY
▪ Three characteristics of pain are classified as Visceral,
Somatic and Referred Pain
▪ Posturing, inability to walk is the usual sign of
abdominal pain.
▪ Pain characteristics are sudden onset, slow onset,
colicky pain and severe chronic pain.
▪ Acute abdominal pain is self-limiting, initial REVIEW QUESTIONS
assessment should focus on severity and whether 1. If pain manifested at the epigastric region, what is
there is a potential surgical cause of abdominal pain. the most probable embryonic derivative involved?
A. Foregut
▪ Chronic Abdominal Pain is recurrent and long lasting.
B. Midgut
▪ Acid Peptic disease is and umbrella term for GERD,
C. Hindgut
Gastritis, PUD and Duodenitis
D. None of the above
APPENDIX C