Free Drug distributed to site of action or some stored, then its metabolized (break down

into smaller particles) and goes for action work (to function as medicine)

Lipophilic – lipid soluble drugs.

Pro drug has to be consumed and metabolized first to become another substance (after
broken down by metabolism) to take action as medication!

Hepatic is liver!

Not all drugs can be converted to hydrophilic in phase I itself.. So the adamant drugs will
undergo phase II to become so.!