Nucles Pic Substitubion Keach'ors “OQ ov! ® ene" “Q) sn @ Arse’ @ so ~ ® GN @ sw! : - ‘@ sn" @& ss* ee SN” (Nucle ophile Sa6ah) tehow ) oN Se Ai mofecalar T Ge 7 , : (192) to a Kon 2, | es fe t oe ED. 36 A5 Nae AN, > D “a ae : Trans) Gor @ State (6t*) Cm yeachion PragrenCharec revises anh eS ot G tt is ere Shep recchen proceed vis TS ov Rate B Sn x / Steric himelyance $ R-x 0 RN QQ kete int x [bueshrate ) [2] a OF ples 2” oydey bineh'es 3 Callet sn ® @ Moleeatarify 22 ® walden inversion Ctmversion of bot) takes place in swt pate Rumverr wh s and 5s orverl inte & conyiurshe only Ushan The prievity sh ly ont attac ing N& is seme acc. fe CE Sequence Rule. @ mre 1s we Learreng cmenk , becouse YO jatermediofe is formed. —) . . @ alfack from back site oF ly in Sa Si he @ Generally nucleo pa ily ot ne driving ec" sa* a factors waice affect sw pes ee @ wet of bubs le @ stet of y OQ hee ve G) ter sf Server™Some tramples cf sn> it y a Naow noe WF @ ee a7 -5 T & 5 Be r—| | 4% , * at" a 2 @ nee 7 vw y wT ne 4 @ wa Se (WES) aon ‘ KE/Nse JASE ; « —" D> eet" GD war , Acetone r+" GD\_%3 5 vt"G3) Suanre Remeron (reece ben) Sta ag w Asf cn -% Ceo mae as c4- F DME Qe oa irs “le shh Wty £7007 OC oere™ ola cotl prFr » au Sf, pT" cw [~7 ae 8 2 se @ orb &2) 4 te ia eee “s S% ert © “bs —~ tte 9 prs 2 oor jeEinkelSbeln Reach'on ie 4 oF IS also halogen exchange pix NS veachon eR NG in Atebone — Xo-br ve a -F i da not give sn! 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SN © Racems hou The move Stable Pex >uRer > ver? <7 a&) eHet laevi Ger: Role t sn hk leaving Fevelenag t'y Note —— Poor lg daNeT jwe cn! ava SN* © Etech o€ nucleophile So a we nO favour so strong SB ferme Su @ Ettect of solvent a Polav prone Solve WE aaa sn! es) _, sv! + Polar Rpwhc Solvent paveur su () (PAS) > sw™ Nace in Ho (ers) a w hoy od on no Gg O~ ° ; “ ~% NS “ Gy CN w / P~ ww art * /7™ a aol Solveliot Solvet cahion Ani or Nucleo Pwhe ty dec ress“ * PPS molecules have anht -& t chive +S Charge 7, They cau Colveke cahon aS well 46 @Ai%,on He ofthe. bord mele cules of PAS Acs only effechve ]@s cherge | lo PAS melecules Solvete Cahors and vapel Gnion, de jncrestes nucleo pails’ eh +t NY ‘cleopaile. 2/9) NACN 24 DMSO = (Pas) > we Noe" ex me So n@ 7s C me CN ¢ eg a 6 u me” ae me7 me Nucleophilre ty in PPS _ case - 2 aft nucleophile akon 15 —_— Same or me longs to Same period ” | order et basicty a nvcizoth boaty — 1s fame — Then Wich, a LL Shae lihy Basiahy ov nou cleo pM4 Besidhy : —_— The Tendeney fo ae vale The pur £€ Elechars fo we js catted GBasidty —__ a nucleophi li aA _—_—_— The Tenclen to Ao nate . “I ate Mhe par of elechons te otter Than HO is jaied wu cleo park o4 = oy FE 2, 25 CAMS for + yeh — C=" o~ puis &7S2 oase yeshon ev “> ¢ @® ve, Xs to ° oem aie © acta ophile es Compare ~ peapuih ie or basi Wy” S rey 6 @) 0-4-4 > OM D FFT oO oS S @) 7 Ne? a> (XY oO e (62) cu? ctNucleophi¥ic atom belong § bo hiperert period golvenen L, Duclos praliey f paich in (ees cose D — size T, Compare nNuc(2o , writ ree Tecee he” : oo , _ a lange 2 - effe a — hv @ density volume t © ep glvahoe +t yu » less pouc epics, S > F> 08> 9 xy Pp L te Ga) Se Ss . C “) (225) Oh su Cin ers) Case D _ Ss ve chevgef ne js mere nwelen philic —_—_ Than its corres porting vet we So o @) ou > H7°>u Gs» up > ny eS a @p oe Rey GD gine > RAL ‘SHO? u-tny Te > aSrucoe Lone por Con fun Gal cert alon jncressed Rucleopr lah Cwpeve poecleope! lie ty ce a ye > Ww ~* GS we, 4s es Ree he tae 2 & RSS, ROO Dy — wee > NK 4 nue feopl: lich, PAS vacleopraliaty x / Steet, Sherie Windrence ply ieportee Noke : ~vle be dete meen UT ey cam-2 > of* Corder G ) Nucleo: < ordey a ” aesicly ay a* ise prory! pnite) Nuaclesphi!* &) Nore LDA C thu OF nor aces Swory Bese es see LteHect of Str’ ' 3° R-* — 3 Alky| holate a — a BP Alkyl holate y ex ——— nN” Cy by = _____» $3” * I’ Al Key | hobile wt es Mam 'yore cevisir Wryourds do ner give sag sn eee G ) cane we 0" ae no sa’ a-€ -f is Poor IZ carbor chad Ys se x % onl © sa nr ae!) wnsrs a or St alc os chef fo Se% coe noe a snl & sw wo sw! (3) He CL no su” xK hm an! (ore) sn Gack sit no te & vt pesste) pan’ vo) x ne an! 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